KR102453078B1 - 진피 및 섬유증성 적응증에서의 rna 간섭 - Google Patents
진피 및 섬유증성 적응증에서의 rna 간섭 Download PDFInfo
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- KR102453078B1 KR102453078B1 KR1020217003374A KR20217003374A KR102453078B1 KR 102453078 B1 KR102453078 B1 KR 102453078B1 KR 1020217003374 A KR1020217003374 A KR 1020217003374A KR 20217003374 A KR20217003374 A KR 20217003374A KR 102453078 B1 KR102453078 B1 KR 102453078B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/351—Conjugate
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
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- C12N2320/00—Applications; Uses
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- C12N2320/32—Special delivery means, e.g. tissue-specific
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content
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- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
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- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31725210P | 2010-03-24 | 2010-03-24 | |
| US61/317,252 | 2010-03-24 | ||
| US31763310P | 2010-03-25 | 2010-03-25 | |
| US61/317,633 | 2010-03-25 | ||
| PCT/US2011/029867 WO2011119887A1 (en) | 2010-03-24 | 2011-03-24 | Rna interference in dermal and fibrotic indications |
| KR1020187010905A KR20180044433A (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187010905A Division KR20180044433A (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20210014780A KR20210014780A (ko) | 2021-02-09 |
| KR102453078B1 true KR102453078B1 (ko) | 2022-10-11 |
Family
ID=44673640
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217003374A Active KR102453078B1 (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
| KR1020187010905A Ceased KR20180044433A (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
| KR1020127027579A Expired - Fee Related KR101852210B1 (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187010905A Ceased KR20180044433A (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
| KR1020127027579A Expired - Fee Related KR101852210B1 (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9340786B2 (https=) |
| EP (2) | EP3560503B1 (https=) |
| JP (4) | JP6060071B2 (https=) |
| KR (3) | KR102453078B1 (https=) |
| CN (3) | CN110042099A (https=) |
| AU (3) | AU2011232365A1 (https=) |
| BR (1) | BR112012024049A2 (https=) |
| CA (1) | CA2794189C (https=) |
| IL (1) | IL265674B2 (https=) |
| WO (1) | WO2011119887A1 (https=) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2715289C (en) | 2008-02-11 | 2019-12-24 | Rxi Pharmaceuticals Corporation | Modified rnai polynucleotides and uses thereof |
| EP2342340A1 (en) | 2008-09-22 | 2011-07-13 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| WO2010059226A2 (en) | 2008-11-19 | 2010-05-27 | Rxi Pharmaceuticals Corporation | Inhibition of map4k4 through rnai |
| WO2010078536A1 (en) | 2009-01-05 | 2010-07-08 | Rxi Pharmaceuticals Corporation | Inhibition of pcsk9 through rnai |
| US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| EP3494790A1 (en) | 2010-03-02 | 2019-06-12 | Phio Pharmaceuticals Corp. | Effective sensitizing dose of a gelled immunomodulating topical composition |
| EP3560503B1 (en) | 2010-03-24 | 2021-11-17 | Phio Pharmaceuticals Corp. | Rna interference in dermal and fibrotic indications |
| RU2615143C2 (ru) | 2010-03-24 | 2017-04-04 | Адвирна | Самодоставляющие PHKi соединения уменьшенного размера |
| CN103200945B (zh) | 2010-03-24 | 2016-07-06 | 雷克西制药公司 | 眼部症候中的rna干扰 |
| AR083445A1 (es) | 2010-10-14 | 2013-02-27 | Univ Mie | siARN CONTRA LA FIBROSIS |
| AU2015261583C1 (en) * | 2010-10-14 | 2017-07-06 | Mie University | Preventative or therapeutic agent for fibrosis |
| US8802839B2 (en) * | 2011-07-15 | 2014-08-12 | Fibrogen, Inc. | Connective tissue growth factor antisense oligonucleotides |
| CA3018046A1 (en) * | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2013177478A2 (en) * | 2012-05-24 | 2013-11-28 | Glaxosmithkline Intellectual Property (No.2) Limited | Treatment method |
| EP2927320B1 (en) * | 2012-11-29 | 2019-09-04 | Gifu University | Rna interference agent, method for producing same, and use thereof |
| US10077446B2 (en) * | 2013-06-25 | 2018-09-18 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Glucan-encapsulated siRNA for treating type 2 diabetes mellitus |
| CN110592082A (zh) * | 2013-07-05 | 2019-12-20 | 柏业公司 | 呼吸疾病相关基因特异性siRNA、含有siRNA的双螺旋寡RNA结构及其用途 |
| CN106061488B (zh) | 2013-12-02 | 2021-04-09 | 菲奥医药公司 | 癌症的免疫治疗 |
| CN105960265A (zh) * | 2013-12-04 | 2016-09-21 | 阿克赛医药公司 | 利用经化学修饰的寡核苷酸处理伤口愈合的方法 |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックmiRNAおよびその用途 |
| CN106068324B (zh) | 2013-12-27 | 2020-12-29 | 株式会社博纳克 | 控制基因表达的人工匹配型miRNA及其用途 |
| CN103933579A (zh) * | 2014-04-03 | 2014-07-23 | 华侨大学 | 一种阳离子脂质体及其制备方法和应用 |
| WO2015168108A2 (en) | 2014-04-28 | 2015-11-05 | Rxi Pharmaceuticals Corporation | Methods for treating cancer using nucleic targeting mdm2 or mycn |
| US10900039B2 (en) | 2014-09-05 | 2021-01-26 | Phio Pharmaceuticals Corp. | Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1 |
| US20180263925A1 (en) * | 2014-12-03 | 2018-09-20 | Rxi Pharmaceuticals Corporation | Methods for the treatment of alopecia areata utilizing gene modulation approaches |
| EP3235906B1 (en) * | 2014-12-15 | 2021-06-23 | Bonac Corporation | Single-stranded nucleic acid molecule for inhibiting tgf- beta 1 expression |
| EP3234134B1 (en) | 2014-12-17 | 2020-05-27 | ProQR Therapeutics II B.V. | Targeted rna editing |
| KR20170098914A (ko) | 2014-12-27 | 2017-08-30 | 가부시키가이샤 보낙 | 유전자 발현 제어를 위한 천연형 miRNA 및 그의 용도 |
| WO2016158809A1 (ja) * | 2015-03-27 | 2016-10-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| US20160319278A1 (en) | 2015-04-03 | 2016-11-03 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| EP3862005A1 (en) | 2015-07-06 | 2021-08-11 | Phio Pharmaceuticals Corp. | Nucleic acid molecules targeting superoxide dismutase 1 (sod1) |
| US10808247B2 (en) | 2015-07-06 | 2020-10-20 | Phio Pharmaceuticals Corp. | Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach |
| WO2017030973A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| WO2017070151A1 (en) | 2015-10-19 | 2017-04-27 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering nucleic acid compounds targeting long non-coding rna |
| SG11201803410RA (en) * | 2015-10-30 | 2018-05-30 | Bonac Corp | COMPOSITION STABLY CONTAINING SINGLE-STRANDED NUCLEIC ACID MOLECULE THAT SUPPRESSES EXPRESSION OF TGF-ß1 GENE |
| US10478503B2 (en) | 2016-01-31 | 2019-11-19 | University Of Massachusetts | Branched oligonucleotides |
| JP7049262B2 (ja) | 2016-04-11 | 2022-04-06 | オリックス ファーマシューティカルズ,インコーポレーテッド | 結合組織成長因子を標的とするrna複合体を用いた特発性肺胞線維症の治療 |
| WO2017220751A1 (en) | 2016-06-22 | 2017-12-28 | Proqr Therapeutics Ii B.V. | Single-stranded rna-editing oligonucleotides |
| CA3033368A1 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| US11246905B2 (en) | 2016-08-15 | 2022-02-15 | President And Fellows Of Harvard College | Treating infections using IdsD from Proteus mirabilis |
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