KR102422625B1 - 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝 - Google Patents

유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝 Download PDF

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KR102422625B1
KR102422625B1 KR1020187012992A KR20187012992A KR102422625B1 KR 102422625 B1 KR102422625 B1 KR 102422625B1 KR 1020187012992 A KR1020187012992 A KR 1020187012992A KR 20187012992 A KR20187012992 A KR 20187012992A KR 102422625 B1 KR102422625 B1 KR 102422625B1
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polynucleic acid
acid polymer
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KR20180098528A (ko
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이고르 보레코브스키
자나 크랄로비코바
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유니버시티 오브 사우스앰톤
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Priority claimed from GB1614744.9A external-priority patent/GB2559100A/en
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KR1020187012992A 2015-10-09 2016-10-07 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝 Active KR102422625B1 (ko)

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KR1020227024328A KR20220105174A (ko) 2015-10-09 2016-10-07 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝

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Application Number Priority Date Filing Date Title
GB1517937.7 2015-10-09
GB1517937.7A GB2546719B (en) 2015-10-09 2015-10-09 Modulation of gene expression and screening for deregulated protein expression
GB1614744.9 2016-08-31
GB1614744.9A GB2559100A (en) 2016-08-31 2016-08-31 Modulation of gene expression and screening for deregulated protein expression
PCT/GB2016/053136 WO2017060731A1 (en) 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression

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KR20180098528A KR20180098528A (ko) 2018-09-04
KR102422625B1 true KR102422625B1 (ko) 2022-07-20

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KR1020227024328A Pending KR20220105174A (ko) 2015-10-09 2016-10-07 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝

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US (4) US10196639B2 (cg-RX-API-DMAC7.html)
EP (1) EP3359685A1 (cg-RX-API-DMAC7.html)
JP (3) JP6923517B2 (cg-RX-API-DMAC7.html)
KR (2) KR102422625B1 (cg-RX-API-DMAC7.html)
CN (1) CN108603230A (cg-RX-API-DMAC7.html)
AU (3) AU2016334804B2 (cg-RX-API-DMAC7.html)
CA (1) CA3000971A1 (cg-RX-API-DMAC7.html)
IL (2) IL308174A (cg-RX-API-DMAC7.html)
SG (1) SG11201802870RA (cg-RX-API-DMAC7.html)
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CN107109411B (zh) 2014-10-03 2022-07-01 冷泉港实验室 核基因输出的定向增加
KR102422625B1 (ko) 2015-10-09 2022-07-20 유니버시티 오브 사우스앰톤 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝
US11096956B2 (en) 2015-12-14 2021-08-24 Stoke Therapeutics, Inc. Antisense oligomers and uses thereof
KR102604132B1 (ko) 2015-12-14 2023-11-17 콜드스프링하버러보러토리 상염색체 우성 정신 지체 5 및 드라베 증후군의 치료를 위한 안티센스 올리고머
IL272413B (en) 2017-08-04 2022-09-01 Skyhawk Therapeutics Inc Methods and compositions for modulating splicing
CN111278991B (zh) 2017-08-25 2022-04-01 斯托克制药公司 用于治疗病况和疾病的反义寡聚体
CN112334157A (zh) * 2018-04-17 2021-02-05 应用干细胞有限公司 治疗脊髓肌萎缩症的组合物和方法
US12060558B2 (en) 2018-05-04 2024-08-13 Stoke Therapeutics, Inc. Methods and compositions for treatment of cholesteryl ester storage disease
US20230158110A1 (en) 2018-05-30 2023-05-25 The Regents Of The University Of California Gene editing of monogenic disorders in human hematopoietic stem cells -- correction of x-linked hyper-igm syndrome (xhim)
CN114007613A (zh) 2019-02-05 2022-02-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
EP3920928A4 (en) 2019-02-06 2022-09-28 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATION OF SPLICING
US11129829B2 (en) * 2019-06-17 2021-09-28 Skyhawk Therapeutics, Inc. Methods for modulating splicing
WO2021034985A1 (en) * 2019-08-19 2021-02-25 Stoke Therapeutics, Inc. Compositions and methods for modulating splicing and protein expression
AU2021218807A1 (en) * 2020-02-12 2022-09-15 The Children's Hospital Of Philadelphia Compositions and methods for inducible alternative splicing regulation of gene expression
CN111349649B (zh) * 2020-03-16 2020-11-17 三峡大学 一种用于双孢蘑菇的基因编辑的方法及应用
CN115867657A (zh) 2020-05-11 2023-03-28 斯托克制药公司 用于治疗疾患和疾病的opa1反义寡聚物
WO2022162020A2 (en) * 2021-01-26 2022-08-04 Syddansk Universitet Splice switching oligonucleotides targeting pseudoexons
CN112908470B (zh) * 2021-02-08 2023-10-03 深圳市人民医院 一种基于rna结合蛋白基因的肝细胞癌预后评分系统及其应用
EP4469572A1 (en) * 2022-01-26 2024-12-04 Syddansk Universitet Allele specific splice switching oligonucleotides targeting pseudoexons
CN119424374A (zh) * 2024-11-14 2025-02-14 中国药科大学 一种具有细菌靶向性的岩藻多糖改良复合物及其制备方法和应用

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