CA3000971A1 - Modulation of gene expression and screening for deregulated protein expression - Google Patents

Modulation of gene expression and screening for deregulated protein expression Download PDF

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Publication number
CA3000971A1
CA3000971A1 CA3000971A CA3000971A CA3000971A1 CA 3000971 A1 CA3000971 A1 CA 3000971A1 CA 3000971 A CA3000971 A CA 3000971A CA 3000971 A CA3000971 A CA 3000971A CA 3000971 A1 CA3000971 A1 CA 3000971A1
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nse
atm
acid polymer
polynucleic acid
subject
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CA3000971A
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English (en)
French (fr)
Inventor
Igor Vorechovsky
Jana KRALOVICOVA
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University of Southampton
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University of Southampton
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Priority claimed from GB1517937.7A external-priority patent/GB2546719B/en
Priority claimed from GB1614744.9A external-priority patent/GB2559100A/en
Application filed by University of Southampton filed Critical University of Southampton
Publication of CA3000971A1 publication Critical patent/CA3000971A1/en
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
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CA3000971A 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression Pending CA3000971A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1517937.7 2015-10-09
GB1517937.7A GB2546719B (en) 2015-10-09 2015-10-09 Modulation of gene expression and screening for deregulated protein expression
GB1614744.9 2016-08-31
GB1614744.9A GB2559100A (en) 2016-08-31 2016-08-31 Modulation of gene expression and screening for deregulated protein expression
PCT/GB2016/053136 WO2017060731A1 (en) 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression

Publications (1)

Publication Number Publication Date
CA3000971A1 true CA3000971A1 (en) 2017-04-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3000971A Pending CA3000971A1 (en) 2015-10-09 2016-10-07 Modulation of gene expression and screening for deregulated protein expression

Country Status (10)

Country Link
US (4) US10196639B2 (cg-RX-API-DMAC7.html)
EP (1) EP3359685A1 (cg-RX-API-DMAC7.html)
JP (3) JP6923517B2 (cg-RX-API-DMAC7.html)
KR (2) KR102422625B1 (cg-RX-API-DMAC7.html)
CN (1) CN108603230A (cg-RX-API-DMAC7.html)
AU (3) AU2016334804B2 (cg-RX-API-DMAC7.html)
CA (1) CA3000971A1 (cg-RX-API-DMAC7.html)
IL (2) IL308174A (cg-RX-API-DMAC7.html)
SG (1) SG11201802870RA (cg-RX-API-DMAC7.html)
WO (1) WO2017060731A1 (cg-RX-API-DMAC7.html)

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CN107109411B (zh) 2014-10-03 2022-07-01 冷泉港实验室 核基因输出的定向增加
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US20230158110A1 (en) 2018-05-30 2023-05-25 The Regents Of The University Of California Gene editing of monogenic disorders in human hematopoietic stem cells -- correction of x-linked hyper-igm syndrome (xhim)
CN114007613A (zh) 2019-02-05 2022-02-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
EP3920928A4 (en) 2019-02-06 2022-09-28 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATION OF SPLICING
US11129829B2 (en) * 2019-06-17 2021-09-28 Skyhawk Therapeutics, Inc. Methods for modulating splicing
WO2021034985A1 (en) * 2019-08-19 2021-02-25 Stoke Therapeutics, Inc. Compositions and methods for modulating splicing and protein expression
AU2021218807A1 (en) * 2020-02-12 2022-09-15 The Children's Hospital Of Philadelphia Compositions and methods for inducible alternative splicing regulation of gene expression
CN111349649B (zh) * 2020-03-16 2020-11-17 三峡大学 一种用于双孢蘑菇的基因编辑的方法及应用
CN115867657A (zh) 2020-05-11 2023-03-28 斯托克制药公司 用于治疗疾患和疾病的opa1反义寡聚物
WO2022162020A2 (en) * 2021-01-26 2022-08-04 Syddansk Universitet Splice switching oligonucleotides targeting pseudoexons
CN112908470B (zh) * 2021-02-08 2023-10-03 深圳市人民医院 一种基于rna结合蛋白基因的肝细胞癌预后评分系统及其应用
EP4469572A1 (en) * 2022-01-26 2024-12-04 Syddansk Universitet Allele specific splice switching oligonucleotides targeting pseudoexons
CN119424374A (zh) * 2024-11-14 2025-02-14 中国药科大学 一种具有细菌靶向性的岩藻多糖改良复合物及其制备方法和应用

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