KR101731739B1 - (2z,5z)-5-(3-클로로-4-((r)-2,3-디하이드록시프로폭시)벤질리덴)-2-(프로필이미노)-3-(o-톨릴)티아졸리딘-4-온의 제조 방법 및 그 방법에 사용되는 중간체 - Google Patents
(2z,5z)-5-(3-클로로-4-((r)-2,3-디하이드록시프로폭시)벤질리덴)-2-(프로필이미노)-3-(o-톨릴)티아졸리딘-4-온의 제조 방법 및 그 방법에 사용되는 중간체 Download PDFInfo
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- KR101731739B1 KR101731739B1 KR1020157006474A KR20157006474A KR101731739B1 KR 101731739 B1 KR101731739 B1 KR 101731739B1 KR 1020157006474 A KR1020157006474 A KR 1020157006474A KR 20157006474 A KR20157006474 A KR 20157006474A KR 101731739 B1 KR101731739 B1 KR 101731739B1
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- Prior art keywords
- iii
- chloro
- viii
- dihydroxypropoxy
- xxi
- Prior art date
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- 0 Cc1ccccc1N(C(SC1=Cc(cc2Cl)ccc2OCCCO)=*)C1=O Chemical compound Cc1ccccc1N(C(SC1=Cc(cc2Cl)ccc2OCCCO)=*)C1=O 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/77—Preparation of chelates of aldehydes or ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12180920.6 | 2012-08-17 | ||
EP12180920 | 2012-08-17 | ||
PCT/IB2013/056662 WO2014027330A1 (en) | 2012-08-17 | 2013-08-15 | Process for the preparation of|(2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-|(o-tolyl)thiazolidin-4-one and intermediate used in said process |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20150042277A KR20150042277A (ko) | 2015-04-20 |
KR101731739B1 true KR101731739B1 (ko) | 2017-05-11 |
Family
ID=46940231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020157006474A KR101731739B1 (ko) | 2012-08-17 | 2013-08-15 | (2z,5z)-5-(3-클로로-4-((r)-2,3-디하이드록시프로폭시)벤질리덴)-2-(프로필이미노)-3-(o-톨릴)티아졸리딘-4-온의 제조 방법 및 그 방법에 사용되는 중간체 |
Country Status (20)
Country | Link |
---|---|
US (1) | US9340518B2 (zh) |
EP (1) | EP2885266B1 (zh) |
JP (2) | JP6322630B2 (zh) |
KR (1) | KR101731739B1 (zh) |
CN (1) | CN104540800B (zh) |
CA (1) | CA2895172C (zh) |
CY (1) | CY1123300T1 (zh) |
DK (1) | DK2885266T3 (zh) |
ES (1) | ES2795105T3 (zh) |
HR (1) | HRP20200883T1 (zh) |
HU (1) | HUE050733T2 (zh) |
IL (1) | IL237198A (zh) |
LT (1) | LT2885266T (zh) |
MX (1) | MX350891B (zh) |
PL (1) | PL2885266T3 (zh) |
PT (1) | PT2885266T (zh) |
RS (1) | RS60408B1 (zh) |
SI (1) | SI2885266T1 (zh) |
TW (1) | TWI606036B (zh) |
WO (1) | WO2014027330A1 (zh) |
Families Citing this family (16)
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SI2278960T2 (sl) | 2008-03-17 | 2020-02-28 | Actelion Pharmaceuticals Ltd. | Režim odmerjanja za selektivni agonist receptorja sip1 |
RS60408B1 (sr) * | 2012-08-17 | 2020-07-31 | Actelion Pharmaceuticals Ltd | Postupak za pripremanje (2z,5z)-5-(3-hloro-4-((r)-2,3-dihidroksipropoksi)benziliden)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona i međujedinjenja upotrebljena u pomenutom postupku |
MA41139A (fr) | 2014-12-11 | 2017-10-17 | Actelion Pharmaceuticals Ltd | Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1 |
WO2016091996A1 (en) | 2014-12-11 | 2016-06-16 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective s1p1 receptor agonist |
CA3009713A1 (en) * | 2015-12-25 | 2017-06-29 | Crystal Pharmatech Co., Ltd. | Crystalline forms of ponesimod and preparation method thereof |
JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
US11220488B2 (en) | 2017-09-19 | 2022-01-11 | Teva Pharmaceuticals International Gmbh | Crystalline polymorph of Ponesimod |
US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
KR102365655B1 (ko) | 2018-11-29 | 2022-02-22 | 원광대학교 산학협력단 | 콩 발효 추출물을 유효성분으로 포함하는 피부 주름 예방 또는 개선용 조성물 |
MX2022005014A (es) | 2019-10-31 | 2022-05-16 | Idorsia Pharmaceuticals Ltd | Combinacion de un antagonista de cxcr7 con un modulador del receptor s1p1. |
WO2023022896A1 (en) | 2021-08-17 | 2023-02-23 | Teva Czech Industries S.R.O | Polymorphs of ponesimod |
EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
WO2023152691A1 (en) * | 2022-02-10 | 2023-08-17 | Metrochem Api Pvt Ltd | Process for the preparation of ponesimod and its intermediates thereof |
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SI2278960T2 (sl) | 2008-03-17 | 2020-02-28 | Actelion Pharmaceuticals Ltd. | Režim odmerjanja za selektivni agonist receptorja sip1 |
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RS60408B1 (sr) * | 2012-08-17 | 2020-07-31 | Actelion Pharmaceuticals Ltd | Postupak za pripremanje (2z,5z)-5-(3-hloro-4-((r)-2,3-dihidroksipropoksi)benziliden)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona i međujedinjenja upotrebljena u pomenutom postupku |
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2013
- 2013-08-15 RS RS20200642A patent/RS60408B1/sr unknown
- 2013-08-15 SI SI201331742T patent/SI2885266T1/sl unknown
- 2013-08-15 PL PL13779378T patent/PL2885266T3/pl unknown
- 2013-08-15 ES ES13779378T patent/ES2795105T3/es active Active
- 2013-08-15 CA CA2895172A patent/CA2895172C/en active Active
- 2013-08-15 CN CN201380042658.2A patent/CN104540800B/zh active Active
- 2013-08-15 PT PT137793782T patent/PT2885266T/pt unknown
- 2013-08-15 WO PCT/IB2013/056662 patent/WO2014027330A1/en active Application Filing
- 2013-08-15 KR KR1020157006474A patent/KR101731739B1/ko active IP Right Grant
- 2013-08-15 JP JP2015527061A patent/JP6322630B2/ja active Active
- 2013-08-15 DK DK13779378.2T patent/DK2885266T3/da active
- 2013-08-15 LT LTEP13779378.2T patent/LT2885266T/lt unknown
- 2013-08-15 HU HUE13779378A patent/HUE050733T2/hu unknown
- 2013-08-15 MX MX2015002127A patent/MX350891B/es active IP Right Grant
- 2013-08-15 US US14/422,167 patent/US9340518B2/en active Active
- 2013-08-15 EP EP13779378.2A patent/EP2885266B1/en active Active
- 2013-08-16 TW TW102129570A patent/TWI606036B/zh active
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2015
- 2015-02-12 IL IL237198A patent/IL237198A/en active IP Right Grant
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2017
- 2017-04-13 JP JP2017079804A patent/JP6424250B2/ja active Active
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2020
- 2020-06-02 HR HRP20200883TT patent/HRP20200883T1/hr unknown
- 2020-06-11 CY CY20201100532T patent/CY1123300T1/el unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007511563A (ja) * | 2003-11-21 | 2007-05-10 | アクテリオン ファマシューティカルズ リミテッド | 新規チアゾリジン−4−オン誘導体 |
JP2008546758A (ja) | 2005-06-24 | 2008-12-25 | アクテリオン ファーマシューティカルズ リミテッド | 新規チオフェン誘導体 |
WO2010065760A1 (en) | 2008-12-04 | 2010-06-10 | Exelixis, Inc. | Imidazo [1,2a] pyridine derivatives, their use as s1p1 agonists and methods for their production |
Non-Patent Citations (1)
Title |
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J. Med. Chem., Vol.53, pp.4198-4211 (2010)* |
Also Published As
Publication number | Publication date |
---|---|
CY1123300T1 (el) | 2021-12-31 |
IL237198A0 (en) | 2015-04-30 |
DK2885266T3 (da) | 2020-06-08 |
TWI606036B (zh) | 2017-11-21 |
JP2017160223A (ja) | 2017-09-14 |
US20150203459A1 (en) | 2015-07-23 |
WO2014027330A1 (en) | 2014-02-20 |
EP2885266B1 (en) | 2020-03-18 |
PT2885266T (pt) | 2020-05-29 |
JP6322630B2 (ja) | 2018-05-09 |
US9340518B2 (en) | 2016-05-17 |
MX350891B (es) | 2017-09-22 |
ES2795105T3 (es) | 2020-11-20 |
SI2885266T1 (sl) | 2020-10-30 |
PL2885266T3 (pl) | 2020-11-16 |
HRP20200883T1 (hr) | 2020-09-04 |
CA2895172A1 (en) | 2014-02-20 |
CN104540800A (zh) | 2015-04-22 |
EP2885266A1 (en) | 2015-06-24 |
MX2015002127A (es) | 2015-05-11 |
CN104540800B (zh) | 2017-05-10 |
JP2015530373A (ja) | 2015-10-15 |
TW201408634A (zh) | 2014-03-01 |
JP6424250B2 (ja) | 2018-11-14 |
LT2885266T (lt) | 2020-07-10 |
HUE050733T2 (hu) | 2021-01-28 |
RS60408B1 (sr) | 2020-07-31 |
IL237198A (en) | 2017-12-31 |
KR20150042277A (ko) | 2015-04-20 |
CA2895172C (en) | 2020-08-18 |
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