KR101116627B1 - 치료제로서 아릴 카르보닐 유도체 - Google Patents
치료제로서 아릴 카르보닐 유도체 Download PDFInfo
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- KR101116627B1 KR101116627B1 KR1020047021359A KR20047021359A KR101116627B1 KR 101116627 B1 KR101116627 B1 KR 101116627B1 KR 1020047021359 A KR1020047021359 A KR 1020047021359A KR 20047021359 A KR20047021359 A KR 20047021359A KR 101116627 B1 KR101116627 B1 KR 101116627B1
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- Prior art keywords
- delete delete
- alkyl
- alkylene
- aryl
- compound according
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- 0 CN(C)C(O*)=O Chemical compound CN(C)C(O*)=O 0.000 description 8
- DIUKWBUIAPFOCF-UHFFFAOYSA-N CC(C)C(c(cc(C)cc1)c1NC(Nc1ncc[s]1)=O)=O Chemical compound CC(C)C(c(cc(C)cc1)c1NC(Nc1ncc[s]1)=O)=O DIUKWBUIAPFOCF-UHFFFAOYSA-N 0.000 description 1
- TYEYGSDMIIXYSZ-UHFFFAOYSA-N CC(C)COc(cc(C)cc1)c1NC(Nc1nc(CC(NC)=O)c[s]1)=O Chemical compound CC(C)COc(cc(C)cc1)c1NC(Nc1nc(CC(NC)=O)c[s]1)=O TYEYGSDMIIXYSZ-UHFFFAOYSA-N 0.000 description 1
- ZBAQILIVDOLIHH-UHFFFAOYSA-N CC(C)COc(cc(C)cc1)c1NC(Nc1nc(CC(NCCOC)=O)c[s]1)=O Chemical compound CC(C)COc(cc(C)cc1)c1NC(Nc1nc(CC(NCCOC)=O)c[s]1)=O ZBAQILIVDOLIHH-UHFFFAOYSA-N 0.000 description 1
- LJAIEQYXXLUNMU-UHFFFAOYSA-N CC(C)COc(cc(C)cc1)c1NC(Nc1nc(CC(O)=O)c[s]1)=O Chemical compound CC(C)COc(cc(C)cc1)c1NC(Nc1nc(CC(O)=O)c[s]1)=O LJAIEQYXXLUNMU-UHFFFAOYSA-N 0.000 description 1
- KWPWCKALNAJKQK-UHFFFAOYSA-N CC(NCCS(c1cnc(NC(Nc(ccc(C)c2)c2C(C2CCCC2)=O)=O)[s]1)(=O)=O)=O Chemical compound CC(NCCS(c1cnc(NC(Nc(ccc(C)c2)c2C(C2CCCC2)=O)=O)[s]1)(=O)=O)=O KWPWCKALNAJKQK-UHFFFAOYSA-N 0.000 description 1
- ISXPKHFYSQLZCP-QGZVFWFLSA-N CC(N[C@H](CSc1cnc(NC(Nc(ccc(C)c2)c2C(C2CCCC2)=O)=O)[s]1)C(O)=O)=O Chemical compound CC(N[C@H](CSc1cnc(NC(Nc(ccc(C)c2)c2C(C2CCCC2)=O)=O)[s]1)C(O)=O)=O ISXPKHFYSQLZCP-QGZVFWFLSA-N 0.000 description 1
- BBYQSCNPTIHGNT-UHFFFAOYSA-N CCC1OC1N Chemical compound CCC1OC1N BBYQSCNPTIHGNT-UHFFFAOYSA-N 0.000 description 1
- GUWOYVNTSLYOQP-UHFFFAOYSA-N CCCN(CC1CC1)c(cc(C)cc1)c1NC(Nc1ncc[s]1)=O Chemical compound CCCN(CC1CC1)c(cc(C)cc1)c1NC(Nc1ncc[s]1)=O GUWOYVNTSLYOQP-UHFFFAOYSA-N 0.000 description 1
- DFYDFNQFADRJQO-UHFFFAOYSA-N CCOC(CCN1CCN(Cc2c[s]c(NC(Nc(ccc(C)c3)c3C(C3CCCC3)=O)=O)n2)CC1)=O Chemical compound CCOC(CCN1CCN(Cc2c[s]c(NC(Nc(ccc(C)c3)c3C(C3CCCC3)=O)=O)n2)CC1)=O DFYDFNQFADRJQO-UHFFFAOYSA-N 0.000 description 1
- OJONTSLQTUBFOD-UHFFFAOYSA-N CCOC(Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc([s]1)ncc1Cl)=O)=O Chemical compound CCOC(Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc([s]1)ncc1Cl)=O)=O OJONTSLQTUBFOD-UHFFFAOYSA-N 0.000 description 1
- JATGHEFWNRJKST-UHFFFAOYSA-N CCOC(Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2ncc[nH]2)[s]1)=O)=O Chemical compound CCOC(Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2ncc[nH]2)[s]1)=O)=O JATGHEFWNRJKST-UHFFFAOYSA-N 0.000 description 1
- BMFNCSQLFCQMIV-UHFFFAOYSA-N CCOC(Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2ncccc2)[s]1)=O)=O Chemical compound CCOC(Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2ncccc2)[s]1)=O)=O BMFNCSQLFCQMIV-UHFFFAOYSA-N 0.000 description 1
- LLLNUAZVDXVWFH-UHFFFAOYSA-N CCOC(Cc1c[s]c(NC(Nc(ccc(Br)c2)c2C(C2CCCC2)=O)=O)n1)=O Chemical compound CCOC(Cc1c[s]c(NC(Nc(ccc(Br)c2)c2C(C2CCCC2)=O)=O)n1)=O LLLNUAZVDXVWFH-UHFFFAOYSA-N 0.000 description 1
- UUMNVXDCIHZJMS-UHFFFAOYSA-N CCOC(c1c(C)nc(NC(Nc(cc(cc2)F)c2Oc(c(OC)ccc2)c2F)=O)[s]1)=O Chemical compound CCOC(c1c(C)nc(NC(Nc(cc(cc2)F)c2Oc(c(OC)ccc2)c2F)=O)[s]1)=O UUMNVXDCIHZJMS-UHFFFAOYSA-N 0.000 description 1
- OXMXNBOOKVHTMK-UHFFFAOYSA-N CCOC(c1c[nH]c(S(Cc2c[s]c(NC(Nc(ccc(C)c3)c3C(C3CCCC3)=O)=O)n2)(=O)=O)n1)=O Chemical compound CCOC(c1c[nH]c(S(Cc2c[s]c(NC(Nc(ccc(C)c3)c3C(C3CCCC3)=O)=O)n2)(=O)=O)n1)=O OXMXNBOOKVHTMK-UHFFFAOYSA-N 0.000 description 1
- SGWFYUIORYPMET-UHFFFAOYSA-N COC(CNC(Cc1c[s]c(NC(Nc2cc(F)ccc2Oc(c(OC)ccc2)c2F)=O)n1)=O)=O Chemical compound COC(CNC(Cc1c[s]c(NC(Nc2cc(F)ccc2Oc(c(OC)ccc2)c2F)=O)n1)=O)=O SGWFYUIORYPMET-UHFFFAOYSA-N 0.000 description 1
- MBWHVBMWTLWFTP-UHFFFAOYSA-N COc1cccc(Oc(c(NC(Nc2nc(C(NCC(O)=O)=O)c[s]2)=O)c2)ccc2F)c1OC Chemical compound COc1cccc(Oc(c(NC(Nc2nc(C(NCC(O)=O)=O)c[s]2)=O)c2)ccc2F)c1OC MBWHVBMWTLWFTP-UHFFFAOYSA-N 0.000 description 1
- JDBZEXFOMGYZMT-UHFFFAOYSA-N COc1cccc(Oc(cccc2)c2NC(Nc2ncc[s]2)=O)c1OC Chemical compound COc1cccc(Oc(cccc2)c2NC(Nc2ncc[s]2)=O)c1OC JDBZEXFOMGYZMT-UHFFFAOYSA-N 0.000 description 1
- ZYVBJBJLIITBHE-UHFFFAOYSA-N COc1cccc(Oc(nccc2)c2NC(Nc2ncc[s]2)=O)c1OC Chemical compound COc1cccc(Oc(nccc2)c2NC(Nc2ncc[s]2)=O)c1OC ZYVBJBJLIITBHE-UHFFFAOYSA-N 0.000 description 1
- YLVLTPVZBSVOEM-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc([s]1)ncc1S(CCC(O)=O)(=O)=O)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc([s]1)ncc1S(CCC(O)=O)(=O)=O)=O YLVLTPVZBSVOEM-UHFFFAOYSA-N 0.000 description 1
- DDYRCECLPLKLNM-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc([s]1)ncc1S(c1ncccn1)(=O)=O)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc([s]1)ncc1S(c1ncccn1)(=O)=O)=O DDYRCECLPLKLNM-UHFFFAOYSA-N 0.000 description 1
- DQORRNDNFKBYIL-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc([s]1)ncc1S(c1nnc[n]1C)(=O)=O)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc([s]1)ncc1S(c1nnc[n]1C)(=O)=O)=O DQORRNDNFKBYIL-UHFFFAOYSA-N 0.000 description 1
- FIPXANYEJBPRFW-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(C(O)=O)c[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(C(O)=O)c[s]1)=O FIPXANYEJBPRFW-UHFFFAOYSA-N 0.000 description 1
- QGXWFBUPENIQIC-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CC(N2CCOCC2)=O)c[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CC(N2CCOCC2)=O)c[s]1)=O QGXWFBUPENIQIC-UHFFFAOYSA-N 0.000 description 1
- BRRLXKQJYHWWPI-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CC(O)=O)c[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CC(O)=O)c[s]1)=O BRRLXKQJYHWWPI-UHFFFAOYSA-N 0.000 description 1
- JLGDRHCSGBXDAG-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CCNCCN2CCOCC2)c[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CCNCCN2CCOCC2)c[s]1)=O JLGDRHCSGBXDAG-UHFFFAOYSA-N 0.000 description 1
- KEOLVUJVBSRSAW-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CCSc2ccncc2)c[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CCSc2ccncc2)c[s]1)=O KEOLVUJVBSRSAW-UHFFFAOYSA-N 0.000 description 1
- VDKSHINTCBGBKD-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CNC(CNCC(OC)=O)=O)c[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CNC(CNCC(OC)=O)=O)c[s]1)=O VDKSHINTCBGBKD-UHFFFAOYSA-N 0.000 description 1
- QGGRZWWPFYADHB-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CNC(NCCN(C)C)=O)c[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CNC(NCCN(C)C)=O)c[s]1)=O QGGRZWWPFYADHB-UHFFFAOYSA-N 0.000 description 1
- PYRJDLIVPGPCDA-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CO)c[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1nc(CO)c[s]1)=O PYRJDLIVPGPCDA-UHFFFAOYSA-N 0.000 description 1
- MGFZBCYTHNJDSX-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2nc(C(O)=O)c[nH]2)[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2nc(C(O)=O)c[nH]2)[s]1)=O MGFZBCYTHNJDSX-UHFFFAOYSA-N 0.000 description 1
- HLRKNJHGPVJSTJ-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2ncccc2)[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2ncccc2)[s]1)=O HLRKNJHGPVJSTJ-UHFFFAOYSA-N 0.000 description 1
- LOXJWQRZKCMSMU-UHFFFAOYSA-N Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2ncccc2C(O)=O)[s]1)=O Chemical compound Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2ncccc2C(O)=O)[s]1)=O LOXJWQRZKCMSMU-UHFFFAOYSA-N 0.000 description 1
- BAGAEWAKPDIVMX-UHFFFAOYSA-N Cc(cc1)cc(N2CCCCC2)c1NC(Nc1ncc[s]1)=O Chemical compound Cc(cc1)cc(N2CCCCC2)c1NC(Nc1ncc[s]1)=O BAGAEWAKPDIVMX-UHFFFAOYSA-N 0.000 description 1
- BXACUCPMJJQGHS-UHFFFAOYSA-N Cc(cc1)cc(Oc(c(OC)ccc2)c2F)c1NC(Nc1nc(CC(O)=O)c[s]1)=O Chemical compound Cc(cc1)cc(Oc(c(OC)ccc2)c2F)c1NC(Nc1nc(CC(O)=O)c[s]1)=O BXACUCPMJJQGHS-UHFFFAOYSA-N 0.000 description 1
- YBILJGBQKWLOLO-UHFFFAOYSA-N Cc1c(C(O)=O)[s]c(NC(Nc(ccc(C)c2)c2C(C2CCCC2)=O)=O)n1 Chemical compound Cc1c(C(O)=O)[s]c(NC(Nc(ccc(C)c2)c2C(C2CCCC2)=O)=O)n1 YBILJGBQKWLOLO-UHFFFAOYSA-N 0.000 description 1
- GMECOZGLQWCIKK-UHFFFAOYSA-N Cc1c[s]c(NC(Nc(ccc(C)c2)c2C(C2CCCC2)=O)=O)n1 Chemical compound Cc1c[s]c(NC(Nc(ccc(C)c2)c2C(C2CCCC2)=O)=O)n1 GMECOZGLQWCIKK-UHFFFAOYSA-N 0.000 description 1
- VTMCQGAVGJAPSL-UHFFFAOYSA-N Cc1n[o]c(C)c1S(Nc(cc1NC(Nc2ncc[s]2)=O)ccc1Oc(c(OC)ccc1)c1F)(=O)=O Chemical compound Cc1n[o]c(C)c1S(Nc(cc1NC(Nc2ncc[s]2)=O)ccc1Oc(c(OC)ccc1)c1F)(=O)=O VTMCQGAVGJAPSL-UHFFFAOYSA-N 0.000 description 1
- UOVTZPXQITWDLV-UHFFFAOYSA-N O=C(C1CCCC1)c(c(NC(Nc([s]1)ncc1Br)=O)c1)ccc1F Chemical compound O=C(C1CCCC1)c(c(NC(Nc([s]1)ncc1Br)=O)c1)ccc1F UOVTZPXQITWDLV-UHFFFAOYSA-N 0.000 description 1
- AJUJWGPONPMDFE-UHFFFAOYSA-N O=C(Nc1ncc[s]1)Nc(cccc1)c1Oc1ccccc1 Chemical compound O=C(Nc1ncc[s]1)Nc(cccc1)c1Oc1ccccc1 AJUJWGPONPMDFE-UHFFFAOYSA-N 0.000 description 1
- FJZZKNZYDNTLJJ-UHFFFAOYSA-N O=C(Nc1ncc[s]1)Nc(cccc1)c1Sc1ccccc1 Chemical compound O=C(Nc1ncc[s]1)Nc(cccc1)c1Sc1ccccc1 FJZZKNZYDNTLJJ-UHFFFAOYSA-N 0.000 description 1
- BIBIDIFBENJSSO-UHFFFAOYSA-N O=C(Nc1ncc[s]1)Nc1cc(C(F)(F)F)ccc1Oc(cc1)ccc1Cl Chemical compound O=C(Nc1ncc[s]1)Nc1cc(C(F)(F)F)ccc1Oc(cc1)ccc1Cl BIBIDIFBENJSSO-UHFFFAOYSA-N 0.000 description 1
- DHOLLYDBPVPVJK-UHFFFAOYSA-N O=C(Nc1ncc[s]1)Nc1cc(F)ccc1Oc1c(C(F)(F)F)cccc1 Chemical compound O=C(Nc1ncc[s]1)Nc1cc(F)ccc1Oc1c(C(F)(F)F)cccc1 DHOLLYDBPVPVJK-UHFFFAOYSA-N 0.000 description 1
- CGBHRXASAOQRPX-UHFFFAOYSA-N O=C(Nc1ncc[s]1)Nc1cc(F)ccc1Oc1cc(cccc2)c2cc1 Chemical compound O=C(Nc1ncc[s]1)Nc1cc(F)ccc1Oc1cc(cccc2)c2cc1 CGBHRXASAOQRPX-UHFFFAOYSA-N 0.000 description 1
- BFYAZPUQCWKXDS-UHFFFAOYSA-N O=C(c1ccccc1)c(cccc1)c1NC(Nc1ncc[s]1)=O Chemical compound O=C(c1ccccc1)c(cccc1)c1NC(Nc1ncc[s]1)=O BFYAZPUQCWKXDS-UHFFFAOYSA-N 0.000 description 1
- FIPAKSYCDYEADC-UHFFFAOYSA-N OC(Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2ccccn2)[s]1)=O)=O Chemical compound OC(Cc(cc1)cc(C(C2CCCC2)=O)c1NC(Nc1ncc(Sc2ccccn2)[s]1)=O)=O FIPAKSYCDYEADC-UHFFFAOYSA-N 0.000 description 1
- FACDUVMTLVONRU-UHFFFAOYSA-N OC(Cc1c[s]c(NC(Nc(cccc2)c2C(C2CCCC2)=O)=O)n1)=O Chemical compound OC(Cc1c[s]c(NC(Nc(cccc2)c2C(C2CCCC2)=O)=O)n1)=O FACDUVMTLVONRU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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CA2488642A1 (en) | 2004-01-08 |
US8063081B2 (en) | 2011-11-22 |
JP2010265306A (ja) | 2010-11-25 |
USRE45670E1 (en) | 2015-09-15 |
CA2488642C (en) | 2011-09-06 |
JP2011168609A (ja) | 2011-09-01 |
US7897628B2 (en) | 2011-03-01 |
US7384967B2 (en) | 2008-06-10 |
AU2003243921B2 (en) | 2009-05-07 |
BR0312023A (pt) | 2005-03-22 |
KR20050019801A (ko) | 2005-03-03 |
NO20111028L (no) | 2005-03-29 |
US20080119455A1 (en) | 2008-05-22 |
JP2005537333A (ja) | 2005-12-08 |
AU2003243921A1 (en) | 2004-01-19 |
IL165532A (en) | 2013-06-27 |
US20040122235A1 (en) | 2004-06-24 |
EP1531815B1 (en) | 2014-09-24 |
JP4881559B2 (ja) | 2012-02-22 |
US20080119454A1 (en) | 2008-05-22 |
MXPA05000130A (es) | 2005-02-17 |
US20110301158A1 (en) | 2011-12-08 |
WO2004002481A1 (en) | 2004-01-08 |
EP2471533A1 (en) | 2012-07-04 |
IL165532A0 (en) | 2006-01-15 |
CA2744893A1 (en) | 2004-01-08 |
PL374920A1 (en) | 2005-11-14 |
EP1531815A1 (en) | 2005-05-25 |
PL215132B1 (pl) | 2013-10-31 |
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