KR100659477B1 - 개선된 약물동태학적 성질을 가지는 변형된 키메라 폴리펩티드 - Google Patents

개선된 약물동태학적 성질을 가지는 변형된 키메라 폴리펩티드 Download PDF

Info

Publication number
KR100659477B1
KR100659477B1 KR1020017015839A KR20017015839A KR100659477B1 KR 100659477 B1 KR100659477 B1 KR 100659477B1 KR 1020017015839 A KR1020017015839 A KR 1020017015839A KR 20017015839 A KR20017015839 A KR 20017015839A KR 100659477 B1 KR100659477 B1 KR 100659477B1
Authority
KR
South Korea
Prior art keywords
flt1
delete delete
domain
fcδc1
vegf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020017015839A
Other languages
English (en)
Korean (ko)
Other versions
KR20020019070A (ko
Inventor
파파도퓨로스니콜라스제이.
데이비스사무엘
얀코퓨로스죠지디.
Original Assignee
리제네론 파라마큐티칼스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22480568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100659477(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 리제네론 파라마큐티칼스 인코포레이티드 filed Critical 리제네론 파라마큐티칼스 인코포레이티드
Publication of KR20020019070A publication Critical patent/KR20020019070A/ko
Application granted granted Critical
Publication of KR100659477B1 publication Critical patent/KR100659477B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
KR1020017015839A 1999-06-08 2000-05-23 개선된 약물동태학적 성질을 가지는 변형된 키메라 폴리펩티드 Expired - Lifetime KR100659477B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13813399P 1999-06-08 1999-06-08
US60/138,133 1999-06-08

Publications (2)

Publication Number Publication Date
KR20020019070A KR20020019070A (ko) 2002-03-09
KR100659477B1 true KR100659477B1 (ko) 2006-12-20

Family

ID=22480568

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017015839A Expired - Lifetime KR100659477B1 (ko) 1999-06-08 2000-05-23 개선된 약물동태학적 성질을 가지는 변형된 키메라 폴리펩티드

Country Status (32)

Country Link
EP (2) EP1183353B1 (enExample)
JP (2) JP4723140B2 (enExample)
KR (1) KR100659477B1 (enExample)
CN (3) CN100523187C (enExample)
AT (2) ATE293164T1 (enExample)
AU (2) AU779303B2 (enExample)
BE (1) BE2013C029I2 (enExample)
BR (2) BRPI0011407B8 (enExample)
CA (1) CA2376379C (enExample)
CY (2) CY1108883T1 (enExample)
CZ (2) CZ303656B6 (enExample)
DE (2) DE60041159D1 (enExample)
DK (2) DK1183353T3 (enExample)
ES (2) ES2319305T3 (enExample)
FR (1) FR13C0028I2 (enExample)
HR (1) HRP20010908B1 (enExample)
HU (3) HU229156B1 (enExample)
IL (3) IL146890A0 (enExample)
LT (1) LTC1183353I2 (enExample)
LU (1) LU92195I2 (enExample)
ME (2) MEP3208A (enExample)
MX (1) MXPA01012630A (enExample)
NO (4) NO330775B1 (enExample)
NZ (1) NZ515913A (enExample)
PL (1) PL208247B1 (enExample)
PT (2) PT1183353E (enExample)
RS (1) RS50073B (enExample)
RU (1) RU2265661C2 (enExample)
SK (1) SK287332B6 (enExample)
UA (1) UA74146C2 (enExample)
WO (1) WO2000075319A1 (enExample)
ZA (1) ZA200110068B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024029876A1 (ko) 2022-08-02 2024-02-08 주식회사 파노로스바이오사이언스 변형된 융합 단백질 및 이의 용도
WO2025033876A1 (ko) 2023-08-04 2025-02-13 주식회사 파노로스바이오사이언스 변형된 융합 단백질과 scFv의 결합체 및 이의 용도

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710174B2 (en) 2001-09-13 2004-03-23 Isis Pharmaceuticals, Inc. Antisense inhibition of vascular endothelial growth factor receptor-1 expression
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US7087411B2 (en) * 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US6833349B2 (en) * 1999-06-08 2004-12-21 Regeneron Pharmaceuticals, Inc. Methods of treating inflammatory skin diseases
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
CA2435503C (en) 2001-01-19 2011-02-22 Ludwig Institute For Cancer Research Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy
US6734017B2 (en) 2001-09-28 2004-05-11 Isis Pharmaceuticals, Inc. Antisense modulation of vascular endothelial growth factor receptor-2 expression
EP1575548B1 (en) 2002-05-04 2011-03-09 Acorda Therapeutics, Inc. Compositions and methods for promoting neuronal outgrowth
ATE354592T1 (de) * 2003-03-28 2007-03-15 Regeneron Pharma Vegf-antagonisten zur behandlung von diabetes
AU2004247025B8 (en) * 2003-05-16 2011-06-30 Acorda Therapeutics, Inc. Fusion proteins for the treatment of CNS
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
US7429375B2 (en) 2003-05-16 2008-09-30 Acorda Therapeutics, Inc. Proteoglycan degrading mutants for the treatment of CNS
MXPA05008973A (es) * 2003-05-28 2006-02-22 Regeneron Pharma Metodo de tratamiento de rechazo de trasplante de cornea.
US7186699B2 (en) 2003-06-03 2007-03-06 Cell Genesys, Inc. Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes
CA2519875C (en) * 2003-06-06 2014-01-14 Regeneron Pharmaceuticals, Inc. Method of tumor regression with vegf inhibitors
US7399612B2 (en) 2003-06-30 2008-07-15 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
AR046510A1 (es) * 2003-07-25 2005-12-14 Regeneron Pharma Composicion de un antagonista de vegf y un agente anti-proliferativo
US20050112061A1 (en) * 2003-08-06 2005-05-26 Jocelyn Holash Use of a VEGF antagonist in combination with radiation therapy
ES2411504T3 (es) 2004-05-18 2013-07-05 Acorda Therapeutics, Inc. Métodos de purificación de condroitinasa y formulaciones estables de la misma
PL1767546T3 (pl) * 2004-06-08 2012-07-31 Chengdu Kanghong Biotechnologies Co Ltd Hamujące angiogenezę białka chimeryczne i ich zastosowanie
CA2567686A1 (en) * 2004-06-10 2005-12-29 Regeneron Pharmaceuticals, Inc. Use of vegf inhibitors for the treatment of human cancer
CN1968709A (zh) * 2004-06-18 2007-05-23 瑞泽恩制药公司 用于治疗恶性胸腔积液的vegf抑制剂
AU2005267741A1 (en) 2004-07-30 2006-02-09 Regeneron Pharmaceuticals, Inc. Methods of treating type I diabetes by blocking VEGF-mediated activity
CN101094688B (zh) 2004-09-13 2013-05-01 建新公司 多聚构建体
FR2878749B1 (fr) * 2004-12-03 2007-12-21 Aventis Pharma Sa Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives
EP1877438A2 (en) 2005-02-02 2008-01-16 Regeneron Pharmaceuticals, Inc. Method of treating eye injury with local administration of a vegf inhibitor
HUE034109T2 (en) 2005-03-25 2018-01-29 Regeneron Pharma VEGF antagonist formulations
WO2007038548A2 (en) 2005-09-26 2007-04-05 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
DK1962895T3 (da) 2005-12-16 2013-03-04 Regeneron Pharma TERAPEUTISK ANVENDELSE AF EN Dll4-ANTAGONIST OG EN VEGF-HÆMMER TIL HÆMNING AF TUMORVÆKST
FR2895258B1 (fr) 2005-12-22 2008-03-21 Aventis Pharma Sa Combinaison comprenant de la combretastatine et des agents anticancereux
US8216575B2 (en) 2006-03-31 2012-07-10 Chengdu Kanghong Biotechnologies Co., Ltd. Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains
CN100502945C (zh) * 2006-03-31 2009-06-24 成都康弘生物科技有限公司 Vegf受体融合蛋白在治疗眼睛疾病中的应用
SI2944306T1 (sl) 2006-06-16 2021-04-30 Regeneron Pharmaceuticals, Inc. Formulacije antagonista VEGF, primerne za intravitrealno dajanje
HUE028379T2 (en) 2006-09-29 2016-12-28 Oncomed Pharm Inc Preparations and procedures for the diagnosis and treatment of cancer
EP2450442B1 (en) 2006-10-10 2017-07-19 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
FR2918279B1 (fr) * 2007-07-05 2010-10-22 Aventis Pharma Sa Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan
CN101575379B (zh) * 2008-05-09 2012-05-30 上海抗体药物国家工程研究中心有限公司 可溶性vegfr双功能融合受体、其制备方法及用途
MX359570B (es) 2008-11-03 2018-10-01 Molecular Partners Ag Proteinas de union que inhiben la interaccion en el receptor de vegf-a.
CN101838329A (zh) 2009-03-18 2010-09-22 嘉和生物药业有限公司 抗血管新生融合蛋白
US8883145B2 (en) 2009-10-16 2014-11-11 Oncomed Pharmaceuticals, Inc. Methods of treatment with DLL4 antagonists and an anti-hypertensive agent
AR081361A1 (es) 2010-04-30 2012-08-29 Molecular Partners Ag Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a
HRP20180154T1 (hr) 2010-08-06 2018-03-09 Genzyme Corporation Pripravci vegf antagonista i njihova uporaba
EP2662385A4 (en) * 2011-01-07 2015-11-11 Chugai Pharmaceutical Co Ltd METHOD FOR IMPROVING THE PHYSICAL PROPERTIES OF ANTIBODIES
CN103533950A (zh) 2011-01-13 2014-01-22 瑞泽恩制药公司 Vegf拮抗剂在治疗血管生成眼病中的用途
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
KR101397088B1 (ko) 2011-06-10 2014-05-19 강원대학교산학협력단 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물
JO3370B1 (ar) * 2011-11-10 2019-03-13 Regeneron Pharma طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
JP6138815B2 (ja) 2011-12-01 2017-05-31 エーピー バイオサイエンシーズ, インコーポレイテッド 補体経路およびvegf経路に対するタンパク質インヒビターおよびそれらの使用方法
CN103304668B (zh) * 2012-03-12 2015-10-28 江苏健德生物药业有限公司 Ultra-VEGF-trap免疫融合蛋白、其制备方法及其应用
PL2846836T3 (pl) 2012-05-07 2020-01-31 Allergan, Inc. Sposób leczenia amd u pacjentów opornych na terapię anty- vegf
WO2014006113A1 (en) 2012-07-03 2014-01-09 Sanofi Method of treating cancer by effective amounts of aflibercept
AR093445A1 (es) 2012-11-14 2015-06-10 Regeneron Pharma Metodos para tratar el cancer de ovario con antagonistas de dll4
MY199344A (en) 2013-02-18 2023-10-24 Vegenics Pty Ltd Ligand binding molecules and uses thereof
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
CN104193828B (zh) * 2013-09-12 2017-04-05 北京韩美药品有限公司 同时阻断her2和vegfr信号通路的重组融合蛋白
EP3628324A1 (en) 2013-11-05 2020-04-01 Allergan, Inc. Method of treating conditions of the eye with an anti-vegf darpin
RU2702748C2 (ru) 2014-05-12 2019-10-11 Формикон Аг Предварительно заполненный пластиковый шприц, содержащий антагонист vegf
WO2016008975A1 (en) 2014-07-18 2016-01-21 Sanofi Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer
JP2016036322A (ja) * 2014-08-11 2016-03-22 日本化薬株式会社 血管新生因子と結合するキメラタンパク質
HUE057653T2 (hu) 2014-12-11 2022-05-28 Bayer Healthcare Llc Kis aktív choroidális neurovaszkularizáció lézióval jellemzett idõskori makuladegeneráció kezelése
GB201503453D0 (en) 2015-03-01 2015-04-15 Jain Arjun Endothelin-1"sponge"
TWI870789B (zh) 2015-08-04 2025-01-21 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
WO2017046140A1 (en) 2015-09-18 2017-03-23 Bayer Pharma Aktiengesellschaft Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia
WO2017065559A1 (ko) 2015-10-15 2017-04-20 (주)알테오젠 Igg fc 도메인을 가지는 융합 단백질의 생산방법
KR101936049B1 (ko) * 2015-10-15 2019-01-08 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 생산방법
WO2018218013A2 (en) 2017-05-24 2018-11-29 Sio2 Medical Products, Inc. Sterilizable pharmaceutical package for ophthalmic formulations
RU2734958C2 (ru) 2015-11-18 2020-10-26 Формикон Аг Предварительно заполненная фармацевтическая упаковка, содержащая жидкий состав на основе антагониста vegf
WO2017085253A1 (en) 2015-11-18 2017-05-26 Formycon Ag Pre-filled plastic syringe containing a vegf antagonist
AU2016356717B2 (en) 2015-11-18 2022-09-29 Sio2 Medical Products, Inc. Pharmaceutical package for ophthalmic formulations
CN108697792A (zh) * 2015-11-19 2018-10-23 珠海泰瑞尚生物医药科技有限公司 用于结合vegf的方法和组合物
PT3384049T (pt) 2015-12-03 2023-08-18 Regeneron Pharma Método de associação de variantes genéticas com um resultado clínico em doentes que sofrem de degeneração macular relacionada à idade tratados com anti-vegf
WO2017129685A1 (en) 2016-01-26 2017-08-03 Formycon Ag Liquid formulation of a vegf antagonist
US20190300607A1 (en) 2016-10-12 2019-10-03 Daiichi Sankyo Company, Limited Composition containing anti-robo4 antibody and other agents
CA3043487A1 (en) 2016-11-21 2018-05-24 Just-Evotec Biologics Inc Aflibercept formulations and uses thereof
EP3630043A1 (en) 2017-05-24 2020-04-08 Formycon AG Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
WO2018215580A1 (en) 2017-05-24 2018-11-29 Formycon Ag Method for sterilizing prefilled plastic syringes containing a vegf antagonist
TW201904610A (zh) 2017-06-14 2019-02-01 德商拜耳製藥公司 用於治療新生血管型青光眼之非抗體vegf拮抗劑
WO2019020777A1 (en) 2017-07-26 2019-01-31 Formycon Ag LIQUID FORMULATION OF A VEGF ANTAGONIST
ES2887046T3 (es) 2017-08-17 2021-12-21 Just Evotec Biologics Inc Método de purificación de proteína glicosilada a partir de galectinas de las células hospedadoras y otros contaminantes
WO2019099965A1 (en) 2017-11-20 2019-05-23 Just Biotherapeutics, Inc. Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof
ES2946747T3 (es) 2017-11-27 2023-07-25 4D Molecular Therapeutics Inc Variantes de cápsides de virus adenoasociado y su utilización para inhibir la angiogénesis
AU2018375398C1 (en) 2017-11-30 2026-01-15 Regeneron Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
US11460452B2 (en) * 2017-12-13 2022-10-04 Regeneron Pharmaceuticals, Inc. Devices and systems for chromatography column bed support management and related methods
EP3730126B1 (en) 2017-12-22 2025-05-14 Samsung Bioepis Co., Ltd. Liquid composition comprising vegf antagonist
US11524053B2 (en) * 2018-01-26 2022-12-13 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof
JP7235770B2 (ja) 2018-05-10 2023-03-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 高濃度vegf受容体融合タンパク質を含む製剤
TW202016125A (zh) * 2018-05-10 2020-05-01 美商再生元醫藥公司 用於定量及調節蛋白質黏度之系統與方法
US11519020B2 (en) 2018-05-25 2022-12-06 Regeneron Pharmaceuticals, Inc. Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF
CN111378044B (zh) 2018-12-28 2022-07-15 长春金赛药业有限责任公司 抗体融合蛋白、制备方法及其应用
US20220204920A1 (en) 2019-05-16 2022-06-30 Formycon Ag Method for reducing methionine oxidation in recombinant proteins
CA3150481A1 (en) 2019-09-03 2021-03-11 Amgen Inc. Injection device for drug delivery and packaging for the injection device
MX2022002980A (es) 2019-09-16 2022-04-06 Amgen Inc Metodo para la esterilizacion externa de un dispositivo de suministro de farmacos.
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
AU2020393842A1 (en) 2019-11-25 2022-06-16 The Regents Of The University Of California Long-acting VEGF inhibitors for intraocular neovascularization
KR20240007293A (ko) 2019-12-06 2024-01-16 리제너론 파아마슈티컬스, 인크. 항-vegf 단백질 조성물 및 이를 생산하는 방법
KR20220110555A (ko) 2019-12-06 2022-08-08 리제너론 파마슈티칼스 인코포레이티드 Vegf 미니-트랩 및 그의 사용 방법
CA3167020A1 (en) 2020-02-24 2021-09-02 Amgen Inc. Containers and systems for use during external sterilization of drug delivery devices
MX2022013812A (es) 2020-05-08 2022-12-15 Regeneron Pharma Trampas y mini-trampas de vegf y metodos para el tratamiento de trastornos oculares y cancer.
WO2022231930A1 (en) 2021-04-26 2022-11-03 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
EP4145456A1 (en) 2021-09-06 2023-03-08 Bayer AG Prediction of a change related to a macular fluid
WO2023092324A1 (zh) 2021-11-24 2023-06-01 苏州光度生物科技有限公司 多特异性配体结合分子及其应用
TW202412840A (zh) 2022-09-16 2024-04-01 大陸商齊魯製藥有限公司 一種穩定的高濃度自緩衝藥物組合物
WO2025213011A1 (en) 2024-04-05 2025-10-09 Amgen Inc. Method of assessing stopper movement in a drug delivery device

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506466D0 (en) * 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
US6100071A (en) * 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024029876A1 (ko) 2022-08-02 2024-02-08 주식회사 파노로스바이오사이언스 변형된 융합 단백질 및 이의 용도
WO2025033876A1 (ko) 2023-08-04 2025-02-13 주식회사 파노로스바이오사이언스 변형된 융합 단백질과 scFv의 결합체 및 이의 용도

Also Published As

Publication number Publication date
CA2376379A1 (en) 2000-12-14
YU86901A (sh) 2004-05-12
ES2319305T3 (es) 2009-05-06
CN1369009A (zh) 2002-09-11
HU229156B1 (en) 2013-09-30
DE60019415D1 (de) 2005-05-19
NO332559B1 (no) 2012-10-29
CN103349781A (zh) 2013-10-16
PL208247B1 (pl) 2011-04-29
ZA200110068B (en) 2002-12-06
IL190234A0 (en) 2008-11-03
FR13C0028I1 (fr) 2013-06-14
JP2011024595A (ja) 2011-02-10
NO2013010I2 (no) 2013-05-15
NO2013010I1 (no) 2013-06-17
NZ515913A (en) 2004-01-30
LTC1183353I2 (lt) 2023-02-27
HUS1300052I1 (hu) 2016-08-29
NO20016036D0 (no) 2001-12-10
ES2237429T3 (es) 2005-08-01
CN100523187C (zh) 2009-08-05
CZ302689B6 (cs) 2011-09-07
CA2376379C (en) 2007-08-07
HRP20010908A2 (en) 2005-04-30
IL146890A0 (en) 2002-08-14
PL352246A1 (en) 2003-08-11
CZ20014387A3 (cs) 2002-10-16
SK287332B6 (sk) 2010-07-07
NO20016036L (no) 2002-02-08
HK1185798A1 (en) 2014-02-28
LTPA2013009I1 (lt) 2013-06-25
DE60041159D1 (de) 2009-01-29
CN101433715B (zh) 2013-04-17
JP5273746B2 (ja) 2013-08-28
HK1043388A1 (en) 2002-09-13
PT1544299E (pt) 2009-03-18
AU2005201365B2 (en) 2007-08-09
DK1183353T3 (da) 2005-08-08
MXPA01012630A (es) 2002-07-22
BRPI0011407B8 (pt) 2021-05-25
MEP3208A (xx) 2010-02-10
HUP0201515A2 (en) 2002-08-28
UA74146C2 (uk) 2005-11-15
ATE293164T1 (de) 2005-04-15
DK1544299T3 (da) 2009-03-23
KR20020019070A (ko) 2002-03-09
FR13C0028I2 (fr) 2014-05-16
RU2265661C2 (ru) 2005-12-10
CY1108883T1 (el) 2014-07-02
JP2003501089A (ja) 2003-01-14
EP1183353B1 (en) 2005-04-13
HRP20010908B1 (en) 2006-05-31
HK1132653A1 (en) 2010-03-05
NO2022060I1 (no) 2022-12-21
NO20100656L (no) 2002-02-08
CY2013019I2 (el) 2015-11-04
EP1183353A1 (en) 2002-03-06
ATE417928T1 (de) 2009-01-15
HUP0201515A3 (en) 2004-12-28
AU779303B2 (en) 2005-01-13
CN103349781B (zh) 2015-04-01
BR0011407A (pt) 2002-04-02
SK17522001A3 (sk) 2003-04-01
PT1183353E (pt) 2005-06-30
EP1544299B1 (en) 2008-12-17
AU2005201365A1 (en) 2005-04-28
ME00024B (me) 2010-02-10
IL146890A (en) 2008-07-08
EP1544299A1 (en) 2005-06-22
LU92195I2 (fr) 2013-07-15
CZ303656B6 (cs) 2013-01-30
NO330775B1 (no) 2011-07-11
WO2000075319A1 (en) 2000-12-14
BRPI0011407B1 (pt) 2018-09-25
DE60019415T2 (de) 2006-03-09
RS50073B (sr) 2009-01-22
JP4723140B2 (ja) 2011-07-13
CY2013019I1 (el) 2015-11-04
HU230159B1 (hu) 2015-09-28
CN101433715A (zh) 2009-05-20
AU5040400A (en) 2000-12-28
BE2013C029I2 (enExample) 2019-03-06

Similar Documents

Publication Publication Date Title
EP1544299B1 (en) VEGF receptor chimeras for the treatment of eye disorders characterized by vascular permeability
US7704500B2 (en) Methods of inhibiting ascites formation with modified chimeric VEGF polypeptides
CA2588221C (en) Modified chimeric polypeptides with improved pharmacokinetic properties
HK1043388B (en) Modified chimeric polypeptides with improved pharmacokinetic properties

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20011208

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20050523

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20060424

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20061012

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20061213

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20061214

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20091202

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20091202

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20101130

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20101130

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20111128

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20111128

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20121127

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20121127

Start annual number: 7

End annual number: 7

A101 Application to extend term of patent right by permit
PA0101 Application to register extension of term of patent right by permit, etc.

Patent event date: 20130619

Patent event code: PA01011R01D

Comment text: Application to Register Extension of Term of Patent Right by Permit, etc.

FPAY Annual fee payment

Payment date: 20131126

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20131126

Start annual number: 8

End annual number: 8

A101 Application to extend term of patent right by permit
PA0101 Application to register extension of term of patent right by permit, etc.

Patent event date: 20140129

Patent event code: PA01011R01D

Comment text: Application to Register Extension of Term of Patent Right by Permit, etc.

FPAY Annual fee payment

Payment date: 20141125

Year of fee payment: 9

PR1001 Payment of annual fee

Payment date: 20141125

Start annual number: 9

End annual number: 9

G170 Re-publication after modification of scope of protection [patent]
PG1701 Publication of correction

Publication date: 20150107

FPAY Annual fee payment

Payment date: 20151201

Year of fee payment: 10

PR1001 Payment of annual fee

Payment date: 20151201

Start annual number: 10

End annual number: 10

FPAY Annual fee payment

Payment date: 20161201

Year of fee payment: 11

PR1001 Payment of annual fee

Payment date: 20161201

Start annual number: 11

End annual number: 11

FPAY Annual fee payment

Payment date: 20171211

Year of fee payment: 12

PR1001 Payment of annual fee

Payment date: 20171211

Start annual number: 12

End annual number: 12

FPAY Annual fee payment

Payment date: 20181130

Year of fee payment: 13

PR1001 Payment of annual fee

Payment date: 20181130

Start annual number: 13

End annual number: 13

FPAY Annual fee payment

Payment date: 20191202

Year of fee payment: 14

PR1001 Payment of annual fee

Payment date: 20191202

Start annual number: 14

End annual number: 14

FPAY Annual fee payment

Payment date: 20201201

Year of fee payment: 15

PR1001 Payment of annual fee

Payment date: 20201201

Start annual number: 15

End annual number: 15

FPAY Annual fee payment

Payment date: 20211122

Year of fee payment: 16

PR1001 Payment of annual fee

Payment date: 20211122

Start annual number: 16

End annual number: 16

FPAY Annual fee payment

Payment date: 20221123

Year of fee payment: 17

PR1001 Payment of annual fee

Payment date: 20221123

Start annual number: 17

End annual number: 17

J206 Request for trial to confirm the scope of a patent right
PJ0206 Trial to confirm the scope of a patent

Patent event code: PJ02062R01D

Patent event date: 20230302

Comment text: Request for Trial

Patent event code: PJ02061E01I

Patent event date: 20061213

Comment text: Registration of Establishment

Request date: 20230302

Appeal identifier: 2023100000983

Appeal kind category: Confirmation of the scope of right_affirmative

PR1001 Payment of annual fee

Payment date: 20231128

Start annual number: 18

End annual number: 18

PC1801 Expiration of term

Termination date: 20240709

Termination category: Expiration of duration

J301 Trial decision

Free format text: TRIAL NUMBER: 2023100000983; TRIAL DECISION FOR CONFIRMATION OF THE SCOPE OF RIGHT_AFFIRMATIVE REQUESTED 20230302

Effective date: 20240314

PJ1301 Trial decision

Patent event code: PJ13011S02D

Patent event date: 20240314

Comment text: Trial Decision for Confirmation of the Scope of a Right (Patent, Utility Model, Industrial Design)

Appeal kind category: Confirmation of the scope of right_affirmative

Request date: 20230302

Decision date: 20240314

Appeal identifier: 2023100000983