KR100504300B1 - Ｇａｂａ ａ 수용체 조절제로서의 벤조디아제핀 유도체 - Google Patents

Ｇａｂａ ａ 수용체 조절제로서의 벤조디아제핀 유도체 Download PDF

Info

Publication number
KR100504300B1
KR100504300B1 KR10-2003-7006609A KR20037006609A KR100504300B1 KR 100504300 B1 KR100504300 B1 KR 100504300B1 KR 20037006609 A KR20037006609 A KR 20037006609A KR 100504300 B1 KR100504300 B1 KR 100504300B1
Authority
KR
South Korea
Prior art keywords
triazolo
imidazo
benzodiazepine
ethyl
oxadiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR10-2003-7006609A
Other languages
English (en)
Korean (ko)
Other versions
KR20030045192A (ko
Inventor
마스시아드리라파엘로
토마스앤드류윌리엄
비크만주에르겐
Original Assignee
에프. 호프만-라 로슈 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR20030045192A publication Critical patent/KR20030045192A/ko
Application granted granted Critical
Publication of KR100504300B1 publication Critical patent/KR100504300B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR10-2003-7006609A 2000-11-16 2001-11-08 Ｇａｂａ ａ 수용체 조절제로서의 벤조디아제핀 유도체 Expired - Fee Related KR100504300B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00124332.8 2000-11-16
EP00124332 2000-11-16
PCT/EP2001/012887 WO2002040487A2 (en) 2000-11-16 2001-11-08 Benzodiazepine derivatives as gaba a receptor modulators

Publications (2)

Publication Number Publication Date
KR20030045192A KR20030045192A (ko) 2003-06-09
KR100504300B1 true KR100504300B1 (ko) 2005-07-28

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7006609A Expired - Fee Related KR100504300B1 (ko) 2000-11-16 2001-11-08 Ｇａｂａ ａ 수용체 조절제로서의 벤조디아제핀 유도체

Country Status (40)

Country Link
US (1) US6743789B2 (enExample)
EP (1) EP1337535B1 (enExample)
JP (1) JP4088151B2 (enExample)
KR (1) KR100504300B1 (enExample)
CN (1) CN1191255C (enExample)
AR (1) AR031345A1 (enExample)
AT (1) ATE268776T1 (enExample)
AU (2) AU2002217007B2 (enExample)
BG (1) BG107817A (enExample)
BR (1) BR0115393A (enExample)
CA (1) CA2427576C (enExample)
CZ (1) CZ295256B6 (enExample)
DE (1) DE60103776T2 (enExample)
DK (1) DK1337535T3 (enExample)
EC (1) ECSP034607A (enExample)
ES (1) ES2220831T3 (enExample)
GC (1) GC0000375A (enExample)
GT (1) GT200100230A (enExample)
HR (1) HRP20030360A2 (enExample)
HU (1) HUP0303281A3 (enExample)
IL (1) IL155813A0 (enExample)
JO (1) JO2359B1 (enExample)
MA (1) MA26962A1 (enExample)
MX (1) MXPA03004251A (enExample)
MY (1) MY141675A (enExample)
NO (1) NO324706B1 (enExample)
NZ (1) NZ525413A (enExample)
PA (1) PA8532401A1 (enExample)
PE (1) PE20020583A1 (enExample)
PL (1) PL362925A1 (enExample)
PT (1) PT1337535E (enExample)
RU (1) RU2278865C2 (enExample)
SI (1) SI1337535T1 (enExample)
SK (1) SK7232003A3 (enExample)
TR (1) TR200402073T4 (enExample)
TW (1) TWI239333B (enExample)
UY (1) UY27026A1 (enExample)
WO (1) WO2002040487A2 (enExample)
YU (1) YU35603A (enExample)
ZA (1) ZA200303435B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
JP4616770B2 (ja) * 2003-06-19 2011-01-19 第一三共株式会社 選択的なアミノ置換基導入法
ES2515092T3 (es) 2003-12-11 2014-10-29 Sunovion Pharmaceuticals Inc. Combinación de un sedante y un modulador neurotransmisor y métodos de mejorar la calidad del sueño y de tratar la depresión
AU2005272627A1 (en) 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
WO2006040038A1 (en) 2004-10-12 2006-04-20 F.Hoffmann-La Roche Ag Imidazo [1, 5-a]triazolo[1, 5-d]benzodiazepine derivatives for the treatment of cognitive disorders
JP4783375B2 (ja) 2004-10-20 2011-09-28 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジゼピン誘導体
CA2584757C (en) 2004-10-20 2012-07-03 F. Hoffmann-La Roche Ag Halogen substituted benzodiazepine derivatives
DE602005007265D1 (de) * 2004-12-14 2008-07-10 Hoffmann La Roche Tetrazyklische imidazobenzodiazepine als gaba-rezeptormodulatoren
WO2007019312A2 (en) * 2005-08-03 2007-02-15 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
JP4885967B2 (ja) * 2005-10-11 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジアゼピン誘導体
AU2006308889A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US9156836B2 (en) * 2008-05-16 2015-10-13 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate HSP90 activity
MX2011005119A (es) 2008-11-18 2011-05-30 Hoffmann La Roche Alquilciclohexileteres de dihidrotetraazabenzoazulenos.
JP5452608B2 (ja) * 2008-11-28 2014-03-26 エフ．ホフマン−ラ ロシュ アーゲー バソプレシン介在受容体アンタゴニストとしての使用のためのジヒドロテトラアザベンゾアズレンのアリールシクロヘキシルエーテル
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
DK2640391T3 (da) 2010-11-15 2016-02-15 Agenebio Inc Pyridazinderivater, sammensætninger og fremgangsmåder til behandling af kognitiv svækkelse
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2885148A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
EP4032889A1 (en) * 2013-12-20 2022-07-27 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MA42624A (fr) * 2015-06-19 2021-04-28 Agenebio Inc Dérivés de benzodiazépine, compositions et méthodes de traitement de la déficience cognitive
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
CN112601749B (zh) * 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (enExample) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
TWI239333B (en) 2005-09-11
PT1337535E (pt) 2004-09-30
MA26962A1 (fr) 2004-12-20
ES2220831T3 (es) 2004-12-16
AU2002217007B2 (en) 2006-11-30
YU35603A (sh) 2006-05-25
JO2359B1 (en) 2006-12-12
HUP0303281A3 (en) 2005-05-30
DE60103776T2 (de) 2005-07-14
PL362925A1 (en) 2004-11-02
MY141675A (en) 2010-06-15
GC0000375A (en) 2007-03-31
DE60103776D1 (de) 2004-07-15
WO2002040487A3 (en) 2002-09-26
GT200100230A (es) 2002-07-04
SI1337535T1 (en) 2004-10-31
RU2003116895A (ru) 2005-02-20
PA8532401A1 (es) 2002-08-26
AR031345A1 (es) 2003-09-17
ECSP034607A (es) 2003-06-25
JP2004517070A (ja) 2004-06-10
JP4088151B2 (ja) 2008-05-21
EP1337535A2 (en) 2003-08-27
NO20032208D0 (no) 2003-05-15
CZ20031597A3 (cs) 2003-11-12
HRP20030360A2 (en) 2005-04-30
HK1062442A1 (en) 2004-11-05
EP1337535B1 (en) 2004-06-09
ZA200303435B (en) 2004-08-05
BG107817A (bg) 2004-07-30
CA2427576C (en) 2007-11-06
BR0115393A (pt) 2004-07-06
ATE268776T1 (de) 2004-06-15
CA2427576A1 (en) 2002-05-23
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
HUP0303281A2 (hu) 2004-01-28
CN1474820A (zh) 2004-02-11
DK1337535T3 (da) 2004-10-25
US6743789B2 (en) 2004-06-01
UY27026A1 (es) 2002-06-20
NO20032208L (no) 2003-05-15
WO2002040487A2 (en) 2002-05-23
KR20030045192A (ko) 2003-06-09
CN1191255C (zh) 2005-03-02
CZ295256B6 (cs) 2005-06-15
MXPA03004251A (es) 2003-09-22
PE20020583A1 (es) 2002-07-06
US20020103371A1 (en) 2002-08-01
SK7232003A3 (en) 2004-03-02
RU2278865C2 (ru) 2006-06-27
NO324706B1 (no) 2007-12-03
AU1700702A (en) 2002-05-27
IL155813A0 (en) 2003-12-23

Similar Documents

Publication Publication Date Title
KR100504300B1 (ko) Ｇａｂａ ａ 수용체 조절제로서의 벤조디아제핀 유도체
AU2002217007A1 (en) Benzodiazepine derivatives as GABA A receptor modulators
KR100533406B1 (ko) Ｇａｂａ ａ 수용체 조절제로서의이미다조[1,5-ａ]피리미도[5,4-ｄ]벤즈아제핀 유도체
MC1355A1 (fr) Derives d'imidazodiazepine
MC1999A1 (fr) Composes tricycliques
CZ185092A3 (en) Imidazodiazepines
RO117698B1 (ro) Derivaţi de imidazodiazepină şi procedee de preparare a acestora
IL182697A (en) Benzodiazepine derivatives converted with halogen
JPH07116195B2 (ja) ベンゾジアゼピン誘導体、その製法、並びにそれを使用する中枢神経病治療剤
AU2005299032A1 (en) Imidazo-benzodiazepine derivatives
JP2008515941A (ja) 置換ベンゾジアゼピン誘導体
RU2107686C1 (ru) Производное 3-оксадиазолил-5,6,7,8-тетрагидро-1,6-нафтиридина и производное 5,6,7,8-тетрагидро-1,6-нафтиридина
JPH11279176A (ja) １，２，４−オキサジアゾリルキノロン誘導体
HK1116173A (en) Halogen substituted benzodiazepine derivatives

Legal Events

Date Code Title Description
A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

FPAY Annual fee payment

Payment date: 20090630

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20100721

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20100721

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000