CZ295256B6 - Benzodiazepinové deriváty jako modulátory receptoru GABA A - Google Patents

Benzodiazepinové deriváty jako modulátory receptoru GABA A Download PDF

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Publication number
CZ295256B6
CZ295256B6 CZ20031597A CZ20031597A CZ295256B6 CZ 295256 B6 CZ295256 B6 CZ 295256B6 CZ 20031597 A CZ20031597 A CZ 20031597A CZ 20031597 A CZ20031597 A CZ 20031597A CZ 295256 B6 CZ295256 B6 CZ 295256B6
Authority
CZ
Czechia
Prior art keywords
benzodiazepine
triazolo
imidazo
ethyl
carboxylate
Prior art date
Application number
CZ20031597A
Other languages
Czech (cs)
English (en)
Other versions
CZ20031597A3 (cs
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of CZ20031597A3 publication Critical patent/CZ20031597A3/cs
Publication of CZ295256B6 publication Critical patent/CZ295256B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CZ20031597A 2000-11-16 2001-11-08 Benzodiazepinové deriváty jako modulátory receptoru GABA A CZ295256B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16

Publications (2)

Publication Number Publication Date
CZ20031597A3 CZ20031597A3 (cs) 2003-11-12
CZ295256B6 true CZ295256B6 (cs) 2005-06-15

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20031597A CZ295256B6 (cs) 2000-11-16 2001-11-08 Benzodiazepinové deriváty jako modulátory receptoru GABA A

Country Status (40)

Country Link
US (1) US6743789B2 (enExample)
EP (1) EP1337535B1 (enExample)
JP (1) JP4088151B2 (enExample)
KR (1) KR100504300B1 (enExample)
CN (1) CN1191255C (enExample)
AR (1) AR031345A1 (enExample)
AT (1) ATE268776T1 (enExample)
AU (2) AU1700702A (enExample)
BG (1) BG107817A (enExample)
BR (1) BR0115393A (enExample)
CA (1) CA2427576C (enExample)
CZ (1) CZ295256B6 (enExample)
DE (1) DE60103776T2 (enExample)
DK (1) DK1337535T3 (enExample)
EC (1) ECSP034607A (enExample)
ES (1) ES2220831T3 (enExample)
GC (1) GC0000375A (enExample)
GT (1) GT200100230A (enExample)
HR (1) HRP20030360A2 (enExample)
HU (1) HUP0303281A3 (enExample)
IL (1) IL155813A0 (enExample)
JO (1) JO2359B1 (enExample)
MA (1) MA26962A1 (enExample)
MX (1) MXPA03004251A (enExample)
MY (1) MY141675A (enExample)
NO (1) NO324706B1 (enExample)
NZ (1) NZ525413A (enExample)
PA (1) PA8532401A1 (enExample)
PE (1) PE20020583A1 (enExample)
PL (1) PL362925A1 (enExample)
PT (1) PT1337535E (enExample)
RU (1) RU2278865C2 (enExample)
SI (1) SI1337535T1 (enExample)
SK (1) SK7232003A3 (enExample)
TR (1) TR200402073T4 (enExample)
TW (1) TWI239333B (enExample)
UY (1) UY27026A1 (enExample)
WO (1) WO2002040487A2 (enExample)
YU (1) YU35603A (enExample)
ZA (1) ZA200303435B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
US7626029B2 (en) * 2003-06-19 2009-12-01 Daiichi Pharmaceutical Co., Ltd. Method of selectively introducing amino substituent
PT1691811E (pt) 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
EP1784390A2 (en) 2004-08-13 2007-05-16 Amgen Inc. Substituted benzofused heterocycles
ATE402707T1 (de) 2004-10-12 2008-08-15 Hoffmann La Roche Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungen
NZ554439A (en) * 2004-10-20 2009-09-25 Hoffmann La Roche Imidazo-benzodiazepine derivatives
RU2007114763A (ru) * 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Галогенозамещенные производные бензодиазепинов
WO2006063708A1 (en) 2004-12-14 2006-06-22 F.Hoffmann-La Roche Ag Tetracyclic imidazo-benzodiazepines as gaba receptors modulators
EP1924712B1 (en) * 2005-08-03 2018-10-03 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
JP4885967B2 (ja) * 2005-10-11 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジアゼピン誘導体
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2009139916A1 (en) * 2008-05-16 2009-11-19 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate hsp90 activity
PE20110590A1 (es) 2008-11-18 2011-08-31 Hoffmann La Roche Alquilciclohexileteres de dihidrotetraazabenzoazulenos
BRPI0922303B1 (pt) * 2008-11-28 2019-11-12 Hoffmann La Roche arilciclo-hexiléteres de di-hidrotetra-azabenzoazulenos, seu processo de preparação, composição farmacêutica que os compreende e uso
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
AU2011328993B2 (en) 2010-11-15 2017-03-02 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2885148A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
EP4032889B1 (en) * 2013-12-20 2026-05-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3310785B1 (en) * 2015-06-19 2024-11-20 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
AU2019288382B2 (en) * 2018-06-19 2024-07-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
EP4572852A1 (en) 2022-08-19 2025-06-25 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (enExample) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
EP1337535A2 (en) 2003-08-27
DK1337535T3 (da) 2004-10-25
US6743789B2 (en) 2004-06-01
HK1062442A1 (en) 2004-11-05
ES2220831T3 (es) 2004-12-16
IL155813A0 (en) 2003-12-23
BR0115393A (pt) 2004-07-06
DE60103776D1 (de) 2004-07-15
HUP0303281A2 (hu) 2004-01-28
HRP20030360A2 (en) 2005-04-30
KR100504300B1 (ko) 2005-07-28
JO2359B1 (en) 2006-12-12
SK7232003A3 (en) 2004-03-02
EP1337535B1 (en) 2004-06-09
MA26962A1 (fr) 2004-12-20
NO324706B1 (no) 2007-12-03
CN1191255C (zh) 2005-03-02
DE60103776T2 (de) 2005-07-14
KR20030045192A (ko) 2003-06-09
HUP0303281A3 (en) 2005-05-30
YU35603A (sh) 2006-05-25
TWI239333B (en) 2005-09-11
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
GC0000375A (en) 2007-03-31
MXPA03004251A (es) 2003-09-22
WO2002040487A2 (en) 2002-05-23
JP2004517070A (ja) 2004-06-10
PT1337535E (pt) 2004-09-30
PL362925A1 (en) 2004-11-02
NO20032208L (no) 2003-05-15
ECSP034607A (es) 2003-06-25
AU2002217007B2 (en) 2006-11-30
US20020103371A1 (en) 2002-08-01
BG107817A (bg) 2004-07-30
NO20032208D0 (no) 2003-05-15
CA2427576A1 (en) 2002-05-23
CA2427576C (en) 2007-11-06
UY27026A1 (es) 2002-06-20
CN1474820A (zh) 2004-02-11
MY141675A (en) 2010-06-15
AR031345A1 (es) 2003-09-17
CZ20031597A3 (cs) 2003-11-12
PE20020583A1 (es) 2002-07-06
GT200100230A (es) 2002-07-04
PA8532401A1 (es) 2002-08-26
ATE268776T1 (de) 2004-06-15
RU2278865C2 (ru) 2006-06-27
AU1700702A (en) 2002-05-27
RU2003116895A (ru) 2005-02-20
WO2002040487A3 (en) 2002-09-26
JP4088151B2 (ja) 2008-05-21
SI1337535T1 (en) 2004-10-31
ZA200303435B (en) 2004-08-05

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Date Code Title Description
MM4A Patent lapsed due to non-payment of fee

Effective date: 20081108