CN1191255C - 作为gaba a受体调节剂的苯并二氮杂䓬衍生物 - Google Patents

作为gaba a受体调节剂的苯并二氮杂䓬衍生物 Download PDF

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Publication number
CN1191255C
CN1191255C CNB018189415A CN01818941A CN1191255C CN 1191255 C CN1191255 C CN 1191255C CN B018189415 A CNB018189415 A CN B018189415A CN 01818941 A CN01818941 A CN 01818941A CN 1191255 C CN1191255 C CN 1191255C
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China
Prior art keywords
benzodiazepine
imidazo
triazolo
cyclopropyl
compound
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB018189415A
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English (en)
Chinese (zh)
Other versions
CN1474820A (zh
Inventor
R·马夏德里
A·W·托马斯
J·维希曼
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN1474820A publication Critical patent/CN1474820A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB018189415A 2000-11-16 2001-11-08 作为gaba a受体调节剂的苯并二氮杂䓬衍生物 Expired - Fee Related CN1191255C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16
EP00124332.8 2000-11-16

Publications (2)

Publication Number Publication Date
CN1474820A CN1474820A (zh) 2004-02-11
CN1191255C true CN1191255C (zh) 2005-03-02

Family

ID=8170315

Family Applications (1)

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CNB018189415A Expired - Fee Related CN1191255C (zh) 2000-11-16 2001-11-08 作为gaba a受体调节剂的苯并二氮杂䓬衍生物

Country Status (40)

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US (1) US6743789B2 (enExample)
EP (1) EP1337535B1 (enExample)
JP (1) JP4088151B2 (enExample)
KR (1) KR100504300B1 (enExample)
CN (1) CN1191255C (enExample)
AR (1) AR031345A1 (enExample)
AT (1) ATE268776T1 (enExample)
AU (2) AU1700702A (enExample)
BG (1) BG107817A (enExample)
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WO (1) WO2002040487A2 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110382501A (zh) * 2016-12-19 2019-10-25 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
EP1634879A4 (en) * 2003-06-19 2007-09-05 Daiichi Seiyaku Co METHOD FOR THE SELECTIVE INTRODUCTION OF AN AMINO SUBSTITUENT
JP5646126B2 (ja) 2003-12-11 2014-12-24 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 鎮静剤と神経伝達物質調節剤の併用、および睡眠の質の向上方法および鬱の治療方法
WO2006020959A2 (en) 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
CA2581918A1 (en) * 2004-10-12 2006-04-20 Henner Knust Imidazo(1,5-a)triazolo(1,5-d) benzodiazepine deratives for the treatment of cognitive disorders
RU2007114763A (ru) * 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Галогенозамещенные производные бензодиазепинов
ES2399439T3 (es) * 2004-10-20 2013-04-01 F. Hoffmann-La Roche Ag Derivados de imidazo-benzodiazepina
BRPI0515800A (pt) * 2004-12-14 2008-08-05 Hoffmann La Roche imidazo-benzodiazepinas tetracìclicas como moduladores de receptores de gaba
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
EP1924712B1 (en) * 2005-08-03 2018-10-03 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
EP1937688B1 (en) 2005-10-11 2010-08-11 F. Hoffmann-La Roche AG Imidazo benzodiazepine derivatives
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US9156836B2 (en) * 2008-05-16 2015-10-13 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate HSP90 activity
KR101385433B1 (ko) * 2008-11-18 2014-04-14 에프. 호프만-라 로슈 아게 다이하이드로테트라아자벤조아줄렌의 알킬사이클로헥실에터
DK2370441T3 (da) * 2008-11-28 2013-10-21 Hoffmann La Roche Arylcyclohexylethere af dihydrotetraazabenzoazulener til anvendelse som vasopressin v1a-receptorantagonister
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
DK3034079T3 (en) 2010-11-15 2018-02-05 Agenebio Inc PYRIDAZINE DERIVATIVES, COMPOSITIONS AND PROCEDURES FOR TREATING COGNITIVE WEAKNESS
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014047413A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
CA3123897C (en) * 2013-12-20 2024-02-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN108026107B (zh) 2015-06-19 2021-07-30 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio Inc derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
WO2019246300A1 (en) 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
US20240132513A1 (en) 2022-08-19 2024-04-25 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (enExample) * 1991-06-17 1993-03-01 Hoffmann La Roche

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110382501A (zh) * 2016-12-19 2019-10-25 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
CN116640143A (zh) * 2016-12-19 2023-08-25 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法

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HRP20030360A2 (en) 2005-04-30
GC0000375A (en) 2007-03-31
PA8532401A1 (es) 2002-08-26
ATE268776T1 (de) 2004-06-15
KR20030045192A (ko) 2003-06-09
BR0115393A (pt) 2004-07-06
AU1700702A (en) 2002-05-27
HUP0303281A2 (hu) 2004-01-28
ECSP034607A (es) 2003-06-25
AR031345A1 (es) 2003-09-17
PT1337535E (pt) 2004-09-30
HK1062442A1 (en) 2004-11-05
WO2002040487A2 (en) 2002-05-23
IL155813A0 (en) 2003-12-23
SK7232003A3 (en) 2004-03-02
MA26962A1 (fr) 2004-12-20
JO2359B1 (en) 2006-12-12
SI1337535T1 (en) 2004-10-31
CZ20031597A3 (cs) 2003-11-12
ES2220831T3 (es) 2004-12-16
DE60103776D1 (de) 2004-07-15
CN1474820A (zh) 2004-02-11
JP4088151B2 (ja) 2008-05-21
RU2278865C2 (ru) 2006-06-27
HUP0303281A3 (en) 2005-05-30
JP2004517070A (ja) 2004-06-10
ZA200303435B (en) 2004-08-05
CZ295256B6 (cs) 2005-06-15
UY27026A1 (es) 2002-06-20
CA2427576A1 (en) 2002-05-23
MXPA03004251A (es) 2003-09-22
NO20032208L (no) 2003-05-15
CA2427576C (en) 2007-11-06
US20020103371A1 (en) 2002-08-01
DK1337535T3 (da) 2004-10-25
RU2003116895A (ru) 2005-02-20
PL362925A1 (en) 2004-11-02
NO324706B1 (no) 2007-12-03
EP1337535B1 (en) 2004-06-09
TWI239333B (en) 2005-09-11
AU2002217007B2 (en) 2006-11-30
PE20020583A1 (es) 2002-07-06
BG107817A (bg) 2004-07-30
WO2002040487A3 (en) 2002-09-26
DE60103776T2 (de) 2005-07-14
NO20032208D0 (no) 2003-05-15
MY141675A (en) 2010-06-15
EP1337535A2 (en) 2003-08-27
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
US6743789B2 (en) 2004-06-01
KR100504300B1 (ko) 2005-07-28
GT200100230A (es) 2002-07-04
YU35603A (sh) 2006-05-25

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