JP4088151B2 - Ｇａｂａａ受容体モデュレーターとしてのベンゾジアゼピン誘導体 - Google Patents

Ｇａｂａａ受容体モデュレーターとしてのベンゾジアゼピン誘導体 Download PDF

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Publication number
JP4088151B2
JP4088151B2 JP2002543495A JP2002543495A JP4088151B2 JP 4088151 B2 JP4088151 B2 JP 4088151B2 JP 2002543495 A JP2002543495 A JP 2002543495A JP 2002543495 A JP2002543495 A JP 2002543495A JP 4088151 B2 JP4088151 B2 JP 4088151B2
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Japan
Prior art keywords
benzodiazepine
triazolo
imidazo
ethyl
oxadiazol
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Expired - Fee Related
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Japanese (ja)
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JP2004517070A5 (enExample
JP2004517070A (ja
Inventor
マスツィアドリ，ラファエロ
トーマス，アンドリュー・ウィリアム
ヴィッヒマン，ユルゲン
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2002543495A 2000-11-16 2001-11-08 Ｇａｂａａ受容体モデュレーターとしてのベンゾジアゼピン誘導体 Expired - Fee Related JP4088151B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16
PCT/EP2001/012887 WO2002040487A2 (en) 2000-11-16 2001-11-08 Benzodiazepine derivatives as gaba a receptor modulators

Publications (3)

Publication Number Publication Date
JP2004517070A JP2004517070A (ja) 2004-06-10
JP2004517070A5 JP2004517070A5 (enExample) 2005-05-26
JP4088151B2 true JP4088151B2 (ja) 2008-05-21

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002543495A Expired - Fee Related JP4088151B2 (ja) 2000-11-16 2001-11-08 Ｇａｂａａ受容体モデュレーターとしてのベンゾジアゼピン誘導体

Country Status (40)

Country Link
US (1) US6743789B2 (enExample)
EP (1) EP1337535B1 (enExample)
JP (1) JP4088151B2 (enExample)
KR (1) KR100504300B1 (enExample)
CN (1) CN1191255C (enExample)
AR (1) AR031345A1 (enExample)
AT (1) ATE268776T1 (enExample)
AU (2) AU1700702A (enExample)
BG (1) BG107817A (enExample)
BR (1) BR0115393A (enExample)
CA (1) CA2427576C (enExample)
CZ (1) CZ295256B6 (enExample)
DE (1) DE60103776T2 (enExample)
DK (1) DK1337535T3 (enExample)
EC (1) ECSP034607A (enExample)
ES (1) ES2220831T3 (enExample)
GC (1) GC0000375A (enExample)
GT (1) GT200100230A (enExample)
HR (1) HRP20030360A2 (enExample)
HU (1) HUP0303281A3 (enExample)
IL (1) IL155813A0 (enExample)
JO (1) JO2359B1 (enExample)
MA (1) MA26962A1 (enExample)
MX (1) MXPA03004251A (enExample)
MY (1) MY141675A (enExample)
NO (1) NO324706B1 (enExample)
NZ (1) NZ525413A (enExample)
PA (1) PA8532401A1 (enExample)
PE (1) PE20020583A1 (enExample)
PL (1) PL362925A1 (enExample)
PT (1) PT1337535E (enExample)
RU (1) RU2278865C2 (enExample)
SI (1) SI1337535T1 (enExample)
SK (1) SK7232003A3 (enExample)
TR (1) TR200402073T4 (enExample)
TW (1) TWI239333B (enExample)
UY (1) UY27026A1 (enExample)
WO (1) WO2002040487A2 (enExample)
YU (1) YU35603A (enExample)
ZA (1) ZA200303435B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
US7626029B2 (en) * 2003-06-19 2009-12-01 Daiichi Pharmaceutical Co., Ltd. Method of selectively introducing amino substituent
PT1691811E (pt) 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
EP1784390A2 (en) 2004-08-13 2007-05-16 Amgen Inc. Substituted benzofused heterocycles
ATE402707T1 (de) 2004-10-12 2008-08-15 Hoffmann La Roche Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungen
NZ554439A (en) * 2004-10-20 2009-09-25 Hoffmann La Roche Imidazo-benzodiazepine derivatives
RU2007114763A (ru) * 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Галогенозамещенные производные бензодиазепинов
WO2006063708A1 (en) 2004-12-14 2006-06-22 F.Hoffmann-La Roche Ag Tetracyclic imidazo-benzodiazepines as gaba receptors modulators
EP1924712B1 (en) * 2005-08-03 2018-10-03 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
JP4885967B2 (ja) * 2005-10-11 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジアゼピン誘導体
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2009139916A1 (en) * 2008-05-16 2009-11-19 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate hsp90 activity
PE20110590A1 (es) 2008-11-18 2011-08-31 Hoffmann La Roche Alquilciclohexileteres de dihidrotetraazabenzoazulenos
BRPI0922303B1 (pt) * 2008-11-28 2019-11-12 Hoffmann La Roche arilciclo-hexiléteres de di-hidrotetra-azabenzoazulenos, seu processo de preparação, composição farmacêutica que os compreende e uso
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
AU2011328993B2 (en) 2010-11-15 2017-03-02 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2885148A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
EP4032889B1 (en) * 2013-12-20 2026-05-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3310785B1 (en) * 2015-06-19 2024-11-20 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
AU2019288382B2 (en) * 2018-06-19 2024-07-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
EP4572852A1 (en) 2022-08-19 2025-06-25 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (enExample) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
EP1337535A2 (en) 2003-08-27
DK1337535T3 (da) 2004-10-25
US6743789B2 (en) 2004-06-01
HK1062442A1 (en) 2004-11-05
ES2220831T3 (es) 2004-12-16
IL155813A0 (en) 2003-12-23
BR0115393A (pt) 2004-07-06
DE60103776D1 (de) 2004-07-15
HUP0303281A2 (hu) 2004-01-28
HRP20030360A2 (en) 2005-04-30
KR100504300B1 (ko) 2005-07-28
JO2359B1 (en) 2006-12-12
SK7232003A3 (en) 2004-03-02
EP1337535B1 (en) 2004-06-09
MA26962A1 (fr) 2004-12-20
NO324706B1 (no) 2007-12-03
CN1191255C (zh) 2005-03-02
DE60103776T2 (de) 2005-07-14
KR20030045192A (ko) 2003-06-09
HUP0303281A3 (en) 2005-05-30
YU35603A (sh) 2006-05-25
TWI239333B (en) 2005-09-11
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
GC0000375A (en) 2007-03-31
MXPA03004251A (es) 2003-09-22
WO2002040487A2 (en) 2002-05-23
JP2004517070A (ja) 2004-06-10
PT1337535E (pt) 2004-09-30
PL362925A1 (en) 2004-11-02
NO20032208L (no) 2003-05-15
ECSP034607A (es) 2003-06-25
AU2002217007B2 (en) 2006-11-30
US20020103371A1 (en) 2002-08-01
BG107817A (bg) 2004-07-30
NO20032208D0 (no) 2003-05-15
CA2427576A1 (en) 2002-05-23
CA2427576C (en) 2007-11-06
UY27026A1 (es) 2002-06-20
CN1474820A (zh) 2004-02-11
MY141675A (en) 2010-06-15
AR031345A1 (es) 2003-09-17
CZ295256B6 (cs) 2005-06-15
CZ20031597A3 (cs) 2003-11-12
PE20020583A1 (es) 2002-07-06
GT200100230A (es) 2002-07-04
PA8532401A1 (es) 2002-08-26
ATE268776T1 (de) 2004-06-15
RU2278865C2 (ru) 2006-06-27
AU1700702A (en) 2002-05-27
RU2003116895A (ru) 2005-02-20
WO2002040487A3 (en) 2002-09-26
SI1337535T1 (en) 2004-10-31
ZA200303435B (en) 2004-08-05

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