ATE268776T1 - Benzodiazepinderivate als gaba-a- rezeptormodulatoren - Google Patents

Benzodiazepinderivate als gaba-a- rezeptormodulatoren

Info

Publication number
ATE268776T1
ATE268776T1 AT01996541T AT01996541T ATE268776T1 AT E268776 T1 ATE268776 T1 AT E268776T1 AT 01996541 T AT01996541 T AT 01996541T AT 01996541 T AT01996541 T AT 01996541T AT E268776 T1 ATE268776 T1 AT E268776T1
Authority
AT
Austria
Prior art keywords
gaba
receptor modulators
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
AT01996541T
Other languages
German (de)
English (en)
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE268776T1 publication Critical patent/ATE268776T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01996541T 2000-11-16 2001-11-08 Benzodiazepinderivate als gaba-a- rezeptormodulatoren ATE268776T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16
PCT/EP2001/012887 WO2002040487A2 (en) 2000-11-16 2001-11-08 Benzodiazepine derivatives as gaba a receptor modulators

Publications (1)

Publication Number Publication Date
ATE268776T1 true ATE268776T1 (de) 2004-06-15

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01996541T ATE268776T1 (de) 2000-11-16 2001-11-08 Benzodiazepinderivate als gaba-a- rezeptormodulatoren

Country Status (40)

Country Link
US (1) US6743789B2 (enExample)
EP (1) EP1337535B1 (enExample)
JP (1) JP4088151B2 (enExample)
KR (1) KR100504300B1 (enExample)
CN (1) CN1191255C (enExample)
AR (1) AR031345A1 (enExample)
AT (1) ATE268776T1 (enExample)
AU (2) AU1700702A (enExample)
BG (1) BG107817A (enExample)
BR (1) BR0115393A (enExample)
CA (1) CA2427576C (enExample)
CZ (1) CZ295256B6 (enExample)
DE (1) DE60103776T2 (enExample)
DK (1) DK1337535T3 (enExample)
EC (1) ECSP034607A (enExample)
ES (1) ES2220831T3 (enExample)
GC (1) GC0000375A (enExample)
GT (1) GT200100230A (enExample)
HR (1) HRP20030360A2 (enExample)
HU (1) HUP0303281A3 (enExample)
IL (1) IL155813A0 (enExample)
JO (1) JO2359B1 (enExample)
MA (1) MA26962A1 (enExample)
MX (1) MXPA03004251A (enExample)
MY (1) MY141675A (enExample)
NO (1) NO324706B1 (enExample)
NZ (1) NZ525413A (enExample)
PA (1) PA8532401A1 (enExample)
PE (1) PE20020583A1 (enExample)
PL (1) PL362925A1 (enExample)
PT (1) PT1337535E (enExample)
RU (1) RU2278865C2 (enExample)
SI (1) SI1337535T1 (enExample)
SK (1) SK7232003A3 (enExample)
TR (1) TR200402073T4 (enExample)
TW (1) TWI239333B (enExample)
UY (1) UY27026A1 (enExample)
WO (1) WO2002040487A2 (enExample)
YU (1) YU35603A (enExample)
ZA (1) ZA200303435B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
US7626029B2 (en) * 2003-06-19 2009-12-01 Daiichi Pharmaceutical Co., Ltd. Method of selectively introducing amino substituent
PT1691811E (pt) 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
EP1784390A2 (en) 2004-08-13 2007-05-16 Amgen Inc. Substituted benzofused heterocycles
ATE402707T1 (de) 2004-10-12 2008-08-15 Hoffmann La Roche Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungen
NZ554439A (en) * 2004-10-20 2009-09-25 Hoffmann La Roche Imidazo-benzodiazepine derivatives
RU2007114763A (ru) * 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Галогенозамещенные производные бензодиазепинов
WO2006063708A1 (en) 2004-12-14 2006-06-22 F.Hoffmann-La Roche Ag Tetracyclic imidazo-benzodiazepines as gaba receptors modulators
EP1924712B1 (en) * 2005-08-03 2018-10-03 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
JP4885967B2 (ja) * 2005-10-11 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジアゼピン誘導体
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2009139916A1 (en) * 2008-05-16 2009-11-19 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate hsp90 activity
PE20110590A1 (es) 2008-11-18 2011-08-31 Hoffmann La Roche Alquilciclohexileteres de dihidrotetraazabenzoazulenos
BRPI0922303B1 (pt) * 2008-11-28 2019-11-12 Hoffmann La Roche arilciclo-hexiléteres de di-hidrotetra-azabenzoazulenos, seu processo de preparação, composição farmacêutica que os compreende e uso
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
AU2011328993B2 (en) 2010-11-15 2017-03-02 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2885148A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
EP4032889B1 (en) * 2013-12-20 2026-05-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3310785B1 (en) * 2015-06-19 2024-11-20 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
AU2019288382B2 (en) * 2018-06-19 2024-07-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
EP4572852A1 (en) 2022-08-19 2025-06-25 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (enExample) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
EP1337535A2 (en) 2003-08-27
DK1337535T3 (da) 2004-10-25
US6743789B2 (en) 2004-06-01
HK1062442A1 (en) 2004-11-05
ES2220831T3 (es) 2004-12-16
IL155813A0 (en) 2003-12-23
BR0115393A (pt) 2004-07-06
DE60103776D1 (de) 2004-07-15
HUP0303281A2 (hu) 2004-01-28
HRP20030360A2 (en) 2005-04-30
KR100504300B1 (ko) 2005-07-28
JO2359B1 (en) 2006-12-12
SK7232003A3 (en) 2004-03-02
EP1337535B1 (en) 2004-06-09
MA26962A1 (fr) 2004-12-20
NO324706B1 (no) 2007-12-03
CN1191255C (zh) 2005-03-02
DE60103776T2 (de) 2005-07-14
KR20030045192A (ko) 2003-06-09
HUP0303281A3 (en) 2005-05-30
YU35603A (sh) 2006-05-25
TWI239333B (en) 2005-09-11
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
GC0000375A (en) 2007-03-31
MXPA03004251A (es) 2003-09-22
WO2002040487A2 (en) 2002-05-23
JP2004517070A (ja) 2004-06-10
PT1337535E (pt) 2004-09-30
PL362925A1 (en) 2004-11-02
NO20032208L (no) 2003-05-15
ECSP034607A (es) 2003-06-25
AU2002217007B2 (en) 2006-11-30
US20020103371A1 (en) 2002-08-01
BG107817A (bg) 2004-07-30
NO20032208D0 (no) 2003-05-15
CA2427576A1 (en) 2002-05-23
CA2427576C (en) 2007-11-06
UY27026A1 (es) 2002-06-20
CN1474820A (zh) 2004-02-11
MY141675A (en) 2010-06-15
AR031345A1 (es) 2003-09-17
CZ295256B6 (cs) 2005-06-15
CZ20031597A3 (cs) 2003-11-12
PE20020583A1 (es) 2002-07-06
GT200100230A (es) 2002-07-04
PA8532401A1 (es) 2002-08-26
RU2278865C2 (ru) 2006-06-27
AU1700702A (en) 2002-05-27
RU2003116895A (ru) 2005-02-20
WO2002040487A3 (en) 2002-09-26
JP4088151B2 (ja) 2008-05-21
SI1337535T1 (en) 2004-10-31
ZA200303435B (en) 2004-08-05

Similar Documents

Publication Publication Date Title
DE60103776D1 (de) Benzodiazepinderivate als gaba-a-rezeptormodulatoren
ATE293962T1 (de) Adenosin-rezeptor modulatoren
NO20021690D0 (no) Benzodiazepin-derivater
NO20021691D0 (no) Benzodiazepinderivater
DE60135685D1 (de) Triazolyltropanderivate als ccr5-modulatoren
EE200300273A (et) Asendatud imidasopüridiinid
ATE283857T1 (de) Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren
ATE253067T1 (de) Diazabicyloderivate als nikotin-acetylcholin- rezeptorliganden
DE50105334D1 (de) Neue carbamat-substituierte pyrazolopyridinderivate
EE200100567A (et) Glükokortikoidretseptori modulaatorid
FI20002367L (fi) Adenosiini A3 -reseptori modulaattorit
PT1303521E (pt) Derivados de tetra-hidro-heterocicloazepinil-pirimidina
NO20013997L (no) Reseptoranalyse
PT1165495E (pt) Derivados de resorcinol
ATE244716T1 (de) Neue n-triazolylmethyl-piperazinderivate als neurokininrezeptor-antagonisten
NO20031354D0 (no) Benzodiazepinderivater
DE60003072D1 (de) Thiazolidindion-derivate als antidiabetika
DE60106974D1 (de) Aminotriazolopyridinderivate als adenosinrezeptorliganden
DE60210333D1 (de) Tetracyclische heteroverbindungen als modulatoren des östrogenrezeptors
NO20021753D0 (no) Pentacykliske taksanforbindelser
NO20021295L (no) Nikotinsyreacetylcholin-reseptor
DE50006201D1 (de) Bohle
DE50015688D1 (de) Pflastersteinsystem
DE60012953D1 (de) 3-amino-2-phenylpiperidinderivate als substanz p antagonisten
NO20015378L (no) Cyklokarbamatderivater som progesteronreseptormodulatorer

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1337535

Country of ref document: EP

REN Ceased due to non-payment of the annual fee