RU2278865C2 - Производные бензодиазепина и фармацевтическая композиция на их основе - Google Patents

Производные бензодиазепина и фармацевтическая композиция на их основе Download PDF

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Publication number
RU2278865C2
RU2278865C2 RU2003116895/04A RU2003116895A RU2278865C2 RU 2278865 C2 RU2278865 C2 RU 2278865C2 RU 2003116895/04 A RU2003116895/04 A RU 2003116895/04A RU 2003116895 A RU2003116895 A RU 2003116895A RU 2278865 C2 RU2278865 C2 RU 2278865C2
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RU
Russia
Prior art keywords
benzodiazepine
triazolo
imidazo
carboxylic acid
ethyl ester
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RU2003116895/04A
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English (en)
Russian (ru)
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RU2003116895A (ru
Inventor
МАСЧИАДРИ Раффаэлло (CH)
МАСЧИАДРИ Раффаэлло
Уилль м ТОМАС Эндрью (CH)
Уилльям ТОМАС Эндрью
Вихманн Юрген (DE)
Вихманн Юрген
Original Assignee
Ф.Хоффманн-Ля Рош Аг
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Publication of RU2003116895A publication Critical patent/RU2003116895A/ru
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Publication of RU2278865C2 publication Critical patent/RU2278865C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2003116895/04A 2000-11-16 2001-11-08 Производные бензодиазепина и фармацевтическая композиция на их основе RU2278865C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16
EP00124332.8 2000-11-16

Publications (2)

Publication Number Publication Date
RU2003116895A RU2003116895A (ru) 2005-02-20
RU2278865C2 true RU2278865C2 (ru) 2006-06-27

Family

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RU2003116895/04A RU2278865C2 (ru) 2000-11-16 2001-11-08 Производные бензодиазепина и фармацевтическая композиция на их основе

Country Status (40)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2393161C2 (ru) * 2004-12-14 2010-06-27 Ф. Хоффманн-Ля Рош Аг Тетрациклические имидазо-бензодиазепины в качестве модуляторов гамк-рецепторов
RU2507205C2 (ru) * 2008-11-28 2014-02-20 Ф. Хоффманн-Ля Рош Аг Арилциклогексилэфиры дигидротетраазабензоазуленов для применения в качестве антагонистов рецептора вазопрессина v1a
RU2510397C2 (ru) * 2008-11-18 2014-03-27 Ф. Хоффманн-Ля Рош Аг Алкилциклогексиловые эфиры дигидротетраазабензоазуленов
RU2775690C2 (ru) * 2013-12-05 2022-07-06 Ф. Хоффманн-Ля Рош Аг Синтез транс-8-хлор-5-метил-1-[4-(пиридин-2-илокси)-циклогексил]-5,6-дигидро-4н-2,3,5,10в-тетраазабензо[e]азулена и его кристаллические формы

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US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
US7626029B2 (en) * 2003-06-19 2009-12-01 Daiichi Pharmaceutical Co., Ltd. Method of selectively introducing amino substituent
PT1691811E (pt) 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
EP1784390A2 (en) 2004-08-13 2007-05-16 Amgen Inc. Substituted benzofused heterocycles
ATE402707T1 (de) 2004-10-12 2008-08-15 Hoffmann La Roche Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungen
NZ554439A (en) * 2004-10-20 2009-09-25 Hoffmann La Roche Imidazo-benzodiazepine derivatives
RU2007114763A (ru) * 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Галогенозамещенные производные бензодиазепинов
EP1924712B1 (en) * 2005-08-03 2018-10-03 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
JP4885967B2 (ja) * 2005-10-11 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジアゼピン誘導体
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2009139916A1 (en) * 2008-05-16 2009-11-19 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate hsp90 activity
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
AU2011328993B2 (en) 2010-11-15 2017-03-02 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2885148A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
EP4032889B1 (en) * 2013-12-20 2026-05-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3310785B1 (en) * 2015-06-19 2024-11-20 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
AU2019288382B2 (en) * 2018-06-19 2024-07-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
EP4572852A1 (en) 2022-08-19 2025-06-25 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

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DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (enExample) 1991-06-17 1993-03-01 Hoffmann La Roche

Non-Patent Citations (1)

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Title
GERECKE MAX et al "HETEROCYCLES" 39(2), p.693-721, 1994. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2393161C2 (ru) * 2004-12-14 2010-06-27 Ф. Хоффманн-Ля Рош Аг Тетрациклические имидазо-бензодиазепины в качестве модуляторов гамк-рецепторов
RU2510397C2 (ru) * 2008-11-18 2014-03-27 Ф. Хоффманн-Ля Рош Аг Алкилциклогексиловые эфиры дигидротетраазабензоазуленов
RU2507205C2 (ru) * 2008-11-28 2014-02-20 Ф. Хоффманн-Ля Рош Аг Арилциклогексилэфиры дигидротетраазабензоазуленов для применения в качестве антагонистов рецептора вазопрессина v1a
RU2775690C2 (ru) * 2013-12-05 2022-07-06 Ф. Хоффманн-Ля Рош Аг Синтез транс-8-хлор-5-метил-1-[4-(пиридин-2-илокси)-циклогексил]-5,6-дигидро-4н-2,3,5,10в-тетраазабензо[e]азулена и его кристаллические формы

Also Published As

Publication number Publication date
EP1337535A2 (en) 2003-08-27
DK1337535T3 (da) 2004-10-25
US6743789B2 (en) 2004-06-01
HK1062442A1 (en) 2004-11-05
ES2220831T3 (es) 2004-12-16
IL155813A0 (en) 2003-12-23
BR0115393A (pt) 2004-07-06
DE60103776D1 (de) 2004-07-15
HUP0303281A2 (hu) 2004-01-28
HRP20030360A2 (en) 2005-04-30
KR100504300B1 (ko) 2005-07-28
JO2359B1 (en) 2006-12-12
SK7232003A3 (en) 2004-03-02
EP1337535B1 (en) 2004-06-09
MA26962A1 (fr) 2004-12-20
NO324706B1 (no) 2007-12-03
CN1191255C (zh) 2005-03-02
DE60103776T2 (de) 2005-07-14
KR20030045192A (ko) 2003-06-09
HUP0303281A3 (en) 2005-05-30
YU35603A (sh) 2006-05-25
TWI239333B (en) 2005-09-11
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
GC0000375A (en) 2007-03-31
MXPA03004251A (es) 2003-09-22
WO2002040487A2 (en) 2002-05-23
JP2004517070A (ja) 2004-06-10
PT1337535E (pt) 2004-09-30
PL362925A1 (en) 2004-11-02
NO20032208L (no) 2003-05-15
ECSP034607A (es) 2003-06-25
AU2002217007B2 (en) 2006-11-30
US20020103371A1 (en) 2002-08-01
BG107817A (bg) 2004-07-30
NO20032208D0 (no) 2003-05-15
CA2427576A1 (en) 2002-05-23
CA2427576C (en) 2007-11-06
UY27026A1 (es) 2002-06-20
CN1474820A (zh) 2004-02-11
MY141675A (en) 2010-06-15
AR031345A1 (es) 2003-09-17
CZ295256B6 (cs) 2005-06-15
CZ20031597A3 (cs) 2003-11-12
PE20020583A1 (es) 2002-07-06
GT200100230A (es) 2002-07-04
PA8532401A1 (es) 2002-08-26
ATE268776T1 (de) 2004-06-15
AU1700702A (en) 2002-05-27
RU2003116895A (ru) 2005-02-20
WO2002040487A3 (en) 2002-09-26
JP4088151B2 (ja) 2008-05-21
SI1337535T1 (en) 2004-10-31
ZA200303435B (en) 2004-08-05

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20081109