MC1355A1 - Derives d'imidazodiazepine - Google Patents
Derives d'imidazodiazepineInfo
- Publication number
- MC1355A1 MC1355A1 MC801474A MC1474A MC1355A1 MC 1355 A1 MC1355 A1 MC 1355A1 MC 801474 A MC801474 A MC 801474A MC 1474 A MC1474 A MC 1474A MC 1355 A1 MC1355 A1 MC 1355A1
- Authority
- MC
- Monaco
- Prior art keywords
- imidazodiazepine derivatives
- imidazodiazepine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH897179 | 1979-10-04 | ||
CH897279 | 1979-10-04 | ||
CH1066479 | 1979-11-30 | ||
CH1066579 | 1979-11-30 | ||
CH571680 | 1980-07-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
MC1355A1 true MC1355A1 (fr) | 1981-08-10 |
Family
ID=27509256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MC801474A MC1355A1 (fr) | 1979-10-04 | 1980-10-02 | Derives d'imidazodiazepine |
Country Status (23)
Country | Link |
---|---|
US (10) | US4316839A (fr) |
EP (1) | EP0027214B1 (fr) |
JP (1) | JPH01156968A (fr) |
AR (1) | AR227293A1 (fr) |
AU (1) | AU533641B2 (fr) |
BR (1) | BR8006404A (fr) |
CA (1) | CA1143728A (fr) |
DE (1) | DE3067868D1 (fr) |
DK (1) | DK168094B1 (fr) |
FI (1) | FI73683C (fr) |
GB (1) | GB2060632B (fr) |
GR (1) | GR70772B (fr) |
HU (1) | HU182675B (fr) |
IE (1) | IE50318B1 (fr) |
IL (1) | IL61160A (fr) |
LU (1) | LU88298I2 (fr) |
MC (1) | MC1355A1 (fr) |
NL (1) | NL930056I2 (fr) |
NO (1) | NO155774C (fr) |
NZ (1) | NZ195071A (fr) |
PH (1) | PH16607A (fr) |
PT (1) | PT71874B (fr) |
ZW (1) | ZW21580A1 (fr) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1143728A (fr) * | 1979-10-04 | 1983-03-29 | Max Gerecke | Derives d'imidazodiazepine |
CA1174673A (fr) * | 1981-02-27 | 1984-09-18 | Walter Hunkeler | Imidazodiazepines |
CA1185602A (fr) * | 1981-02-27 | 1985-04-16 | Emilio Kyburz | Imidazodiazepines |
US4352817A (en) * | 1981-02-27 | 1982-10-05 | Hoffmann-La Roche Inc. | Imidazo-diazepines and their use |
CA1173441A (fr) * | 1981-02-27 | 1984-08-28 | Hoffmann-La Roche Limited | Imidazodiazepines |
CA1184175A (fr) * | 1981-02-27 | 1985-03-19 | Walter Hunkeler | Imidazodiazepines |
MC1528A1 (fr) * | 1982-07-21 | 1984-04-13 | Hoffmann La Roche | Imidazobenzodiazepines |
DK151808C (da) * | 1982-11-16 | 1988-06-20 | Ferrosan As | Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater |
US4723003A (en) * | 1983-05-18 | 1988-02-02 | Hoechst-Roussel Pharmaceuticals Inc. | Benzopyrrolobenzodiazepines and quinobenzodiazepines |
EP0150040B1 (fr) * | 1984-01-19 | 1994-08-31 | F. Hoffmann-La Roche Ag | Dérivés de imidazobenzodiazépine |
AU587802B2 (en) * | 1985-03-08 | 1989-08-31 | Ferrosan A/S | Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds |
US4622320A (en) * | 1985-05-17 | 1986-11-11 | As Ferrosan | Oxadiazolylimidazobenzodiazepine, compositions, and method |
US4745112A (en) * | 1985-05-17 | 1988-05-17 | A/S Ferrosan | Oxadiazolylimidazobenzodiazepine, compositions, and method III |
DK174086D0 (da) * | 1986-04-16 | 1986-04-16 | Ferrosan As | Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme |
FI880814A (fi) * | 1987-03-10 | 1988-09-11 | Hoffmann La Roche | Imidazodiazepin-derivat. |
GB8720414D0 (en) * | 1987-08-28 | 1987-10-07 | Roussel Lab Ltd | Chemical compounds |
US5096695A (en) * | 1988-08-05 | 1992-03-17 | Hoffmann-Laroche Inc. | Radioiodine benzodiazepines as brain imaging agents |
ES2052837T3 (es) * | 1988-08-05 | 1994-07-16 | Hoffmann La Roche | Derivados marcados radioactivamente de la benzodiazepina. |
CA1327572C (fr) * | 1988-08-31 | 1994-03-08 | F. Hoffmann-La Roche Ag | Derives imidazodiazepine |
GB8909700D0 (en) * | 1989-04-27 | 1989-06-14 | Roussel Lab Ltd | Chemical compounds |
CA2015336A1 (fr) * | 1989-05-19 | 1990-11-19 | F. Hoffmann-La Roche Ag | Imidazodiazepines pour le traitement des symptomes neurologiques |
FR2660310B1 (fr) * | 1990-03-27 | 1992-06-05 | Adir | Nouveaux derives de la 4h-pyrrolo[1,2a] thieno[2,3-f] diazepine[1,4], leur procede de preparation et les compositions pharmaceutiques les renfermant. |
US5371080A (en) * | 1990-06-22 | 1994-12-06 | Novo Nordisk A/S | Imidazoquinazoline compounds and their use |
US5276028A (en) * | 1990-06-22 | 1994-01-04 | Nordisk A/S | Imidazoquinoxaline compounds |
TW201311B (fr) * | 1991-06-17 | 1993-03-01 | Hoffmann La Roche | |
US5250679A (en) * | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
US5674863A (en) * | 1991-10-18 | 1997-10-07 | Genentech, Inc. | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor |
US5438035A (en) * | 1994-06-24 | 1995-08-01 | American Cyanamid Company | Methods for controlling undesirable plant species with benzodiazepine compounds |
TW349100B (en) * | 1994-11-11 | 1999-01-01 | Hoffmann La Roche | Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines |
US5670640A (en) | 1996-02-02 | 1997-09-23 | Hoffmann-La Roche Inc. | Process for the manufacture of imidazodiazepine derivatives |
GB2328940B (en) * | 1997-09-05 | 1999-12-08 | Dong Kook Pharm Co Ltd | A process for preparing benzodiazepine derivatives |
ES2515092T3 (es) | 2003-12-11 | 2014-10-29 | Sunovion Pharmaceuticals Inc. | Combinación de un sedante y un modulador neurotransmisor y métodos de mejorar la calidad del sueño y de tratar la depresión |
EP1809297B1 (fr) | 2004-10-12 | 2008-07-30 | F. Hoffmann-Roche AG | Derives d'imidazo [1, 5-a]triazolo[1, 5-d]benzodiazepine pour le traitement de troubles cognitifs |
WO2006045429A1 (fr) | 2004-10-20 | 2006-05-04 | F. Hoffmann-La Roche Ag | Dérivés de benzodiazépine à substitution halogène |
WO2006045430A1 (fr) | 2004-10-20 | 2006-05-04 | F. Hoffmann-La Roche Ag | Derives d'imidazo-benzodiazepine |
BRPI0515800A (pt) | 2004-12-14 | 2008-08-05 | Hoffmann La Roche | imidazo-benzodiazepinas tetracìclicas como moduladores de receptores de gaba |
US7595395B2 (en) * | 2005-05-16 | 2009-09-29 | Wisys Technology Foundation | Gabaergic agents to treat memory deficits |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
EP2258359A3 (fr) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline |
AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
CA2625210A1 (fr) * | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Modulation de la neurogenese dont la mediation est assuree par recepteur gaba |
AU2007223036A1 (en) * | 2006-03-08 | 2007-09-13 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (fr) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogénèse par modulation de l'angiotensine |
US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
EP2026813A2 (fr) * | 2006-05-09 | 2009-02-25 | Braincells, Inc. | Neurogenèse induite par le récepteur 5ht |
US7998971B2 (en) * | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
EP2066355A2 (fr) * | 2006-09-19 | 2009-06-10 | Braincells, Inc. | Combinaison comprenant un agent ppar et un deuxième agent neurogène pour le traitement d'une maladie du système nerveux central, pour augmenter la différentiation neuronale et pour augmenter la neurogenèse |
US20090054412A1 (en) * | 2007-08-20 | 2009-02-26 | John Alan Kemp | Treatment of Sleep Disorders |
KR101589314B1 (ko) | 2007-08-20 | 2016-01-28 | 에보텍 인터내셔널 게엠베하 | 수면 장애의 치료 |
US20090270373A1 (en) * | 2008-04-11 | 2009-10-29 | Cypress Biosciences, Inc. | Treatment of down syndrom with benzodiazepine receptor antagonists |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
GB0917612D0 (en) * | 2009-10-08 | 2009-11-25 | Ge Healthcare Ltd | In vivo imaging agents |
CN103502224A (zh) * | 2011-02-23 | 2014-01-08 | 克鲁莱斯有限公司 | 氟马西尼络合物、包含该络合物的组合物及其用途 |
CN102267999B (zh) * | 2011-07-15 | 2013-05-29 | 海南美兰史克制药有限公司 | 一种氟马西尼化合物及其制法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3933794A (en) * | 1971-08-04 | 1976-01-20 | The Upjohn Company | 2-(2-Alkynylamino)-3H-1,4-benzodiazepines |
US4031079A (en) * | 1975-09-22 | 1977-06-21 | Mcneil Laboratories, Incorporated | Intermediates for 2-aminobenzodiazepine-5-ones |
US4002610A (en) * | 1975-09-22 | 1977-01-11 | Mcneil Laboratories, Incorporated | 2-Aminobenzodiazepine-5-ones |
US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
ZA806016B (en) * | 1979-10-04 | 1981-09-30 | Hoffmann La Roche | Imidazodiazepine derivatives |
CA1143728A (fr) * | 1979-10-04 | 1983-03-29 | Max Gerecke | Derives d'imidazodiazepine |
JPH089074B2 (ja) * | 1987-07-02 | 1996-01-31 | 株式会社アマダ | タレツトパンチプレス |
-
1980
- 1980-09-10 CA CA000360028A patent/CA1143728A/fr not_active Expired
- 1980-09-15 DK DK391280A patent/DK168094B1/da not_active IP Right Cessation
- 1980-09-19 ZW ZW215/80A patent/ZW21580A1/xx unknown
- 1980-09-26 NZ NZ195071A patent/NZ195071A/en unknown
- 1980-09-29 AU AU62782/80A patent/AU533641B2/en not_active Expired
- 1980-09-29 IL IL61160A patent/IL61160A/xx not_active IP Right Cessation
- 1980-09-30 PH PH24651A patent/PH16607A/en unknown
- 1980-10-01 HU HU802390A patent/HU182675B/hu unknown
- 1980-10-02 MC MC801474A patent/MC1355A1/fr unknown
- 1980-10-02 DE DE8080105970T patent/DE3067868D1/de not_active Expired
- 1980-10-02 FI FI803135A patent/FI73683C/fi not_active IP Right Cessation
- 1980-10-02 GR GR63031A patent/GR70772B/el unknown
- 1980-10-02 EP EP80105970A patent/EP0027214B1/fr not_active Expired
- 1980-10-03 BR BR8006404A patent/BR8006404A/pt unknown
- 1980-10-03 IE IE2056/80A patent/IE50318B1/en not_active IP Right Cessation
- 1980-10-03 US US06/193,775 patent/US4316839A/en not_active Expired - Lifetime
- 1980-10-03 GB GB8031902A patent/GB2060632B/en not_active Expired
- 1980-10-03 AR AR282769A patent/AR227293A1/es active
- 1980-10-03 PT PT71874A patent/PT71874B/pt unknown
- 1980-10-03 NO NO802946A patent/NO155774C/no unknown
-
1981
- 1981-11-16 US US06/322,031 patent/US4346035A/en not_active Expired - Lifetime
- 1981-11-16 US US06/322,091 patent/US4363762A/en not_active Expired - Lifetime
- 1981-11-16 US US06/321,491 patent/US4346030A/en not_active Expired - Lifetime
- 1981-11-16 US US06/322,113 patent/US4346036A/en not_active Expired - Lifetime
- 1981-11-16 US US06/321,519 patent/US4346032A/en not_active Expired - Lifetime
- 1981-11-16 US US06/321,821 patent/US4346033A/en not_active Expired - Lifetime
- 1981-11-16 US US06/321,941 patent/US4346034A/en not_active Expired - Lifetime
- 1981-11-16 US US06/321,942 patent/US4359420A/en not_active Expired - Lifetime
- 1981-11-16 US US06/321,492 patent/US4346031A/en not_active Expired - Lifetime
-
1988
- 1988-10-25 JP JP63267347A patent/JPH01156968A/ja active Granted
-
1993
- 1993-06-09 LU LU88298C patent/LU88298I2/fr unknown
- 1993-06-11 NL NL930056C patent/NL930056I2/nl unknown
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Legal Events
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YP | Annual fee paid |