IL61160A - Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them - Google Patents

Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL61160A
IL61160A IL61160A IL6116080A IL61160A IL 61160 A IL61160 A IL 61160A IL 61160 A IL61160 A IL 61160A IL 6116080 A IL6116080 A IL 6116080A IL 61160 A IL61160 A IL 61160A
Authority
IL
Israel
Prior art keywords
manufacture
pharmaceutical compositions
compositions containing
imidazodiazepine derivatives
imidazodiazepine
Prior art date
Application number
IL61160A
Other languages
English (en)
Other versions
IL61160A0 (en
Original Assignee
Sparamedica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27509256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL61160(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sparamedica Ag filed Critical Sparamedica Ag
Publication of IL61160A0 publication Critical patent/IL61160A0/xx
Publication of IL61160A publication Critical patent/IL61160A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL61160A 1979-10-04 1980-09-29 Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them IL61160A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH897279 1979-10-04
CH897179 1979-10-04
CH1066579 1979-11-30
CH1066479 1979-11-30
CH571680 1980-07-25

Publications (2)

Publication Number Publication Date
IL61160A0 IL61160A0 (en) 1980-11-30
IL61160A true IL61160A (en) 1983-07-31

Family

ID=27509256

Family Applications (1)

Application Number Title Priority Date Filing Date
IL61160A IL61160A (en) 1979-10-04 1980-09-29 Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (10) US4316839A (fr)
EP (1) EP0027214B1 (fr)
JP (1) JPH01156968A (fr)
AR (1) AR227293A1 (fr)
AU (1) AU533641B2 (fr)
BR (1) BR8006404A (fr)
CA (1) CA1143728A (fr)
DE (1) DE3067868D1 (fr)
DK (1) DK168094B1 (fr)
FI (1) FI73683C (fr)
GB (1) GB2060632B (fr)
GR (1) GR70772B (fr)
HU (1) HU182675B (fr)
IE (1) IE50318B1 (fr)
IL (1) IL61160A (fr)
LU (1) LU88298I2 (fr)
MC (1) MC1355A1 (fr)
NL (1) NL930056I2 (fr)
NO (1) NO155774C (fr)
NZ (1) NZ195071A (fr)
PH (1) PH16607A (fr)
PT (1) PT71874B (fr)
ZW (1) ZW21580A1 (fr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1143728A (fr) * 1979-10-04 1983-03-29 Max Gerecke Derives d'imidazodiazepine
CA1185602A (fr) * 1981-02-27 1985-04-16 Emilio Kyburz Imidazodiazepines
CA1173441A (fr) * 1981-02-27 1984-08-28 Hoffmann-La Roche Limited Imidazodiazepines
CA1184175A (fr) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
CA1174673A (fr) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
MC1528A1 (fr) * 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4723003A (en) * 1983-05-18 1988-02-02 Hoechst-Roussel Pharmaceuticals Inc. Benzopyrrolobenzodiazepines and quinobenzodiazepines
NZ210850A (en) * 1984-01-19 1988-10-28 Hoffmann La Roche Imidazodiazepine derivatives and pharmaceutical compositions
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
US4745112A (en) * 1985-05-17 1988-05-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method III
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
FI880814A (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
GB8720414D0 (en) * 1987-08-28 1987-10-07 Roussel Lab Ltd Chemical compounds
CA1318668C (fr) * 1988-08-05 1993-06-01 Heinz Carmann Derives radioiodes de la benzodiazepine
US5096695A (en) * 1988-08-05 1992-03-17 Hoffmann-Laroche Inc. Radioiodine benzodiazepines as brain imaging agents
CA1327572C (fr) * 1988-08-31 1994-03-08 F. Hoffmann-La Roche Ag Derives imidazodiazepine
GB8909700D0 (en) * 1989-04-27 1989-06-14 Roussel Lab Ltd Chemical compounds
CA2015336A1 (fr) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines pour le traitement des symptomes neurologiques
FR2660310B1 (fr) * 1990-03-27 1992-06-05 Adir Nouveaux derives de la 4h-pyrrolo[1,2a] thieno[2,3-f] diazepine[1,4], leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5371080A (en) * 1990-06-22 1994-12-06 Novo Nordisk A/S Imidazoquinazoline compounds and their use
US5276028A (en) * 1990-06-22 1994-01-04 Nordisk A/S Imidazoquinoxaline compounds
TW201311B (fr) * 1991-06-17 1993-03-01 Hoffmann La Roche
US5674865A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5670640A (en) 1996-02-02 1997-09-23 Hoffmann-La Roche Inc. Process for the manufacture of imidazodiazepine derivatives
GB2328940B (en) * 1997-09-05 1999-12-08 Dong Kook Pharm Co Ltd A process for preparing benzodiazepine derivatives
EP1691811B1 (fr) 2003-12-11 2014-07-23 Sunovion Pharmaceuticals Inc. Combinaison d'un sedatif et d'un modulateur des neurotransmetteurs, et methodes permettant d'ameliorer la qualite du sommeil et de traiter la depression
ATE402707T1 (de) 2004-10-12 2008-08-15 Hoffmann La Roche Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungen
WO2006045429A1 (fr) 2004-10-20 2006-05-04 F. Hoffmann-La Roche Ag Dérivés de benzodiazépine à substitution halogène
CA2584259C (fr) 2004-10-20 2013-04-02 F. Hoffmann-La Roche Ag Derives d'imidazo-benzodiazepine
CN101115756B (zh) 2004-12-14 2010-06-16 弗·哈夫曼-拉罗切有限公司 作为gaba受体调节剂的四环咪唑并-苯并二氮杂*
US7595395B2 (en) * 2005-05-16 2009-09-29 Wisys Technology Foundation Gabaergic agents to treat memory deficits
EP2258359A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
CA2625153A1 (fr) 2005-10-21 2007-04-26 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
US20070112017A1 (en) * 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007104035A1 (fr) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation de neurogenèse par des agents nootropes
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2377531A2 (fr) 2006-05-09 2011-10-19 Braincells, Inc. Neurogénèse par modulation de l'angiotensine
WO2008030651A1 (fr) * 2006-09-08 2008-03-13 Braincells, Inc. Combinaisons contenant un dérivé de 4-acylaminopyridine
CA2663347A1 (fr) * 2006-09-19 2008-03-27 Braincells, Inc. Modulation induite par ppar de la neurogenese
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
KR101589314B1 (ko) * 2007-08-20 2016-01-28 에보텍 인터내셔널 게엠베하 수면 장애의 치료
US20090270373A1 (en) * 2008-04-11 2009-10-29 Cypress Biosciences, Inc. Treatment of down syndrom with benzodiazepine receptor antagonists
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
GB0917612D0 (en) * 2009-10-08 2009-11-25 Ge Healthcare Ltd In vivo imaging agents
AU2012221704B2 (en) 2011-02-23 2013-12-05 Coeruleus Ltd. Flumazenil complexes, compositions comprising same and uses thereof
CN102267999B (zh) * 2011-07-15 2013-05-29 海南美兰史克制药有限公司 一种氟马西尼化合物及其制法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933794A (en) * 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
US4002610A (en) * 1975-09-22 1977-01-11 Mcneil Laboratories, Incorporated 2-Aminobenzodiazepine-5-ones
US4031079A (en) * 1975-09-22 1977-06-21 Mcneil Laboratories, Incorporated Intermediates for 2-aminobenzodiazepine-5-ones
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
ZA806016B (en) * 1979-10-04 1981-09-30 Hoffmann La Roche Imidazodiazepine derivatives
CA1143728A (fr) * 1979-10-04 1983-03-29 Max Gerecke Derives d'imidazodiazepine
JPH089074B2 (ja) * 1987-07-02 1996-01-31 株式会社アマダ タレツトパンチプレス

Also Published As

Publication number Publication date
NO155774B (no) 1987-02-16
US4346032A (en) 1982-08-24
ZW21580A1 (en) 1981-04-29
US4363762A (en) 1982-12-14
US4346031A (en) 1982-08-24
AU6278280A (en) 1981-04-09
FI73683B (fi) 1987-07-31
JPH01156968A (ja) 1989-06-20
DK168094B1 (da) 1994-02-07
GB2060632A (en) 1981-05-07
US4346033A (en) 1982-08-24
HU182675B (en) 1984-02-28
AU533641B2 (en) 1983-12-01
DK391280A (da) 1981-04-05
NL930056I1 (nl) 1993-09-01
US4346034A (en) 1982-08-24
PH16607A (en) 1983-11-24
FI803135L (fi) 1981-04-05
US4346030A (en) 1982-08-24
IE50318B1 (en) 1986-04-02
IL61160A0 (en) 1980-11-30
CA1143728A (fr) 1983-03-29
LU88298I2 (fr) 1994-05-04
NL930056I2 (nl) 1993-11-16
GB2060632B (en) 1983-11-02
BR8006404A (pt) 1981-04-14
FI73683C (fi) 1987-11-09
PT71874B (en) 1982-03-31
US4359420A (en) 1982-11-16
IE802056L (en) 1981-04-04
US4346036A (en) 1982-08-24
NO155774C (no) 1987-05-27
PT71874A (en) 1980-11-01
AR227293A1 (es) 1982-10-15
MC1355A1 (fr) 1981-08-10
EP0027214B1 (fr) 1984-05-16
NO802946L (no) 1981-04-06
US4316839A (en) 1982-02-23
DE3067868D1 (en) 1984-06-20
JPH0369913B2 (fr) 1991-11-05
EP0027214A1 (fr) 1981-04-22
US4346035A (en) 1982-08-24
NZ195071A (en) 1984-08-24
GR70772B (fr) 1983-03-22

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Legal Events

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