DK168094B1 - Analogifremgangsmaade til fremstilling af imidazodiazepin-derivater eller syreadditionssalte deraf samt mellemprodukter til anvendelse ved fremgangsmaaden - Google Patents

Analogifremgangsmaade til fremstilling af imidazodiazepin-derivater eller syreadditionssalte deraf samt mellemprodukter til anvendelse ved fremgangsmaaden Download PDF

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Publication number
DK168094B1
DK168094B1 DK391280A DK391280A DK168094B1 DK 168094 B1 DK168094 B1 DK 168094B1 DK 391280 A DK391280 A DK 391280A DK 391280 A DK391280 A DK 391280A DK 168094 B1 DK168094 B1 DK 168094B1
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Prior art keywords
general formula
methyl
ethyl
group
benzodiazepine
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DK391280A
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Danish (da)
English (en)
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DK391280A (da
Inventor
Willy Hafely
Walter Hunkeler
Emilio Kyburz
Hanns Moehler
Lorenzo Pieri
Petar Polc
Max Gerecke
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Hoffmann La Roche
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Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK391280A publication Critical patent/DK391280A/da
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Publication of DK168094B1 publication Critical patent/DK168094B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK391280A 1979-10-04 1980-09-15 Analogifremgangsmaade til fremstilling af imidazodiazepin-derivater eller syreadditionssalte deraf samt mellemprodukter til anvendelse ved fremgangsmaaden DK168094B1 (da)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
CH897279 1979-10-04
CH897279 1979-10-04
CH897179 1979-10-04
CH897179 1979-10-04
CH1066479 1979-11-30
CH1066579 1979-11-30
CH1066579 1979-11-30
CH1066479 1979-11-30
CH571680 1980-07-25
CH571680 1980-07-25

Publications (2)

Publication Number Publication Date
DK391280A DK391280A (da) 1981-04-05
DK168094B1 true DK168094B1 (da) 1994-02-07

Family

ID=27509256

Family Applications (1)

Application Number Title Priority Date Filing Date
DK391280A DK168094B1 (da) 1979-10-04 1980-09-15 Analogifremgangsmaade til fremstilling af imidazodiazepin-derivater eller syreadditionssalte deraf samt mellemprodukter til anvendelse ved fremgangsmaaden

Country Status (23)

Country Link
US (10) US4316839A (fr)
EP (1) EP0027214B1 (fr)
JP (1) JPH01156968A (fr)
AR (1) AR227293A1 (fr)
AU (1) AU533641B2 (fr)
BR (1) BR8006404A (fr)
CA (1) CA1143728A (fr)
DE (1) DE3067868D1 (fr)
DK (1) DK168094B1 (fr)
FI (1) FI73683C (fr)
GB (1) GB2060632B (fr)
GR (1) GR70772B (fr)
HU (1) HU182675B (fr)
IE (1) IE50318B1 (fr)
IL (1) IL61160A (fr)
LU (1) LU88298I2 (fr)
MC (1) MC1355A1 (fr)
NL (1) NL930056I2 (fr)
NO (1) NO155774C (fr)
NZ (1) NZ195071A (fr)
PH (1) PH16607A (fr)
PT (1) PT71874B (fr)
ZW (1) ZW21580A1 (fr)

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* Cited by examiner, † Cited by third party
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CA1143728A (fr) * 1979-10-04 1983-03-29 Max Gerecke Derives d'imidazodiazepine
CA1173441A (fr) * 1981-02-27 1984-08-28 Hoffmann-La Roche Limited Imidazodiazepines
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
CA1184175A (fr) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
CA1174673A (fr) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
CA1185602A (fr) * 1981-02-27 1985-04-16 Emilio Kyburz Imidazodiazepines
MC1528A1 (fr) * 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4723003A (en) * 1983-05-18 1988-02-02 Hoechst-Roussel Pharmaceuticals Inc. Benzopyrrolobenzodiazepines and quinobenzodiazepines
CS249146B2 (en) * 1984-01-19 1987-03-12 Hoffmann La Roche Method of new imidazodiazepine's derivatives production
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4745112A (en) * 1985-05-17 1988-05-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method III
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
FI880814A (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
GB8720414D0 (en) * 1987-08-28 1987-10-07 Roussel Lab Ltd Chemical compounds
US5096695A (en) * 1988-08-05 1992-03-17 Hoffmann-Laroche Inc. Radioiodine benzodiazepines as brain imaging agents
NZ230193A (en) * 1988-08-05 1992-01-29 Hoffmann La Roche A radioiodinated benzodiazepine derivative and brain imaging composition
CA1327572C (fr) * 1988-08-31 1994-03-08 F. Hoffmann-La Roche Ag Derives imidazodiazepine
GB8909700D0 (en) * 1989-04-27 1989-06-14 Roussel Lab Ltd Chemical compounds
CA2015336A1 (fr) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines pour le traitement des symptomes neurologiques
FR2660310B1 (fr) * 1990-03-27 1992-06-05 Adir Nouveaux derives de la 4h-pyrrolo[1,2a] thieno[2,3-f] diazepine[1,4], leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5371080A (en) * 1990-06-22 1994-12-06 Novo Nordisk A/S Imidazoquinazoline compounds and their use
US5276028A (en) * 1990-06-22 1994-01-04 Nordisk A/S Imidazoquinoxaline compounds
TW201311B (fr) * 1991-06-17 1993-03-01 Hoffmann La Roche
US5565449A (en) * 1991-10-18 1996-10-15 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5670640A (en) * 1996-02-02 1997-09-23 Hoffmann-La Roche Inc. Process for the manufacture of imidazodiazepine derivatives
GB2328940B (en) * 1997-09-05 1999-12-08 Dong Kook Pharm Co Ltd A process for preparing benzodiazepine derivatives
AU2004305563C1 (en) 2003-12-11 2011-07-07 Sunovion Pharmaceuticals Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
JP5117192B2 (ja) 2004-10-12 2013-01-09 エフ．ホフマン−ラ ロシュ アーゲー 置換ベンゾジアゼピン誘導体
CA2584757C (fr) 2004-10-20 2012-07-03 F. Hoffmann-La Roche Ag Derives de benzodiazepine a substitution halogene
RU2007112940A (ru) 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные имидазобензодиазепина
CA2590333C (fr) 2004-12-14 2013-01-08 F. Hoffmann-La Roche Ag Imidazo-benzodiazepines tetracycliques en tant que modulateurs des recepteurs gaba
AU2006276998A1 (en) * 2005-05-16 2007-02-15 Wisys Technology Foundation, Inc. Gabaergic agents to treat memory deficits
EP2258358A3 (fr) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenèse avec un inhibiteur de l'acetylcholinestérase
CA2620333A1 (fr) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenese par modulation du recepteur muscarinique
EP1940389A2 (fr) 2005-10-21 2008-07-09 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
CA2625210A1 (fr) * 2005-10-31 2007-05-10 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
WO2007104035A1 (fr) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation de neurogenèse par des agents nootropes
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
MX2009002496A (es) * 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
EP2066355A2 (fr) * 2006-09-19 2009-06-10 Braincells, Inc. Combinaison comprenant un agent ppar et un deuxième agent neurogène pour le traitement d'une maladie du système nerveux central, pour augmenter la différentiation neuronale et pour augmenter la neurogenèse
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
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US20090270373A1 (en) * 2008-04-11 2009-10-29 Cypress Biosciences, Inc. Treatment of down syndrom with benzodiazepine receptor antagonists
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
GB0917612D0 (en) * 2009-10-08 2009-11-25 Ge Healthcare Ltd In vivo imaging agents
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CN102267999B (zh) * 2011-07-15 2013-05-29 海南美兰史克制药有限公司 一种氟马西尼化合物及其制法

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US3933794A (en) * 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
US4031079A (en) * 1975-09-22 1977-06-21 Mcneil Laboratories, Incorporated Intermediates for 2-aminobenzodiazepine-5-ones
US4002610A (en) * 1975-09-22 1977-01-11 Mcneil Laboratories, Incorporated 2-Aminobenzodiazepine-5-ones
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
ZA806016B (en) * 1979-10-04 1981-09-30 Hoffmann La Roche Imidazodiazepine derivatives
CA1143728A (fr) * 1979-10-04 1983-03-29 Max Gerecke Derives d'imidazodiazepine
JPH089074B2 (ja) * 1987-07-02 1996-01-31 株式会社アマダ タレツトパンチプレス

Also Published As

Publication number Publication date
CA1143728A (fr) 1983-03-29
US4346033A (en) 1982-08-24
US4346032A (en) 1982-08-24
IL61160A (en) 1983-07-31
JPH0369913B2 (fr) 1991-11-05
NO155774C (no) 1987-05-27
LU88298I2 (fr) 1994-05-04
AU6278280A (en) 1981-04-09
BR8006404A (pt) 1981-04-14
ZW21580A1 (en) 1981-04-29
DK391280A (da) 1981-04-05
DE3067868D1 (en) 1984-06-20
US4346031A (en) 1982-08-24
HU182675B (en) 1984-02-28
NL930056I1 (nl) 1993-09-01
MC1355A1 (fr) 1981-08-10
US4316839A (en) 1982-02-23
GB2060632A (en) 1981-05-07
IE802056L (en) 1981-04-04
GR70772B (fr) 1983-03-22
US4346035A (en) 1982-08-24
GB2060632B (en) 1983-11-02
US4346030A (en) 1982-08-24
EP0027214A1 (fr) 1981-04-22
US4346034A (en) 1982-08-24
FI73683C (fi) 1987-11-09
US4363762A (en) 1982-12-14
NL930056I2 (nl) 1993-11-16
NZ195071A (en) 1984-08-24
NO155774B (no) 1987-02-16
NO802946L (no) 1981-04-06
IL61160A0 (en) 1980-11-30
PT71874B (en) 1982-03-31
IE50318B1 (en) 1986-04-02
FI803135L (fi) 1981-04-05
PH16607A (en) 1983-11-24
US4346036A (en) 1982-08-24
AU533641B2 (en) 1983-12-01
PT71874A (en) 1980-11-01
FI73683B (fi) 1987-07-31
US4359420A (en) 1982-11-16
AR227293A1 (es) 1982-10-15
JPH01156968A (ja) 1989-06-20
EP0027214B1 (fr) 1984-05-16

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B1 Patent granted (law 1993)
PUP Patent expired