NL930056I1 - Imidazodiazepine-derivaten werkwijze en tussenprodukten voor de bereiding ervan deze bevattende geneesmiddelen en de therapeutische toepassing ervan - Google Patents

Imidazodiazepine-derivaten werkwijze en tussenprodukten voor de bereiding ervan deze bevattende geneesmiddelen en de therapeutische toepassing ervan

Info

Publication number
NL930056I1
NL930056I1 NL930056C NL930056C NL930056I1 NL 930056 I1 NL930056 I1 NL 930056I1 NL 930056 C NL930056 C NL 930056C NL 930056 C NL930056 C NL 930056C NL 930056 I1 NL930056 I1 NL 930056I1
Authority
NL
Netherlands
Prior art keywords
intermediates
preparation
therapeutic use
containing drugs
derivatives method
Prior art date
Application number
NL930056C
Other languages
English (en)
Other versions
NL930056I2 (nl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27509256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL930056(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL930056I1 publication Critical patent/NL930056I1/nl
Publication of NL930056I2 publication Critical patent/NL930056I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
NL930056C 1979-10-04 1993-06-11 Imidazodiazepine-derivaten, werkwijze en tussenpr odukten voor de bereiding ervan, deze bevattende geneesmiddelen en de therapeutische toepassing ervan. NL930056I2 (nl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH897179 1979-10-04
CH897279 1979-10-04
CH1066479 1979-11-30
CH1066579 1979-11-30
CH571680 1980-07-25

Publications (2)

Publication Number Publication Date
NL930056I1 true NL930056I1 (nl) 1993-09-01
NL930056I2 NL930056I2 (nl) 1993-11-16

Family

ID=27509256

Family Applications (1)

Application Number Title Priority Date Filing Date
NL930056C NL930056I2 (nl) 1979-10-04 1993-06-11 Imidazodiazepine-derivaten, werkwijze en tussenpr odukten voor de bereiding ervan, deze bevattende geneesmiddelen en de therapeutische toepassing ervan.

Country Status (23)

Country Link
US (10) US4316839A (nl)
EP (1) EP0027214B1 (nl)
JP (1) JPH01156968A (nl)
AR (1) AR227293A1 (nl)
AU (1) AU533641B2 (nl)
BR (1) BR8006404A (nl)
CA (1) CA1143728A (nl)
DE (1) DE3067868D1 (nl)
DK (1) DK168094B1 (nl)
FI (1) FI73683C (nl)
GB (1) GB2060632B (nl)
GR (1) GR70772B (nl)
HU (1) HU182675B (nl)
IE (1) IE50318B1 (nl)
IL (1) IL61160A (nl)
LU (1) LU88298I2 (nl)
MC (1) MC1355A1 (nl)
NL (1) NL930056I2 (nl)
NO (1) NO155774C (nl)
NZ (1) NZ195071A (nl)
PH (1) PH16607A (nl)
PT (1) PT71874B (nl)
ZW (1) ZW21580A1 (nl)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
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CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
CA1185602A (en) * 1981-02-27 1985-04-16 Emilio Kyburz Imidazodiazepines
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
CA1173441A (en) * 1981-02-27 1984-08-28 Hoffmann-La Roche Limited Imidazodiazepines
CA1184175A (en) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
MC1528A1 (fr) * 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4723003A (en) * 1983-05-18 1988-02-02 Hoechst-Roussel Pharmaceuticals Inc. Benzopyrrolobenzodiazepines and quinobenzodiazepines
EP0150040B1 (de) * 1984-01-19 1994-08-31 F. Hoffmann-La Roche Ag Imidazodiazepin-Derivate
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
US4745112A (en) * 1985-05-17 1988-05-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method III
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
FI880814A (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
GB8720414D0 (en) * 1987-08-28 1987-10-07 Roussel Lab Ltd Chemical compounds
US5096695A (en) * 1988-08-05 1992-03-17 Hoffmann-Laroche Inc. Radioiodine benzodiazepines as brain imaging agents
ES2052837T3 (es) * 1988-08-05 1994-07-16 Hoffmann La Roche Derivados marcados radioactivamente de la benzodiazepina.
CA1327572C (en) * 1988-08-31 1994-03-08 F. Hoffmann-La Roche Ag Imidazodiazepine derivatives
GB8909700D0 (en) * 1989-04-27 1989-06-14 Roussel Lab Ltd Chemical compounds
CA2015336A1 (en) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines for the treatment of neurological symptoms
FR2660310B1 (fr) * 1990-03-27 1992-06-05 Adir Nouveaux derives de la 4h-pyrrolo[1,2a] thieno[2,3-f] diazepine[1,4], leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5371080A (en) * 1990-06-22 1994-12-06 Novo Nordisk A/S Imidazoquinazoline compounds and their use
US5276028A (en) * 1990-06-22 1994-01-04 Nordisk A/S Imidazoquinoxaline compounds
TW201311B (nl) * 1991-06-17 1993-03-01 Hoffmann La Roche
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5674863A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5670640A (en) 1996-02-02 1997-09-23 Hoffmann-La Roche Inc. Process for the manufacture of imidazodiazepine derivatives
GB2328940B (en) * 1997-09-05 1999-12-08 Dong Kook Pharm Co Ltd A process for preparing benzodiazepine derivatives
ES2515092T3 (es) 2003-12-11 2014-10-29 Sunovion Pharmaceuticals Inc. Combinación de un sedante y un modulador neurotransmisor y métodos de mejorar la calidad del sueño y de tratar la depresión
EP1809297B1 (en) 2004-10-12 2008-07-30 F. Hoffmann-Roche AG Imidazo[1,5a]triazolo[1,5d]benzodiazepine derivatives for the treatment of cognitive disorders
WO2006045429A1 (en) 2004-10-20 2006-05-04 F. Hoffmann-La Roche Ag Halogen substituted benzodiazepine derivatives
WO2006045430A1 (en) 2004-10-20 2006-05-04 F. Hoffmann-La Roche Ag Imidazo-benzodiazepine derivatives
BRPI0515800A (pt) 2004-12-14 2008-08-05 Hoffmann La Roche imidazo-benzodiazepinas tetracìclicas como moduladores de receptores de gaba
US7595395B2 (en) * 2005-05-16 2009-09-29 Wisys Technology Foundation Gabaergic agents to treat memory deficits
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
AU2007223036A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2026813A2 (en) * 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
US7998971B2 (en) * 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
EP2066355A2 (en) * 2006-09-19 2009-06-10 Braincells, Inc. Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
KR101589314B1 (ko) 2007-08-20 2016-01-28 에보텍 인터내셔널 게엠베하 수면 장애의 치료
US20090270373A1 (en) * 2008-04-11 2009-10-29 Cypress Biosciences, Inc. Treatment of down syndrom with benzodiazepine receptor antagonists
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
GB0917612D0 (en) * 2009-10-08 2009-11-25 Ge Healthcare Ltd In vivo imaging agents
CN103502224A (zh) * 2011-02-23 2014-01-08 克鲁莱斯有限公司 氟马西尼络合物、包含该络合物的组合物及其用途
CN102267999B (zh) * 2011-07-15 2013-05-29 海南美兰史克制药有限公司 一种氟马西尼化合物及其制法

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US3933794A (en) * 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
US4031079A (en) * 1975-09-22 1977-06-21 Mcneil Laboratories, Incorporated Intermediates for 2-aminobenzodiazepine-5-ones
US4002610A (en) * 1975-09-22 1977-01-11 Mcneil Laboratories, Incorporated 2-Aminobenzodiazepine-5-ones
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
ZA806016B (en) * 1979-10-04 1981-09-30 Hoffmann La Roche Imidazodiazepine derivatives
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
JPH089074B2 (ja) * 1987-07-02 1996-01-31 株式会社アマダ タレツトパンチプレス

Also Published As

Publication number Publication date
NZ195071A (en) 1984-08-24
US4346032A (en) 1982-08-24
ZW21580A1 (en) 1981-04-29
DK391280A (da) 1981-04-05
IE802056L (en) 1981-04-04
NL930056I2 (nl) 1993-11-16
EP0027214B1 (de) 1984-05-16
HU182675B (en) 1984-02-28
CA1143728A (en) 1983-03-29
BR8006404A (pt) 1981-04-14
NO802946L (no) 1981-04-06
DK168094B1 (da) 1994-02-07
JPH0369913B2 (nl) 1991-11-05
JPH01156968A (ja) 1989-06-20
NO155774C (no) 1987-05-27
NO155774B (no) 1987-02-16
PH16607A (en) 1983-11-24
AU6278280A (en) 1981-04-09
US4346030A (en) 1982-08-24
IL61160A0 (en) 1980-11-30
GB2060632B (en) 1983-11-02
AU533641B2 (en) 1983-12-01
US4346033A (en) 1982-08-24
FI803135L (fi) 1981-04-05
LU88298I2 (fr) 1994-05-04
DE3067868D1 (en) 1984-06-20
GR70772B (nl) 1983-03-22
MC1355A1 (fr) 1981-08-10
PT71874A (en) 1980-11-01
US4346031A (en) 1982-08-24
IE50318B1 (en) 1986-04-02
US4316839A (en) 1982-02-23
GB2060632A (en) 1981-05-07
US4346034A (en) 1982-08-24
US4346036A (en) 1982-08-24
US4363762A (en) 1982-12-14
FI73683B (fi) 1987-07-31
PT71874B (en) 1982-03-31
IL61160A (en) 1983-07-31
FI73683C (fi) 1987-11-09
US4346035A (en) 1982-08-24
US4359420A (en) 1982-11-16
EP0027214A1 (de) 1981-04-22
AR227293A1 (es) 1982-10-15

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