KR100441362B1 - 혈관 형성 억제 활성을 갖는 프탈라진 - Google Patents

혈관 형성 억제 활성을 갖는 프탈라진 Download PDF

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Publication number
KR100441362B1
KR100441362B1 KR10-1999-7007317A KR19997007317A KR100441362B1 KR 100441362 B1 KR100441362 B1 KR 100441362B1 KR 19997007317 A KR19997007317 A KR 19997007317A KR 100441362 B1 KR100441362 B1 KR 100441362B1
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South Korea
Prior art keywords
formula
compound
pyridylmethyl
phenyl
phthalazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR10-1999-7007317A
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English (en)
Korean (ko)
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KR20000071049A (ko
Inventor
구이도 볼트
외르크 프라이
페터 트락슬러
칼-하인쯔 알트만
헬무트 메트
데이비드 레이먼드 스토버
쟈네테 우드
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노파르티스 아게
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Publication of KR20000071049A publication Critical patent/KR20000071049A/ko
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Publication of KR100441362B1 publication Critical patent/KR100441362B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR10-1999-7007317A 1997-02-13 1998-02-11 혈관 형성 억제 활성을 갖는 프탈라진 Expired - Fee Related KR100441362B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH31597 1997-02-13
CH315/97 1997-02-13
PCT/EP1998/000764 WO1998035958A1 (en) 1997-02-13 1998-02-11 Phthalazines with angiogenesis inhibiting activity

Publications (2)

Publication Number Publication Date
KR20000071049A KR20000071049A (ko) 2000-11-25
KR100441362B1 true KR100441362B1 (ko) 2004-07-23

Family

ID=4184213

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1999-7007317A Expired - Fee Related KR100441362B1 (ko) 1997-02-13 1998-02-11 혈관 형성 억제 활성을 갖는 프탈라진

Country Status (32)

Country Link
US (3) US6258812B1 (https=)
EP (1) EP0970070B1 (https=)
JP (1) JP3544675B2 (https=)
KR (1) KR100441362B1 (https=)
CN (1) CN1251097B (https=)
AR (1) AR011135A1 (https=)
AT (1) ATE278686T1 (https=)
AU (1) AU731852B2 (https=)
BR (1) BR9807685B1 (https=)
CA (1) CA2281721C (https=)
CO (1) CO4950519A1 (https=)
CY (1) CY2550B1 (https=)
CZ (1) CZ297534B6 (https=)
DE (1) DE69826841T2 (https=)
DK (1) DK0970070T3 (https=)
ES (1) ES2234097T3 (https=)
HU (1) HU227972B1 (https=)
ID (1) ID23698A (https=)
IL (1) IL131273A0 (https=)
MY (1) MY128645A (https=)
NO (1) NO317367B1 (https=)
NZ (1) NZ337064A (https=)
PE (1) PE52499A1 (https=)
PL (1) PL197371B1 (https=)
PT (1) PT970070E (https=)
RU (1) RU2207132C2 (https=)
SI (1) SI0970070T1 (https=)
SK (1) SK285757B6 (https=)
TR (1) TR199901953T2 (https=)
TW (1) TWI250151B (https=)
WO (1) WO1998035958A1 (https=)
ZA (1) ZA981155B (https=)

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