JP7150823B2 - ＫＲａｓ Ｇ１２Ｃの阻害剤及びそれを使用する方法 - Google Patents

ＫＲａｓ Ｇ１２Ｃの阻害剤及びそれを使用する方法 Download PDF

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JP7150823B2
JP7150823B2 JP2020508026A JP2020508026A JP7150823B2 JP 7150823 B2 JP7150823 B2 JP 7150823B2 JP 2020508026 A JP2020508026 A JP 2020508026A JP 2020508026 A JP2020508026 A JP 2020508026A JP 7150823 B2 JP7150823 B2 JP 7150823B2
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cancer
mmol
pyrimidin
compound
pyrido
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JP2020533277A5 (enExample
JP2020533277A (ja
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ランマン，ブライアン・アラン
ブッカー，ション
グッドマン，クリフォード
リード，アンソニー・ビー
ロー，ジョナサン・ディー
ワン，フイ－リン
チェン，ニン
ミナッチ，アナ・エレナ
ブルツ，ライアン
シー，ビクター・ジェイ
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2020508026A 2017-09-08 2018-09-07 ＫＲａｓ Ｇ１２Ｃの阻害剤及びそれを使用する方法 Active JP7150823B2 (ja)

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JP2022153381A JP7362868B2 (ja) 2017-09-08 2022-09-27 ＫＲａｓ Ｇ１２Ｃの阻害剤及びそれを使用する方法
JP2023171856A JP7595724B2 (ja) 2017-09-08 2023-10-03 ＫＲａｓ Ｇ１２Ｃの阻害剤及びそれを使用する方法

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US201762556223P 2017-09-08 2017-09-08
US62/556,223 2017-09-08
PCT/US2018/050044 WO2019051291A1 (en) 2017-09-08 2018-09-07 Inhibitors of kras g12c and methods of using the same

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JP2022153381A Active JP7362868B2 (ja) 2017-09-08 2022-09-27 ＫＲａｓ Ｇ１２Ｃの阻害剤及びそれを使用する方法
JP2023171856A Active JP7595724B2 (ja) 2017-09-08 2023-10-03 ＫＲａｓ Ｇ１２Ｃの阻害剤及びそれを使用する方法

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US (4) US10640504B2 (enExample)
EP (3) EP3679040B1 (enExample)
JP (3) JP7150823B2 (enExample)
CN (2) CN116003405A (enExample)
AR (1) AR112797A1 (enExample)
AU (1) AU2018329920B2 (enExample)
CA (1) CA3075046A1 (enExample)
ES (2) ES2928576T3 (enExample)
IL (2) IL293443A (enExample)
MA (1) MA50077A (enExample)
MX (1) MX2020002502A (enExample)
SG (1) SG11202001499WA (enExample)
TW (1) TWI731264B (enExample)
UY (1) UY37870A (enExample)
WO (1) WO2019051291A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021526132A (ja) * 2018-06-12 2021-09-30 アムジエン・インコーポレーテツド ＫＲａｓ Ｇ１２Ｃ阻害剤及びそれを使用する方法

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