ES2928576T3 - Inhibidores de KRAS G12C y métodos de uso de los mismos - Google Patents

Inhibidores de KRAS G12C y métodos de uso de los mismos Download PDF

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Publication number
ES2928576T3
ES2928576T3 ES18778775T ES18778775T ES2928576T3 ES 2928576 T3 ES2928576 T3 ES 2928576T3 ES 18778775 T ES18778775 T ES 18778775T ES 18778775 T ES18778775 T ES 18778775T ES 2928576 T3 ES2928576 T3 ES 2928576T3
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mmol
compound
pyrimidin
cancer
pyrido
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Spanish (es)
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Brian Alan Lanman
Shon Booker
Clifford Goodman
Anthony B Reed
Jonathan D Low
Hui-Ling Wang
Ning Chen
Ana Elena Minatti
Ryan Wurz
Victor J Cee
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Amgen Inc
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Amgen Inc
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES18778775T 2017-09-08 2018-09-07 Inhibidores de KRAS G12C y métodos de uso de los mismos Active ES2928576T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762556223P 2017-09-08 2017-09-08
PCT/US2018/050044 WO2019051291A1 (en) 2017-09-08 2018-09-07 Inhibitors of kras g12c and methods of using the same

Publications (1)

Publication Number Publication Date
ES2928576T3 true ES2928576T3 (es) 2022-11-21

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Application Number Title Priority Date Filing Date
ES18778775T Active ES2928576T3 (es) 2017-09-08 2018-09-07 Inhibidores de KRAS G12C y métodos de uso de los mismos
ES22176014T Active ES2985118T3 (es) 2017-09-08 2018-09-07 Inhibidores de KRAS G12C y métodos de uso de los mismos

Family Applications After (1)

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ES22176014T Active ES2985118T3 (es) 2017-09-08 2018-09-07 Inhibidores de KRAS G12C y métodos de uso de los mismos

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US (4) US10640504B2 (enExample)
EP (3) EP4403175A3 (enExample)
JP (3) JP7150823B2 (enExample)
CN (2) CN111051306B (enExample)
AR (1) AR112797A1 (enExample)
AU (1) AU2018329920B2 (enExample)
CA (1) CA3075046A1 (enExample)
ES (2) ES2928576T3 (enExample)
IL (2) IL293443A (enExample)
MA (1) MA50077A (enExample)
MX (1) MX2020002502A (enExample)
SG (1) SG11202001499WA (enExample)
TW (1) TWI731264B (enExample)
UY (1) UY37870A (enExample)
WO (1) WO2019051291A1 (enExample)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
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