JP7126577B2 - 制御薬物送達の特徴を有する移植片及びそれを使用する方法 - Google Patents
制御薬物送達の特徴を有する移植片及びそれを使用する方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
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Description
(Ci-Co)=装置の内側と外側の薬物濃度差
Claims (29)
- 薬物送達眼移植片であって、
開口近位端、遠位端を有する外殻であって、前記外殻は内部空洞を画定する形状である、外殻と、
前記内部空洞内に配置された少なくとも1つの薬物と、
前記外殻の前記開口近位端と相互作用するように構成されたキャップであって、
前記キャップは、少なくとも1個の開口部を含むキャップと、
前記キャップと前記外殻の前記開口近位端の間に配置された前記少なくとも1つの薬物に対して透過性又は半透過性である膜であって、
前記膜は、前記キャップによって押し付けられ、
前記膜は前記少なくとも1個の開口部を閉鎖し、それによって前記少なくとも1つの薬物の溶出が前記膜を通してのみ起こるようにする膜と、
前記内部空洞と前記薬物送達眼移植片が配置された眼腔との間の流体連通を前記膜を介したものだけに制限する遠位に配置されたシールと、
前記外殻の前記遠位端上の保持突出部であって、前記保持突出部は、前記薬物送達眼移植片を眼内の標的組織部位に固定するように構成される保持突出部と、
を含む薬物送達眼移植片。 - 前記膜の厚さが50から100μmである請求項1に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物が前記薬物送達眼移植片から12から24か月の期間溶出する請求項2に記載の薬物送達眼移植片。
- 前記膜の厚さが90から200μmである請求項1に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物が前記薬物送達眼移植片から24から48か月の期間溶出する請求項4に記載の薬物送達眼移植片。
- 少なくとも1つの流体経路は、眼液を前房から生理的流出経路に送達するように構成される請求項1に記載の薬物送達眼移植片。
- 前記生理的流出経路がシュレム管である請求項6に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物が、プロスタグランジン、プロスタグランジン類似体、プロスタグランジン阻害剤及び/又はその組合せを含む請求項1に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物がRho-キナーゼ阻害剤である請求項1に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物がシクロスポリンである請求項1に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物が緑内障治療薬である請求項1に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物がステロイドである請求項1に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物がビマトプロスト、ラタノプロスト、トラボプロスト又はウノプロストンである請求項1に記載の薬物送達眼移植片。
- 前記キャップは、圧着キャップである請求項1に記載の薬物送達眼移植片。
- 前記膜は、弾性特性を有し、前記膜を所定の位置に保持するために、前記膜を前記キャップに対して自動ロックするように構成される請求項1に記載の薬物送達眼移植片。
- 薬物送達眼移植片であって、
開口近位端、閉じた遠位端を有する外殻であって、前記外殻は内部管腔を画定する形状である、外殻と、
前記内部管腔内に配置された少なくとも1つの薬物と、
前記外殻の前記開口近位端を覆って配置されるように構成されたキャップであって、少なくとも1個のオリフィスを含むキャップと、
前記キャップと前記外殻の前記開口近位端の間に配置された膜であって、
前記膜は、前記少なくとも1つの薬物に対して透過性又は半透過性があり、
前記膜は、前記キャップによって押し付けられ、
前記膜は、前記少なくとも1個のオリフィスを覆い、それによって前記膜を通る前記少なくとも1つの薬物の溶出を制御する膜と、
前記内部管腔と前記薬物送達眼移植片が配置された眼腔との間の流体連通を前記膜を介したものだけに制限する遠位に配置されたシールと、
前記外殻の前記遠位端の近位に配置された少なくとも1つの流体流出経路であって、
少なくとも1つの流体経路は、眼液を前房から生理的流出経路に送達するように構成される少なくとも1つの流体流出経路と、
前記外殻の前記遠位端上の保持突出部であって、前記保持突出部は、前記薬物送達眼移植片を眼内の標的組織部位に固定するように構成される保持突出部と、
を含む薬物送達眼移植片。 - 前記膜の厚さが50から100μmである請求項16に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物が前記薬物送達眼移植片から12から24か月の期間溶出する請求項17に記載の薬物送達眼移植片。
- 前記膜の厚さが90から200μmである請求項16に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物が前記薬物送達眼移植片から24から48か月の期間溶出する請求項19に記載の薬物送達眼移植片。
- 前記生理的流出経路がシュレム管である請求項16に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物が、プロスタグランジン、プロスタグランジン類似体、プロスタグランジン阻害剤及び/又はその組合せを含む請求項16に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物がRho-キナーゼ阻害剤である請求項16に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物がシクロスポリンである請求項16に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物が緑内障治療薬である請求項16に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物がステロイドである請求項16に記載の薬物送達眼移植片。
- 前記少なくとも1つの薬物がビマトプロスト、ラタノプロスト、トラボプロスト又はウノプロストンである請求項16に記載の薬物送達眼移植片。
- 前記キャップは、圧着キャップである請求項16に記載の薬物送達眼移植片。
- 前記膜は、弾性特性を有し、前記膜を所定の位置に保持するために、前記膜を前記キャップに対して自動ロックするように構成される請求項16に記載の薬物送達眼移植片。
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US (8) | US10206813B2 (ja) |
EP (4) | EP3603590B1 (ja) |
JP (4) | JP6491636B2 (ja) |
AU (4) | AU2014237278B2 (ja) |
CA (1) | CA2901476C (ja) |
HK (1) | HK1259482A1 (ja) |
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