JP2022166178A - 制御薬物送達の特徴を有する移植片及びそれを使用する方法 - Google Patents
制御薬物送達の特徴を有する移植片及びそれを使用する方法 Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
(Ci-Co)=装置の内側と外側の薬物濃度差
Claims (15)
- 眼内に移植可能な薬物送達眼移植片であって、
近位端、遠位端を有する外殻であって、前記外殻は内部管腔を画定する形状である、外殻と、
前記内部管腔内に配置された少なくとも1つの第1の活性薬物と、
前記外殻の前記近位端と可逆的相互作用するように構成されたキャップであって、
前記キャップは、少なくとも1個の開口部を含むキャップと、
前記キャップと前記外殻の前記近位端の間に配置された膜であって、
前記膜は、前記少なくとも1つの第1の活性薬物に対して透過性があり、
前記膜は、前記少なくとも1つの第1の活性薬物に対する前記膜の透過性及び前記第1の活性薬物の所望の溶出期間に基づいた寸法であり、
前記キャップを前記外殻の前記近位端の上に配置すると、前記膜は、前記キャップと前記近位端の間に保持され、
前記膜は前記少なくとも1個の開口部を閉鎖し、それによって前記少なくとも1つの第1の活性薬物の溶出が前記膜を通してのみ起こるようにする膜と、
前記外殻の前記遠位端に隣接した少なくとも1つの流体流入経路及び1つの流体流出経路であって、
前記少なくとも1つの流体流入経路及び1つの流体流出経路は、眼液を生理的流出経路に送達するように構成される、少なくとも1つの流体流入経路及び1つの流体流出経路と、
前記外殻の前記遠位端上の保持突出部であって、前記保持突出部は、前記薬物送達眼移植片を眼内の標的組織部位に固定するように構成される保持突出部と、
を含む薬物送達眼移植片。 - 前記膜の厚さが50から100μmである請求項1に記載の薬物送達眼移植片。
- 前記少なくとも1つの第1の活性薬物が前記薬物送達眼移植片から12から24か月の期間溶出する請求項2に記載の薬物送達眼移植片。
- 前記膜の厚さが90から200μmである請求項1に記載の薬物送達眼移植片。
- 前記少なくとも1つの第1の活性薬物が前記薬物送達眼移植片から24から48か月の期間溶出する請求項4に記載の薬物送達眼移植片。
- さらに、前記内部管腔と前記薬物送達眼移植片が配置された眼腔との間の流体連通を前記膜を介したものだけに制限する遠位に配置されたシールを含む請求項1に記載の薬物送達眼移植片。
- 前記生理的流出経路がシュレム管である請求項1に記載の薬物送達眼移植片。
- 前記少なくとも1つの第1の活性薬物が、プロスタグランジン、プロスタグランジン類似体、プロスタグランジン阻害剤及び/又はその組合せを含む請求項1に記載の薬物送達眼移植片。
- 前記第1の活性薬物がRho-キナーゼ阻害剤である請求項1に記載の薬物送達眼移植片。
- 前記第1の活性薬物がシクロスポリンである請求項1に記載の薬物送達眼移植片。
- 前記第1の活性薬物がシクロスポリンAである請求項1に記載の薬物送達眼移植片。
- 前記第1の活性薬物がモキシフロキサシンである請求項1に記載の薬物送達眼移植片。
- 前記第1の活性薬物が緑内障治療薬である請求項1に記載の薬物送達眼移植片。
- 前記第1の活性薬物がステロイドである請求項1に記載の薬物送達眼移植片。
- 前記第1の活性薬物がビマトプロスト、ラタノプロスト、トラボプロスト又はウノプロストンである請求項1に記載の薬物送達眼移植片。
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JP2011522575A (ja) * | 2008-05-07 | 2011-08-04 | ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド | 活性薬剤の制御放出のための眼科用デバイス |
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JP2012527318A (ja) * | 2009-05-18 | 2012-11-08 | ドーズ メディカル コーポレーション | 薬剤溶出眼内インプラント |
JP2021090811A (ja) * | 2013-03-15 | 2021-06-17 | ドーズ メディカル コーポレーションDose Medical Corporation | 制御薬物送達の特徴を有する移植片及びそれを使用する方法 |
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