JP6513297B2 - 自動注射器、受け入れフレーム及び自動注射器におけるカートリッジの接続方法 - Google Patents
自動注射器、受け入れフレーム及び自動注射器におけるカートリッジの接続方法 Download PDFInfo
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Description
(図2)本発明の一実施形態の自動注射器アセンブリに対してカートリッジの移動を抑えるための方法の概要図である。
(図3A)本発明の一実施形態の自動注射器の構成部品を取り付けると共に静止させるための遠位形状及び近位形状を有する例示的な一体的な受け入れフレームを示す図である。
(図3B)本発明の一実施形態の自動注射器の様々な構成部品が取り付けられた例示的な一体的な受け入れフレームを示す図である。
(図4)本発明の一実施形態の受け入れフレームと接続するための遠位装着ピン及び近位装着ピンを有する例示的なカートリッジを示す図である。
(図5)図5は、本発明の一実施形態のカートリッジが装着されていると共にカバーで覆われている自動注射器の分解組立図である。
(図6)本発明の一実施形態における一体的な受け入れフレームの近位部分とカートリッジの近位部分との干渉接続を示す例示的形状の近接断面図である。
(図7)本発明の一実施形態のカートリッジ及びそのカートリッジの駆動システムの例示的な隣り合わせの構成を示す上面斜視図である。
(図8A)本発明の一実施形態のスナップ取り付け具によるカートリッジの静止を説明するための側面断面図である。
(図8B)本発明の一実施形態のスナップ取り付け具によるカートリッジの静止を説明するための部分的な斜視図である。
(図9)本発明の一実施形態における静止システムのうちのカバー伸長部の組み込みを説明するための自動注射器の側面断面図である。
(図10)本発明の一実施形態におけるカートリッジの遠位取り付け具を説明するための受け入れフレームの底面斜視図である。
本発明の一実施形態における一態様は、自動注射器装着プレートに対してカートリッジを静止させる(移動を抑える)ものであり、その装着プレートは、使用時において注射対象に装着される。一実施形態において、上記した静止させることは、カートリッジの軸方向並進、例えば、注射針を備えた端部である装着プレートの遠位端部に向かうカートリッジの軸方向並進を抑制すること、及び/又は、プランジャを備えた端部である装着プレートの近位端部に向かうカートリッジの軸方向並進を抑制することを含む。これに代えて、あるいはこれに加えて、静止させることは、例えば、カートリッジの回転運動、例えば、カートリッジの長手方向軸を中心とした回転の動きを抑制することを含む。
ここで図面を参照すると、図1は、本発明の一実施形態のカートリッジ及びそのカートリッジの駆動システムを取り付けるための自動注射器装着フレームを表すブロック図である。
ここで図2を参照すると、図2は、本発明の一実施形態において自動注射器の筐体に対するカートリッジの移動を静止させるための方法の概要を示している。
ここで、図3Aを参照すると、本発明の一実施形態の注射器の構成部品を取り付けると共に静止させるための遠位形状及び近位形状を有する例示的な一体的な装着フレームを示している。
ここで、図3Bを参照すると、本発明の一実施形態の自動注射器の一部の構成部品が取り付けられた例示的な一体的な装着フレームを示している。
ここで、図4を参照すると、図4は、本発明の一実施形態の装着フレームと接続するための遠位装着ピン及び近位装着ピンを有する例示的なカートリッジを示している。
ここで、図5を参照すると、図5は、本発明の一の実施形態の自動注射器の分解組立図であり、自動注射器がカートリッジに装着されていると共にカバーで覆われている状態を示している。
ここで、図6を参照すると、図6は、本発明の一実施形態における一体的な装着フレームの近位部分とカートリッジの近位部分との干渉接続を示す例示的形状の近接断面図である。
ここで、図7を参照すると、図7は、本発明の一実施形態のカートリッジ及びその駆動システムの例示的な隣り合わせの構成を示す上面斜視図である。
ここで、図8A及び図8Bを参照すると、本発明の一実施形態のスナップ取り付け具の側面図を示しており、カートリッジの押え込みを図示している。図8Aは、図8Bの断面図を示しており、図8Bは、部分的な斜視図を示している。
ここで、図9を参照すると、図9は、本発明の一実施形態における押え込みシステムのうちのカバー伸長部の組み込みを説明するために、自動注射器の側面断面図を示している。
ここで、図10を参照すると、本発明の一実施形態におけるカートリッジの遠位取り付け具を説明するために、例示的な一体的な装着フレームの底面斜視図を示している。
一実施形態において、リザーバ(例:シリンジ)のペイロードは、例えば、0.5〜2mL、及び/又は2〜4mL、及び/又は4〜6mL、及び/又は4〜10mL、及び/又はそれ以上の範囲の量の薬剤を含んでいる。一実施形態において、注射器は、1回の投与においてペイロード全量を注出してもよい。薬剤送給装置は、例えば、パッチ型自己注射器及び/又はプランジャを駆動するため、及び/又はペイロードを注出するために、内部電源駆動装置を含んでいてもよい。この用途のために、内部で駆動される注射器装置は、注射器内に少なくとも一時的に格納されたエネルギーによって駆動される駆動機構でもよい。動力は、例えば、化学ポテンシャルとして電源に貯蔵されてよいし(例として膨張ガスを生成する化学物質及び/又はバッテリ)、及び/又は機械的ポテンシャル(例として弾性部材及び/又はばね及び/又は圧縮ガス内に蓄えられる)であってもよい。例えば、駆動装置は、ペイロードを20〜120秒、及び/又は120〜600秒、及び/又は600秒〜1時間、及び/又は1時間〜1日、及び/又はそれ以上の範囲の時間にわたって注出してよい。
本明細書において用いられている「約」という用語は、±25%を意味する。
(符号の説明)
101…装着プレート、104…遠位端部、106…近位端部、110…受け入れフレーム、116…針、120…カートリッジ、140…プランジャ駆動装置、141…プランジャ、170…モータ、315…プランジャ駆動装置装着部、317…モータ装着部、327…カートリッジ装着部、410…リザーバ。
Claims (20)
- カートリッジのリザーバから医薬物質を送給すると共に、前記カートリッジの遠位端部が針と相互に接続されていると共に前記カートリッジの近位端部がプランジャ駆動装置と機械的に接続されている自動注射器であって、
接続特徴部を有する前記カートリッジと、注射対象と接触する接触表面と、前記接触表面に接続されたフレームとを備え、
前記フレームは、遠位停止部を有する干渉部と、スナップ部とを含み、
前記干渉部は、前記接続特徴部と摺動可能に連結されていると共に、前記カートリッジを前記遠位停止部まで摺動可能となるようにサイズ調整されており、
前記スナップ部は、前記干渉部が前記接続特徴部を受け入れ可能とすると共に、前記カートリッジの取外れを防止し、
前記フレームは、プランジャ駆動装置を収容及び固定する駆動装置部を含み、
前記プランジャ駆動装置は、プランジャを駆動して前記針を介して前記リザーバの内容物を移動させることにより、前記リザーバから前記注射対象に流体を注射する、
自動注射器。 - 前記フレームは、一体的である、
請求項1記載の自動注射器。 - 前記フレームは、前記プランジャ駆動装置と連動可能なモータを収容すると共に固定するモータ装着部を含む、
請求項1記載の自動注射器。 - 前記モータ、前記駆動装置及び前記リザーバは、同一平面上に配置された長手方向軸を有する、
請求項3記載の自動注射器。 - さらに、筐体を備え、
前記フレームは、前記筐体の近位部に配置されている、
請求項1記載の自動注射器。 - 前記フレームは、前記カートリッジの並進運動を抑制することに適している、
請求項1記載の自動注射器。 - 前記フレームは、前記カートリッジの回転運動を抑制することに適している、
請求項1記載の自動注射器。 - 前記駆動装着部は、上部開口部を有する壁付き容器を含む、
請求項1記載の自動注射器。 - さらに、前記壁付き容器内における少なくとも1つの窪みに係合される少なくとも1つの伸長部を含む上部カバーを備えた、
請求項8記載の自動注射器。 - 前記上部カバーは、前記プランジャ駆動装置が遠位方向に摺動した際に前記壁付き容器の近位壁における窪みと前記プランジャ駆動装置の近位部との間に嵌合するようにサイズ調整された伸長部を含む、
請求項9記載の自動注射器。 - 自動注射器の筐体に対して接続特徴部を有するカートリッジを静止させると共に、前記カートリッジが遠位端部に針を有していると共に前記カートリッジの近位端部がプランジャ駆動装置と機械的に接続されている受け入れフレームであって、
前記自動注射器のベース部に適合する腹面部と、背面部とを備え、
前記背面部は、前記カートリッジを上方から受け入れるカートリッジ装着部と、前記プランジャ駆動装置を収容すると共に固定する駆動装置装着部とを含み、
前記カートリッジ装着部は、遠位停止部を有する干渉部と、スナップ部とを含み、
前記干渉部は、前記接続特徴部と摺動可能に連結されていると共に、前記カートリッジを前記遠位停止部まで摺動可能となるようにサイズ調整されており、
前記スナップ部は、前記干渉部が前記接続特徴部を受け入れ可能とすると共に、前記カートリッジの取外れを防止し、
前記駆動装置装着部は、壁付き容器を含み、
前記壁付き容器は、前記プランジャ駆動装置を少なくとも部分的に囲むようにサイズ調整されていると共に、上方から前記プランジャ駆動装置を受け入れる開口上部を有し、
前記カートリッジと前記駆動装置装着部とは、前記プランジャ駆動装置を介して機械的に接続されている、
受け入れフレーム。 - さらに、前記プランジャ駆動装置と連動可能なモータを収容すると共に固定するモータ装着部を含み、
前記モータ装着部は、前記モータを少なくとも部分的に囲むようにサイズ調整されていると共に、上方から前記モータを受け入れる開口上部を有する壁付き容器を含む、
請求項11記載の受け入れフレーム。 - 前記カートリッジ装着部、前記駆動装置装着部及び前記モータ装着部は、一体的な部品からなる、
請求項11記載の受け入れフレーム。 - 前記カートリッジ、前記プランジャ駆動装置及び前記モータの長手方向軸は、同一平面
上に配置されている、
請求項11記載の受け入れフレーム。 - 前記駆動装置装着部は、少なくとも20Kg・cmの力を抑制する、
請求項11記載の受け入れフレーム。 - 前記干渉部は、前記カートリッジの背面側、遠位側及び腹部側から前記カートリッジの一部を囲むように形成されている、
請求項11記載の受け入れフレーム。 - モータを備えた自動注射器において接続特徴部を有するカートリッジを接続させると共に、前記カートリッジの遠位端部が針と相互に接続されていると共に前記カートリッジの近位端部がプランジャ駆動装置と機械的に接続されている方法であって、
前記プランジャ駆動装置と機械的に接続させながら、前記自動注射器のうちの開口上部を有する受け入れフレームまで前記カートリッジを降下させることと、
遠位停止部に到達するまで前記カートリッジを前記遠位端部の方向に摺動させることと、
前記接続特徴部を前記受け入れフレームの干渉部に連結させることと、
前記接続特徴部をスナップ運動させることにより、前記カートリッジの取外れを防止することと、
前記プランジャ駆動装置によって前記カートリッジ上において前記受け入れフレームを介して発生した力を抑制することにより、前記自動注射器において前記カートリッジを静止させることと
を含む、方法。 - 前記力を抑制することは、前記カートリッジの軸方向並進を機械的に抑制することを含む、
請求項17記載の方法。 - 前記力を抑制することは、前記カートリッジの回転並進を機械的に抑制することを含む、
請求項17記載の方法。 - 前記連結させることは、背面側、腹部側、近位側及び遠位側のうちの少なくとも4つの方向から前記カートリッジの一部を囲むことを含む、
請求項17記載の方法。
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2016
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CN111544704B (zh) | 2022-06-03 |
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CN109219456B (zh) | 2020-05-15 |
CN109219456A (zh) | 2019-01-15 |
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US20200009316A1 (en) | 2020-01-09 |
US20190030241A1 (en) | 2019-01-31 |
EP3711793A1 (en) | 2020-09-23 |
JP2019502489A (ja) | 2019-01-31 |
CN111544704A (zh) | 2020-08-18 |
EP3405227B1 (en) | 2020-06-17 |
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