JP6224084B2 - 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 - Google Patents
糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 Download PDFInfo
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- JP6224084B2 JP6224084B2 JP2015512016A JP2015512016A JP6224084B2 JP 6224084 B2 JP6224084 B2 JP 6224084B2 JP 2015512016 A JP2015512016 A JP 2015512016A JP 2015512016 A JP2015512016 A JP 2015512016A JP 6224084 B2 JP6224084 B2 JP 6224084B2
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- dpp
- nephropathy
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- YLTXBUGZVMPESA-OAHLLOKOSA-N Cc1ccnc(CN(C(c([n]2CC#CC)c(N3C)nc2N(CCC2)C[C@@H]2N)=O)C3=O)n1 Chemical compound Cc1ccnc(CN(C(c([n]2CC#CC)c(N3C)nc2N(CCC2)C[C@@H]2N)=O)C3=O)n1 YLTXBUGZVMPESA-OAHLLOKOSA-N 0.000 description 1
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167953 | 2012-05-14 | ||
| EP12167953.4 | 2012-05-14 | ||
| EP12170888 | 2012-06-05 | ||
| EP12170888.7 | 2012-06-05 | ||
| EP12006812.7 | 2012-09-28 | ||
| EP12006812 | 2012-09-28 | ||
| EP12190447.8 | 2012-10-29 | ||
| EP12190447 | 2012-10-29 | ||
| PCT/EP2013/059831 WO2013171167A1 (en) | 2012-05-14 | 2013-05-13 | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017194101A Division JP6473208B2 (ja) | 2012-05-14 | 2017-10-04 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516456A JP2015516456A (ja) | 2015-06-11 |
| JP2015516456A5 JP2015516456A5 (enExample) | 2016-06-30 |
| JP6224084B2 true JP6224084B2 (ja) | 2017-11-01 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512016A Active JP6224084B2 (ja) | 2012-05-14 | 2013-05-13 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
| JP2017194101A Active JP6473208B2 (ja) | 2012-05-14 | 2017-10-04 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
| JP2019009897A Active JP6759373B2 (ja) | 2012-05-14 | 2019-01-24 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017194101A Active JP6473208B2 (ja) | 2012-05-14 | 2017-10-04 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
| JP2019009897A Active JP6759373B2 (ja) | 2012-05-14 | 2019-01-24 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
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| US (6) | US20130303462A1 (enExample) |
| EP (2) | EP2849755A1 (enExample) |
| JP (3) | JP6224084B2 (enExample) |
| WO (1) | WO2013171167A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| BRPI0711558A2 (pt) | 2006-05-04 | 2011-11-08 | Boeringer Ingelheim Internat Gmbh | polimorfos |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| AU2009331471B2 (en) | 2008-12-23 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Salt forms of organic compound |
| PH12012501037A1 (en) | 2009-11-27 | 2013-01-14 | Boehringer Ingelheim Int | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
| CA2797310C (en) | 2010-05-05 | 2020-03-31 | Boehringer Ingelheim International Gmbh | Glp-1 receptor agonist and dpp-4 inhibitor combination therapy |
| KR20230051307A (ko) | 2010-06-24 | 2023-04-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| ES2713566T3 (es) | 2011-07-15 | 2019-05-22 | Boehringer Ingelheim Int | Derivado de quinazolina dimérico sustituido, su preparación y su uso en composiciones farmacéuticas para el tratamiento de la diabetes de tipo I y II |
| US9561145B2 (en) | 2012-02-07 | 2017-02-07 | Roger P. Jackson | Fail-safe release mechanism for use with patient positioning support apparati |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
| EP4151218A1 (en) | 2012-05-14 | 2023-03-22 | Boehringer Ingelheim International GmbH | Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| JP2016510795A (ja) * | 2013-03-15 | 2016-04-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 心臓保護及び腎臓保護の抗糖尿病治療におけるリナグリプチンの使用 |
| EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| WO2016016853A1 (en) * | 2014-07-31 | 2016-02-04 | Sun Pharmaceutical Industries Limited | Method of controlling carbamoyl impurity in pharmaceutical compositions of dabigatran |
| US9968659B2 (en) | 2016-03-04 | 2018-05-15 | Novo Nordisk A/S | Liraglutide in cardiovascular conditions |
| WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
| CA3079081A1 (en) | 2017-10-19 | 2019-04-25 | Michael D. Bartberger | Benzimidazole derivatives and their uses |
| JP7055429B2 (ja) * | 2017-10-27 | 2022-04-18 | 学校法人北里研究所 | 慢性腎臓病の予防又は治療剤 |
| US10828310B2 (en) * | 2018-02-02 | 2020-11-10 | Bayer Pharma Aktiengesellschaft | Reducing the risk of cardiovascular events |
| CN108358925B (zh) * | 2018-02-24 | 2021-04-06 | 中山大学 | 一种7,8-取代-3-甲基黄嘌呤类化合物及其制备方法和应用 |
| EP3823625A1 (en) * | 2018-07-17 | 2021-05-26 | Boehringer Ingelheim International GmbH | Cardio- and renosafe antidiabetic therapy |
| US20210299129A1 (en) * | 2018-07-17 | 2021-09-30 | Boehringer Ingelheim International Gmbh | Cardiosafe Antidiabetic Therapy |
| WO2022244846A1 (ja) * | 2021-05-19 | 2022-11-24 | Kagami株式会社 | 細胞増殖の調整のための組成物及び細胞増殖の調整方法 |
| CN115137785B (zh) * | 2022-07-21 | 2023-06-20 | 湖北省中医院 | 用于治疗特发性膜性肾病的膜肾方 |
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| US2056046A (en) | 1933-05-19 | 1936-09-29 | Rhone Poulenc Sa | Manufacture of bases derived from benz-dioxane |
| US2375138A (en) | 1942-05-01 | 1945-05-01 | American Cyanamid Co | Alkamine esters of aryloxymethyl benzoic acid |
| US2629736A (en) | 1951-02-24 | 1953-02-24 | Searle & Co | Basically substituted n-alkyl derivatives of alpha, beta, beta-triarylpropionamides |
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2013
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- 2013-05-13 EP EP13722419.2A patent/EP2849755A1/en not_active Withdrawn
- 2013-05-13 JP JP2015512016A patent/JP6224084B2/ja active Active
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| US20160082011A1 (en) | 2016-03-24 |
| US20170065595A1 (en) | 2017-03-09 |
| EP3685839A1 (en) | 2020-07-29 |
| US20240299399A1 (en) | 2024-09-12 |
| JP2015516456A (ja) | 2015-06-11 |
| EP2849755A1 (en) | 2015-03-25 |
| JP6473208B2 (ja) | 2019-02-20 |
| WO2013171167A1 (en) | 2013-11-21 |
| JP2018030872A (ja) | 2018-03-01 |
| US20190099427A1 (en) | 2019-04-04 |
| JP6759373B2 (ja) | 2020-09-23 |
| US9526730B2 (en) | 2016-12-27 |
| JP2019089797A (ja) | 2019-06-13 |
| US20210379073A1 (en) | 2021-12-09 |
| US10195203B2 (en) | 2019-02-05 |
| US20130303462A1 (en) | 2013-11-14 |
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