JP6133211B2 - 骨髄線維症を処置するための組成物及び方法 - Google Patents

骨髄線維症を処置するための組成物及び方法 Download PDF

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JP6133211B2
JP6133211B2 JP2013537919A JP2013537919A JP6133211B2 JP 6133211 B2 JP6133211 B2 JP 6133211B2 JP 2013537919 A JP2013537919 A JP 2013537919A JP 2013537919 A JP2013537919 A JP 2013537919A JP 6133211 B2 JP6133211 B2 JP 6133211B2
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crystalline cellulose
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JP2013541595A (ja
JP2013541595A5 (enExample
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アーヴィンド・ジェヤン
ジャニス・カカーセ
アヤリュー・テフェリー
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ターゲジェン インコーポレーティッド
ターゲジェン インコーポレーティッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2013537919A 2010-11-07 2011-11-07 骨髄線維症を処置するための組成物及び方法 Active JP6133211B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41092410P 2010-11-07 2010-11-07
US61/410,924 2010-11-07
PCT/US2011/059643 WO2012061833A1 (en) 2010-11-07 2011-11-07 Compositions and methods for treating myelofibrosis

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JP2013541595A JP2013541595A (ja) 2013-11-14
JP2013541595A5 JP2013541595A5 (enExample) 2014-12-25
JP6133211B2 true JP6133211B2 (ja) 2017-05-24

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JP2013537919A Active JP6133211B2 (ja) 2010-11-07 2011-11-07 骨髄線維症を処置するための組成物及び方法

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US (5) US20130252988A1 (enExample)
EP (2) EP2635282B1 (enExample)
JP (1) JP6133211B2 (enExample)
KR (4) KR20240029118A (enExample)
CN (2) CN103282036B (enExample)
AU (2) AU2010363329A1 (enExample)
BR (1) BR112013011184A2 (enExample)
CA (2) CA2816957A1 (enExample)
CL (1) CL2013001252A1 (enExample)
CO (1) CO6801724A2 (enExample)
DK (1) DK2635282T3 (enExample)
DO (1) DOP2013000097A (enExample)
EC (1) ECSP13012658A (enExample)
ES (1) ES2930650T3 (enExample)
HR (1) HRP20221269T1 (enExample)
HU (1) HUE060254T2 (enExample)
IL (1) IL226101A (enExample)
LT (1) LT2635282T (enExample)
MA (1) MA34723B1 (enExample)
MX (2) MX360246B (enExample)
MY (1) MY161164A (enExample)
NI (1) NI201300038A (enExample)
NZ (1) NZ611363A (enExample)
PE (1) PE20140389A1 (enExample)
PH (1) PH12013500924A1 (enExample)
PL (1) PL2635282T3 (enExample)
PT (1) PT2635282T (enExample)
RS (1) RS63996B1 (enExample)
RU (1) RU2616262C2 (enExample)
SG (1) SG190134A1 (enExample)
SI (1) SI2635282T1 (enExample)
SM (1) SMT202200453T1 (enExample)
TW (1) TWI531389B (enExample)
UA (1) UA114076C2 (enExample)
WO (2) WO2012060847A1 (enExample)
ZA (1) ZA201303423B (enExample)

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AU2010363329A1 (en) * 2010-11-07 2013-05-09 Targegen, Inc. Compositions and methods for treating myelofibrosis
WO2013059548A1 (en) * 2011-10-19 2013-04-25 Sanofi Compositions and methods for treating cancer using jak2 inhibitor
MX370175B (es) * 2013-03-06 2019-12-04 Novartis Ag Formulaciones de compuestos orgánicos.
CN104771761A (zh) * 2015-03-19 2015-07-15 深圳国源国药有限公司 一种创新药用辅料硅化微晶纤维素及其制备方法
EP3327441B1 (en) * 2015-07-24 2021-02-17 Public University Corporation Nagoya City University Method for assisting diagnosis of conditions of myelofibrosis, method for monitoring therapeutic effect, and a device therefor
CN105919955A (zh) * 2016-06-13 2016-09-07 佛山市腾瑞医药科技有限公司 一种鲁索利替尼制剂及其应用
PT3490582T (pt) 2016-07-27 2024-08-21 Acceleron Pharma Inc Composições para utilização no tratamento da mielofibrose
WO2019140953A1 (zh) * 2018-01-16 2019-07-25 深圳市塔吉瑞生物医药有限公司 用于抑制激酶活性的二苯氨基嘧啶类化合物
US20220031699A1 (en) * 2018-09-25 2022-02-03 Impact Biomedicines, Inc. Methods of treating myeloproliferative disorders
KR20250134004A (ko) * 2018-09-25 2025-09-09 임팩트 바이오메디신스, 인코포레이티드 골수증식성 장애를 치료하는 방법
JP2022519885A (ja) * 2019-02-12 2022-03-25 インパクト バイオメディシンズ インコーポレイテッド Ｊａｋ２阻害剤の結晶形態
FR3092581A1 (fr) * 2019-02-12 2020-08-14 Impact Biomedicines, Inc Formes cristallines d'un inhibiteur de jak2
US20220372135A1 (en) 2019-09-27 2022-11-24 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
US11306062B2 (en) 2019-10-29 2022-04-19 Johnson Matthey Public Limited Forms of fedratinib dihydrochloride
FI4076404T3 (fi) * 2019-12-20 2024-01-31 Intervet Int Bv Farmaseuttinen pyratsolikoostumus
WO2021207051A1 (en) * 2020-04-06 2021-10-14 Bristol-Myers Squibb Company Methods of treating acute respiratory disorders
IL297437A (en) 2020-05-13 2022-12-01 Disc Medicine Inc Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
IL303118A (en) 2020-12-16 2023-07-01 Impact Biomedicines Inc Dosing of fedratinib
EP4297750A1 (en) 2021-02-25 2024-01-03 Impact Biomedicines, Inc. Use of a bet inhibitor alone or in combination with fedratinib or ruxolitinib for treating a hematological malignancy such as myelofibrosis
WO2023044297A1 (en) 2021-09-14 2023-03-23 Impact Biomedicines, Inc. Fedratinib for treating myeloproliferative disorders

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