MX360246B - Composiciones y metodos para el tratamiento de la mielofibrosis. - Google Patents

Composiciones y metodos para el tratamiento de la mielofibrosis.

Info

Publication number
MX360246B
MX360246B MX2013005020A MX2013005020A MX360246B MX 360246 B MX360246 B MX 360246B MX 2013005020 A MX2013005020 A MX 2013005020A MX 2013005020 A MX2013005020 A MX 2013005020A MX 360246 B MX360246 B MX 360246B
Authority
MX
Mexico
Prior art keywords
methods
compositions
treating myelofibrosis
amino
subject
Prior art date
Application number
MX2013005020A
Other languages
English (en)
Other versions
MX2013005020A (es
Inventor
Jayan Arvind
Cacace Janice
Tefferi Ayalew
Original Assignee
Targegen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46024747&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX360246(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Targegen Inc filed Critical Targegen Inc
Publication of MX2013005020A publication Critical patent/MX2013005020A/es
Publication of MX360246B publication Critical patent/MX360246B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

En la presente se proporcionan las composiciones y métodos para tratar mielofibrosis en un sujeto. Los métodos comprenden administrar al sujeto una cantidad eficaz de compuesto que es N-ter-butil-3-[(5-metil-2-{ [4-(2-pirrolidin-1-iletoxi)fenil]amino }pirimidin-4-il)amino]bencensulfonamida o una sal farmacéuticamente aceptable del mismo o un hidrato del mismo.
MX2013005020A 2010-11-07 2011-11-07 Composiciones y metodos para el tratamiento de la mielofibrosis. MX360246B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41092410P 2010-11-07 2010-11-07
PCT/US2011/059643 WO2012061833A1 (en) 2010-11-07 2011-11-07 Compositions and methods for treating myelofibrosis

Publications (2)

Publication Number Publication Date
MX2013005020A MX2013005020A (es) 2013-07-29
MX360246B true MX360246B (es) 2018-10-26

Family

ID=46024747

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013005020A MX360246B (es) 2010-11-07 2011-11-07 Composiciones y metodos para el tratamiento de la mielofibrosis.
MX2018007660A MX381913B (es) 2010-11-07 2011-11-07 Composiciones y metodos para el tratamiento de la mielofibrosis.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018007660A MX381913B (es) 2010-11-07 2011-11-07 Composiciones y metodos para el tratamiento de la mielofibrosis.

Country Status (36)

Country Link
US (5) US20130252988A1 (es)
EP (2) EP4159216A1 (es)
JP (1) JP6133211B2 (es)
KR (4) KR101940979B1 (es)
CN (2) CN108125923A (es)
AU (2) AU2010363329A1 (es)
BR (1) BR112013011184A2 (es)
CA (2) CA2816957A1 (es)
CL (1) CL2013001252A1 (es)
CO (1) CO6801724A2 (es)
DK (1) DK2635282T3 (es)
DO (1) DOP2013000097A (es)
EC (1) ECSP13012658A (es)
ES (1) ES2930650T3 (es)
HR (1) HRP20221269T1 (es)
HU (1) HUE060254T2 (es)
IL (1) IL226101A (es)
LT (1) LT2635282T (es)
MA (1) MA34723B1 (es)
MX (2) MX360246B (es)
MY (1) MY161164A (es)
NI (1) NI201300038A (es)
NZ (1) NZ611363A (es)
PE (1) PE20140389A1 (es)
PH (1) PH12013500924A1 (es)
PL (1) PL2635282T3 (es)
PT (1) PT2635282T (es)
RS (1) RS63996B1 (es)
RU (1) RU2616262C2 (es)
SG (1) SG190134A1 (es)
SI (1) SI2635282T1 (es)
SM (1) SMT202200453T1 (es)
TW (1) TWI531389B (es)
UA (1) UA114076C2 (es)
WO (2) WO2012060847A1 (es)
ZA (1) ZA201303423B (es)

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WO2012060847A1 (en) * 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
WO2013059548A1 (en) * 2011-10-19 2013-04-25 Sanofi Compositions and methods for treating cancer using jak2 inhibitor
EA028301B1 (ru) * 2013-03-06 2017-10-31 Новартис Аг Составы с органическими соединениями
CN104771761A (zh) * 2015-03-19 2015-07-15 深圳国源国药有限公司 一种创新药用辅料硅化微晶纤维素及其制备方法
WO2017018385A1 (ja) * 2015-07-24 2017-02-02 公立大学法人名古屋市立大学 骨髄線維症の状態の診断を補助する方法、予後の予測を補助する方法、及び治療効果のモニター方法、並びにそれらの方法に用いるマーカー及び装置
CN105919955A (zh) * 2016-06-13 2016-09-07 佛山市腾瑞医药科技有限公司 一种鲁索利替尼制剂及其应用
AU2017302282B2 (en) 2016-07-27 2024-07-25 Acceleron Pharma Inc. Methods and compositions for treating myelofibrosis
US11384069B2 (en) 2018-01-16 2022-07-12 Shenzhen Targetrx, Inc. Diphenylaminopyrimidine compound for inhibiting kinase activity
WO2020068754A1 (en) * 2018-09-25 2020-04-02 Impact Biomedicines, Inc. Methods of treating myeloproliferative disorders
KR20250164332A (ko) * 2018-09-25 2025-11-24 임팩트 바이오메디신스, 인코포레이티드 골수증식성 장애를 치료하는 방법
FR3092581A1 (fr) * 2019-02-12 2020-08-14 Impact Biomedicines, Inc Formes cristallines d'un inhibiteur de jak2
JP2022519885A (ja) * 2019-02-12 2022-03-25 インパクト バイオメディシンズ インコーポレイテッド Ｊａｋ２阻害剤の結晶形態
CN114761013A (zh) 2019-09-27 2022-07-15 迪斯克医药公司 治疗骨髓纤维化和相关病症的方法
US11306062B2 (en) 2019-10-29 2022-04-19 Johnson Matthey Public Limited Forms of fedratinib dihydrochloride
KR20220119024A (ko) * 2019-12-20 2022-08-26 인터벳 인터내셔널 비.브이. 피라졸 제약 조성물
WO2021207051A1 (en) * 2020-04-06 2021-10-14 Bristol-Myers Squibb Company Methods of treating acute respiratory disorders
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
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CA3206708A1 (en) 2021-02-25 2022-09-01 Ida ARONCHIK Use of a bet inhibitor alone or in combination with fedratinib or ruxolitinib for treating a hematological malignancy such as myelofibrosis
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