JP5813321B2 - 体細胞の再プログラム化 - Google Patents
体細胞の再プログラム化 Download PDFInfo
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- JP5813321B2 JP5813321B2 JP2010501136A JP2010501136A JP5813321B2 JP 5813321 B2 JP5813321 B2 JP 5813321B2 JP 2010501136 A JP2010501136 A JP 2010501136A JP 2010501136 A JP2010501136 A JP 2010501136A JP 5813321 B2 JP5813321 B2 JP 5813321B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- A61P25/00—Drugs for disorders of the nervous system
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- C12N5/10—Cells modified by introduction of foreign genetic material
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- C12N2501/603—Oct-3/4
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- C12N2501/604—Klf-4
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- C12N2501/608—Lin28
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91968707P | 2007-03-23 | 2007-03-23 | |
| US60/919,687 | 2007-03-23 | ||
| US97498007P | 2007-09-25 | 2007-09-25 | |
| US60/974,980 | 2007-09-25 | ||
| US98905807P | 2007-11-19 | 2007-11-19 | |
| US60/989,058 | 2007-11-19 | ||
| PCT/US2008/057924 WO2008118820A2 (en) | 2007-03-23 | 2008-03-21 | Somatic cell reprogramming |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094203A Division JP6788329B2 (ja) | 2007-03-23 | 2015-05-01 | 体細胞の再プログラム化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010521990A JP2010521990A (ja) | 2010-07-01 |
| JP2010521990A5 JP2010521990A5 (https=) | 2011-04-14 |
| JP5813321B2 true JP5813321B2 (ja) | 2015-11-17 |
Family
ID=39708430
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501136A Active JP5813321B2 (ja) | 2007-03-23 | 2008-03-21 | 体細胞の再プログラム化 |
| JP2015094203A Active JP6788329B2 (ja) | 2007-03-23 | 2015-05-01 | 体細胞の再プログラム化 |
| JP2018147684A Pending JP2018183183A (ja) | 2007-03-23 | 2018-08-06 | 体細胞の再プログラム化 |
| JP2018147683A Active JP6924732B2 (ja) | 2007-03-23 | 2018-08-06 | 体細胞の再プログラム化 |
| JP2021126772A Pending JP2021176331A (ja) | 2007-03-23 | 2021-08-02 | 体細胞の再プログラム化 |
| JP2024010931A Pending JP2024038501A (ja) | 2007-03-23 | 2024-01-29 | 体細胞の再プログラム化 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094203A Active JP6788329B2 (ja) | 2007-03-23 | 2015-05-01 | 体細胞の再プログラム化 |
| JP2018147684A Pending JP2018183183A (ja) | 2007-03-23 | 2018-08-06 | 体細胞の再プログラム化 |
| JP2018147683A Active JP6924732B2 (ja) | 2007-03-23 | 2018-08-06 | 体細胞の再プログラム化 |
| JP2021126772A Pending JP2021176331A (ja) | 2007-03-23 | 2021-08-02 | 体細胞の再プログラム化 |
| JP2024010931A Pending JP2024038501A (ja) | 2007-03-23 | 2024-01-29 | 体細胞の再プログラム化 |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US8440461B2 (https=) |
| EP (2) | EP3399025B1 (https=) |
| JP (6) | JP5813321B2 (https=) |
| KR (1) | KR101516833B1 (https=) |
| CN (1) | CN101743306A (https=) |
| AU (1) | AU2008231020B2 (https=) |
| CA (1) | CA2684242C (https=) |
| DK (1) | DK3399025T3 (https=) |
| IL (1) | IL200982A (https=) |
| SG (2) | SG193653A1 (https=) |
| WO (1) | WO2008118820A2 (https=) |
Families Citing this family (250)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| AU2006252576B2 (en) * | 2005-06-01 | 2011-01-20 | Wisconsin Alumni Research Foundation | Method of forming dendritic cells from embryonic stem cells |
| US8034613B2 (en) | 2005-06-01 | 2011-10-11 | Wisconsin Alumni Research Foundation | Multipotent lymphohematopoietic progenitor cells |
| US8129187B2 (en) * | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| AU2007215276B2 (en) * | 2006-02-09 | 2013-09-19 | Maryna E. Gumenyuk | Erythroid cells producing adult-type beta-hemoglobin generated from human embryonic stem cells |
| JP5813321B2 (ja) * | 2007-03-23 | 2015-11-17 | ウィスコンシン アラムニ リサーチ ファンデーション | 体細胞の再プログラム化 |
| CN105861443A (zh) | 2007-04-07 | 2016-08-17 | 怀特黑德生物医学研究所 | 体细胞重编程 |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| US20110236971A2 (en) * | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
| KR101564044B1 (ko) * | 2007-10-31 | 2015-10-28 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 핵초기화 방법 |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| JP5558097B2 (ja) * | 2007-12-10 | 2014-07-23 | 国立大学法人京都大学 | 効率的な核初期化方法 |
| US20100279404A1 (en) | 2008-05-02 | 2010-11-04 | Shinya Yamanaka | Method of nuclear reprogramming |
| CA2723820A1 (en) * | 2008-05-09 | 2009-11-12 | Vistagen Therapeutics, Inc. | Pancreatic endocrine progenitor cells derived from pluripotent stem cells |
| EP3279314A1 (en) | 2008-06-04 | 2018-02-07 | Cellular Dynamics International, Inc. | Methods for the production of ips cells using non-viral approach |
| EP3231869A1 (en) | 2008-06-13 | 2017-10-18 | Whitehead Institute for Biomedical Research | Programming and reprogramming of cells |
| CA2695590C (en) | 2008-06-27 | 2018-01-09 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| EP2307539B1 (en) | 2008-07-30 | 2014-11-19 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| CA2734128A1 (en) | 2008-08-12 | 2010-02-18 | Cellular Dynamics International, Inc. | Methods for the production of ips cells |
| US20120021519A1 (en) * | 2008-09-19 | 2012-01-26 | Presidents And Fellows Of Harvard College | Efficient induction of pluripotent stem cells using small molecule compounds |
| WO2010042800A1 (en) * | 2008-10-10 | 2010-04-15 | Nevada Cancer Institute | Methods of reprogramming somatic cells and methods of use for such cells |
| DK2356221T3 (en) | 2008-10-24 | 2019-02-18 | Wisconsin Alumni Res Found | Pluripotent stem cells obtained by non-viral reprogramming |
| JP2012507258A (ja) * | 2008-10-30 | 2012-03-29 | 国立大学法人京都大学 | 人工多能性幹細胞の作製方法 |
| US20110318830A1 (en) * | 2008-11-12 | 2011-12-29 | The Regents Of The University Of California | Compositions and methods for re-programming and re-differentiating cells |
| EP2376626A4 (en) * | 2008-12-13 | 2012-10-17 | Dna Microarray | MICRO-ENVIRONMENTAL NICHE ASSAY FOR SCREENING OF INDUCED PLURIPOTENT STEM CELLS (CIPS) |
| WO2010085326A1 (en) * | 2009-01-20 | 2010-07-29 | Stemnion, Inc. | Dedifferentiation and reprogramming of cells |
| WO2010096746A1 (en) | 2009-02-20 | 2010-08-26 | Cellular Dynamics International, Inc. | Methods and compositions for the differentiation of stem cells |
| WO2010098419A1 (en) * | 2009-02-27 | 2010-09-02 | Kyoto University | Novel nuclear reprogramming substance |
| US9487756B2 (en) | 2009-03-20 | 2016-11-08 | Mesoblast, Inc. | Production of reprogrammed pluripotent cells |
| EP2421957B1 (en) | 2009-04-22 | 2020-11-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| EP2438159B1 (en) | 2009-05-29 | 2018-10-03 | Kyoto University | Method for selecting clone of induced pluripotent stem cells |
| WO2010141801A2 (en) | 2009-06-05 | 2010-12-09 | Cellular Dynamics International, Inc. | Reprogramming t cells and hematophietic cells |
| WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
| JP5645197B2 (ja) * | 2009-06-23 | 2014-12-24 | 学校法人日本大学 | 幹細胞の未分化状態を維持する新規方法 |
| CA2770412C (en) | 2009-08-07 | 2018-09-11 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US8709805B2 (en) | 2009-08-07 | 2014-04-29 | Kyoto University | Canine iPS cells and method of producing same |
| JP5709015B2 (ja) | 2009-08-19 | 2015-04-30 | 国立大学法人大阪大学 | 角膜移植用シート |
| US8993329B2 (en) | 2009-09-24 | 2015-03-31 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| GB2474492B (en) * | 2009-10-19 | 2014-05-21 | Tristem Trading Cyprus Ltd | Treatment using reprogrammed mature adult cells |
| EP2494032A4 (en) | 2009-10-29 | 2013-06-05 | Univ Mcmaster | GENERATION OF INDUCED PLURIPOTENTER STEM CELLS AND FIBROBLAST PRECURSOR CELLS |
| PL2494035T3 (pl) * | 2009-10-29 | 2018-07-31 | Janssen Biotech, Inc. | Pluripotencjalne komórki macierzyste |
| WO2011056971A2 (en) * | 2009-11-04 | 2011-05-12 | Cellular Dynamics International, Inc. | Episomal reprogramming with chemicals |
| EP2511366A4 (en) | 2009-12-09 | 2014-04-30 | Univ Kyoto | NITROVINE MEDICINE FOR PROMOTING THE DIFFERENTIATION OF PLURIPOTENTAL STEM CELLS IN HEART MUSCLES |
| WO2011074690A1 (en) | 2009-12-14 | 2011-06-23 | Kyoto University | Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis |
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