JP5761997B2 - ヒトｏｘ４０受容体に対する結合分子 - Google Patents

ヒトｏｘ４０受容体に対する結合分子 Download PDF

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Publication number
JP5761997B2
JP5761997B2 JP2010538157A JP2010538157A JP5761997B2 JP 5761997 B2 JP5761997 B2 JP 5761997B2 JP 2010538157 A JP2010538157 A JP 2010538157A JP 2010538157 A JP2010538157 A JP 2010538157A JP 5761997 B2 JP5761997 B2 JP 5761997B2
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antibody
human
ox40r
cells
binding molecule
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Expired - Fee Related
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JP2011505836A (ja
Inventor
ジン・ミン
ヤンリー・ウー
ローリー・フランシス・フィン
バレット・リチャード・シエレ
ウェイ・リヤオ
ロナルド・ポール・グラデュー
アルヴィンド・ラージパル
ティモシー・ジョウゼフ・パラダイス
ペーター・ブラームス
ブリジット・デヴォークス
イー・ウー
クリストファー・トイ
ハイディー・エヌ・レブランク
ハイチュン・フアーン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
JP2010538157A 2007-12-14 2008-12-11 ヒトｏｘ４０受容体に対する結合分子 Expired - Fee Related JP5761997B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1394707P 2007-12-14 2007-12-14
US61/013,947 2007-12-14
PCT/US2008/086417 WO2009079335A1 (en) 2007-12-14 2008-12-11 Binding molecules to the human ox40 receptor

Related Child Applications (1)

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JP2014222800A Division JP6248024B2 (ja) 2007-12-14 2014-10-31 ヒトｏｘ４０受容体に対する結合分子

Publications (2)

Publication Number Publication Date
JP2011505836A JP2011505836A (ja) 2011-03-03
JP5761997B2 true JP5761997B2 (ja) 2015-08-12

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2010538157A Expired - Fee Related JP5761997B2 (ja) 2007-12-14 2008-12-11 ヒトｏｘ４０受容体に対する結合分子
JP2014222800A Expired - Fee Related JP6248024B2 (ja) 2007-12-14 2014-10-31 ヒトｏｘ４０受容体に対する結合分子
JP2017008103A Expired - Fee Related JP6420379B2 (ja) 2007-12-14 2017-01-20 ヒトｏｘ４０受容体に対する結合分子
JP2018191343A Pending JP2019030313A (ja) 2007-12-14 2018-10-10 ヒトｏｘ４０受容体に対する結合分子

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JP2014222800A Expired - Fee Related JP6248024B2 (ja) 2007-12-14 2014-10-31 ヒトｏｘ４０受容体に対する結合分子
JP2017008103A Expired - Fee Related JP6420379B2 (ja) 2007-12-14 2017-01-20 ヒトｏｘ４０受容体に対する結合分子
JP2018191343A Pending JP2019030313A (ja) 2007-12-14 2018-10-10 ヒトｏｘ４０受容体に対する結合分子

Country Status (29)

Country Link
US (7) US7960515B2 (https=)
EP (4) EP2851374B1 (https=)
JP (4) JP5761997B2 (https=)
KR (2) KR101577843B1 (https=)
CN (1) CN101918447B (https=)
AR (2) AR069681A1 (https=)
AU (1) AU2008338591B8 (https=)
BR (1) BRPI0820875B1 (https=)
CA (2) CA2707773C (https=)
CL (1) CL2008003706A1 (https=)
CO (1) CO6280541A2 (https=)
DK (3) DK2851374T3 (https=)
ES (3) ES2628093T3 (https=)
HR (1) HRP20141188T8 (https=)
HU (1) HUE032735T2 (https=)
IL (3) IL206297A (https=)
MX (1) MX2010006466A (https=)
PA (1) PA8807601A1 (https=)
PE (1) PE20091269A1 (https=)
PH (1) PH12015500806B1 (https=)
PL (2) PL2242771T3 (https=)
PT (3) PT2594590E (https=)
RU (1) RU2010129045A (https=)
SG (2) SG10201604770VA (https=)
SI (3) SI2242771T1 (https=)
TW (1) TW200932268A (https=)
UY (1) UY31533A1 (https=)
WO (1) WO2009079335A1 (https=)
ZA (1) ZA201003579B (https=)

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JP2011505836A (ja) 2011-03-03
TW200932268A (en) 2009-08-01
CO6280541A2 (es) 2011-05-20
AU2008338591A8 (en) 2014-02-20
IL239674A (en) 2017-08-31
IL239674A0 (en) 2015-08-31
KR20150061041A (ko) 2015-06-03
DK2242771T3 (da) 2013-08-26
BRPI0820875B1 (pt) 2021-10-19
US20120225086A1 (en) 2012-09-06
IL245876A (en) 2017-08-31
DK2594590T3 (en) 2015-01-12
PA8807601A1 (es) 2009-09-17
KR20100102657A (ko) 2010-09-24
ZA201003579B (en) 2011-07-27
HRP20141188T1 (en) 2015-03-13
PL2242771T3 (pl) 2013-12-31
KR101577843B1 (ko) 2015-12-16
SI2851374T1 (sl) 2017-08-31
MX2010006466A (es) 2010-09-28
CN101918447B (zh) 2014-06-11
AR069681A1 (es) 2010-02-10
PH12015500806A1 (en) 2015-12-02
PT2851374T (pt) 2017-06-20
IL206297A0 (en) 2010-12-30
BRPI0820875A2 (pt) 2015-06-16
ES2526887T3 (es) 2015-01-16
SG186656A1 (en) 2013-01-30
US9028824B2 (en) 2015-05-12
PT2594590E (pt) 2015-01-14
US20220002428A1 (en) 2022-01-06
ES2628093T3 (es) 2017-08-01
AR109355A2 (es) 2018-11-21
EP2242771B1 (en) 2013-07-17
IL245876A0 (en) 2016-07-31
CA2707773A1 (en) 2009-06-25
EP2851374B1 (en) 2017-05-03
EP3239178A1 (en) 2017-11-01
AU2008338591A1 (en) 2009-06-25
PT2242771E (pt) 2013-08-29
CL2008003706A1 (es) 2009-06-12
EP2851374A1 (en) 2015-03-25
PH12015500806B1 (en) 2015-12-02
US20190135932A1 (en) 2019-05-09
JP2017114866A (ja) 2017-06-29
SI2242771T1 (sl) 2013-09-30
JP2015110558A (ja) 2015-06-18
EP2594590A1 (en) 2013-05-22
US20090214560A1 (en) 2009-08-27
US8236930B2 (en) 2012-08-07
CA2707773C (en) 2017-01-10
EP2242771A1 (en) 2010-10-27
US20180057600A1 (en) 2018-03-01
HUE032735T2 (en) 2017-10-30
US7960515B2 (en) 2011-06-14
JP6248024B2 (ja) 2017-12-13
UY31533A1 (es) 2009-08-03
IL206297A (en) 2016-06-30
SI2594590T1 (sl) 2015-03-31
RU2010129045A (ru) 2012-01-20
EP2594590B1 (en) 2014-11-12
CA2949772A1 (en) 2009-06-25
PE20091269A1 (es) 2009-09-09
WO2009079335A1 (en) 2009-06-25
SG10201604770VA (en) 2016-08-30
CN101918447A (zh) 2010-12-15
HRP20141188T8 (en) 2015-05-22
AU2008338591B2 (en) 2014-01-23

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