JP5543609B2 - 新規ｎｅｐ阻害剤としての置換カルバモイルメチルアミノ酢酸誘導体 - Google Patents
新規ｎｅｐ阻害剤としての置換カルバモイルメチルアミノ酢酸誘導体 Download PDFInfo
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- JP5543609B2 JP5543609B2 JP2012538365A JP2012538365A JP5543609B2 JP 5543609 B2 JP5543609 B2 JP 5543609B2 JP 2012538365 A JP2012538365 A JP 2012538365A JP 2012538365 A JP2012538365 A JP 2012538365A JP 5543609 B2 JP5543609 B2 JP 5543609B2
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- Prior art keywords
- alkyl
- halo
- pharmaceutically acceptable
- acceptable salt
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C*1(C2)[C@@]2CCCC1 Chemical compound C*1(C2)[C@@]2CCCC1 0.000 description 2
- FUQNXLHKJIQDOW-GLBCWIETSA-N NN/C(/NC(C(C1)([C@@H]1c(cc1)ccc1-c1cc(Cl)ccc1)N[C@@H](CO)C(O)=O)=O)=N\N Chemical compound NN/C(/NC(C(C1)([C@@H]1c(cc1)ccc1-c1cc(Cl)ccc1)N[C@@H](CO)C(O)=O)=O)=N\N FUQNXLHKJIQDOW-GLBCWIETSA-N 0.000 description 1
- QSESULPFSVBNIK-GLBCWIETSA-N NN/C(/NC(C(C1)([C@@H]1c(cc1)ccc1-c1ccccc1)N[C@@H](CO)C(O)=O)=O)=N\N Chemical compound NN/C(/NC(C(C1)([C@@H]1c(cc1)ccc1-c1ccccc1)N[C@@H](CO)C(O)=O)=O)=N\N QSESULPFSVBNIK-GLBCWIETSA-N 0.000 description 1
- LDKRANIEDTWJSE-VMODYCNZSA-N NN/C(/NC([C@@](C1)([C@@H]1c(cc1)ccc1-c1cc(Cl)ccc1)N[C@@H](COCc1ccccc1)C(O)=O)=O)=N\N Chemical compound NN/C(/NC([C@@](C1)([C@@H]1c(cc1)ccc1-c1cc(Cl)ccc1)N[C@@H](COCc1ccccc1)C(O)=O)=O)=N\N LDKRANIEDTWJSE-VMODYCNZSA-N 0.000 description 1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
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- C07D261/14—Nitrogen atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26313709P | 2009-11-20 | 2009-11-20 | |
| US61/263,137 | 2009-11-20 | ||
| US35991410P | 2010-06-30 | 2010-06-30 | |
| US61/359,914 | 2010-06-30 | ||
| PCT/EP2010/067781 WO2011061271A1 (en) | 2009-11-20 | 2010-11-18 | Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014096844A Division JP2014167015A (ja) | 2009-11-20 | 2014-05-08 | 新規ｎｅｐ阻害剤としての置換カルバモイルメチルアミノ酢酸誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013510835A JP2013510835A (ja) | 2013-03-28 |
| JP5543609B2 true JP5543609B2 (ja) | 2014-07-09 |
Family
ID=43431937
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538365A Expired - Fee Related JP5543609B2 (ja) | 2009-11-20 | 2010-11-18 | 新規ｎｅｐ阻害剤としての置換カルバモイルメチルアミノ酢酸誘導体 |
| JP2014096844A Pending JP2014167015A (ja) | 2009-11-20 | 2014-05-08 | 新規ｎｅｐ阻害剤としての置換カルバモイルメチルアミノ酢酸誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014096844A Pending JP2014167015A (ja) | 2009-11-20 | 2014-05-08 | 新規ｎｅｐ阻害剤としての置換カルバモイルメチルアミノ酢酸誘導体 |
Country Status (37)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014167015A (ja) * | 2009-11-20 | 2014-09-11 | Novartis Ag | 新規ｎｅｐ阻害剤としての置換カルバモイルメチルアミノ酢酸誘導体 |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5466759B2 (ja) * | 2009-05-28 | 2014-04-09 | ノバルティス アーゲー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
| RS53664B1 (sr) | 2009-05-28 | 2015-04-30 | Novartis Ag | Supstituisani derivati aminopropionske kiseline kao inhibitori neprilizina |
| US8993631B2 (en) * | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
| CN103261168B (zh) | 2010-12-15 | 2015-08-05 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| CA2817368C (en) | 2010-12-15 | 2019-12-31 | Theravance, Inc. | Neprilysin inhibitors |
| CA2825737C (en) | 2011-02-17 | 2018-11-13 | Theravance, Inc. | Substituted aminobutyric derivatives as neprilysin inhibitors |
| US8449890B2 (en) | 2011-02-17 | 2013-05-28 | Theravance, Inc. | Neprilysin inhibitors |
| EP2714660B1 (en) | 2011-05-31 | 2018-09-26 | Theravance Biopharma R&D IP, LLC | Neprilysin inhibitors |
| CN103596928B (zh) | 2011-05-31 | 2017-02-15 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| US8686184B2 (en) | 2011-05-31 | 2014-04-01 | Theravance, Inc. | Neprilysin inhibitors |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| EP2855464B1 (en) | 2012-05-31 | 2016-10-26 | Theravance Biopharma R&D IP, LLC | Nitric oxide donor neprilysin inhibitors |
| US8871792B2 (en) | 2012-06-08 | 2014-10-28 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| ES2700152T3 (es) | 2012-06-08 | 2019-02-14 | Theravance Biopharma R&D Ip Llc | Inhibidores de neprilisina |
| RU2650114C2 (ru) | 2012-08-08 | 2018-04-09 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | Ингибиторы неприлизина |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014167015A (ja) * | 2009-11-20 | 2014-09-11 | Novartis Ag | 新規ｎｅｐ阻害剤としての置換カルバモイルメチルアミノ酢酸誘導体 |
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