JP5498940B2 - サーチュイン調節性チアゾロピリジン化合物 - Google Patents

サーチュイン調節性チアゾロピリジン化合物 Download PDF

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Publication number
JP5498940B2
JP5498940B2 JP2010513267A JP2010513267A JP5498940B2 JP 5498940 B2 JP5498940 B2 JP 5498940B2 JP 2010513267 A JP2010513267 A JP 2010513267A JP 2010513267 A JP2010513267 A JP 2010513267A JP 5498940 B2 JP5498940 B2 JP 5498940B2
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sirtuin
compound
activity
protein
modulating
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JP2010530432A5 (enExample
JP2010530432A (ja
Inventor
ジーン・ベミス
ジェレミー・エス・ディッシュ
プイ・イー・ヌグ
クリストファー・オールマン
ロバート・ビー・パーニ
チ・ビー・ブ
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サートリス ファーマシューティカルズ, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2010513267A 2007-06-20 2008-06-20 サーチュイン調節性チアゾロピリジン化合物 Expired - Fee Related JP5498940B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93663607P 2007-06-20 2007-06-20
US60/936,636 2007-06-20
PCT/US2008/007776 WO2008156869A2 (en) 2007-06-20 2008-06-20 Sirtuin modulating thiazolopyridine compounds

Publications (3)

Publication Number Publication Date
JP2010530432A JP2010530432A (ja) 2010-09-09
JP2010530432A5 JP2010530432A5 (enExample) 2011-08-04
JP5498940B2 true JP5498940B2 (ja) 2014-05-21

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JP2010513267A Expired - Fee Related JP5498940B2 (ja) 2007-06-20 2008-06-20 サーチュイン調節性チアゾロピリジン化合物

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Country Link
US (2) US7893086B2 (enExample)
EP (1) EP2170905A2 (enExample)
JP (1) JP5498940B2 (enExample)
KR (1) KR20100051048A (enExample)
CN (2) CN101801981A (enExample)
AR (1) AR067107A1 (enExample)
AU (1) AU2008266749C1 (enExample)
BR (1) BRPI0813651A2 (enExample)
CA (1) CA2691733A1 (enExample)
CL (1) CL2008001822A1 (enExample)
CO (1) CO6251248A2 (enExample)
CR (1) CR11232A (enExample)
DO (1) DOP2009000284A (enExample)
EA (1) EA018922B1 (enExample)
IL (1) IL202730A0 (enExample)
MA (1) MA31506B1 (enExample)
MX (1) MX2009013977A (enExample)
NZ (1) NZ581990A (enExample)
PE (1) PE20090694A1 (enExample)
TW (1) TW200916472A (enExample)
UY (1) UY31169A1 (enExample)
WO (1) WO2008156869A2 (enExample)
ZA (1) ZA200908883B (enExample)

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CN101910184A (zh) * 2007-11-08 2010-12-08 西特里斯药业公司 可溶性噻唑并吡啶
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RU2519779C2 (ru) 2008-09-29 2014-06-20 Сертрис Фармасьютикалз Инк. Хиназолинон, хинолон и родственные аналоги в качестве модуляторов сиртуина
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