JP4937112B2 - Ｊａｋおよび他のプロテインキナーゼの阻害剤として有用なアザインドール - Google Patents

Ｊａｋおよび他のプロテインキナーゼの阻害剤として有用なアザインドール Download PDF

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JP4937112B2
JP4937112B2 JP2007506535A JP2007506535A JP4937112B2 JP 4937112 B2 JP4937112 B2 JP 4937112B2 JP 2007506535 A JP2007506535 A JP 2007506535A JP 2007506535 A JP2007506535 A JP 2007506535A JP 4937112 B2 JP4937112 B2 JP 4937112B2
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heteroatoms
optionally substituted
nitrogen
alkyl
sulfur
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JP2007531760A (ja
JP2007531760A5 (enExample
Inventor
フランセスコ サリテュロ，
ルーク ファーマー，
ランディー ベシール，
エドマンド ハリントン，
ジェレミー グリーン，
ジョン コート，
ジョン カム，
デイビッド ラウファー，
アレックス アロノフ，
ヘイレイ ビンチ，
ディーン ボヨール，
ジーン−デミアン シャリア，
サイモン エバリット，
デミアン フライス，
マイケル モルティモア，
フランソワーズ ピエラルド，
ダニエル ロビンソン，
ジャン ワン，
ジョアンヌ ピンダー，
ティアンシェン ワン，
アルバート ピアス，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of JP2007531760A publication Critical patent/JP2007531760A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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US8188281B2 (en) 2012-05-29
KR20120126121A (ko) 2012-11-20
AU2005228904C1 (en) 2012-12-13
EP2332940A1 (en) 2011-06-15
RU2403252C2 (ru) 2010-11-10
AU2012203382A1 (en) 2012-06-28
RS51830B (sr) 2012-02-29
TWI372624B (en) 2012-09-21
AU2005228904B2 (en) 2012-05-10
PT2332940E (pt) 2013-01-30
IL177807A (en) 2012-02-29
TW200602052A (en) 2006-01-16
NZ549880A (en) 2010-04-30
RU2006138040A (ru) 2008-05-10
KR101216372B1 (ko) 2013-01-04
MXPA06011327A (es) 2006-12-15
AR048454A1 (es) 2006-04-26
DK2332940T3 (da) 2013-02-11
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ATE508129T1 (de) 2011-05-15
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US8987454B2 (en) 2015-03-24
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US20120258958A1 (en) 2012-10-11
NO340403B1 (no) 2017-04-10
US20140249138A1 (en) 2014-09-04
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CY1113560T1 (el) 2016-06-22
ES2398712T3 (es) 2013-03-21
PL1730146T3 (pl) 2011-10-31
KR101298967B1 (ko) 2013-09-02
CN101676285A (zh) 2010-03-24
KR20070027542A (ko) 2007-03-09
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US8722889B2 (en) 2014-05-13
TWI465437B (zh) 2014-12-21
IL216734A0 (en) 2012-01-31
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