JP4493725B1 - 脂肪分解促進作用を有する組成物 - Google Patents
脂肪分解促進作用を有する組成物 Download PDFInfo
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- JP4493725B1 JP4493725B1 JP2009230493A JP2009230493A JP4493725B1 JP 4493725 B1 JP4493725 B1 JP 4493725B1 JP 2009230493 A JP2009230493 A JP 2009230493A JP 2009230493 A JP2009230493 A JP 2009230493A JP 4493725 B1 JP4493725 B1 JP 4493725B1
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Abstract
【解決手段】脂肪分解促進作用及びACE阻害作用を有する食品用組成物を提供すべく種々の食材について鋭意検討した結果、サケ白子抽出物、ビール酵母抽出物、大麦若葉エキス、及びトリコラーゲンを組み合わせて調製した組成物が、優れた脂肪分解促進作用及びACE阻害活性作用を有する。組成物を有効成分として用いることにより、脂肪分解促進作用及びACE阻害作用を有する飲食品やサプリメント。
【選択図】なし
Description
(1)サケ白子抽出物、ビール酵母抽出物、大麦若葉エキス、及びトリコラーゲンを含む組成物であって、脂肪分解促進作用を有し、かつ、そのペプシン及びトリプシン分解物がアンジオテンシン変換酵素(ACE)阻害作用を有する組成物を含むことを特徴とする経口用脂肪分解促進剤、
(2)組成物が、大麦若葉エキス100重量部あたり、サケ白子抽出物14.0〜14.5重量部、ビール酵母抽出物2.8〜3.2重量部、及びトリコラーゲン5.7〜6.2重量部を含むことを特徴とする、上記(1)記載の経口用脂肪分解促進剤、
(3)サケ白子抽出物が、サケ白子を酵素処理することにより得られる、オリゴヌクレオチドとオリゴペプチドまで分解した低分子成分を含む抽出物であることを特徴とする、上記(1)又は(2)記載の経口用脂肪分解促進剤、
(4)ビール酵母抽出物が、ビール酵母を酵素処理することにより得られる、低分子化したRNA成分を含む抽出物であることを特徴とする、上記(1)又は(2)記載の経口用脂肪分解促進剤、
(5)大麦若葉エキスが、30%難消化性デキストリンを含むことを特徴とする上記(1)又は(2)記載の経口用脂肪分解促進剤に関する。
上記サケ白子抽出物としては、食品用として使用できるものであれば特に制限されるものではないが、サケ白子を酵素処理することにより、オリゴヌクレオチドとオリゴペプチドまで分解した低分子成分を含むサケ白子抽出物が好ましい。特に分子量1000〜3000のオリゴヌクレオチド、オリゴペプチドを20〜50%含有するサケ白子抽出物が好ましい。このようなサケ白子抽出物は、例えば日生バイオ株式会社等より入手することができる。
上記ビール酵母抽出物としては、食品用として使用できるものであれば特に制限されるものではないが、ビール酵母を酵素処理することにより、低分子化したRNAを含むビール酵母抽出物が好ましい。特に分子量1000〜3000のRNAを20〜50%含有するビール酵母抽出物が好ましい。このようなビール酵母抽出物は、例えば日生バイオ株式会社等より入手することができる。
上記大麦若葉エキスとしては、特に制限されるものではないが、食品用に低温でスプレードライした大麦若葉エキスを好適に用いることができる。大麦若葉エキスに難消化性デキストリンを含んでいるものも用いることができる。難消化性デキストリンを含んだ大麦若葉エキスとしては20〜30%の難消化性デキストリンを含有しているラクソン社製の大麦若葉エキスを好適に挙げることができる。
上記トリコラーゲンとしては、特に制限されるものではないが、食品用のトリコラーゲンを好適に用いることができ、例えば株式会社エル・エス・ファクトリー社製のトリコラーゲンを好適に挙げることができる。
本発明の実施例において、評価に用いた試料は、サケ白子抽出物(日生バイオ株式会社製)、ビール酵母抽出物(日生バイオ株式会社製)、大麦若葉エキス(ラクソン社製、30%難消化性デキストリン含有)、チキンコラーゲン(トリコラーゲン:株式会社エル・エス・ファクトリー社製)を単独又は組み合わせて調製した。試料の調製に用いた各成分の濃度を表1に示す。
マウス前駆脂肪細胞株3T3−L1細胞を、96well培養プレートに3×104cells/250μl/wellとなるように播種し、10%CSを含むDMEM培地(10%CS/DMEM)を用いて2日間プレインキュベートを行い、コンフルエント (day0)になるまで培養した。脂肪細胞分化誘導剤[0.5mMイソブチルメチルキサンチン(IBMX)、1μMデキサメサゾン(DEX)、10μg/mlインスリン]を培地に添加し、さらに3日間培養することにより脂肪細胞への分化誘導を行った。分化誘導後の細胞を、10μg/mlインスリンを含む10%FBS/DMEM培地にて3日間培養した後、基本培地で6日間培養した。この6日間の培養中、培地を2日間おきに交換し脂肪滴を蓄積させた。その後、表1に記載の混合物、及び、サケ白子抽出物、ビール酵母抽出物、大麦若葉エキス、チキンコラーゲンを単独で添加して、さらに、48時間の培養を行った。培養終了後に上清を回収し、Adipolysis assay kitを用いて培養上清中のグリセロール量を測定した。この培養上清中のグリセロール量を脂肪分解の指標とした。グリセロール遊離率はコントロールの値を100%とした場合の相対的な値である。
脂肪分解促進率%=[A/B]×100
A:抽出物添加時の遊離グリセロール量
B:抽出物無添加時の遊離グリセロール量
上述のように、脂肪分解促進作用の判定は、脂肪分解により生成するグリセロール量の測定値を指標として求めた。結果をグラフにしたものを図1に、数値化したものを表2にそれぞれ示す。大麦若葉エキスを含む混合物(試料)を添加した区において、1mg/mlと5mg/ml濃度において、それぞれcontrolの208.67%、504.17%の値を示した。一方、各成分を単独で添加した区における脂肪分解率は、大麦エキス810μg/ml添加区で141.57%、 4.05mg/ml添加区で255.22%;サケ白子抽出物116μg/ml添加区で95%、580μg/ml添加区で95.44%;ビール酵母抽出物24μg/ml添加区で95%、120μg/ml添加区で81.6%;チキンコラーゲン48μg/ml添加区で87.67%、240μg/ml添加区で116.7%を示した。以上のように、大麦若葉エキス、サケ白子抽出物、ビール酵母抽出物、チキンコラーゲン成分を組み合わせて調製した試料が示すような顕著な脂肪分解促進作用は、各成分単独では認められないことが明らかとなり、大麦若葉エキス、サケ白子抽出物、ビール酵母抽出物、チキンコラーゲン成分の組み合わせることにより顕著な相乗効果が認められることが示された。
さらに、上清を回収した後の細胞生存率を、Cell counting Kit-8(Dojindo社製)を用いて測定した。図2に結果を示すように、混合物及び各成分の添加区において生存率には差が認められないことを確認した。
0.1M HCl・KCl(pH2.5)を用いて、表1に示す混合物及び各成分の10%溶液を調製し、ペプシンを加えて、37℃で2.5時間酵素処理した。処理後、沸騰水浴中90℃で10分間加熱し、ペプシンを失活させた。この処理液を、0.1M リン酸カリウム緩衝液(pH7.5)を用いて5倍希釈し、さらに、トリプシンを加えて、37℃で24時間酵素処理した。処理後、沸騰水浴中90℃で10分間加熱し、トリプシンを失活させた。この処理液を遠心し、上清を凍結乾燥し、以下の実験に用いた。
ACE阻害活性の測定はLieberman測定法の変法に基づいて行った。上記のようにして酵素処理した凍結乾燥試料を酵素処理前の濃度と同様に表1に記載の濃度となるように調製した。この調製液(30μL)に、400mM NaClを含むホウ酸緩衝液(pH8.3)で5mMに希釈したHip−His−Leu基質溶液(250μl)を添加し、37℃の恒温水槽中で5分間保温した。600mu/ml(6mU)のACE溶液(100μl)を添加し、直ちに撹拌した後、37℃で60分間反応を行った。1N塩酸(250μl)を添加し、撹拌して反応を停止させた後、酢酸エチル(1.5ml)を添加し、十分に撹拌することにより馬尿酸を遊離させた。3,000rpm、10分間の遠心分離後に上層の酢酸エチル層を1.0ml回収し、エバポレーターで乾固した。さらに減圧デシケーター内で60分間乾燥させた後、超純水を3ml添加し、その溶液の吸光値(228nm)を測定した。なお、阻害活性は以下の式により阻害率(%)として算出した。
阻害率(%)=(EC−ES/EC−EB)×100
図3に結果に示すように、混合物1mg/ml、10mg/mlの場合、対応する濃度の各組成物単独の場合に比べてACE阻害活性が顕著に高いことが明らかとなり、相乗的な効果が認められた。
Claims (5)
- サケ白子抽出物、ビール酵母抽出物、大麦若葉エキス、及びトリコラーゲンを含む組成物であって、脂肪分解促進作用を有し、かつ、そのペプシン及びトリプシン分解物がアンジオテンシン変換酵素(ACE)阻害作用を有する組成物を含むことを特徴とする経口用脂肪分解促進剤。
- 組成物が、大麦若葉エキス100重量部あたり、サケ白子抽出物14.0〜14.5重量部、ビール酵母抽出物2.8〜3.2重量部、及びトリコラーゲン5.7〜6.2重量部を含むことを特徴とする、請求項1記載の経口用脂肪分解促進剤。
- サケ白子抽出物が、サケ白子を酵素処理することにより得られる、オリゴヌクレオチドとオリゴペプチドまで分解した低分子成分を含む抽出物であることを特徴とする、請求項1又は2記載の経口用脂肪分解促進剤。
- ビール酵母抽出物が、ビール酵母を酵素処理することにより得られる、低分子化したRNA成分を含む抽出物であることを特徴とする、請求項1又は2記載の経口用脂肪分解促進剤。
- 大麦若葉エキスが、30%難消化性デキストリンを含むことを特徴とする請求項1又は2記載の経口用脂肪分解促進剤。
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- 2010-09-28 WO PCT/JP2010/005833 patent/WO2011039999A1/ja active Application Filing
- 2010-09-28 US US13/261,242 patent/US9399043B2/en active Active
- 2010-09-28 CN CN201080043430.1A patent/CN102573885B/zh active Active
- 2010-09-28 EP EP10820121.1A patent/EP2484370B1/en active Active
- 2010-09-30 TW TW099133418A patent/TWI520741B/zh active
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JP2002000228A (ja) * | 2000-06-21 | 2002-01-08 | Toyo Shinyaku:Kk | 麦若葉由来の素材を含む抗高血圧食品 |
WO2005118619A1 (ja) * | 2004-06-03 | 2005-12-15 | Kirin Beer Kabushiki Kaisha | 血圧降下作用を有するジペプチド |
Also Published As
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US9399043B2 (en) | 2016-07-26 |
EP2484370B1 (en) | 2019-09-11 |
CN102573885A (zh) | 2012-07-11 |
US20120244236A1 (en) | 2012-09-27 |
CN102573885B (zh) | 2014-12-17 |
TW201119660A (en) | 2011-06-16 |
EP2484370A1 (en) | 2012-08-08 |
KR101761112B1 (ko) | 2017-07-25 |
TWI520741B (zh) | 2016-02-11 |
JP2011074051A (ja) | 2011-04-14 |
KR20120080580A (ko) | 2012-07-17 |
HK1169306A1 (en) | 2013-01-25 |
EP2484370A4 (en) | 2014-02-26 |
WO2011039999A1 (ja) | 2011-04-07 |
BR112012006872A2 (pt) | 2016-06-07 |
IN2012DN02486A (ja) | 2015-08-28 |
BR112012006872B1 (pt) | 2020-05-26 |
BR112012006872B8 (pt) | 2020-06-16 |
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