JP2865211B2 - ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類 - Google Patents

５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類

Info

Publication number
JP2865211B2
JP2865211B2 JP1509255A JP50925589A JP2865211B2 JP 2865211 B2 JP2865211 B2 JP 2865211B2 JP 1509255 A JP1509255 A JP 1509255A JP 50925589 A JP50925589 A JP 50925589A JP 2865211 B2 JP2865211 B2 JP 2865211B2
Authority
JP
Japan
Prior art keywords
alkyl
acetamidomethyl
oxazolidine
oxazolidin
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP1509255A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04500665A (ja
Inventor
ブリックナー，スティーブン・ジェイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FUARUMASHIA ANDO ATSUPUJON CO
Original Assignee
FUARUMASHIA ANDO ATSUPUJON CO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FUARUMASHIA ANDO ATSUPUJON CO filed Critical FUARUMASHIA ANDO ATSUPUJON CO
Publication of JPH04500665A publication Critical patent/JPH04500665A/ja
Application granted granted Critical
Publication of JP2865211B2 publication Critical patent/JP2865211B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP1509255A 1988-09-15 1989-08-22 ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類 Expired - Fee Related JP2865211B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24498888A 1988-09-15 1988-09-15
US244,988 1988-09-15
US25385088A 1988-10-05 1988-10-05
US253,850 1988-10-05
US32494289A 1989-03-17 1989-03-17
US324,942 1989-03-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP19194998A Division JP3188418B2 (ja) 1988-09-15 1998-07-07 ３−（縮合環置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類および３−（窒素原子置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類

Publications (2)

Publication Number Publication Date
JPH04500665A JPH04500665A (ja) 1992-02-06
JP2865211B2 true JP2865211B2 (ja) 1999-03-08

Family

ID=27399816

Family Applications (2)

Application Number Title Priority Date Filing Date
JP1509255A Expired - Fee Related JP2865211B2 (ja) 1988-09-15 1989-08-22 ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類
JP19194998A Expired - Fee Related JP3188418B2 (ja) 1988-09-15 1998-07-07 ３−（縮合環置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類および３−（窒素原子置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP19194998A Expired - Fee Related JP3188418B2 (ja) 1988-09-15 1998-07-07 ３−（縮合環置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類および３−（窒素原子置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類

Country Status (13)

Country Link
EP (3) EP0359418B1 (OSRAM)
JP (2) JP2865211B2 (OSRAM)
KR (1) KR0138262B1 (OSRAM)
AT (2) ATE112773T1 (OSRAM)
AU (1) AU617871B2 (OSRAM)
CA (1) CA1335103C (OSRAM)
DE (2) DE68918792T2 (OSRAM)
DK (2) DK175696B1 (OSRAM)
ES (1) ES2157934T3 (OSRAM)
GR (1) GR3036491T3 (OSRAM)
LV (1) LV12888B (OSRAM)
TW (1) TW219936B (OSRAM)
WO (1) WO1990002744A1 (OSRAM)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
DE69132691T2 (de) * 1990-06-07 2002-06-20 Astrazeneca Ab, Soedertaelje Indolderivate als 5-HT1-like Agonisten
CA2115029C (en) * 1991-08-14 2002-03-26 Stanford Salvatore Pelosi, Jr. Cyclic urethanes useful as antiarrhythmic and antifibrillatory agents
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
KR950702417A (ko) * 1992-07-08 1995-07-29 로렌스 티. 웰츠 마이코박테륨 투베르쿨로시스에 대해 유용한 5′-인돌리닐 옥사졸리디논(5′-indolinyl oxazolidinones useful against mycobacterium tuberculosis)
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE19514313A1 (de) * 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
SI0788498T1 (en) * 1994-10-26 2001-12-31 Upjohn Co Phenyloxazolidinone antimicrobials
KR100392216B1 (ko) * 1994-11-15 2003-10-17 파마시아 앤드 업존 캄파니 이환상옥사진및티아진옥사졸리디논항세균물질
EP0807112B1 (en) * 1995-02-03 2001-09-05 PHARMACIA & UPJOHN COMPANY Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DK0828741T3 (da) * 1995-05-11 2001-11-26 Upjohn Co Spirocykliske og bicykliske diazinyl- og carbazinyloxazolidinoner
US5883093A (en) * 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
DE19601265A1 (de) 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601627A1 (de) 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
HRP970049A2 (en) 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
US6255304B1 (en) 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
RU2208613C2 (ru) 1997-05-30 2003-07-20 Фармация Энд Апджон Компани Оксазолидиноновые антибактериальные агенты, содержащие тиокарбонильную функциональную группу
DE19730847A1 (de) * 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
US5998406A (en) * 1997-11-12 1999-12-07 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
DE19802239A1 (de) * 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
CN1288462A (zh) 1998-01-23 2001-03-21 法玛西雅厄普约翰美国公司 噁唑烷酮组合库、组合物和制备方法
JP2003501351A (ja) * 1999-05-27 2003-01-14 ファルマシア・アンド・アップジョン・カンパニー 抗菌剤としての二環系オキサゾリジノン
CA2374383A1 (en) * 1999-07-28 2001-02-08 Pharmacia & Upjohn Company Oxazolidinones and their use as antiinfectives
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
RU2292345C9 (ru) 2000-07-17 2007-05-10 Ранбакси Лабораторис Лимитед Производные оксазолидинона
EP1330459B1 (en) 2000-10-02 2006-08-02 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
PE20020689A1 (es) 2000-11-17 2002-08-03 Upjohn Co Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
GB0118407D0 (en) * 2001-07-27 2001-09-19 Cipla Ltd Oxazolidinone derivatives as antibacterial agents
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
US7012088B2 (en) * 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
EP1781643A1 (en) * 2004-08-06 2007-05-09 Pharmacia & Upjohn Company LLC Oxindole oxazolidinones as antibacterial agents
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
AU2006231919A1 (en) 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
KR20070116989A (ko) * 2005-04-06 2007-12-11 파마시아 앤드 업존 캄파니 엘엘씨 항균제로서의 옥신돌 옥사졸리디논
NZ585752A (en) * 2007-12-24 2011-11-25 Cipla Ltd Process for the synthesis of propargylated aminoindan derivatives
US8598156B2 (en) 2010-03-25 2013-12-03 Glaxosmithkline Llc Chemical compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES533097A0 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
HK1002234A1 (en) 1998-08-07
DE68918792D1 (de) 1994-11-17
EP0609905A1 (en) 1994-08-10
ATE201870T1 (de) 2001-06-15
DE68918792T2 (de) 1995-03-30
AU4195789A (en) 1990-04-02
EP0434714A1 (en) 1991-07-03
EP0609905B1 (en) 2001-06-06
JP3188418B2 (ja) 2001-07-16
DE68929303D1 (de) 2001-07-12
DK200401246A (da) 2004-08-18
DK175696B1 (da) 2005-01-24
KR0138262B1 (ko) 1998-05-15
LV12888B (en) 2002-12-20
EP0359418B1 (en) 1994-10-12
TW219936B (OSRAM) 1994-02-01
EP0359418A1 (en) 1990-03-21
JPH1180139A (ja) 1999-03-26
CA1335103C (en) 1995-04-04
GR3036491T3 (en) 2001-11-30
ATE112773T1 (de) 1994-10-15
JPH04500665A (ja) 1992-02-06
AU617871B2 (en) 1991-12-05
DK175940B1 (da) 2005-08-01
DK45591A (da) 1991-03-13
DK45591D0 (da) 1991-03-13
WO1990002744A1 (en) 1990-03-22
ES2157934T3 (es) 2001-09-01
KR900701780A (ko) 1990-12-04
DE68929303T2 (de) 2002-05-02

Similar Documents

Publication Publication Date Title
JP2865211B2 (ja) ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類
US5164510A (en) 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
US5182403A (en) Substituted 3(5'indazolyl) oxazolidin-2-ones
JP3176626B2 (ja) 抗菌剤として有用な置換アリール−およびヘテロアリールフェニルオキサゾリジノン類
TWI299991B (en) Cetp inhibitors
EP3634958B1 (en) Cyclopropyl urea formyl peptide 2 receptor and formyl peptide 1 receptor agonists
JPS61134379A (ja) アミノメチルオキソオキサゾリジニルベンゼン誘導体
JPH10508824A (ja) タキキニンアンタゴニストとしてのベンゾフラン誘導体
AU2019310508B2 (en) 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same
JP2001522828A (ja) オキサゾリジノンの製法
JP2006518370A (ja) Ｃ型肝炎ウイルスｒｎａ依存ｒｎａポリメラーゼ阻害剤ならびにそれを用いた組成物および治療
BRPI0709101A2 (pt) derivados de triazolona e medicamento e agente terapêutico e/ou profilático compreendendo os mesmos
WO2006124687A1 (en) Opioid receptor subtype-selective agents
JPS594417B2 (ja) シンキノ １− アリ−ルオキシ −２− ヒドロキシ −３− アルキニルアミノプロパンノ セイゾウホウホウ
NO325656B1 (no) Anti-syrefaste bakterielle midler inneholdende pyridonkarboksylsyrer som den aktive bestanddel
WO1994001110A1 (en) 5'-INDOLINYL OXAZOLIDINONES USEFUL AGAINST $i(MYCOBACTERIUM TUBERCULOSIS)
JP3856829B2 (ja) オキサゾリジノン誘導体、その製造及び治療的使用
JP2012515188A (ja) 抗菌薬として有用なナフチリジン―２（１ｈ）−オン化合物
JP3174382B2 (ja) ６−複素環−４−アミノ−１，２，２ａ，３，４，５−ヘキサヒドロベンズ［ｃｄ］インドール類
JP2994459B2 (ja) 三環［６，５，５］／［６，６，５］―縮合オキサゾリジノン抗菌剤
FR2536398A1 (fr) Nouveaux composes heterocycliques
KR19980702304A (ko) 장운동 촉진성 옥사디아졸
US6365612B2 (en) Benzosultam oxazolidinone antibacterial agents
JPH02502455A (ja) ピリドンカルボン酸または酸誘導体を含有する抗生物質β‐ラクタム
RU2752088C1 (ru) Композиции для лечения гипертензии и/или фиброза

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20071218

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20081218

Year of fee payment: 10

LAPS Cancellation because of no payment of annual fees