JP2021019589A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021019589A5 JP2021019589A5 JP2020155809A JP2020155809A JP2021019589A5 JP 2021019589 A5 JP2021019589 A5 JP 2021019589A5 JP 2020155809 A JP2020155809 A JP 2020155809A JP 2020155809 A JP2020155809 A JP 2020155809A JP 2021019589 A5 JP2021019589 A5 JP 2021019589A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- cell
- isolated cell
- seq
- cell according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461977751P | 2014-04-10 | 2014-04-10 | |
| US61/977,751 | 2014-04-10 | ||
| US201461986479P | 2014-04-30 | 2014-04-30 | |
| US61/986,479 | 2014-04-30 | ||
| US201462058973P | 2014-10-02 | 2014-10-02 | |
| US62/058,973 | 2014-10-02 | ||
| US201462088363P | 2014-12-05 | 2014-12-05 | |
| US62/088,363 | 2014-12-05 | ||
| US201462089730P | 2014-12-09 | 2014-12-09 | |
| US62/089,730 | 2014-12-09 | ||
| US201462090845P | 2014-12-11 | 2014-12-11 | |
| US62/090,845 | 2014-12-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016561659A Division JP6765968B2 (ja) | 2014-04-10 | 2015-04-08 | 薬物制御による導入遺伝子の発現 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021019589A JP2021019589A (ja) | 2021-02-18 |
| JP2021019589A5 true JP2021019589A5 (https=) | 2021-07-26 |
| JP7093385B2 JP7093385B2 (ja) | 2022-06-29 |
Family
ID=54288361
Family Applications (12)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016561722A Active JP6772068B2 (ja) | 2014-04-10 | 2015-04-08 | 導入遺伝子の遺伝子タグおよびその使用方法 |
| JP2016561839A Pending JP2017515464A (ja) | 2014-04-10 | 2015-04-08 | 細胞免疫療法のための方法および組成物 |
| JP2016561635A Active JP6765967B2 (ja) | 2014-04-10 | 2015-04-08 | 特定の組成を有する遺伝子により改変されたｔ細胞製剤 |
| JP2017504604A Active JP6788573B6 (ja) | 2014-04-10 | 2015-04-08 | メトトレキサートによる選択と組み合わせたＳｌｅｅｐｉｎｇ Ｂｅａｕｔｙトランスポゾンによる遺伝子改変Ｔ細胞の製造 |
| JP2016561659A Active JP6765968B2 (ja) | 2014-04-10 | 2015-04-08 | 薬物制御による導入遺伝子の発現 |
| JP2020105133A Active JP7062720B2 (ja) | 2014-04-10 | 2020-06-18 | 細胞免疫療法のための方法および組成物 |
| JP2020155809A Expired - Fee Related JP7093385B2 (ja) | 2014-04-10 | 2020-09-16 | 薬物制御による導入遺伝子の発現 |
| JP2020155429A Active JP7148580B2 (ja) | 2014-04-10 | 2020-09-16 | 特定の組成を有する遺伝子により改変されたｔ細胞製剤 |
| JP2020164326A Active JP7106610B2 (ja) | 2014-04-10 | 2020-09-30 | 導入遺伝子の遺伝子タグおよびその使用方法 |
| JP2022069142A Active JP7542270B2 (ja) | 2014-04-10 | 2022-04-20 | 細胞免疫療法のための方法および組成物 |
| JP2022112278A Active JP7402933B2 (ja) | 2014-04-10 | 2022-07-13 | 導入遺伝子の遺伝子タグおよびその使用方法 |
| JP2022150928A Active JP7508516B2 (ja) | 2014-04-10 | 2022-09-22 | 特定の組成を有する遺伝子により改変されたｔ細胞製剤 |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016561722A Active JP6772068B2 (ja) | 2014-04-10 | 2015-04-08 | 導入遺伝子の遺伝子タグおよびその使用方法 |
| JP2016561839A Pending JP2017515464A (ja) | 2014-04-10 | 2015-04-08 | 細胞免疫療法のための方法および組成物 |
| JP2016561635A Active JP6765967B2 (ja) | 2014-04-10 | 2015-04-08 | 特定の組成を有する遺伝子により改変されたｔ細胞製剤 |
| JP2017504604A Active JP6788573B6 (ja) | 2014-04-10 | 2015-04-08 | メトトレキサートによる選択と組み合わせたＳｌｅｅｐｉｎｇ Ｂｅａｕｔｙトランスポゾンによる遺伝子改変Ｔ細胞の製造 |
| JP2016561659A Active JP6765968B2 (ja) | 2014-04-10 | 2015-04-08 | 薬物制御による導入遺伝子の発現 |
| JP2020105133A Active JP7062720B2 (ja) | 2014-04-10 | 2020-06-18 | 細胞免疫療法のための方法および組成物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020155429A Active JP7148580B2 (ja) | 2014-04-10 | 2020-09-16 | 特定の組成を有する遺伝子により改変されたｔ細胞製剤 |
| JP2020164326A Active JP7106610B2 (ja) | 2014-04-10 | 2020-09-30 | 導入遺伝子の遺伝子タグおよびその使用方法 |
| JP2022069142A Active JP7542270B2 (ja) | 2014-04-10 | 2022-04-20 | 細胞免疫療法のための方法および組成物 |
| JP2022112278A Active JP7402933B2 (ja) | 2014-04-10 | 2022-07-13 | 導入遺伝子の遺伝子タグおよびその使用方法 |
| JP2022150928A Active JP7508516B2 (ja) | 2014-04-10 | 2022-09-22 | 特定の組成を有する遺伝子により改変されたｔ細胞製剤 |
Country Status (19)
| Country | Link |
|---|---|
| US (12) | US10611837B2 (https=) |
| EP (8) | EP3943507A1 (https=) |
| JP (12) | JP6772068B2 (https=) |
| KR (8) | KR20160144431A (https=) |
| CN (7) | CN106574246A (https=) |
| AU (8) | AU2015243920B2 (https=) |
| BR (3) | BR112016023500B1 (https=) |
| CA (4) | CA2945305C (https=) |
| ES (2) | ES2867224T3 (https=) |
| IL (5) | IL248238B2 (https=) |
| MX (6) | MX389797B (https=) |
| MY (4) | MY192522A (https=) |
| NZ (3) | NZ725079A (https=) |
| PH (4) | PH12016502011B1 (https=) |
| RU (5) | RU2752275C2 (https=) |
| SA (1) | SA516380056B1 (https=) |
| SG (8) | SG11201608395PA (https=) |
| WO (5) | WO2015157432A1 (https=) |
| ZA (3) | ZA201607061B (https=) |
Families Citing this family (210)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100548667C (zh) * | 2003-01-20 | 2009-10-14 | 日本瑞翁株式会社 | 层合件及其制造方法 |
| EP4282419A1 (en) | 2012-12-20 | 2023-11-29 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| MX373687B (es) * | 2013-11-21 | 2020-07-07 | Ucl Business Ltd | Célula natural (nk) |
| US10611837B2 (en) | 2014-04-10 | 2020-04-07 | Seattle Children's Hospital | Transgene genetic tags and methods of use |
| CA2946312A1 (en) | 2014-04-23 | 2015-10-29 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| US10494422B2 (en) | 2014-04-29 | 2019-12-03 | Seattle Children's Hospital | CCR5 disruption of cells expressing anti-HIV chimeric antigen receptor (CAR) derived from broadly neutralizing antibodies |
| MX392487B (es) | 2014-10-20 | 2025-03-21 | Juno Therapeutics Inc | Métodos y composiciones para dosificación en terapia celular adoptiva. |
| US20170335331A1 (en) | 2014-10-31 | 2017-11-23 | The Trustees Of The University Of Pennsylvania | Altering Gene Expression in CART Cells and Uses Thereof |
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| ES2819553T3 (es) | 2014-12-03 | 2021-04-16 | Juno Therapeutics Inc | Métodos y composiciones para terapia celular adoptiva |
| SI3226897T1 (sl) | 2014-12-05 | 2021-08-31 | Memorial Sloan Kettering Cancer Center | Protitelesa, ki ciljajo na B-celični maturacijski antigen, in postopki uporabe |
| FI3240805T3 (fi) | 2014-12-15 | 2025-02-17 | Univ California | Cd19- ja cd20-vasteellinen bispesifinen tai-veräjän kimeerinen antigeenireseptori |
| EP3234120B1 (en) | 2014-12-15 | 2025-09-03 | The Regents of the University of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
| MA41346A (fr) | 2015-01-12 | 2017-11-21 | Juno Therapeutics Inc | Eléments régulateurs post-transcriptionnels d'hépatite modifiée |
| ES2818103T3 (es) | 2015-01-16 | 2021-04-09 | Juno Therapeutics Inc | Anticuerpos y receptores de antígenos quiméricos específicos para ROR1 |
| US10808230B2 (en) | 2015-02-24 | 2020-10-20 | Board Of Regents, The University Of Texas System | Selection methods for genetically-modified T cells |
| JP7237449B2 (ja) | 2015-02-27 | 2023-03-13 | アイセル・ジーン・セラピューティクス・エルエルシー | 血液系腫瘍を標的としたキメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
| JP6961490B2 (ja) * | 2015-04-08 | 2021-11-05 | ノバルティス アーゲー | Ｃｄ２０療法、ｃｄ２２療法、およびｃｄ１９キメラ抗原受容体（ｃａｒ）発現細胞との併用療法 |
| US11655452B2 (en) | 2015-06-25 | 2023-05-23 | Icell Gene Therapeutics Inc. | Chimeric antigen receptors (CARs), compositions and methods of use thereof |
| US11173179B2 (en) | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
| AU2016306209B2 (en) | 2015-08-07 | 2023-07-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Bispecific CAR T-cells for solid tumor targeting |
| ES3063691T3 (en) * | 2015-09-22 | 2026-04-20 | Univ Wuerzburg J Maximilians | A method for high level and stable gene transfer in lymphocytes |
| EP3359574B1 (en) | 2015-10-06 | 2020-04-22 | City of Hope | Chimeric antigen receptors targeted to psca |
| WO2017070709A1 (en) * | 2015-10-23 | 2017-04-27 | The Regents Of The University Of Colorado A Body Corporate | Prognosis and treatment of squamous cell carcinomas |
| SG11201803098VA (en) | 2015-10-30 | 2018-05-30 | Nbe Therapeutics Ag | Anti-ror1 antibodies |
| PL3368571T3 (pl) | 2015-10-30 | 2023-05-02 | The Regents Of The University Of California | Polipeptydy odpowiadające na transformujący czynnik wzrostu beta i sposoby ich zastosowania |
| US11020429B2 (en) | 2015-11-05 | 2021-06-01 | Juno Therapeutics, Inc. | Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy |
| FI3380620T3 (fi) * | 2015-11-23 | 2024-08-01 | Novartis Ag | Optimoituja lentiviruksen siirtovektoreita ja niiden käyttötapoja |
| KR102249982B1 (ko) * | 2015-12-14 | 2021-05-11 | 게놈프론티어 테라퓨틱스 인코포레이티드 | 트랜스포존 시스템, 이를 포함한 키트, 및 이들의 용도 |
| WO2017112877A1 (en) * | 2015-12-22 | 2017-06-29 | Icell Gene Therapeutics, Llc | Chimeric antigen receptors and enhancement of anti-tumor activity |
| UA125718C2 (uk) | 2016-01-20 | 2022-05-25 | Зе Скріппс Ресеарч Інстітьют | Композиції антитіл до ror1 і пов'язані з ними способи |
| EP3202783A1 (en) * | 2016-02-02 | 2017-08-09 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Engineered antigen presenting cells and uses thereof |
| WO2017161212A1 (en) | 2016-03-16 | 2017-09-21 | Juno Therapeutics, Inc. | Methods for adaptive design of a treatment regimen and related treatments |
| EP3439675A4 (en) | 2016-04-08 | 2019-12-18 | Purdue Research Foundation | METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY |
| US12060394B2 (en) | 2016-04-28 | 2024-08-13 | The Trustees Of Dartmouth College | Nucleic acid constructs for co-expression of chimeric antigen receptor and transcription factor, cells containing and therapeutic use thereof |
| SG10202012157QA (en) * | 2016-06-07 | 2021-01-28 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Chimeric antigen receptor and car-t cells that bind bcma |
| CA3025667A1 (en) | 2016-06-08 | 2017-12-14 | Intrexon Corporation | Cd33 specific chimeric antigen receptors |
| CN109562126A (zh) * | 2016-06-24 | 2019-04-02 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(car)、组合物及其使用方法 |
| US20190119636A1 (en) * | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
| JP7623784B2 (ja) | 2016-10-13 | 2025-01-29 | ジュノー セラピューティクス インコーポレイテッド | トリプトファン代謝経路調節剤を含む免疫療法の方法および組成物 |
| US11739129B2 (en) * | 2016-10-21 | 2023-08-29 | Washington University | AP4 and methods of promoting T cell activation |
| KR20190090390A (ko) * | 2016-11-30 | 2019-08-01 | 인트렉손 코포레이션 | 스테로이드 투여 및 면역요법 |
| CA3045339A1 (en) | 2016-12-03 | 2018-06-07 | Juno Therapeutics, Inc. | Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors |
| US11408005B2 (en) | 2016-12-12 | 2022-08-09 | Seattle Children's Hospital | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
| CN106800601B (zh) * | 2017-01-19 | 2021-04-06 | 广东昭泰体内生物医药科技有限公司 | 一种嵌合抗原受体及其应用 |
| CA3050085A1 (en) | 2017-01-20 | 2018-07-26 | Juno Therapeutics Gmbh | Cell surface conjugates and related cell compositions and methods |
| BR112019017767A2 (pt) | 2017-02-27 | 2020-04-07 | Juno Therapeutics Inc | composições, artigos de fabricação e métodos relacionados à dosagem em terapia celular |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| MX2019010906A (es) | 2017-03-14 | 2020-02-12 | Juno Therapeutics Inc | Metodos para almacenamiento criogenico. |
| CN106963945A (zh) * | 2017-03-27 | 2017-07-21 | 山东兴瑞生物科技有限公司 | 一种加强型人乳头瘤病毒hpv‑16/18的二价dc疫苗 |
| WO2018191490A1 (en) * | 2017-04-13 | 2018-10-18 | The Trustees Of The University Of Pennsylvania | Use of gene editing to generate universal tcr re-directed t cells for adoptive immunotherapy |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| CN108728477B (zh) * | 2017-04-24 | 2022-02-22 | 华东理工大学 | 一种高效的转座突变系统及构建方法 |
| CN118374493A (zh) * | 2017-05-17 | 2024-07-23 | 西雅图儿童医院（Dba西雅图儿童研究所） | 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法 |
| CA3064000A1 (en) | 2017-05-24 | 2018-11-29 | Effector Therapeutics, Inc. | Methods and compositions for cellular immunotherapy |
| EP3633029A4 (en) * | 2017-05-26 | 2021-06-09 | Green Cross Lab Cell Corporation | METHOD OF DEVELOPING A NATURAL KILLER CELL USING A T-CELL |
| AU2018275894B2 (en) | 2017-06-02 | 2025-04-24 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| CA3287539A1 (en) | 2017-06-21 | 2026-03-02 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF |
| CN107335054B (zh) * | 2017-06-30 | 2021-01-15 | 山东兴瑞生物科技有限公司 | 一种慢性乙肝治疗性dc疫苗 |
| KR20230008269A (ko) | 2017-08-07 | 2023-01-13 | 엔비이-테라퓨틱스 아게 | 생체 내 내성이 높은 항체 약물 결합체 |
| US20200247851A1 (en) * | 2017-08-11 | 2020-08-06 | Tribiotica Llc | Methods For Generating Epitopes For Binding To Recognition Molecules By Templated Assembly |
| SG11202001011XA (en) * | 2017-08-23 | 2020-03-30 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Chimeric antigen receptor and car-t cells that bind cxcr5 |
| MX2020007357A (es) * | 2017-09-26 | 2021-08-11 | Longwood Univ | Reporte de antígeno quimérico específico de pd1 como una inmunoterapia. |
| CN107759700A (zh) * | 2017-10-18 | 2018-03-06 | 银丰生物工程集团有限公司 | 靶向cd19抗原的转基因t细胞及其制备方法与应用 |
| US11771718B2 (en) | 2017-10-18 | 2023-10-03 | Precigen, Inc. | Polypeptide compositions comprising spacers |
| US10329543B2 (en) | 2017-10-23 | 2019-06-25 | Poseida Therapeutics, Inc. | Modified stem cell memory T cells, methods of making and methods of using same |
| WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| US11851679B2 (en) | 2017-11-01 | 2023-12-26 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
| SG11202003501XA (en) | 2017-11-01 | 2020-05-28 | Juno Therapeutics Inc | Antibodies and chimeric antigen receptors specific for b-cell maturation antigen |
| US12258580B2 (en) * | 2017-11-01 | 2025-03-25 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| PT3703750T (pt) | 2017-11-01 | 2025-01-17 | Memorial Sloan Kettering Cancer Center | Recetores de antigénio quimérico específicos para o antigénio de maturação das células b e polinucleótidos codificantes |
| MX2020004568A (es) | 2017-11-06 | 2020-10-05 | Juno Therapeutics Inc | Combinación de una terapia celular y un inhibidor de gamma secretasa. |
| CN111683962B (zh) | 2017-11-10 | 2025-05-16 | 美国政府(由卫生和人类服务部的部长所代表) | 靶向肿瘤抗原的嵌合抗原受体 |
| AU2018367452B2 (en) | 2017-11-14 | 2024-06-13 | Memorial Sloan-Kettering Cancer Center | IL-36 secreting immunoresponsive cells and uses thereof |
| US12161670B2 (en) | 2017-12-08 | 2024-12-10 | Juno Therapeutics, Inc. | Phenotypic markers for cell therapy and related methods |
| CN119193493A (zh) | 2017-12-08 | 2024-12-27 | 朱诺治疗学股份有限公司 | 生产工程化t细胞组合物的过程 |
| MX2020005907A (es) | 2017-12-08 | 2020-10-19 | Juno Therapeutics Inc | Formulacion de medio libre de suero para cultivar celulas y metodos de uso de la misma. |
| WO2019123339A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| EP3735265A4 (en) | 2018-01-03 | 2021-11-10 | Qu Biologics Inc. | INNATE TARGETING OF ADOPTIVE CELL THERAPIES |
| CN110028588A (zh) * | 2018-01-11 | 2019-07-19 | 上海细胞治疗研究院 | 抗原-Fc融合蛋白及其检测阳性CAR-T细胞的应用 |
| US10561686B2 (en) | 2018-01-12 | 2020-02-18 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| US11311576B2 (en) | 2018-01-22 | 2022-04-26 | Seattle Children's Hospital | Methods of use for CAR T cells |
| CN108103027B (zh) * | 2018-02-02 | 2021-12-24 | 中国医学科学院血液病医院（血液学研究所） | 高效率血细胞重编程同时实现基因编辑的方法 |
| CR20200347A (es) | 2018-02-13 | 2020-09-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
| AU2019225174B2 (en) | 2018-02-23 | 2025-11-20 | Endocyte, Inc. | Sequencing method for CAR T cell therapy |
| CN108383914A (zh) * | 2018-02-23 | 2018-08-10 | 北京美康基免生物科技有限公司 | 一种基于cd19的嵌合抗原受体及其应用 |
| EP3765601A1 (en) * | 2018-03-16 | 2021-01-20 | Immusoft Corporation | B cells genetically engineered to secrete follistatin and methods of using the same to treat follistatin-related diseases, conditions, disorders and to enhance muscle growth and strength |
| JP7334985B2 (ja) | 2018-04-02 | 2023-08-29 | ナショナル ユニヴァーシティー オブ シンガポール | 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
| KR102551319B1 (ko) | 2018-05-14 | 2023-07-05 | 길리애드 사이언시즈, 인코포레이티드 | Mcl-1 억제제 |
| CA3100446A1 (en) * | 2018-05-15 | 2019-11-21 | Carsgen Therapeutics Co., Ltd. | Genetically engineered cell and application thereof |
| CA3100837A1 (en) * | 2018-05-15 | 2019-11-21 | Case Western Reserve University | Long lived chimeric antigen receptor (car) expressing t cells for cancer therapy |
| WO2020003210A1 (en) | 2018-06-29 | 2020-01-02 | Kangwon National University University-Industry Cooperation Foundation | Anti-l1cam antibodies and uses thereof |
| SG11202012425QA (en) | 2018-07-13 | 2021-01-28 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors |
| US12516099B2 (en) | 2018-08-09 | 2026-01-06 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| US12497611B2 (en) | 2018-08-17 | 2025-12-16 | Yale University | Compositions and methods for high-throughput activation screening to boost T cell effector function |
| CN110845621A (zh) * | 2018-08-21 | 2020-02-28 | 上海恒润达生生物科技有限公司 | 一种靶向egfr和cd19双靶点的嵌合抗原受体方法 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| CN113039206A (zh) * | 2018-08-31 | 2021-06-25 | 西雅图儿童医院（Dba西雅图儿童研究所） | 包含b7h3嵌合抗原受体的方法和组合物 |
| EP3860717A1 (en) | 2018-10-03 | 2021-08-11 | Gilead Sciences, Inc. | Imidozopyrimidine derivatives |
| EP3868783A4 (en) * | 2018-10-19 | 2022-01-19 | Cartexell Inc. | ANTI-L1CAM ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF AND CHIMERIC ANTIGEN RECEPTOR THEREOF |
| WO2020086556A1 (en) | 2018-10-24 | 2020-04-30 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| AU2019372673A1 (en) | 2018-11-01 | 2021-05-27 | Gracell Biotechnologies (Shanghai) Co., Ltd. | Compositions and methods for T cell engineering |
| MA54078A (fr) | 2018-11-01 | 2021-09-15 | Juno Therapeutics Inc | Méthodes pour le traitement au moyen de récepteurs antigéniques chimériques spécifiques de l'antigene de maturation des lymphocytes b |
| AU2019381526B2 (en) | 2018-11-14 | 2023-02-23 | Green Cross Lab Cell Corporation | Method for culturing cord blood-derived natural killer cells using transformed T-cells |
| IL283218B2 (en) * | 2018-11-16 | 2025-11-01 | Juno Therapeutics Inc | Dosing methods of engineered T cells for the treatment of malignant B cells |
| US10918667B2 (en) | 2018-11-20 | 2021-02-16 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expressing therapeutic agent and uses thereof |
| KR20210111244A (ko) * | 2018-11-30 | 2021-09-10 | 셀룰래리티 인코포레이티드 | 태반-유래 동종이계 car-t 세포 및 이의 용도 |
| CN113692285A (zh) * | 2018-11-30 | 2021-11-23 | 朱诺治疗学股份有限公司 | 在过继细胞疗法中给药和治疗b细胞恶性肿瘤的方法 |
| PT3886875T (pt) * | 2018-11-30 | 2024-06-27 | Juno Therapeutics Inc | Métodos para tratamento utilizando terapia celular adotiva |
| CA3124103A1 (en) * | 2018-12-20 | 2020-06-25 | Poseida Therapeutics, Inc. | Nanotransposon compositions and methods of use |
| SG11202107976SA (en) | 2019-01-29 | 2021-08-30 | Juno Therapeutics Inc | Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1) |
| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| EP3934757B1 (en) | 2019-03-07 | 2023-02-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| WO2020178770A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| US20200297768A1 (en) * | 2019-03-19 | 2020-09-24 | Immatics US, Inc. | Cd28 t cell cultures, compositions, and methods of using thereof |
| US20200308248A1 (en) * | 2019-03-26 | 2020-10-01 | ST Phi Therapeutics | Chimeric Natural Killer Cell Receptors and Method of Using Thereof |
| EP3953383A4 (en) * | 2019-04-08 | 2023-01-18 | Russell Biotech, Inc. | Improved manufacturing procedures for cell based therapies |
| CN110010200A (zh) * | 2019-04-16 | 2019-07-12 | 长沙三济生物科技有限公司 | 一种基因身份识别系统 |
| CN109994176A (zh) * | 2019-04-16 | 2019-07-09 | 北京中佰耀因医药科技有限公司 | 一种含样本类型信息管理模块的精准用药智能报告系统 |
| CN109979545A (zh) * | 2019-04-16 | 2019-07-05 | 北京中佰耀因医药科技有限公司 | 一种含样本状态信息管理模块的精准用药智能报告系统 |
| CN109872792A (zh) * | 2019-04-16 | 2019-06-11 | 北京中佰耀因医药科技有限公司 | 一种用于指导精准用药的基因检测智能报告系统 |
| CN109994156A (zh) * | 2019-04-16 | 2019-07-09 | 北京中佰耀因医药科技有限公司 | 一种含报告模板信息管理模块的精准用药智能报告系统 |
| CN110010222A (zh) * | 2019-04-16 | 2019-07-12 | 长沙三济生物科技有限公司 | 一种基于精准用药知识库的基因身份识别系统 |
| CN109994180A (zh) * | 2019-04-16 | 2019-07-09 | 北京中佰耀因医药科技有限公司 | 一种含基因位点信息管理模块的精准用药智能报告系统 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| EP3980453A4 (en) * | 2019-06-07 | 2023-07-05 | The Trustees of the University of Pennsylvania | Dual car expressing t cells individually linked to cd28 and 4-1bb |
| US20210030795A1 (en) * | 2019-06-17 | 2021-02-04 | Enochian BioPharma, Inc. | Allogeneic t-cell-based hiv vaccine to induce cellular and humoral immunity |
| WO2020254591A1 (en) * | 2019-06-19 | 2020-12-24 | Julius-Maximilians-Universität Würzburg | Ultramodular igg3-based spacer domain and multi-function site for implementation in chimeric antigen receptor design |
| WO2020263830A1 (en) | 2019-06-25 | 2020-12-30 | Gilead Sciences, Inc. | Flt3l-fc fusion proteins and methods of use |
| CN110608991B (zh) * | 2019-09-09 | 2022-04-29 | 浙江普罗亭健康科技有限公司 | 基于质谱流式检测技术的细胞周期检测试剂盒及检测方法 |
| ES2973832T3 (es) | 2019-10-18 | 2024-06-24 | Forty Seven Inc | Terapias combinadas para el tratamiento de síndromes mielodisplásicos y leucemia mieloide aguda |
| JP2022552748A (ja) | 2019-10-31 | 2022-12-19 | フォーティ セブン， インコーポレイテッド | 抗ｃｄ４７及び抗ｃｄ２０による血液癌の治療 |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| IL294032A (en) | 2019-12-24 | 2022-08-01 | Carna Biosciences Inc | Compounds that regulate diacylglycerol kinase |
| TWI890283B (zh) | 2020-02-14 | 2025-07-11 | 美商基利科學股份有限公司 | 結合ccr8之抗體及融合蛋白及其用途 |
| US12076343B2 (en) | 2020-02-19 | 2024-09-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Engineered safety in cell therapy |
| CN111533808B (zh) * | 2020-03-10 | 2021-02-09 | 南京医科大学 | 一种可自分泌TLR4 scFv且靶向cMet的嵌合抗原受体修饰的T细胞及其应用 |
| WO2021189008A1 (en) | 2020-03-20 | 2021-09-23 | Lyell Immunopharma, Inc. | Novel recombinant cell surface markers |
| IL297327B2 (en) | 2020-05-01 | 2026-01-01 | Gilead Sciences Inc | 4,2-dioxopyrimidine compounds CD73 inhibitors |
| GB202007169D0 (en) * | 2020-05-14 | 2020-07-01 | Ospedale San Raffaele Srl | Epidermal growth factor receptor |
| EP3915575A1 (en) * | 2020-05-29 | 2021-12-01 | Imnate Sarl | Vaccine formulations |
| US12043654B2 (en) | 2020-06-02 | 2024-07-23 | Innovative Cellular Therapeutics Holdings, Ltd. | Anti-GCC antibody and CAR thereof for treating digestive system cancer |
| CA3186029A1 (en) * | 2020-06-08 | 2021-12-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Anti-cd171 chimeric antigen receptors |
| US20230338422A1 (en) * | 2020-07-09 | 2023-10-26 | Nanjing Legend Biotech Co., Ltd. | Engineering gamma delta t cells with interleukin-36 for immunotherapy |
| JP2023535371A (ja) | 2020-07-17 | 2023-08-17 | シミュレックス インコーポレイテッド | 免疫抑制シグナル伝達をリダイレクトするためのキメラＭｙＤ８８受容体ならびに関連する組成物および方法 |
| JP2023552810A (ja) * | 2020-12-08 | 2023-12-19 | シアトル チルドレンズ ホスピタル （ディービーエイ シアトル チルドレンズ リサーチ インスティテュート） | 抗ｅｇｆｒキメラ抗原受容体 |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| EP4277639A4 (en) * | 2021-01-15 | 2025-03-05 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | HYBRID AND TRUNCATED IMMUNE CELL PROTEINS |
| US12144827B2 (en) | 2021-02-25 | 2024-11-19 | Lyell Immunopharma, Inc. | ROR1 targeting chimeric antigen receptor |
| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
| WO2022245671A1 (en) | 2021-05-18 | 2022-11-24 | Gilead Sciences, Inc. | Methods of using flt3l-fc fusion proteins |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| MX2023014762A (es) | 2021-06-23 | 2024-01-15 | Gilead Sciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| JP7651018B2 (ja) | 2021-06-23 | 2025-03-25 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| CN118056012B (zh) * | 2021-08-24 | 2025-05-30 | 赛斯尔擎生物技术（上海）有限公司 | 一种修饰细胞的方法 |
| JP2024537991A (ja) | 2021-10-14 | 2024-10-18 | アーセナル バイオサイエンシズ インコーポレイテッド | 共発現されるｓｈＲＮＡと論理ゲートシステムとを有する免疫細胞 |
| AU2022375782B2 (en) | 2021-10-28 | 2026-02-26 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
| JP7787991B2 (ja) | 2021-10-29 | 2025-12-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｃｄ７３化合物 |
| US12122764B2 (en) | 2021-12-22 | 2024-10-22 | Gilead Sciences, Inc. | IKAROS zinc finger family degraders and uses thereof |
| KR20240123836A (ko) | 2021-12-22 | 2024-08-14 | 길리애드 사이언시즈, 인코포레이티드 | 이카로스 아연 핑거 패밀리 분해제 및 이의 용도 |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| US20250228940A1 (en) * | 2022-03-11 | 2025-07-17 | Yale University | Compositions and methods for efficient and stable genetic modification of eukaryotic cells |
| WO2023178181A1 (en) | 2022-03-17 | 2023-09-21 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| KR20240165995A (ko) | 2022-03-24 | 2024-11-25 | 길리애드 사이언시즈, 인코포레이티드 | Trop-2 발현 암의 치료를 위한 병용요법 |
| US20250255959A1 (en) * | 2022-04-01 | 2025-08-14 | Miltenyi Biotec B.V. & Co. KG | A system for drug-inducible expression of a polynucleotide |
| TWI876305B (zh) | 2022-04-05 | 2025-03-11 | 美商基利科學股份有限公司 | 用於治療結腸直腸癌之組合療法 |
| CR20240451A (es) | 2022-04-21 | 2024-12-04 | Gilead Sciences Inc | Compuestos de modulación de kras g12d |
| US20230348561A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof |
| EP4514821A1 (en) | 2022-04-28 | 2025-03-05 | Immatics US, Inc. | Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof |
| EP4514829A1 (en) | 2022-04-28 | 2025-03-05 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
| CN114990069B (zh) * | 2022-05-17 | 2023-09-22 | 郑州大学第一附属医院 | 一种过表达slc43a2的嵌合抗原受体t细胞的制备方法和应用 |
| WO2023227900A1 (en) * | 2022-05-27 | 2023-11-30 | Autolus Limited | Method |
| PY2342670A (es) * | 2022-06-10 | 2023-12-19 | Biocad Joint Stock Co | Ácido nucleico con actividad promotora y uso del mismo |
| WO2024006702A1 (en) * | 2022-06-27 | 2024-01-04 | Foundation Medicine, Inc. | Methods and systems for predicting genotypic calls from whole-slide images |
| KR20250028371A (ko) | 2022-07-01 | 2025-02-28 | 길리애드 사이언시즈, 인코포레이티드 | Cd73 화합물 |
| WO2024064668A1 (en) | 2022-09-21 | 2024-03-28 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY |
| CN116179495B (zh) * | 2022-11-28 | 2025-06-06 | 上海恩凯细胞技术有限公司 | 转基因免疫细胞及其应用 |
| EP4633649A1 (en) * | 2022-12-15 | 2025-10-22 | The Board of Trustees of the Leland Stanford Junior University | Homology-independent targeted dna insertion in human t cells |
| WO2024137652A2 (en) * | 2022-12-20 | 2024-06-27 | Abata Therapeutics, Inc. | Cell therapies for type 1 diabetes |
| AU2023409398A1 (en) | 2022-12-22 | 2025-06-05 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| CN118359729A (zh) * | 2023-01-19 | 2024-07-19 | 武汉昭智生物技术有限公司 | 一种car分子、包含其的细胞或外泌体及它们的应用 |
| US20240290628A1 (en) * | 2023-02-24 | 2024-08-29 | American Air Liquide, Inc. | Etching method using oxygen-containing hydrofluorocarbon |
| IL322949A (en) | 2023-03-03 | 2025-10-01 | Arsenal Biosciences Inc | Systems targeting PSMA and CA9 |
| AU2024252725A1 (en) | 2023-04-11 | 2025-11-06 | Gilead Sciences, Inc. | Kras modulating compounds |
| CR20250446A (es) | 2023-04-21 | 2025-12-02 | Gilead Sciences Inc | Inhibidores de prmt5 y usos de los mismos |
| AU2024306338A1 (en) | 2023-06-30 | 2026-01-08 | Gilead Sciences, Inc. | Kras modulating compounds |
| CN116844685B (zh) * | 2023-07-03 | 2024-04-12 | 广州默锐医药科技有限公司 | 一种免疫治疗效果评估方法、装置、电子设备及存储介质 |
| KR20260046403A (ko) | 2023-07-26 | 2026-04-07 | 길리애드 사이언시즈, 인코포레이티드 | Parp7 저해제 |
| CN121620513A (zh) | 2023-07-26 | 2026-03-06 | 吉利德科学公司 | Parp7抑制剂 |
| US20250101042A1 (en) | 2023-09-08 | 2025-03-27 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| US20250109147A1 (en) | 2023-09-08 | 2025-04-03 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| WO2025096649A1 (en) | 2023-11-01 | 2025-05-08 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
| US20250154172A1 (en) | 2023-11-03 | 2025-05-15 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025207642A1 (en) * | 2024-03-25 | 2025-10-02 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Cxcr3 isoforms to improve recombinant receptor trafficking |
| WO2025245003A1 (en) | 2024-05-21 | 2025-11-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| US20260098049A1 (en) | 2024-08-12 | 2026-04-09 | Gilead Sciences, Inc. | Kras modulating compounds |
Family Cites Families (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE913929A1 (en) | 1990-11-13 | 1992-05-20 | Immunex Corp | Bifunctional selectable fusion genes |
| US20020111474A1 (en) * | 1990-12-14 | 2002-08-15 | Capon Daniel J. | Chimeric chains for receptor-associated signal transduction pathways |
| EP0650367A4 (en) | 1992-06-01 | 1998-04-15 | New England Medical Center Inc | BLOCKING OF INTERCELLULAR INTERACTIONS WITH CD43 CHEMICAL MOLECULES. |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US5783186A (en) * | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
| US6133027A (en) * | 1996-08-07 | 2000-10-17 | City Of Hope | Inducible expression system |
| US6660257B1 (en) * | 1996-10-25 | 2003-12-09 | Pharmacia Corporation | Circular permuteins of flt3 ligand |
| US6410319B1 (en) * | 1998-10-20 | 2002-06-25 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| US20040037816A1 (en) | 1999-04-15 | 2004-02-26 | Monash University | Graft acceptance through manipulation of thymic regeneration |
| US6912492B1 (en) * | 1999-05-25 | 2005-06-28 | University Of Medicine & Dentistry Of New Jersey | Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors |
| JP4045713B2 (ja) | 2000-01-31 | 2008-02-13 | 松下電器産業株式会社 | 自動機用溶接機 |
| GB0015119D0 (en) * | 2000-06-20 | 2000-08-09 | Angeletti P Ist Richerche Bio | Methods and means for regulation of gene expression |
| KR100545945B1 (ko) | 2000-07-03 | 2006-01-25 | 갈라 디자인, 인크. | 발현 벡터 |
| GB0025307D0 (en) | 2000-10-16 | 2000-11-29 | Celltech Chiroscience Ltd | Biological products |
| ATE338124T1 (de) | 2000-11-07 | 2006-09-15 | Hope City | Cd19-spezifische umgezielte immunzellen |
| RU2003129528A (ru) | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| WO2002097099A1 (en) * | 2001-05-29 | 2002-12-05 | Valentis, Inc. | Regulated expression of ghrh |
| EP1397382B1 (en) | 2001-05-31 | 2008-08-06 | Novartis AG | Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions |
| US20050004017A1 (en) | 2001-09-18 | 2005-01-06 | Yuval Reiss | Methods and compositions for treating hcap associated diseases |
| US20030148982A1 (en) | 2001-11-13 | 2003-08-07 | Brenner Malcolm K. | Bi-spcific chimeric T cells |
| WO2003087338A2 (en) | 2002-04-11 | 2003-10-23 | Amgen, Inc. | Her-2 receptor tyrosine kinase molecules and uses thereof |
| US20040115814A1 (en) | 2002-09-30 | 2004-06-17 | Protein Design Labs, Inc. | Efficient generation of stable expression cell lines through the use of scorable homeostatic reporter genes |
| JP5356648B2 (ja) | 2003-02-20 | 2013-12-04 | シアトル ジェネティックス， インコーポレイテッド | 抗ｃｄ７０抗体−医薬結合体、ならびに癌および免疫障害の処置のためのそれらの使用 |
| US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
| US20060160090A1 (en) | 2003-04-11 | 2006-07-20 | Macina Robert A | Composition splice variants and methods relating to cancer specific genes and proteins |
| CN1809277A (zh) * | 2003-04-18 | 2006-07-26 | 诺伍德免疫学有限公司 | 先于胸腺再活化的移植物耐受 |
| WO2005017102A2 (en) | 2003-05-30 | 2005-02-24 | Diadexus, Inc. | Compositions, splice variants and methods relating to ovarian specific nucleic acids and proteins |
| CN101173282B (zh) | 2003-07-21 | 2011-04-06 | P.安杰莱蒂分子生物学研究所 | 编码人表皮生长因子2/neu抗原的合成基因及其用途 |
| EP1680447A2 (en) | 2003-10-24 | 2006-07-19 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Orthogonal gene switches |
| US20130266551A1 (en) | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| US8071364B2 (en) | 2003-12-24 | 2011-12-06 | Transgenrx, Inc. | Gene therapy using transposon-based vectors |
| US7935510B2 (en) | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| US20090098142A1 (en) | 2004-06-09 | 2009-04-16 | Kasaian Marion T | Methods and compositions for treating and monitoring treatment of IL-13-associated disorders |
| US7910101B2 (en) * | 2004-10-25 | 2011-03-22 | Centocor, Inc. | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
| DE202005002921U1 (de) | 2005-02-23 | 2005-04-21 | Magcode Ag | Verbindungssystem, insbesondere elektrisches Verbindungssystem |
| US20070020237A1 (en) | 2005-06-01 | 2007-01-25 | Biotech Institute For International Innovation, Inc. | Glucose inducible insulin expression and methods of treating diabetes |
| RU2008129827A (ru) | 2005-12-21 | 2010-01-27 | МЕДИММЬЮН, ЭлЭлСи (US) | МОЛЕКУЛЫ EphA2-BiTE И ИХ ПРИМЕНЕНИЕ |
| NZ572884A (en) | 2006-05-22 | 2011-12-22 | Hiprocell Llc | Transformation of eukaryotic cells using two different recombination sites recognised by two different unidirectional site-specific recombinases |
| US8148129B2 (en) | 2006-06-30 | 2012-04-03 | The Regents Of The University Of California | Generation of potent dominant negative transcriptional inhibitors |
| WO2008012237A1 (en) * | 2006-07-24 | 2008-01-31 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Multi-antigen construct and uses thereof |
| US7709253B2 (en) * | 2006-08-04 | 2010-05-04 | The Board Of Trustees Of The Leland Stanford Junior University | Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists |
| CA2693155A1 (en) | 2007-07-25 | 2009-01-29 | Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Self coupling recombinant antibody fusion proteins |
| WO2009091826A2 (en) | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| US8450112B2 (en) | 2008-04-09 | 2013-05-28 | Maxcyte, Inc. | Engineering and delivery of therapeutic compositions of freshly isolated cells |
| EP2331566B1 (en) | 2008-08-26 | 2015-10-07 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| US8829173B2 (en) | 2008-09-26 | 2014-09-09 | Tocagen Inc. | Recombinant vectors |
| CN102227503B (zh) * | 2008-09-26 | 2015-10-21 | 托卡根公司 | 重组载体 |
| US8329882B2 (en) | 2009-02-18 | 2012-12-11 | California Institute Of Technology | Genetic control of mammalian cells with synthetic RNA regulatory systems |
| WO2010141543A1 (en) | 2009-06-02 | 2010-12-09 | Targeted Molecular Diagnostics, Llc | Methods for the detection and quantitation of the p95 component of her2/neu (erbb2) |
| US9873035B2 (en) * | 2009-07-09 | 2018-01-23 | Cfph, Llc | Amusement device for a game of chance involving one or more rolling indicators on a rotating element with position indicators |
| US8075895B2 (en) | 2009-09-22 | 2011-12-13 | Janssen Pharmaceutica N.V. | Identification of antigenic peptides from multiple myeloma cells |
| CA2776143A1 (en) | 2009-10-01 | 2011-04-07 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| TR201904484T4 (tr) * | 2009-11-03 | 2019-05-21 | Hope City | Transdüse T hücre seçimine yönelik kesik epiderimal büyüme faktörü reseptörü (EGFRt). |
| JP5285678B2 (ja) | 2010-06-18 | 2013-09-11 | 株式会社エヌ・ティ・ティ・ドコモ | 移動通信方法及びコアネットワーク装置 |
| ES2602743T3 (es) | 2010-09-08 | 2017-02-22 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Receptores de antígenos quiméricos con una región bisagra optimizada |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| KR20140004174A (ko) | 2011-01-18 | 2014-01-10 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암 치료를 위한 조성물 및 방법 |
| US9987308B2 (en) | 2011-03-23 | 2018-06-05 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| CN103502439B (zh) * | 2011-04-13 | 2016-10-12 | 因缪尼卡姆股份公司 | 用于抗原特异性t细胞增殖的方法 |
| US20130071414A1 (en) * | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| EP2714936B1 (en) | 2011-06-01 | 2018-12-12 | Precision Biosciences, Inc. | Methods and products for producing engineered mammalian cell lines with amplified transgenes |
| CN103649125A (zh) | 2011-06-22 | 2014-03-19 | 霍夫曼-拉罗奇有限公司 | 利用包含mhc i类的复合物通过循环中的病毒特异性细胞毒性t细胞清除靶细胞 |
| ES2654060T3 (es) | 2011-10-20 | 2018-02-12 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Receptores de antígenos quiméricos anti-CD22 |
| DE102011118018B4 (de) | 2011-10-25 | 2017-10-26 | Plasmidfactory Gmbh & Co. Kg | Minicircles mit Transpositionskassetten und ihre Verwendung zur Transformation von Zellen |
| US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| CA2861491C (en) | 2012-02-13 | 2020-08-25 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| ITRM20120058A1 (it) | 2012-02-20 | 2013-08-21 | Pisanelli Giovanni Codacci | Famiglia di molecole a base di zuccheri ad uso terapeutico e relativo procedimento di produzione |
| EP2817330B1 (en) * | 2012-02-22 | 2020-07-08 | The Trustees of the University of Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| RU2766608C2 (ru) * | 2012-04-11 | 2022-03-15 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток |
| US20130280220A1 (en) | 2012-04-20 | 2013-10-24 | Nabil Ahmed | Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes |
| WO2013177533A1 (en) | 2012-05-25 | 2013-11-28 | California Institute Of Technology | Expression of secreted and cell-surface polypeptides |
| CA2876860A1 (en) | 2012-05-30 | 2013-12-05 | Baylor College Of Medicine | Supercoiled minivectors as a tool for dna repair, alteration and replacement |
| EP2669378A1 (en) | 2012-05-31 | 2013-12-04 | Helmut Hanenberg | Cytochrome P450 suicide gene system |
| JP6079775B2 (ja) | 2012-06-01 | 2017-02-15 | 日本電気株式会社 | スイッチングシステム、ラインカード、スイッチカード、ｆｄｂ学習方法、ｆｄｂ学習調停方法及びプログラム |
| BR122020002986A8 (pt) * | 2012-08-20 | 2023-04-18 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Método e composições para imunoterapia celular |
| US10316289B2 (en) | 2012-09-06 | 2019-06-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing T memory stem cell populations |
| MX370148B (es) | 2012-10-02 | 2019-12-03 | Memorial Sloan Kettering Cancer Center | Composiciones y su uso para inmunoterapia. |
| WO2014055771A1 (en) * | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| AU2013329186B2 (en) | 2012-10-10 | 2019-02-14 | Sangamo Therapeutics, Inc. | T cell modifying compounds and uses thereof |
| US20150329640A1 (en) | 2012-12-20 | 2015-11-19 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
| CN104781789B (zh) | 2012-12-20 | 2018-06-05 | 三菱电机株式会社 | 车载装置 |
| ES2671004T3 (es) | 2013-03-07 | 2018-06-04 | Baylor College Of Medicine | Dirección a CD138 en cáncer |
| EP2777711A1 (en) * | 2013-03-11 | 2014-09-17 | Icon Genetics GmbH | Her2/Neu cancer vaccine |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| EP3783098A1 (en) * | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| CA2913052A1 (en) | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
| CN105873952A (zh) | 2013-10-31 | 2016-08-17 | 弗莱德哈钦森癌症研究中心 | 经修饰的造血干细胞/祖细胞和非t效应细胞及其用途 |
| MX373687B (es) | 2013-11-21 | 2020-07-07 | Ucl Business Ltd | Célula natural (nk) |
| EP3082847A1 (en) | 2013-12-20 | 2016-10-26 | Indiana University Research and Technology Corporation | Lipidated incretin receptor ligand human immunoglobulin fc-region fusion polypeptides |
| WO2015092024A2 (en) | 2013-12-20 | 2015-06-25 | Cellectis | Method of engineering multi-input signal sensitive t cell for immunotherapy |
| CN113307880B (zh) | 2014-01-13 | 2025-07-04 | 希望之城公司 | 在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法 |
| CN113248613B (zh) | 2014-01-15 | 2024-08-23 | 豪夫迈·罗氏有限公司 | 具有修饰的FCRN结合性质的Fc区变体 |
| KR102375998B1 (ko) | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| US20170335281A1 (en) | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| US10611837B2 (en) | 2014-04-10 | 2020-04-07 | Seattle Children's Hospital | Transgene genetic tags and methods of use |
| US10604740B2 (en) | 2014-05-14 | 2020-03-31 | Carsgen Therapeutics Limited | Nucleic acids encoding chimeric antigen receptor proteins which bind epidermal growth factor receptor and T lymphocyte expressing the protein |
| ES2836743T3 (es) | 2014-06-02 | 2021-06-28 | Us Health | Receptores de antígeno quiméricos que seleccionan como diana CD-19 |
| TWI751102B (zh) | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | 對ｃｄ１９具專一性之抗體及嵌合抗原受體 |
| HK1243631A1 (zh) | 2014-10-27 | 2018-07-20 | Fred Hutchinson Cancer Research Center | 用於提高过继细胞免疫疗法效力的组合物和方法 |
| GB201503742D0 (en) | 2015-03-05 | 2015-04-22 | Ucl Business Plc | Chimeric antigen receptor |
| PL3298033T5 (pl) | 2015-05-18 | 2023-10-30 | TCR2 Therapeutics Inc. | Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych |
| EP3307876B1 (en) | 2015-06-10 | 2023-09-13 | ImmunityBio, Inc. | Modified nk-92 cells for treating cancer |
| EP4286511A3 (en) | 2015-06-12 | 2024-03-06 | Lentigen Technology, Inc. | Method to treat cancer with engineered t-cells |
| AU2016306209B2 (en) | 2015-08-07 | 2023-07-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Bispecific CAR T-cells for solid tumor targeting |
| IL287889B2 (en) | 2016-02-05 | 2024-03-01 | Hope City | Administration of engineered t cells for treatment of cancers in the central nervous system |
| WO2017172952A1 (en) | 2016-04-01 | 2017-10-05 | Promab Biotechnologies, Inc. | Flag tagged cd19-car-t cells |
| US10626187B2 (en) | 2016-09-28 | 2020-04-21 | Kite Pharma, Inc. | Antigen binding molecules specific for an anti-CD19 scFv |
| DK3523326T3 (da) | 2016-10-04 | 2020-08-03 | Prec Biosciences Inc | Samstimulerende domæner til anvendelse i genetisk modificerede celler |
| US11408005B2 (en) | 2016-12-12 | 2022-08-09 | Seattle Children's Hospital | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
| AU2018257894A1 (en) | 2017-04-24 | 2019-10-31 | Kite Pharma, Inc. | Humanized antigen-binding domains against CD19 and methods of use |
| US12312416B2 (en) | 2018-02-06 | 2025-05-27 | Seattle Children's Hospital | Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| KR20210074274A (ko) | 2018-08-06 | 2021-06-21 | 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 | 합텐 표지된 세포로의 키메라 항원 수용체 t 세포의 자극을 위한 방법 및 조성물 |
| US10714296B2 (en) | 2018-12-12 | 2020-07-14 | Axcelis Technologies, Inc. | Ion source with tailored extraction shape |
| US11104732B2 (en) | 2019-04-24 | 2021-08-31 | Innovative Cellular Therapeutics Holdings, Ltd. | Reducing immune inhibition induced by SIGLEC-15 |
-
2015
- 2015-04-08 US US15/302,420 patent/US10611837B2/en active Active
- 2015-04-08 RU RU2016143381A patent/RU2752275C2/ru active
- 2015-04-08 EP EP21175647.3A patent/EP3943507A1/en not_active Withdrawn
- 2015-04-08 BR BR112016023500-2A patent/BR112016023500B1/pt not_active IP Right Cessation
- 2015-04-08 WO PCT/US2015/024947 patent/WO2015157432A1/en not_active Ceased
- 2015-04-08 RU RU2016143385A patent/RU2751921C2/ru active
- 2015-04-08 WO PCT/US2015/024868 patent/WO2015157386A1/en not_active Ceased
- 2015-04-08 PH PH1/2016/502011A patent/PH12016502011B1/en unknown
- 2015-04-08 US US15/302,426 patent/US20170015746A1/en not_active Abandoned
- 2015-04-08 US US15/302,403 patent/US10865242B2/en active Active
- 2015-04-08 NZ NZ725079A patent/NZ725079A/en not_active IP Right Cessation
- 2015-04-08 MY MYPI2016703722A patent/MY192522A/en unknown
- 2015-04-08 AU AU2015243920A patent/AU2015243920B2/en not_active Ceased
- 2015-04-08 CN CN201580030056.4A patent/CN106574246A/zh active Pending
- 2015-04-08 EP EP15777065.2A patent/EP3129399B1/en active Active
- 2015-04-08 MY MYPI2016703720A patent/MY186846A/en unknown
- 2015-04-08 IL IL248238A patent/IL248238B2/en unknown
- 2015-04-08 SG SG11201608395PA patent/SG11201608395PA/en unknown
- 2015-04-08 EP EP15776501.7A patent/EP3129480A4/en active Pending
- 2015-04-08 CN CN201580027077.0A patent/CN106573969B/zh not_active Expired - Fee Related
- 2015-04-08 SG SG10201808819XA patent/SG10201808819XA/en unknown
- 2015-04-08 EP EP22151326.0A patent/EP4056201A1/en not_active Withdrawn
- 2015-04-08 KR KR1020167031069A patent/KR20160144431A/ko not_active Abandoned
- 2015-04-08 CN CN202110842538.7A patent/CN113528581A/zh active Pending
- 2015-04-08 KR KR1020227038237A patent/KR102618955B1/ko active Active
- 2015-04-08 CA CA2945305A patent/CA2945305C/en active Active
- 2015-04-08 ES ES15776745T patent/ES2867224T3/es active Active
- 2015-04-08 SG SG11201608392WA patent/SG11201608392WA/en unknown
- 2015-04-08 SG SG10201808811QA patent/SG10201808811QA/en unknown
- 2015-04-08 MX MX2016013159A patent/MX389797B/es unknown
- 2015-04-08 JP JP2016561722A patent/JP6772068B2/ja active Active
- 2015-04-08 RU RU2016143388A patent/RU2751920C2/ru active
- 2015-04-08 PH PH1/2016/502009A patent/PH12016502009B1/en unknown
- 2015-04-08 EP EP15776211.3A patent/EP3129053A4/en not_active Withdrawn
- 2015-04-08 AU AU2015243927A patent/AU2015243927B2/en not_active Ceased
- 2015-04-08 KR KR1020167031068A patent/KR102387243B1/ko active Active
- 2015-04-08 KR KR1020237007831A patent/KR102730216B1/ko active Active
- 2015-04-08 US US15/302,415 patent/US10266592B2/en active Active
- 2015-04-08 PH PH1/2016/502010A patent/PH12016502010B1/en unknown
- 2015-04-08 SG SG10201808825XA patent/SG10201808825XA/en unknown
- 2015-04-08 NZ NZ725081A patent/NZ725081A/en not_active IP Right Cessation
- 2015-04-08 CA CA2945303A patent/CA2945303C/en active Active
- 2015-04-08 AU AU2015243922A patent/AU2015243922B2/en active Active
- 2015-04-08 AU AU2015243849A patent/AU2015243849B2/en not_active Ceased
- 2015-04-08 JP JP2016561839A patent/JP2017515464A/ja active Pending
- 2015-04-08 US US15/302,449 patent/US20170029774A1/en not_active Abandoned
- 2015-04-08 WO PCT/US2015/024866 patent/WO2015157384A1/en not_active Ceased
- 2015-04-08 KR KR1020227011931A patent/KR102600544B1/ko active Active
- 2015-04-08 CN CN201580029752.3A patent/CN106535934A/zh active Pending
- 2015-04-08 KR KR1020167031064A patent/KR102463529B1/ko active Active
- 2015-04-08 EP EP15777020.7A patent/EP3129471A4/en active Pending
- 2015-04-08 ES ES15777065T patent/ES2880932T3/es active Active
- 2015-04-08 KR KR1020167031070A patent/KR102509481B1/ko active Active
- 2015-04-08 CN CN201580030815.7A patent/CN106661570B/zh active Active
- 2015-04-08 RU RU2016143389A patent/RU2016143389A/ru not_active Application Discontinuation
- 2015-04-08 EP EP15776745.0A patent/EP3129405B1/en active Active
- 2015-04-08 SG SG10201808833XA patent/SG10201808833XA/en unknown
- 2015-04-08 JP JP2016561635A patent/JP6765967B2/ja active Active
- 2015-04-08 JP JP2017504604A patent/JP6788573B6/ja active Active
- 2015-04-08 CA CA2945320A patent/CA2945320A1/en active Pending
- 2015-04-08 IL IL297591A patent/IL297591B2/en unknown
- 2015-04-08 BR BR112016023523A patent/BR112016023523A2/pt not_active Application Discontinuation
- 2015-04-08 KR KR1020167031067A patent/KR102508166B1/ko active Active
- 2015-04-08 JP JP2016561659A patent/JP6765968B2/ja active Active
- 2015-04-08 NZ NZ73944815A patent/NZ739448A/en not_active IP Right Cessation
- 2015-04-08 WO PCT/US2015/024882 patent/WO2015157391A1/en not_active Ceased
- 2015-04-08 AU AU2015243882A patent/AU2015243882C1/en not_active Ceased
- 2015-04-08 WO PCT/US2015/024895 patent/WO2015157399A1/en not_active Ceased
- 2015-04-08 SG SG11201608393TA patent/SG11201608393TA/en unknown
- 2015-04-08 BR BR112016023517A patent/BR112016023517A2/pt not_active Application Discontinuation
- 2015-04-08 MY MYPI2016703719A patent/MY185678A/en unknown
- 2015-04-08 RU RU2016143384A patent/RU2729112C2/ru active
- 2015-04-08 MX MX2016013149A patent/MX2016013149A/es unknown
- 2015-04-08 SG SG11201608396YA patent/SG11201608396YA/en unknown
- 2015-04-08 IL IL248243A patent/IL248243B2/en unknown
- 2015-04-08 CN CN202110101875.0A patent/CN112877291A/zh active Pending
- 2015-04-08 MX MX2016013158A patent/MX2016013158A/es unknown
- 2015-04-08 MX MX2016013160A patent/MX387465B/es unknown
- 2015-04-08 MX MX2016013144A patent/MX395574B/es unknown
- 2015-04-08 MY MYPI2016703721A patent/MY184163A/en unknown
- 2015-04-08 EP EP21180797.9A patent/EP3954708A1/en active Pending
- 2015-04-08 CN CN201580030814.2A patent/CN106536558A/zh active Pending
- 2015-04-08 CA CA2945308A patent/CA2945308C/en active Active
-
2016
- 2016-10-06 IL IL248235A patent/IL248235B/en active IP Right Grant
- 2016-10-06 IL IL248229A patent/IL248229B2/en unknown
- 2016-10-06 MX MX2022010807A patent/MX2022010807A/es unknown
- 2016-10-10 PH PH12016502012A patent/PH12016502012A1/en unknown
- 2016-10-10 SA SA516380056A patent/SA516380056B1/ar unknown
- 2016-10-13 ZA ZA2016/07061A patent/ZA201607061B/en unknown
- 2016-10-13 ZA ZA2016/07060A patent/ZA201607060B/en unknown
- 2016-10-13 ZA ZA2016/07053A patent/ZA201607053B/en unknown
-
2019
- 2019-02-27 US US16/287,074 patent/US11155616B2/en not_active Expired - Fee Related
-
2020
- 2020-02-19 US US16/794,673 patent/US11414486B2/en active Active
- 2020-06-18 JP JP2020105133A patent/JP7062720B2/ja active Active
- 2020-09-16 JP JP2020155809A patent/JP7093385B2/ja not_active Expired - Fee Related
- 2020-09-16 JP JP2020155429A patent/JP7148580B2/ja active Active
- 2020-09-30 JP JP2020164326A patent/JP7106610B2/ja active Active
- 2020-11-12 US US17/096,138 patent/US12258397B2/en active Active
- 2020-11-13 US US17/097,630 patent/US20210371517A1/en active Pending
-
2021
- 2021-01-04 AU AU2021200007A patent/AU2021200007B2/en not_active Ceased
- 2021-03-17 AU AU2021201679A patent/AU2021201679B2/en not_active Ceased
- 2021-09-10 US US17/472,284 patent/US12202897B2/en active Active
- 2021-11-26 AU AU2021273652A patent/AU2021273652A1/en not_active Abandoned
-
2022
- 2022-04-20 JP JP2022069142A patent/JP7542270B2/ja active Active
- 2022-04-21 US US17/660,114 patent/US12503507B2/en active Active
- 2022-07-13 JP JP2022112278A patent/JP7402933B2/ja active Active
- 2022-07-15 US US17/812,848 patent/US12448445B2/en active Active
- 2022-09-22 JP JP2022150928A patent/JP7508516B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021019589A5 (https=) | ||
| JP7755890B2 (ja) | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 | |
| US10766943B2 (en) | Universal chimeric antigen expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders | |
| Sun et al. | Construction and evaluation of a novel humanized HER2-specific chimeric receptor | |
| Han et al. | Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges | |
| KR102308597B1 (ko) | 다중 종양에 대항하여 항체-의존성 세포 세포독성을 촉발시키는 키메라 수용체 | |
| CN104822705B (zh) | M971嵌合抗原受体 | |
| FI3824905T3 (fi) | Menetelmä ja koostumuksia soluimmunoterapiaa varten | |
| JP2018523485A5 (https=) | ||
| JP2019500894A5 (https=) | ||
| JP2017515464A5 (https=) | ||
| JP2016534717A5 (https=) | ||
| JP2017513478A5 (https=) | ||
| JP2017513470A5 (https=) | ||
| IL259120A (en) | Her2-targeted antigen chimeric receptors2 | |
| JP2016520074A5 (https=) | ||
| JP2021536265A5 (https=) | ||
| RU2016143381A (ru) | Способ и композиции для клеточной иммунотерапии | |
| JP2017537627A5 (https=) | ||
| JP7812549B2 (ja) | 人工免疫監視キメラ抗原受容体（ａｉ－ｃａｒ）及びそれを発現する細胞 | |
| JP2023513157A5 (https=) | ||
| WO2017192536A1 (en) | Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy | |
| Li et al. | Genetically modified T-cells affinity to tumor cells-development of adoptive T-cell immunotherapy | |
| Krebs et al. | T cells redirected to IL13Rα2 with IL13 mutein-CARs have antiglioma activity but also recognize IL13Rα1 | |
| HK40068149A (en) | Universal chimeric antigen receptor expressing immune cells and method of manufacturing the same and the therapeutic use of the same |