JP2021536265A5 - - Google Patents
Info
- Publication number
- JP2021536265A5 JP2021536265A5 JP2021512773A JP2021512773A JP2021536265A5 JP 2021536265 A5 JP2021536265 A5 JP 2021536265A5 JP 2021512773 A JP2021512773 A JP 2021512773A JP 2021512773 A JP2021512773 A JP 2021512773A JP 2021536265 A5 JP2021536265 A5 JP 2021536265A5
- Authority
- JP
- Japan
- Prior art keywords
- genetically modified
- modified hematopoietic
- nucleic acid
- nucleotide sequence
- domain
- Prior art date
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862728306P | 2018-09-07 | 2018-09-07 | |
| US201862728338P | 2018-09-07 | 2018-09-07 | |
| US62/728,338 | 2018-09-07 | ||
| US62/728,306 | 2018-09-07 | ||
| PCT/US2019/050013 WO2020051493A1 (en) | 2018-09-07 | 2019-09-06 | Chimeric receptor polypeptides in combination with trans metabolism molecules modulating intracellular lactate concentrations and therapeutic uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021536265A JP2021536265A (ja) | 2021-12-27 |
| JP2021536265A5 true JP2021536265A5 (https=) | 2022-09-14 |
| JPWO2020051493A5 JPWO2020051493A5 (https=) | 2022-09-14 |
Family
ID=69722785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021512773A Pending JP2021536265A (ja) | 2018-09-07 | 2019-09-06 | 細胞内乳酸濃度を調節するトランス代謝分子と組み合わせたキメラ受容体ポリペプチド及びその治療的使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20210340219A1 (https=) |
| EP (1) | EP3847260A4 (https=) |
| JP (1) | JP2021536265A (https=) |
| KR (1) | KR20210056377A (https=) |
| CN (1) | CN112888786A (https=) |
| AU (1) | AU2019336229A1 (https=) |
| CA (1) | CA3111706A1 (https=) |
| IL (1) | IL281294A (https=) |
| WO (1) | WO2020051493A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3104862A1 (en) * | 2018-07-03 | 2020-01-09 | Sotio, LLC | Chimeric receptors in combination with trans metabolism molecules enhancing glucose import and therapeutic uses thereof |
| IL322315A (en) | 2019-05-14 | 2025-09-01 | Provention Bio Inc | Methods and preparations for preventing type 1 diabetes |
| CN115867294A (zh) * | 2020-06-04 | 2023-03-28 | 凯瑞斯马治疗公司 | 嵌合抗原受体的新型构建体 |
| AU2021287998B2 (en) | 2020-06-11 | 2026-03-12 | Benaroya Research Institute At Virginia Mason | Methods and compositions for preventing type 1 diabetes |
| EP4192586A4 (en) * | 2020-08-10 | 2024-10-16 | Arizona Board of Regents on behalf of Arizona State University | Metabolism-based chimeric antigen receptors and methods of treatment |
| KR20240007179A (ko) * | 2021-04-30 | 2024-01-16 | 셀렉티스 에스.에이. | 고형 종양 암 면역 요법을 위한 새로운 항-muc1 car 및 유전자 편집된 면역세포 |
| US12565529B2 (en) | 2021-05-24 | 2026-03-03 | Provention Bio, Inc. | Methods for treating type 1 diabetes |
| US20250000906A1 (en) | 2021-11-16 | 2025-01-02 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
| US20250099503A1 (en) * | 2022-01-25 | 2025-03-27 | Ramot At Tel-Aviv University Ltd. | Engineering b cells to express chimeric antigen receptors (cars) and uses thereof for t cell independent activation |
| CN114410588B (zh) * | 2022-01-29 | 2022-11-04 | 西安电子科技大学 | 一种α1β1整合素依赖增强型CAR巨噬细胞及其制备方法和应用 |
| CN114478806B (zh) * | 2022-04-14 | 2022-07-01 | 呈诺再生医学科技(北京)有限公司 | 一种提升免疫细胞杀伤活性的嵌合受体及其应用 |
| WO2024040207A1 (en) | 2022-08-19 | 2024-02-22 | Sotio Biotech Inc. | Genetically engineered natural killer (nk) cells with chimeric receptor polypeptides in combination with trans metabolism molecules and therapeutic uses thereof |
| US20260053924A1 (en) | 2022-08-19 | 2026-02-26 | Sotio Biotech Inc. | Genetically engineered immune cells with chimeric receptor polypeptides in combination with multiple trans metabolism molecules and therapeutic uses thereof |
| WO2024215987A1 (en) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES |
| EP4694916A1 (en) | 2023-04-14 | 2026-02-18 | SOTIO Biotech Inc. | Engineered immune cells for treating cancer in combination with il-2/il-15 receptor ?? agonists |
| CN121002374A (zh) * | 2023-04-24 | 2025-11-21 | 南特生物公司 | 作为缺氧驱动肿瘤生长和治疗的生物标志物的单羧酸转运蛋白4 |
| CN116286666B (zh) * | 2023-05-15 | 2023-08-04 | 成都云测医学生物技术有限公司 | 滋养层细胞及其制备方法、应用和扩增nk细胞的方法 |
| WO2025235862A1 (en) * | 2024-05-10 | 2025-11-13 | Inndura Therapeutics Inc. | A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8450112B2 (en) * | 2008-04-09 | 2013-05-28 | Maxcyte, Inc. | Engineering and delivery of therapeutic compositions of freshly isolated cells |
| JP2014513520A (ja) * | 2010-12-29 | 2014-06-05 | シグマ−アルドリッチ・カンパニー、エルエルシー | Ａｄｍｅおよび毒物学的プロセスに関与するタンパク質の乱された発現を有する細胞 |
| CN114262690A (zh) * | 2011-04-15 | 2022-04-01 | 吉恩勒克斯公司 | 减毒的痘苗病毒的克隆毒株及其使用方法 |
| KR20160145802A (ko) * | 2014-04-23 | 2016-12-20 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법 |
| SI3151672T1 (sl) * | 2014-06-06 | 2021-03-31 | Bluebird Bio, Inc. | Izboljšani T-celični sestavki |
| WO2016090365A1 (en) * | 2014-12-05 | 2016-06-09 | Dessain Scott Kendall | Pdk1 binding molecules and uses thereof |
| AU2016297014B2 (en) * | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| US11020429B2 (en) * | 2015-11-05 | 2021-06-01 | Juno Therapeutics, Inc. | Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy |
| JP6735224B2 (ja) * | 2016-01-28 | 2020-08-05 | 花王株式会社 | アストロサイトのグルコース代謝活性化剤 |
| EP3430036A4 (en) * | 2016-03-18 | 2019-08-14 | Unum Therapeutics | MODIFIED CHIMERIC RECEPTORS AND USES IN IMMUNOTHERAPY |
| JP2019524721A (ja) * | 2016-07-15 | 2019-09-05 | ポセイダ セラピューティクス， インコーポレイテッド | キメラ抗原受容体および使用方法 |
| MA45779A (fr) * | 2016-07-29 | 2019-06-05 | Juno Therapeutics Inc | Polypeptides immunomdulateurs et compositions et procédés associés |
| EP3494141A4 (en) * | 2016-08-03 | 2020-04-08 | Bio-Techne Corporation | Identification of vsig3/vista as a novel immune checkpoint and use thereof for immunotherapy |
| WO2018106595A1 (en) * | 2016-12-05 | 2018-06-14 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
| WO2018157000A1 (en) * | 2017-02-23 | 2018-08-30 | Olema Pharmaceuticals, Inc. | Compositions and methods for regulating immune system activity |
-
2019
- 2019-09-06 AU AU2019336229A patent/AU2019336229A1/en not_active Abandoned
- 2019-09-06 CN CN201980067513.5A patent/CN112888786A/zh active Pending
- 2019-09-06 US US17/274,021 patent/US20210340219A1/en not_active Abandoned
- 2019-09-06 KR KR1020217009807A patent/KR20210056377A/ko not_active Ceased
- 2019-09-06 CA CA3111706A patent/CA3111706A1/en active Pending
- 2019-09-06 JP JP2021512773A patent/JP2021536265A/ja active Pending
- 2019-09-06 EP EP19857632.4A patent/EP3847260A4/en not_active Withdrawn
- 2019-09-06 WO PCT/US2019/050013 patent/WO2020051493A1/en not_active Ceased
-
2021
- 2021-03-07 IL IL281294A patent/IL281294A/en unknown
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