CN112888786A - 与调节细胞内乳酸浓度的反式代谢分子组合的嵌合受体多肽及其治疗用途 - Google Patents
与调节细胞内乳酸浓度的反式代谢分子组合的嵌合受体多肽及其治疗用途 Download PDFInfo
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- CN112888786A CN112888786A CN201980067513.5A CN201980067513A CN112888786A CN 112888786 A CN112888786 A CN 112888786A CN 201980067513 A CN201980067513 A CN 201980067513A CN 112888786 A CN112888786 A CN 112888786A
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| PCT/US2019/050013 WO2020051493A1 (en) | 2018-09-07 | 2019-09-06 | Chimeric receptor polypeptides in combination with trans metabolism molecules modulating intracellular lactate concentrations and therapeutic uses thereof |
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Cited By (2)
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| CN112638402A (zh) * | 2018-07-03 | 2021-04-09 | Sotio有限责任公司 | 与增强葡萄糖输入的反式代谢分子组合的嵌合受体及其治疗用途 |
| CN114478806A (zh) * | 2022-04-14 | 2022-05-13 | 呈诺再生医学科技(北京)有限公司 | 一种提升免疫细胞杀伤活性的嵌合受体及其应用 |
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| IL322315A (en) | 2019-05-14 | 2025-09-01 | Provention Bio Inc | Methods and preparations for preventing type 1 diabetes |
| CN115867294A (zh) * | 2020-06-04 | 2023-03-28 | 凯瑞斯马治疗公司 | 嵌合抗原受体的新型构建体 |
| AU2021287998B2 (en) | 2020-06-11 | 2026-03-12 | Benaroya Research Institute At Virginia Mason | Methods and compositions for preventing type 1 diabetes |
| EP4192586A4 (en) * | 2020-08-10 | 2024-10-16 | Arizona Board of Regents on behalf of Arizona State University | Metabolism-based chimeric antigen receptors and methods of treatment |
| KR20240007179A (ko) * | 2021-04-30 | 2024-01-16 | 셀렉티스 에스.에이. | 고형 종양 암 면역 요법을 위한 새로운 항-muc1 car 및 유전자 편집된 면역세포 |
| US12565529B2 (en) | 2021-05-24 | 2026-03-03 | Provention Bio, Inc. | Methods for treating type 1 diabetes |
| US20250000906A1 (en) | 2021-11-16 | 2025-01-02 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
| US20250099503A1 (en) * | 2022-01-25 | 2025-03-27 | Ramot At Tel-Aviv University Ltd. | Engineering b cells to express chimeric antigen receptors (cars) and uses thereof for t cell independent activation |
| CN114410588B (zh) * | 2022-01-29 | 2022-11-04 | 西安电子科技大学 | 一种α1β1整合素依赖增强型CAR巨噬细胞及其制备方法和应用 |
| WO2024040207A1 (en) | 2022-08-19 | 2024-02-22 | Sotio Biotech Inc. | Genetically engineered natural killer (nk) cells with chimeric receptor polypeptides in combination with trans metabolism molecules and therapeutic uses thereof |
| US20260053924A1 (en) | 2022-08-19 | 2026-02-26 | Sotio Biotech Inc. | Genetically engineered immune cells with chimeric receptor polypeptides in combination with multiple trans metabolism molecules and therapeutic uses thereof |
| WO2024215987A1 (en) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES |
| EP4694916A1 (en) | 2023-04-14 | 2026-02-18 | SOTIO Biotech Inc. | Engineered immune cells for treating cancer in combination with il-2/il-15 receptor ?? agonists |
| CN121002374A (zh) * | 2023-04-24 | 2025-11-21 | 南特生物公司 | 作为缺氧驱动肿瘤生长和治疗的生物标志物的单羧酸转运蛋白4 |
| CN116286666B (zh) * | 2023-05-15 | 2023-08-04 | 成都云测医学生物技术有限公司 | 滋养层细胞及其制备方法、应用和扩增nk细胞的方法 |
| WO2025235862A1 (en) * | 2024-05-10 | 2025-11-13 | Inndura Therapeutics Inc. | A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112638402A (zh) * | 2018-07-03 | 2021-04-09 | Sotio有限责任公司 | 与增强葡萄糖输入的反式代谢分子组合的嵌合受体及其治疗用途 |
| CN114478806A (zh) * | 2022-04-14 | 2022-05-13 | 呈诺再生医学科技(北京)有限公司 | 一种提升免疫细胞杀伤活性的嵌合受体及其应用 |
| CN114478806B (zh) * | 2022-04-14 | 2022-07-01 | 呈诺再生医学科技(北京)有限公司 | 一种提升免疫细胞杀伤活性的嵌合受体及其应用 |
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| Publication number | Publication date |
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| JP2021536265A (ja) | 2021-12-27 |
| CA3111706A1 (en) | 2020-03-12 |
| KR20210056377A (ko) | 2021-05-18 |
| AU2019336229A1 (en) | 2021-03-18 |
| WO2020051493A1 (en) | 2020-03-12 |
| EP3847260A1 (en) | 2021-07-14 |
| EP3847260A4 (en) | 2022-09-07 |
| US20210340219A1 (en) | 2021-11-04 |
| IL281294A (en) | 2021-04-29 |
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