|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4447233A
(en)
|
1981-04-10 |
1984-05-08 |
Parker-Hannifin Corporation |
Medication infusion pump
|
|
US4439196A
(en)
|
1982-03-18 |
1984-03-27 |
Merck & Co., Inc. |
Osmotic drug delivery system
|
|
US4447224A
(en)
|
1982-09-20 |
1984-05-08 |
Infusaid Corporation |
Variable flow implantable infusion apparatus
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4740461A
(en)
|
1983-12-27 |
1988-04-26 |
Genetics Institute, Inc. |
Vectors and methods for transformation of eucaryotic cells
|
|
DE3572982D1
(en)
|
1984-03-06 |
1989-10-19 |
Takeda Chemical Industries Ltd |
Chemically modified lymphokine and production thereof
|
|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
EP0216846B2
(en)
|
1985-04-01 |
1995-04-26 |
Celltech Limited |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4959455A
(en)
|
1986-07-14 |
1990-09-25 |
Genetics Institute, Inc. |
Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
|
|
EP0281604B1
(en)
|
1986-09-02 |
1993-03-31 |
Enzon Labs Inc. |
Single polypeptide chain binding molecules
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4912040A
(en)
|
1986-11-14 |
1990-03-27 |
Genetics Institute, Inc. |
Eucaryotic expression system
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・２・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
GB8809129D0
(en)
|
1988-04-18 |
1988-05-18 |
Celltech Ltd |
Recombinant dna methods vectors and host cells
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5420245A
(en)
|
1990-04-18 |
1995-05-30 |
Board Of Regents, The University Of Texas |
Tetrapeptide-based inhibitors of farnesyl transferase
|
|
ATE207080T1
(de)
|
1991-11-25 |
2001-11-15 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
CA2111902A1
(en)
|
1992-12-21 |
1994-06-22 |
Jack Beuford Campbell |
Antitumor compositions and methods of treatment
|
|
WO1994019357A1
(en)
|
1993-02-23 |
1994-09-01 |
Merrell Dow Pharmaceuticals Inc. |
Farnesyl:protein transferase inhibitors as anticancer agents
|
|
CA2118985A1
(en)
|
1993-04-02 |
1994-10-03 |
Dinesh V. Patel |
Heterocyclic inhibitors of farnesyl protein transferase
|
|
AU6909194A
(en)
|
1993-05-14 |
1994-12-12 |
Board Of Regents, The University Of Texas System |
Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole
|
|
US5602098A
(en)
|
1993-05-18 |
1997-02-11 |
University Of Pittsburgh |
Inhibition of farnesyltransferase
|
|
AU691811B2
(en)
|
1993-06-16 |
1998-05-28 |
Celltech Therapeutics Limited |
Antibodies
|
|
US5728830A
(en)
|
1993-09-22 |
1998-03-17 |
Kyowa Hakko Kogyo Co., Ltd. |
Farnesyltransferase inhibitor
|
|
US5721236A
(en)
|
1993-10-15 |
1998-02-24 |
Schering Corporation |
Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
CA2174105C
(en)
|
1993-10-15 |
2002-02-12 |
W. Robert Bishop |
Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
US5719148A
(en)
|
1993-10-15 |
1998-02-17 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
IL111235A
(en)
|
1993-10-15 |
2001-03-19 |
Schering Plough Corp |
Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
|
|
US5661152A
(en)
|
1993-10-15 |
1997-08-26 |
Schering Corporation |
Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
IL111257A0
(en)
|
1993-10-15 |
1994-12-29 |
Schering Corp |
Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
KR100378615B1
(ko)
|
1993-10-25 |
2003-10-10 |
파크데이비스앤드캄파니 |
단백질:파르네실트랜스퍼라제의치환된테트라및펜타펩티드억제제
|
|
CA2152822A1
(en)
|
1993-11-04 |
1995-05-11 |
William R. Baker |
Cyclobutane derivatives as inhibitors of squalene synthetase and protein farnesyltransferase
|
|
US5783593A
(en)
|
1993-11-04 |
1998-07-21 |
Abbott Laboratories |
Inhibitors of squalene synthetase and protein farnesyltransferase
|
|
CA2170766A1
(en)
|
1993-11-05 |
1995-05-11 |
Gary Louis Bolton |
Substituted di- and tripeptide inhibitors of protein:farnesyl transferase
|
|
US5484799A
(en)
|
1993-12-09 |
1996-01-16 |
Abbott Laboratories |
Antifungal dorrigocin derivatives
|
|
WO1995024612A1
(de)
|
1994-03-07 |
1995-09-14 |
International Business Machines Corporation |
Verfahren und vorrichtung zur schnellen interpolation von zwischenwerten aus periodischen phasenverschobenen signalen und zur erkennung von defekten in einem drehkörper
|
|
HUT77406A
(hu)
|
1994-03-15 |
1998-04-28 |
Eisai Co., Ltd., |
1-(4-Amino-5-tio-pent-2-en)-il oldalláncot tartalmazó peptidomimetikumok és az ezeket tartalmazó gyógyszerkészítmények
|
|
AU1615895A
(en)
|
1994-03-31 |
1995-10-12 |
Bristol-Myers Squibb Company |
Imidazole-containing inhibitors of farnesyl protein transferase
|
|
US5523430A
(en)
|
1994-04-14 |
1996-06-04 |
Bristol-Myers Squibb Company |
Protein farnesyl transferase inhibitors
|
|
US5510510A
(en)
|
1994-05-10 |
1996-04-23 |
Bristol-Meyers Squibb Company |
Inhibitors of farnesyl protein transferase
|
|
US5563255A
(en)
|
1994-05-31 |
1996-10-08 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
|
US5532210A
(en)
|
1994-06-08 |
1996-07-02 |
E. I. Du Pont De Nemours And Company |
High temperature superconductor dielectric slow wave structures for accelerators and traveling wave tubes
|
|
DE69507476D1
(de)
|
1994-06-10 |
1999-03-04 |
Rhone Poulenc Rorer Sa |
Farnesyl-transferase-inhibitoren, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen
|
|
US5571792A
(en)
|
1994-06-30 |
1996-11-05 |
Warner-Lambert Company |
Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
|
|
WO1996005529A1
(en)
|
1994-08-09 |
1996-02-22 |
Micron Optics, Inc. |
Temperature compensated fiber fabry-perot filters
|
|
CA2155448A1
(en)
|
1994-08-11 |
1996-02-12 |
Katerina Leftheris |
Inhibitors of farnesyl protein transferase
|
|
EP0776884B1
(en)
|
1994-08-11 |
2000-01-05 |
Banyu Pharmaceutical Co., Ltd. |
Substituted amide derivative
|
|
EP0805154A1
(en)
|
1994-08-12 |
1997-11-05 |
Banyu Pharmaceutical Co., Ltd. |
N,n-disubstituted amic acid derivative
|
|
DE4429506B4
(de)
|
1994-08-19 |
2007-09-13 |
Degussa Gmbh |
Verfahren zur Extraktion natürlicher Carotinoid-Farbstoffe
|
|
DE4429653C2
(de)
|
1994-08-20 |
1997-04-03 |
Anton Dr More |
Konverter und Verfahren zum Frischen von Metallschmelzen insbesondere von Roheisen zu Stahl
|
|
JP4319251B2
(ja)
|
1994-11-22 |
2009-08-26 |
エヌエックスピー ビー ヴィ |
半導体素子を有し導体トラックが形成されている基板が接着層により結合されている支持本体を有する半導体装置
|
|
CA2204144A1
(en)
|
1994-12-09 |
1996-06-13 |
Francis J. Tinney |
Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase
|
|
WO1996021701A2
(en)
|
1995-01-09 |
1996-07-18 |
Magla International Ltd. |
Wear resistant image printing on latex surfaces
|
|
AU4915796A
(en)
|
1995-01-12 |
1996-07-31 |
University Of Pittsburgh |
Inhibitors of prenyl transferases
|
|
FR2729390A1
(fr)
|
1995-01-18 |
1996-07-19 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
FR2730491B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
FR2730492B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5684013A
(en)
|
1995-03-24 |
1997-11-04 |
Schering Corporation |
Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
US5700806A
(en)
|
1995-03-24 |
1997-12-23 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
IL117580A0
(en)
|
1995-03-29 |
1996-07-23 |
Merck & Co Inc |
Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
|
|
US5891872A
(en)
|
1995-04-07 |
1999-04-06 |
Schering Corporation |
Tricyclic compounds
|
|
DE69628559T2
(de)
|
1995-04-07 |
2004-04-29 |
Schering Corp. |
Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase
|
|
US5712280A
(en)
|
1995-04-07 |
1998-01-27 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
IL117798A
(en)
|
1995-04-07 |
2001-11-25 |
Schering Plough Corp |
Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5831115A
(en)
|
1995-04-21 |
1998-11-03 |
Abbott Laboratories |
Inhibitors of squalene synthase and protein farnesyltransferase
|
|
IL118101A0
(en)
|
1995-05-03 |
1996-09-12 |
Abbott Lab |
Inhibitors of farnesyltransferase
|
|
AU6034296A
(en)
|
1995-06-16 |
1997-01-15 |
Warner-Lambert Company |
Tricyclic inhibitors of protein farnesyltransferase
|
|
FR2736641B1
(fr)
|
1995-07-10 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
AT402617B
(de)
|
1995-07-11 |
1997-07-25 |
Datacon Schweitzer & Zeindl Gm |
Anlage zum automatisierten, hermetischen anlage zum automatisierten, hermetischen verschliessen von gehäusen verschliessen von gehäusen
|
|
FR2736638B1
(fr)
|
1995-07-12 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
CH690163A5
(fr)
|
1995-07-28 |
2000-05-31 |
Symphar Sa |
Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
|
|
EP0873123B1
(en)
|
1995-11-06 |
2003-04-09 |
University Of Pittsburgh |
Inhibitors of protein isoprenyl transferases
|
|
JP4183099B2
(ja)
|
1995-11-17 |
2008-11-19 |
ゲゼルシャフト・フュア・ビオテヒノロジッシェ・フォルシュング・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ） |
エポチロンｃおよびｄ、製造法ならびに組成物
|
|
JP2000500502A
(ja)
|
1995-11-22 |
2000-01-18 |
メルク エンド カンパニー インコーポレーテッド |
ファルネシル―タンパク質トランスフェラーゼ阻害剤
|
|
SK283335B6
(sk)
|
1995-12-08 |
2003-06-03 |
Janssen Pharmaceutica N. V. |
(Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze
|
|
IL125062A
(en)
|
1995-12-22 |
2003-11-23 |
Schering Corp |
Tricyclic amides and pharmaceutical compositions containing them for inhibition of g-protein function and for treatment of proliferative diseases
|
|
AU1529997A
(en)
|
1996-01-16 |
1997-08-11 |
Warner-Lambert Company |
Substituted histidine inhibitors of protein farnesyltransferase
|
|
US6673927B2
(en)
|
1996-02-16 |
2004-01-06 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Farnesyl transferase inhibitors
|
|
EP0944388A4
(en)
|
1996-04-03 |
2001-08-16 |
Merck & Co Inc |
INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
|
|
WO1997044350A1
(en)
|
1996-05-22 |
1997-11-27 |
Warner-Lambert Company |
Inhibitors of protein farnesyl transferase
|
|
WO1998002436A1
(en)
|
1996-07-15 |
1998-01-22 |
Bristol-Myers Squibb Company |
Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase
|
|
CA2273083C
(en)
|
1996-12-03 |
2012-09-18 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto, analogues and uses thereof
|
|
EP0951285A1
(en)
|
1996-12-30 |
1999-10-27 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
CA2276081A1
(en)
|
1996-12-30 |
1998-07-09 |
Lekhanh O. Tran |
Inhibitors of farnesyl-protein transferase
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
EP0983303B1
(en)
|
1997-05-21 |
2006-03-08 |
Biovation Limited |
Method for the production of non-immunogenic proteins
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
GB9818110D0
(en)
|
1998-08-19 |
1998-10-14 |
Weston Medical Ltd |
Needleless injectors and other devices
|
|
US6096002A
(en)
|
1998-11-18 |
2000-08-01 |
Bioject, Inc. |
NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method
|
|
HK1044159A1
(zh)
|
1998-12-01 |
2002-10-11 |
蛋白质设计实验室股份有限公司 |
抗γ-干扰素的人化抗体
|
|
JP2002536968A
(ja)
|
1999-01-29 |
2002-11-05 |
イムクローン システムズ インコーポレイティド |
Ｋｄｒに特異的な抗体およびその使用
|
|
GB9904387D0
(en)
|
1999-02-25 |
1999-04-21 |
Pharmacia & Upjohn Spa |
Antitumour synergistic composition
|
|
EP1187633A4
(en)
|
1999-04-08 |
2005-05-11 |
Arch Dev Corp |
USE OF ANTI-VEGF ANTIBODIES TO ENHANCE RADIATION IN ANTICANCER THERAPY
|
|
CA2704600C
(en)
|
1999-04-09 |
2016-10-25 |
Kyowa Kirin Co., Ltd. |
A method for producing antibodies with increased adcc activity
|
|
EP1048299A1
(en)
*
|
1999-04-28 |
2000-11-02 |
Faculteit der Geneeskunde van de Vrije Universiteit |
Method for inhibiting cell functioning for use in anti-inflammatory and anti-tumour therapies
|
|
WO2001040307A1
(de)
*
|
1999-11-30 |
2001-06-07 |
Eberhard-Karls-Universität Tübingen Universitätsklinikum |
Antikörper gegen signal-regulator-proteine
|
|
ES2252261T3
(es)
|
2000-06-28 |
2006-05-16 |
Glycofi, Inc. |
Metodos para producir glicoproteinas modificadas.
|
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
US6958334B2
(en)
|
2001-04-10 |
2005-10-25 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
US20040106540A1
(en)
|
2001-04-10 |
2004-06-03 |
Barnett Stanley F |
Method of treating cancer
|
|
WO2002083139A1
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
US6960584B2
(en)
|
2001-04-10 |
2005-11-01 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
US7034026B2
(en)
|
2001-04-10 |
2006-04-25 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
JP2005511581A
(ja)
|
2001-11-07 |
2005-04-28 |
メルク エンド カムパニー インコーポレーテッド |
有糸分裂キネシン阻害剤
|
|
US20050107404A1
(en)
|
2001-12-06 |
2005-05-19 |
Fraley Mark E. |
Mitotic kinesin inhibitors
|
|
JP2005515208A
(ja)
|
2001-12-06 |
2005-05-26 |
メルク エンド カムパニー インコーポレーテッド |
有糸分裂性キネシン阻害剤
|
|
WO2003049527A2
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
CA2468156A1
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Azolopyrimidinone compounds and their use
|
|
CA2467722A1
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Thienopyrimidinone derivatives as mitotic kinesin inhibitors
|
|
AU2003249597B2
(en)
|
2002-03-08 |
2007-06-28 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
|
JP4394959B2
(ja)
|
2002-04-08 |
2010-01-06 |
メルク エンド カムパニー インコーポレーテッド |
Ａｋｔ活性の阻害剤
|
|
EP1496906A4
(en)
|
2002-04-08 |
2006-05-03 |
Merck & Co Inc |
HEMMER OF ACT ACTIVITY
|
|
US7273869B2
(en)
|
2002-04-08 |
2007-09-25 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
EP1496981A2
(en)
|
2002-04-08 |
2005-01-19 |
Merck & Co., Inc. |
Method of treating cancer
|
|
US7223738B2
(en)
|
2002-04-08 |
2007-05-29 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
AU2003226356A1
(en)
|
2002-04-12 |
2003-10-27 |
Ramot At Tel Aviv University Ltd. |
Prevention of brain inflammation as a result of induced autoimmune response
|
|
EP1509507A4
(en)
|
2002-05-23 |
2006-09-13 |
Merck & Co Inc |
INHIBITORS OF MITOTIC KINESINE
|
|
EP1517904A4
(en)
|
2002-05-23 |
2007-02-21 |
Merck & Co Inc |
INHIBITORS OF MITOTIC KINESINE
|
|
ATE356804T1
(de)
|
2002-06-14 |
2007-04-15 |
Merck & Co Inc |
Inhibitoren von mitotischem kinesin
|
|
EP1515724B1
(en)
|
2002-06-14 |
2009-10-21 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
WO2004037171A2
(en)
|
2002-10-18 |
2004-05-06 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
JP2006507299A
(ja)
|
2002-10-30 |
2006-03-02 |
メルク エンド カムパニー インコーポレーテッド |
Ａｋｔ活性の阻害薬
|
|
US20040102360A1
(en)
|
2002-10-30 |
2004-05-27 |
Barnett Stanley F. |
Combination therapy
|
|
BR0316923A
(pt)
|
2002-12-06 |
2005-10-18 |
Pharmacia Corp |
Polipeptìdeo mitoneet de membranas mitocondriais, seus moduladores e métodos para utilização do mesmo
|
|
CA2509212A1
(en)
|
2002-12-20 |
2004-07-15 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
US7622489B2
(en)
|
2002-12-20 |
2009-11-24 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
CN1809354A
(zh)
|
2003-04-24 |
2006-07-26 |
麦克公司 |
Akt活性抑制剂
|
|
ATE461179T1
(de)
|
2003-04-24 |
2010-04-15 |
Merck Sharp & Dohme |
Hemmer der akt aktivität
|
|
EP1620095A4
(en)
|
2003-04-24 |
2009-04-01 |
Merck & Co Inc |
HEMMER OF ACT ACTIVITY
|
|
US7414055B2
(en)
|
2003-04-24 |
2008-08-19 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
US7410483B2
(en)
|
2003-05-23 |
2008-08-12 |
Novare Surgical Systems, Inc. |
Hand-actuated device for remote manipulation of a grasping tool
|
|
AU2004249138B2
(en)
|
2003-06-12 |
2008-07-17 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
|
CA2475186C
(en)
|
2003-07-17 |
2010-01-05 |
At&T Corp. |
Method and apparatus for windowing in entropy encoding
|
|
EP1648511A1
(en)
*
|
2003-07-29 |
2006-04-26 |
Morphotek, Inc. |
Antibodies and methods for generating genetically altered antibodies with enhanced effector function
|
|
KR100536215B1
(ko)
|
2003-08-05 |
2005-12-12 |
삼성에스디아이 주식회사 |
플라즈마 디스플레이 패널
|
|
WO2005018638A1
(en)
|
2003-08-13 |
2005-03-03 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
PE20050730A1
(es)
|
2003-08-15 |
2005-09-20 |
Merck & Co Inc |
Derivados de 2,5-dihidropirrol 2,2-disustituidos como inhibidores de quinesinas mitoticas
|
|
EP1664026B1
(en)
|
2003-08-15 |
2009-01-21 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
WO2005017190A2
(en)
|
2003-08-15 |
2005-02-24 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
JP2007502773A
(ja)
|
2003-08-15 |
2007-02-15 |
メルク エンド カムパニー インコーポレーテッド |
有糸分裂キネシン阻害薬
|
|
US7294640B2
(en)
|
2004-02-06 |
2007-11-13 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
WO2005089777A1
(en)
|
2004-03-15 |
2005-09-29 |
Karaolis David K R |
A method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis
|
|
CA2561311A1
(en)
|
2004-04-09 |
2005-10-27 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
EP1737861A4
(en)
|
2004-04-09 |
2010-04-28 |
Merck Sharp & Dohme |
HEMMER OF ACT ACTIVITY
|
|
US20110142858A1
(en)
|
2004-06-07 |
2011-06-16 |
Ramot At Tel Aviv University Ltd. |
Method of Passsive Immunization Against Disease or Disorder Charcterized by Amyloid Aggregation with Diminished Risk of Neuroinflammation
|
|
MX2007000998A
(es)
|
2004-07-30 |
2007-07-11 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos.
|
|
EP1782826A1
(en)
|
2005-11-08 |
2007-05-09 |
GBF Gesellschaft für Biotechnologische Forschung mbH |
PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions
|
|
ES2582340T3
(es)
|
2008-01-15 |
2016-09-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Métodos para manipular fagocitosis mediada por CD47
|
|
EP2111869A1
(en)
|
2008-04-23 |
2009-10-28 |
Stichting Sanquin Bloedvoorziening |
Compositions and methods to enhance the immune system
|
|
EP3130607B1
(en)
*
|
2008-10-06 |
2024-04-17 |
Minerva Biotechnologies Corporation |
Muc1* antibodies
|
|
US8450293B2
(en)
|
2010-08-10 |
2013-05-28 |
Rutgers, The State University Of New Jersey |
Synthesis and characterization of C8 analogs of c-di-GMP
|
|
TWI452136B
(zh)
*
|
2010-11-17 |
2014-09-11 |
中外製藥股份有限公司 |
A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation
|
|
US8790651B2
(en)
*
|
2011-07-21 |
2014-07-29 |
Zoetis Llc |
Interleukin-31 monoclonal antibody
|
|
WO2013056352A1
(en)
*
|
2011-10-19 |
2013-04-25 |
University Health Network |
Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers
|
|
US9695212B2
(en)
|
2012-12-13 |
2017-07-04 |
Aduro Biotech, Inc. |
Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
|
|
CA2908819A1
(en)
*
|
2013-04-22 |
2014-10-30 |
Glycotope Gmbh |
Anti-cancer treatments with anti-egfr antibodies having a low fucosylation
|
|
US9840533B2
(en)
|
2013-04-29 |
2017-12-12 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for altering second messenger signaling
|
|
WO2014179760A1
(en)
|
2013-05-03 |
2014-11-06 |
The Regents Of The University Of California |
Cyclic di-nucleotide induction of type i interferon
|
|
PE20160080A1
(es)
|
2013-05-18 |
2016-02-21 |
Aduro Biotech Inc |
Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon
|
|
CN106456749B
(zh)
*
|
2014-03-11 |
2021-03-30 |
小利兰·斯坦福大学托管委员会 |
抗SIRPα抗体和双特异性巨噬细胞增强型抗体
|
|
RU2699717C2
(ru)
*
|
2014-04-18 |
2019-09-09 |
Дзе Ресёч Фаундэйшен Фор Дзе Штат Юниверсити Ов Нью-Йорк |
Гуманизированные антитела к антигену Томсена-Фриденрайха
|
|
CR20160564A
(es)
|
2014-06-04 |
2017-01-20 |
Glaxosmithkline Ip Dev Ltd |
Dinucleótidos cíclicos como moduladores de sting
|
|
EP3546473B1
(en)
|
2014-12-16 |
2025-12-10 |
Kayla Therapeutics |
Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction
|
|
GB201501462D0
(en)
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
EA035817B1
(ru)
|
2015-03-10 |
2020-08-14 |
Адуро Байотек, Инк. |
Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона"
|
|
WO2017011444A1
(en)
|
2015-07-13 |
2017-01-19 |
The Wistar Institute Of Anatomy And Biology |
Methods and compositions for treating b cell cancers
|
|
KR102222186B1
(ko)
|
2015-08-13 |
2021-03-03 |
머크 샤프 앤드 돔 코포레이션 |
Sting 효능제로서 시클릭 디-뉴클레오티드 화합물
|
|
KR102789862B1
(ko)
|
2016-01-11 |
2025-04-03 |
인네이트 튜머 이뮤니티, 인코포레이티드 |
Sting 활성과 연관된 상태 예컨대 암의 치료를 위한 시클릭 디뉴클레오티드
|
|
US10723756B2
(en)
|
2016-01-11 |
2020-07-28 |
Innate Tumor Immunity Inc. |
Cyclic dinucleotides for treating conditions associated with STING activity such as cancer
|
|
PT3440076T
(pt)
|
2016-04-07 |
2022-07-29 |
Glaxosmithkline Ip Dev Ltd |
Amidas heterocíclicas úteis como modeladores de proteína
|
|
JP2019510802A
(ja)
|
2016-04-07 |
2019-04-18 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ |
タンパク質調節物質として有用な複素環アミド
|
|
BR112018070823A2
(pt)
*
|
2016-04-14 |
2019-02-05 |
Ose Immunotherapeutics |
anticorpo sirpa anti-humano ou fragmento de ligação a antígeno do mesmo ou mimético de anticorpo de ligação a antígeno, composição farmacêutica, produto de combinação, molécula de ácido nucleico isolada, vetor, célula hospedeira isolada, polipeptídeo, métodos para fabricar um anticorpo, in vitro ou ex vivo para determinar células positivas para sirpa, de diagnóstico e para prever a resposta de um sujeito, e, uso de um anticorpo anti-sirpa ou um fragmento de ligação a antígeno do mesmo ou um mimético de ligação a anticorpo e in vitro ou ex vivo de pelo menos um anticorpo sirpa anti-humano ou fragmento de ligação a antígeno do mesmo ou mimético de anticorpo de ligação a antígeno.
|
|
WO2018008470A1
(ja)
|
2016-07-05 |
2018-01-11 |
国立大学法人神戸大学 |
抗腫瘍剤
|
|
IL264049B2
(en)
|
2016-07-06 |
2023-11-01 |
Sperovie Biosciences Inc |
Compounds, preparations and methods for treating the disease
|
|
CN106200187B
(zh)
|
2016-07-07 |
2019-04-09 |
京东方科技集团股份有限公司 |
可调光玻璃、可控遮光装置、方法和车辆
|
|
CN109715202A
(zh)
|
2016-07-15 |
2019-05-03 |
斯必乐维生物科学公司 |
用于治疗疾病的化合物、组合物和方法
|
|
WO2018013887A1
(en)
|
2016-07-15 |
2018-01-18 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
CN109862910A
(zh)
|
2016-08-03 |
2019-06-07 |
小利兰·斯坦福大学托管委员会 |
破坏巨噬细胞上的Fc受体接合增强抗SIRPα抗体疗法的功效
|
|
US20190345191A1
(en)
|
2016-08-31 |
2019-11-14 |
Innate Tumor Immunity, Inc. |
Cyclic dinucleotide analogs for treating conditions associated with sting (stimulator of interferon genes) activity
|
|
JOP20190009A1
(ar)
|
2016-09-21 |
2019-01-27 |
Alx Oncology Inc |
أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
|
|
US10537590B2
(en)
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
|
PT3523287T
(pt)
|
2016-10-04 |
2021-10-06 |
Merck Sharp & Dohme |
Compostos de benzo[b]tiofeno como agonistas de sting
|
|
AU2017371070B2
(en)
|
2016-12-09 |
2025-01-02 |
Alector Llc |
Anti-SIRP-alpha antibodies and methods of use thereof
|
|
KR102702926B1
(ko)
|
2017-04-13 |
2024-09-06 |
사이로파 비.브이. |
항-sirp 알파 항체
|
|
CN118271443A
(zh)
|
2017-05-16 |
2024-07-02 |
拜奥迪斯私人有限公司 |
抗SIRPα抗体
|
|
BR112020001653A2
(pt)
|
2017-07-26 |
2020-07-21 |
Forty Seven, Inc. |
anticorpos anti-sirp-alfa e métodos relacionados
|
|
SG11202012338QA
(en)
*
|
2018-07-10 |
2021-01-28 |
Univ Kobe Nat Univ Corp |
ANTI-SIRPa ANTIBODY
|
|
JP7451520B2
(ja)
*
|
2018-11-15 |
2024-03-18 |
ビョンディス・ビー．ブイ． |
ヒト化抗ＳＩＲＰα抗体
|
|
CN111635458B
(zh)
*
|
2020-03-20 |
2026-02-17 |
健信生物科技(宁波)有限公司 |
靶向Sirpα的抗体或其抗原结合片段及其制备和应用
|
|
JP7663265B2
(ja)
*
|
2020-11-30 |
2025-04-16 |
クレ バイオテクノロジ （シャンハイ） カンパニー リミテッド |
抗ＳＩＲＰα抗体またはその抗原結合断片および適用
|
|
TW202317620A
(zh)
*
|
2021-06-04 |
2023-05-01 |
德商百靈佳殷格翰國際股份有限公司 |
抗ＳＩＲＰα抗體
|