JP2002521391A5 - - Google Patents
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- Publication number
- JP2002521391A5 JP2002521391A5 JP2000561222A JP2000561222A JP2002521391A5 JP 2002521391 A5 JP2002521391 A5 JP 2002521391A5 JP 2000561222 A JP2000561222 A JP 2000561222A JP 2000561222 A JP2000561222 A JP 2000561222A JP 2002521391 A5 JP2002521391 A5 JP 2002521391A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- hepatitis
- polynucleotide
- subject
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 description 9
- 102000040430 polynucleotide Human genes 0.000 description 9
- 239000002157 polynucleotide Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 239000000427 antigen Substances 0.000 description 7
- 102000036639 antigens Human genes 0.000 description 7
- 108091007433 antigens Proteins 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 108010073141 Hepatitis C virus glycoprotein E2 Proteins 0.000 description 5
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 239000012634 fragment Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 208000006154 Chronic hepatitis C Diseases 0.000 description 2
- 241000711549 Hepacivirus C Species 0.000 description 2
- 208000005176 Hepatitis C Diseases 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 208000010710 hepatitis C virus infection Diseases 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98113595 | 1998-07-21 | ||
| EP98113595.7 | 1998-07-21 | ||
| PCT/EP1999/005173 WO2000005266A1 (en) | 1998-07-21 | 1999-07-20 | Anti hepatitis c virus antibody and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002521391A JP2002521391A (ja) | 2002-07-16 |
| JP2002521391A5 true JP2002521391A5 (https=) | 2006-08-03 |
| JP4593783B2 JP4593783B2 (ja) | 2010-12-08 |
Family
ID=8232320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000561222A Expired - Fee Related JP4593783B2 (ja) | 1998-07-21 | 1999-07-20 | 抗ｃ型肝炎ウイルス抗体およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6951646B1 (https=) |
| EP (1) | EP1097172A1 (https=) |
| JP (1) | JP4593783B2 (https=) |
| CN (2) | CN101088561A (https=) |
| AU (1) | AU5285899A (https=) |
| CA (1) | CA2339045A1 (https=) |
| WO (1) | WO2000005266A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091324B2 (en) * | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| US7101551B2 (en) | 2000-02-14 | 2006-09-05 | Mitsubishi Pharma Corporation | Remedies for hepatitis C |
| IL137522A (en) * | 2000-07-26 | 2007-06-17 | Drk Blutspendediendst Baden Wu | Human monoclonal antibody against hepatitis c virus e2 glycoprotein |
| EP1178116A1 (en) * | 2000-08-03 | 2002-02-06 | Hybrigenics S.A. | Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof |
| GB0021859D0 (en) * | 2000-09-06 | 2000-10-18 | Imp College Innovations Ltd | Methods |
| GB0114629D0 (en) * | 2001-06-15 | 2001-08-08 | Pfizer Ltd | Method |
| ITRM20020049A1 (it) | 2002-01-30 | 2003-07-30 | Biostrands S R L | Frammenti fab di anticorpi monoclonali umani diretti contro la glicoproteina e2 di hcv e dotati di potere neutralizzante in vitro. |
| WO2004064608A2 (en) * | 2003-01-17 | 2004-08-05 | Aethlon Medical, Inc. | Method for removal of viruses from blood by lectin affinity hemodialysis |
| WO2004087760A1 (en) | 2003-04-01 | 2004-10-14 | Inserm (Institut National De La Sante De La Reche Rche Medicale) | Antibodies directed against hepatitis c virus e1e2 complex, compositions of hcv particles, and pharmaceutical compositions |
| GB0309126D0 (en) * | 2003-04-17 | 2003-05-28 | Neutec Pharma Plc | Clostridium difficile focussed antibodies |
| CA2572881A1 (en) * | 2004-07-08 | 2006-01-19 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Antigen binding proteins directed against scavenger receptor b1 that inhibit hcv replication |
| AU2006301171B9 (en) * | 2005-10-07 | 2012-03-29 | Proyecto De Biomedicina Cima, S.L. | Immunostimulatory combination for the prophylactics and treatment of hepatitis C |
| MX2009003306A (es) | 2006-10-02 | 2009-04-23 | Medarex Inc | Anticuerpos humanos que se unen a cxcr4 y sus usos. |
| US8481683B2 (en) | 2006-12-01 | 2013-07-09 | Medarex, Inc. | Human antibodies that bind CD22 and uses thereof |
| CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| MX2009006277A (es) | 2006-12-14 | 2009-07-24 | Medarex Inc | Anticuerpos humanos que se enlazan a cd70 y usos de los mismos. |
| JP5642972B2 (ja) * | 2007-02-21 | 2014-12-17 | ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ | Ｃ型肝炎ウイルス（ｈｃｖ）に対するヒト抗体およびその使用 |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
| AU2009324092A1 (en) | 2008-12-03 | 2011-06-23 | Genmab A/S | Antibody variants having modifications in the constant region |
| WO2010129033A2 (en) * | 2009-04-29 | 2010-11-11 | Calmune Corporation | Modified antibodies for passive immunotherapy |
| EP2495256A4 (en) * | 2009-10-30 | 2013-09-25 | Toray Industries | ANTIBODIES WITH HEMMETAL EFFECT ON INFECTIONS WITH HEPATITIS C VIRUS (HCV) AND ITS USE |
| WO2011147863A1 (en) | 2010-05-25 | 2011-12-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination of anti-envelope antibodies and anti-receptor antibodies for the treatment and prevention of hcv infection |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| CN103308697B (zh) * | 2013-06-09 | 2014-11-26 | 卫生部北京医院 | 检测抗丙型肝炎病毒编码的非结构蛋白ns3和ns5的天然双特异性抗体的试剂盒 |
| CN103472233A (zh) * | 2013-06-21 | 2013-12-25 | 温州大学 | 丙型肝炎检测试剂盒及其应用 |
| AU2014303375B2 (en) | 2013-08-09 | 2019-07-04 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
| CN104974246A (zh) * | 2014-04-01 | 2015-10-14 | 中国科学院上海巴斯德研究所 | 一种中和丙型肝炎病毒的全人单克隆抗体及其用途 |
| GB201415714D0 (en) * | 2014-09-05 | 2014-10-22 | Medical Res Council | Antibodies and antigen binding fragments thereof |
| CN105254756B (zh) * | 2015-11-27 | 2018-09-07 | 武汉大学 | 一种针对丙型肝炎病毒包膜蛋白e2的单克隆抗体及应用 |
| CN107286238B (zh) * | 2017-08-07 | 2019-11-26 | 广州泰诺迪生物科技有限公司 | 抗hcv广谱中和抗体的制备、检测以及应用 |
| EP3810649A1 (en) | 2018-06-22 | 2021-04-28 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| WO2020020281A1 (zh) | 2018-07-25 | 2020-01-30 | 信达生物制药(苏州)有限公司 | 抗tigit抗体及其用途 |
| FI3898668T3 (fi) * | 2018-12-19 | 2023-11-28 | Humabs Biomed Sa | B-hepatiittivirusta neutraloivia vasta-aineita ja niiden käyttöjä |
| RS67553B1 (sr) | 2018-12-20 | 2026-01-30 | Humabs Biomed Sa | Kombinovana hbv terapija |
| CN109762067B (zh) | 2019-01-17 | 2020-02-28 | 北京天广实生物技术股份有限公司 | 结合人Claudin 18.2的抗体及其用途 |
| US10570210B1 (en) | 2019-03-04 | 2020-02-25 | Beijing Mabworks Biotech Co.Ltd | Antibodies binding CD40 and uses thereof |
| BR112022017174A2 (pt) | 2020-02-27 | 2022-10-18 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Anticorpo monoclonal isolado, ou uma porção de ligação ao antígeno do mesmo, nucleotídeo, vetor de expressão, célula hospedeira, composição farmacêutica e métodos de tratamento de uma doença alérgica e de um tumor |
| CN121851171A (zh) | 2020-05-12 | 2026-04-14 | 正大天晴药业集团股份有限公司 | St2抗原结合蛋白 |
| KR20230119179A (ko) * | 2020-12-10 | 2023-08-16 | 우시 바이올로직스 아일랜드 리미티드 | P-캐드히린에 대한 항체 및 이의 용도 |
| TW202330617A (zh) | 2021-11-25 | 2023-08-01 | 大陸商正大天晴藥業集團股份有限公司 | 抗Siglec-15抗體及其應用 |
| WO2023173393A1 (zh) | 2022-03-18 | 2023-09-21 | 北京天广实生物技术股份有限公司 | 结合b7-h3的抗体及其用途 |
| CN118684767B (zh) * | 2024-06-27 | 2025-02-18 | 山东省大健康精准医疗产业技术研究院 | 一种丙肝核心抗原单链抗体及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE520499C (de) | 1929-09-14 | 1931-03-11 | Heinrich Elsner | Vorrichtung zum Biegen von Pappe, Fiber u. dgl. |
| CA2072249C (en) * | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
| ES2174957T5 (es) | 1994-07-29 | 2006-12-16 | Innogenetics N.V. | Proteinas purificadas de envoltura de virus de la hepatitis c para uso diagnostico y terapeutico. |
| US6747136B2 (en) * | 1996-04-19 | 2004-06-08 | Karolinska Innovations Ab | Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen |
| AU1462300A (en) | 1998-11-05 | 2000-05-22 | Board Of Trustees Of The Leland Stanford Junior University | Human pan-hcv human monoclonal antibodies |
| AU2001292667A1 (en) | 2000-09-13 | 2002-03-26 | Hawaii Biotechnology Group, Inc. | Immunogenic composition of hepatitis c and methods of use thereof |
-
1999
- 1999-07-20 JP JP2000561222A patent/JP4593783B2/ja not_active Expired - Fee Related
- 1999-07-20 CA CA002339045A patent/CA2339045A1/en not_active Abandoned
- 1999-07-20 US US09/744,176 patent/US6951646B1/en not_active Expired - Fee Related
- 1999-07-20 CN CNA2007101063440A patent/CN101088561A/zh active Pending
- 1999-07-20 CN CNB99808641XA patent/CN1325517C/zh not_active Expired - Fee Related
- 1999-07-20 AU AU52858/99A patent/AU5285899A/en not_active Abandoned
- 1999-07-20 EP EP99938301A patent/EP1097172A1/en not_active Withdrawn
- 1999-07-20 WO PCT/EP1999/005173 patent/WO2000005266A1/en not_active Ceased
-
2004
- 2004-10-25 US US10/972,296 patent/US7507408B2/en not_active Expired - Fee Related
-
2008
- 2008-09-09 US US12/207,460 patent/US20090104188A1/en not_active Abandoned
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