JP2020536488A5 - - Google Patents

Info

Publication number

JP2020536488A5

JP2020536488A5 JP2020505360A JP2020505360A JP2020536488A5 JP 2020536488 A5 JP2020536488 A5 JP 2020536488A5 JP 2020505360 A JP2020505360 A JP 2020505360A JP 2020505360 A JP2020505360 A JP 2020505360A JP 2020536488 A5 JP2020536488 A5 JP 2020536488A5

Authority

JP

Japan

Prior art keywords

seq

variable region

chain variable

polypeptide sequence

heavy chain

Prior art date

2018-07-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229920001184 polypeptide Polymers 0.000 claims 77
• 108090000765 processed proteins & peptides Proteins 0.000 claims 77
• 102000004196 processed proteins & peptides Human genes 0.000 claims 77
• 239000000427 antigen Substances 0.000 claims 15
• 102000036639 antigens Human genes 0.000 claims 15
• 108091007433 antigens Proteins 0.000 claims 15
• 239000012634 fragment Substances 0.000 claims 15
• 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 6
• 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
• 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 2
• 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 206010057249 Phagocytosis Diseases 0.000 claims 1
• 230000000903 blocking effect Effects 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 230000006378 damage Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 210000003743 erythrocyte Anatomy 0.000 claims 1
• 102000044459 human CD47 Human genes 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 210000002540 macrophage Anatomy 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 238000002156 mixing Methods 0.000 claims 1
• 230000008782 phagocytosis Effects 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 230000005855 radiation Effects 0.000 claims 1
• 102000034285 signal transducing proteins Human genes 0.000 claims 1
• 108091006024 signal transducing proteins Proteins 0.000 claims 1