JP2021517459A5 - - Google Patents
Info
- Publication number
- JP2021517459A5 JP2021517459A5 JP2020548760A JP2020548760A JP2021517459A5 JP 2021517459 A5 JP2021517459 A5 JP 2021517459A5 JP 2020548760 A JP2020548760 A JP 2020548760A JP 2020548760 A JP2020548760 A JP 2020548760A JP 2021517459 A5 JP2021517459 A5 JP 2021517459A5
- Authority
- JP
- Japan
- Prior art keywords
- chain variable
- variable region
- seq
- polypeptide sequence
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024016283A JP2024056787A (ja) | 2018-03-13 | 2024-02-06 | 抗葉酸受容体１抗体及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642213P | 2018-03-13 | 2018-03-13 | |
| US62/642,213 | 2018-03-13 | ||
| PCT/US2019/021084 WO2019177854A1 (en) | 2018-03-13 | 2019-03-07 | Anti-folate receptor 1 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024016283A Division JP2024056787A (ja) | 2018-03-13 | 2024-02-06 | 抗葉酸受容体１抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021517459A JP2021517459A (ja) | 2021-07-26 |
| JP2021517459A5 true JP2021517459A5 (https=) | 2022-03-14 |
| JP7433236B2 JP7433236B2 (ja) | 2024-02-19 |
Family
ID=67906883
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548760A Active JP7433236B2 (ja) | 2018-03-13 | 2019-03-07 | 抗葉酸受容体１抗体及びその使用 |
| JP2024016283A Pending JP2024056787A (ja) | 2018-03-13 | 2024-02-06 | 抗葉酸受容体１抗体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024016283A Pending JP2024056787A (ja) | 2018-03-13 | 2024-02-06 | 抗葉酸受容体１抗体及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11873335B2 (https=) |
| EP (1) | EP3765521A4 (https=) |
| JP (2) | JP7433236B2 (https=) |
| KR (1) | KR102808710B1 (https=) |
| CN (2) | CN111954681B (https=) |
| AU (1) | AU2019236091B2 (https=) |
| BR (1) | BR112020016469A2 (https=) |
| CA (1) | CA3091683A1 (https=) |
| EA (1) | EA202092125A1 (https=) |
| IL (1) | IL276949A (https=) |
| MX (1) | MX2020009522A (https=) |
| SG (1) | SG11202007494TA (https=) |
| WO (1) | WO2019177854A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102275930B1 (ko) * | 2018-03-14 | 2021-07-12 | (주)알테오젠 | Folr1에 특이적으로 결합하는 항체 및 그의 용도 |
| CA3160436A1 (en) * | 2019-12-17 | 2021-06-24 | Jack Chongyang LI | Bispecific antibodies with alternatively matched interchain cysteines and uses thereof |
| TW202233684A (zh) * | 2020-11-18 | 2022-09-01 | 美商泰尼歐生物公司 | 結合於葉酸受體α之重鏈抗體 |
| CN115491358B (zh) * | 2021-06-17 | 2024-09-06 | 复星凯特生物科技有限公司 | 一种靶向b7-h3和folr1双打靶点car t的制备及应用 |
| CN116462768B (zh) * | 2023-06-13 | 2023-09-22 | 浙江时迈药业有限公司 | 针对folr1的双特异性抗体及其用途 |
| WO2025140416A1 (zh) * | 2023-12-28 | 2025-07-03 | 上海宏成药业有限公司 | 抗folr1特异性抗体的发明及应用 |
| WO2025161939A1 (en) * | 2024-01-31 | 2025-08-07 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Antibodies and uses thereof |
| CN118344485B (zh) * | 2024-06-18 | 2024-10-15 | 南京欧凯生物科技有限公司 | 抗叶酸及其结合蛋白复合物的单克隆抗体或其抗原结合片段、其制备方法及应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3101034A1 (en) | 2004-02-12 | 2016-12-07 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| CA2607444C (en) | 2005-04-22 | 2015-03-10 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| EP1900752A1 (en) | 2006-09-15 | 2008-03-19 | DOMPE' pha.r.ma s.p.a. | Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma |
| JP5059119B2 (ja) * | 2006-12-14 | 2012-10-24 | シェーリング コーポレイション | 操作された抗ｔｓｌｐ抗体 |
| WO2008145136A1 (en) | 2007-05-30 | 2008-12-04 | Aarhus Universitet | Stat3 inactivation by inhibition of the folate receptor pathway |
| FR2929946B1 (fr) * | 2008-04-11 | 2010-05-28 | Pf Medicament | Nouveaux anticorps anti-cd151 et leur utilisation pour le traitement du cancer |
| US9487582B2 (en) * | 2010-01-08 | 2016-11-08 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for treating pancreatic cancer |
| TWI622402B (zh) * | 2010-02-24 | 2018-05-01 | 免疫遺傳股份有限公司 | 葉酸受體１抗體類和免疫共軛物類及彼等之用途 |
| CN103347537A (zh) | 2010-10-20 | 2013-10-09 | 莫弗泰克股份有限公司 | 抗叶酸受体α抗体糖型 |
| MX343607B (es) | 2010-11-05 | 2016-11-11 | Morphotek Inc | Receptor alfa de folato como marcador de diagnóstico y pronóstico para cánceres que expresan receptor alfa de folato. |
| KR20140004174A (ko) | 2011-01-18 | 2014-01-10 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암 치료를 위한 조성물 및 방법 |
| BR112013025415B1 (pt) | 2011-04-01 | 2021-03-16 | Immunogen, Inc | uso de um imunoconjugado antirreceptor de folato 1 (folr1) |
| SI2731972T1 (en) | 2011-07-15 | 2018-04-30 | Eisai R&D Management Co., Ltd. | Anti-folate receptor alpha antibodies and uses thereof |
| BR112014028306A2 (pt) | 2012-05-15 | 2018-04-17 | Morphotek, Inc. | métodos para tratamento de câncer gástrico. |
| US9200073B2 (en) | 2012-08-31 | 2015-12-01 | Immunogen, Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
| WO2014055771A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| US9207238B2 (en) | 2012-12-07 | 2015-12-08 | Kyowa Hakko Kirin Co., Ltd. | Anti-FOLR1 antibody |
| US9522196B2 (en) | 2012-12-25 | 2016-12-20 | Kagoshima University | Antibody recognizing folate receptors α and β |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| SG11201509043RA (en) | 2013-05-14 | 2015-12-30 | Immunogen Inc | Anti-folr1 immunoconjugate dosing regimens |
| CA2914237A1 (en) | 2013-06-20 | 2014-12-24 | Morphotek, Inc. | Methods for treatment of ovarian cancer |
| CN113150145B (zh) | 2013-08-30 | 2025-02-14 | 伊缪诺金公司 | 用于检测叶酸受体1的抗体和测定 |
| PL3055332T3 (pl) | 2013-10-08 | 2020-02-28 | Immunogen, Inc. | Schematy dawkowania immunokoniugatu anty-FOLR1 |
| KR20160088930A (ko) | 2013-12-04 | 2016-07-26 | 이뮤노젠 아이엔씨 | 항체 생산용 조성물 및 항체 생성 방법 |
| US9950077B2 (en) | 2014-06-20 | 2018-04-24 | Bioalliance C.V. | Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof |
| KR102508023B1 (ko) | 2014-09-03 | 2023-03-10 | 이뮤노젠 아이엔씨 | 세포-결합제 및 세포독성 약물을 포함하는 콘주게이트 |
| PT3221356T (pt) | 2014-11-20 | 2020-10-29 | Hoffmann La Roche | Moléculas de ligação ao antigénio biespecíficas ativadoras das células t contra folr1 e cd3 |
| EP4141032B1 (en) | 2014-11-20 | 2024-05-29 | F. Hoffmann-La Roche AG | Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| EP3283886B1 (en) | 2015-04-17 | 2020-01-15 | Eisai Inc. | Methods for treating lung cancer |
| CN116440279B (zh) | 2015-09-17 | 2026-02-24 | 伊缪诺金公司 | 包含抗folr1免疫缀合物的治疗组合 |
| EP3526254A1 (en) | 2016-10-12 | 2019-08-21 | Sutro Biopharma, Inc. | Anti-folate receptor antibodies, compositions comprising anti-folate receptor antibodies and methods of making and using anti-folate receptor antibodies |
| EP3544999A1 (en) | 2016-11-23 | 2019-10-02 | Eisai R&D Management Co., Ltd. | Anti-folate receptor alpha antibodies and uses thereof |
| US20180333503A1 (en) | 2017-05-16 | 2018-11-22 | Immunogen, Inc. | Anti-folr1 immunoconjugates and anti-pd-1 antibody combinations |
-
2019
- 2019-03-07 AU AU2019236091A patent/AU2019236091B2/en active Active
- 2019-03-07 KR KR1020207028499A patent/KR102808710B1/ko active Active
- 2019-03-07 EP EP19767635.6A patent/EP3765521A4/en active Pending
- 2019-03-07 JP JP2020548760A patent/JP7433236B2/ja active Active
- 2019-03-07 CN CN201980019246.4A patent/CN111954681B/zh active Active
- 2019-03-07 CN CN202211567226.0A patent/CN115925952A/zh active Pending
- 2019-03-07 EA EA202092125A patent/EA202092125A1/ru unknown
- 2019-03-07 BR BR112020016469-0A patent/BR112020016469A2/pt not_active IP Right Cessation
- 2019-03-07 MX MX2020009522A patent/MX2020009522A/es unknown
- 2019-03-07 CA CA3091683A patent/CA3091683A1/en active Pending
- 2019-03-07 SG SG11202007494TA patent/SG11202007494TA/en unknown
- 2019-03-07 WO PCT/US2019/021084 patent/WO2019177854A1/en not_active Ceased
- 2019-03-07 US US15/733,541 patent/US11873335B2/en active Active
-
2020
- 2020-08-26 IL IL276949A patent/IL276949A/en unknown
-
2024
- 2024-02-06 JP JP2024016283A patent/JP2024056787A/ja active Pending
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