MX343607B - Receptor alfa de folato como marcador de diagnóstico y pronóstico para cánceres que expresan receptor alfa de folato. - Google Patents
Receptor alfa de folato como marcador de diagnóstico y pronóstico para cánceres que expresan receptor alfa de folato.Info
- Publication number
- MX343607B MX343607B MX2013005067A MX2013005067A MX343607B MX 343607 B MX343607 B MX 343607B MX 2013005067 A MX2013005067 A MX 2013005067A MX 2013005067 A MX2013005067 A MX 2013005067A MX 343607 B MX343607 B MX 343607B
- Authority
- MX
- Mexico
- Prior art keywords
- receptor alpha
- folate receptor
- fra
- subject
- methods
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a métodos y equipos para evaluar si un sujeto padece de un cáncer que expresa FRa, métodos y equipos para anticipar el progreso de un cáncer de ovario en un sujeto que padece de un cáncer que expresa FRa, métodos y equipos para evaluar el nivel de riesgo que tiene un sujeto de desarrollar un cáncer que expresa FRa, y métodos para estratificar a un sujeto con un cáncer que expresa FRa en grupos de terapia de cáncer. Los métodos implican determinar el nivel de receptor alfa de folato FRa que no está enlazado a una célula en una muestra derivada del sujeto, y comparar este nivel con el nivel de FRa en una muestra de control.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41049710P | 2010-11-05 | 2010-11-05 | |
US201161508444P | 2011-07-15 | 2011-07-15 | |
PCT/US2011/059411 WO2012061759A2 (en) | 2010-11-05 | 2011-11-04 | Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013005067A MX2013005067A (es) | 2013-07-02 |
MX343607B true MX343607B (es) | 2016-11-11 |
Family
ID=45003076
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016011546A MX368394B (es) | 2010-11-05 | 2011-11-04 | Receptor alfa de folato como marcador de diagnostico y pronostico para canceres que expresan receptor alfa de folato. |
MX2013005067A MX343607B (es) | 2010-11-05 | 2011-11-04 | Receptor alfa de folato como marcador de diagnóstico y pronóstico para cánceres que expresan receptor alfa de folato. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016011546A MX368394B (es) | 2010-11-05 | 2011-11-04 | Receptor alfa de folato como marcador de diagnostico y pronostico para canceres que expresan receptor alfa de folato. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20120207771A1 (es) |
EP (2) | EP3130605B1 (es) |
JP (2) | JP6224456B2 (es) |
KR (2) | KR102057438B1 (es) |
CN (2) | CN108562744A (es) |
AU (3) | AU2011323124C1 (es) |
BR (1) | BR112013011072B1 (es) |
CA (1) | CA2816991C (es) |
ES (2) | ES2780192T3 (es) |
IL (2) | IL225871B (es) |
MX (2) | MX368394B (es) |
RU (2) | RU2764592C2 (es) |
SG (3) | SG10201509145XA (es) |
WO (1) | WO2012061759A2 (es) |
Families Citing this family (31)
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US20060239910A1 (en) * | 2005-04-22 | 2006-10-26 | Morphotek Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
AR080301A1 (es) | 2010-02-24 | 2012-03-28 | Immunogen Inc | Anticuerpos e inmunoconjugados del receptor 1 de folato y sus usos |
US20120189620A1 (en) * | 2011-01-21 | 2012-07-26 | Emory University | Methods for treating non-functioning pituitary adenoma |
WO2012119077A1 (en) * | 2011-03-02 | 2012-09-07 | Morphotek Inc. | Co -administration of eribulin and farletuzumab for the treatment of breast cancer |
RS56916B1 (sr) | 2011-04-01 | 2018-05-31 | Immunogen Inc | Postupci za povećanje efikasnosti terapije kancera usmerene na folr1 |
AU2012284321C1 (en) | 2011-07-15 | 2017-07-13 | Eisai R&D Management Co., Ltd. | Anti-folate receptor alpha antibodies and uses thereof |
ES2766836T3 (es) * | 2012-05-15 | 2020-06-15 | Eisai Inc | Métodos para el tratamiento de cáncer gástrico |
EP2890717B1 (en) * | 2012-08-31 | 2020-03-04 | ImmunoGen, Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
MX2015017950A (es) | 2013-06-20 | 2016-05-10 | Morphotek Inc | Metodos para el tratamiento de cancer de ovario. |
UA120166C2 (uk) | 2013-08-30 | 2019-10-25 | Іммуноджен, Інк. | Антитіло, що специфічно зв'язується з folr1, та спосіб виявлення рецептора фолієвої кислоти 1 |
DK3653228T3 (da) * | 2013-10-08 | 2024-07-15 | Immunogen Inc | Anti-folr1-immunkonjugatdoseringsregimer |
WO2016079050A1 (en) | 2014-11-20 | 2016-05-26 | F. Hoffmann-La Roche Ag | Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists |
CA2983126A1 (en) | 2015-04-17 | 2016-10-20 | Morphotek, Inc. | Methods for treating lung cancer |
MA42844A (fr) | 2015-09-17 | 2018-07-25 | Immunogen Inc | Combinaisons thérapeutiques comprenant des immunoconjugués anti-folr1 |
CA3033077C (en) | 2016-08-12 | 2024-06-18 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
JP7072571B2 (ja) * | 2016-11-23 | 2022-05-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗葉酸受容体アルファ抗体およびその使用 |
CN107353325B (zh) * | 2017-07-26 | 2020-08-11 | 中国药科大学 | 叶酸受体α特异性结合肽1及其应用 |
CN107446021B (zh) * | 2017-07-26 | 2020-08-11 | 中国药科大学 | 叶酸受体α特异性结合肽5及其应用 |
CN107446020B (zh) * | 2017-07-28 | 2019-10-01 | 中国药科大学 | 叶酸受体α特异性结合肽2及其应用 |
JP2020532751A (ja) * | 2017-09-05 | 2020-11-12 | イミュノジェン, インコーポレイテッド | 患者の試料中のヒト葉酸受容体1を検出するための方法 |
US12076402B2 (en) | 2018-02-07 | 2024-09-03 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
WO2019157129A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
CN111954531A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | α聚谷氨酸化培美曲塞及其用途 |
US12048767B2 (en) | 2018-02-14 | 2024-07-30 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
WO2019160734A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
CA3090992A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated tetrahydrofolates and uses thereof |
US11873335B2 (en) * | 2018-03-13 | 2024-01-16 | Phanes Therapeutics, Inc. | Anti-folate receptor 1 antibodies and uses thereof |
EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
AU2020265568A1 (en) | 2019-04-29 | 2021-11-04 | Immunogen, Inc. | Biparatopic FR-alpha antibodies and immunoconjugates |
WO2022256507A1 (en) * | 2021-06-04 | 2022-12-08 | Immunogen, Inc. | Treatment of cancer in patients with soluble fr-alpha |
CN117700557B (zh) * | 2024-02-05 | 2024-04-30 | 卡秋(江苏)生物科技有限公司 | 一种特异性结合叶酸受体α的抗体或抗原结合片段 |
Family Cites Families (29)
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US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5646253A (en) | 1994-03-08 | 1997-07-08 | Memorial Sloan-Kettering Cancer Center | Recombinant human anti-LK26 antibodies |
DK1589107T3 (da) | 1992-08-21 | 2010-04-26 | Univ Bruxelles | Immonuglobuliner uden lette kæder |
US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
ATE267877T1 (de) | 1993-01-07 | 2004-06-15 | Sequenom Inc | Dns - sequenzierung durch massenspektronomie |
JPH08507926A (ja) | 1993-03-19 | 1996-08-27 | シーケノム・インコーポレーテツド | エキソヌクレアーゼ分解を介した質量分析法によるdna配列決定 |
US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
EP0971946B1 (en) | 1997-01-21 | 2006-07-05 | The General Hospital Corporation | Selection of proteins using rna-protein fusions |
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US7741019B2 (en) * | 2000-11-01 | 2010-06-22 | Mount Sinai Hospital | Detection of ovarian cancer |
US20100120078A1 (en) * | 2001-08-16 | 2010-05-13 | Tony Baker | Urine Stabilization System |
AU2002340683C1 (en) * | 2001-11-13 | 2009-11-12 | Id Biomedical Corporation Of Quebec | Polypeptides of pseudomonas aeruginosa |
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WO2004082463A2 (en) * | 2003-03-17 | 2004-09-30 | Medical College Of Ohio | Folate receptor gene modulation for cancer diagnosis and therapy |
WO2004113388A2 (en) * | 2003-05-23 | 2004-12-29 | Morphotek, Inc. | Anti alpha - folate - receptor - tetramer antibodies |
JP2007512807A (ja) * | 2003-10-28 | 2007-05-24 | バイエル ヘルスケア アーゲー | 悪性腫瘍の処置に対する応答予測のための方法および組成物 |
AU2005214331B2 (en) | 2004-02-12 | 2011-09-15 | Eisai, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
WO2006105141A1 (en) * | 2005-03-30 | 2006-10-05 | Purdue Research Foundation | Method for cancer prognosis using cellular folate vitamin receptor quantification |
US20060239910A1 (en) * | 2005-04-22 | 2006-10-26 | Morphotek Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
KR20080114689A (ko) * | 2006-02-09 | 2008-12-31 | 유니버시티 오브 사우스 플로리다 | 증가된 bcl-2에 의한 암의 발견 |
CA2685300C (en) * | 2006-06-01 | 2017-01-03 | Mayo Foundation For Medical Education And Research | Immunity to folate receptors |
EP1900752A1 (en) * | 2006-09-15 | 2008-03-19 | DOMPE' pha.r.ma s.p.a. | Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma |
US7754698B2 (en) | 2007-01-09 | 2010-07-13 | Isis Pharmaceuticals, Inc. | Modulation of FR-alpha expression |
AU2008317404B2 (en) * | 2007-10-19 | 2014-12-18 | Cell Signaling Technology, Inc. | Cancer classification and methods of use |
WO2009132081A2 (en) | 2008-04-24 | 2009-10-29 | The Research Foundation Of State University Of New York | Monoclonal antibody-based targeting of folate receptors |
US20110177525A1 (en) * | 2010-01-19 | 2011-07-21 | Predictive Biosciences, Inc. | Antibodies and methods of diagnosing diseases |
EP2606353A4 (en) * | 2010-08-18 | 2014-10-15 | Caris Life Sciences Luxembourg Holdings | CIRCULATING BIOMARKERS FOR DISEASE |
-
2011
- 2011-11-04 KR KR1020187036506A patent/KR102057438B1/ko active IP Right Grant
- 2011-11-04 AU AU2011323124A patent/AU2011323124C1/en active Active
- 2011-11-04 ES ES16186634T patent/ES2780192T3/es active Active
- 2011-11-04 BR BR112013011072-4A patent/BR112013011072B1/pt active IP Right Grant
- 2011-11-04 SG SG10201509145XA patent/SG10201509145XA/en unknown
- 2011-11-04 MX MX2016011546A patent/MX368394B/es unknown
- 2011-11-04 SG SG10201701933XA patent/SG10201701933XA/en unknown
- 2011-11-04 MX MX2013005067A patent/MX343607B/es active IP Right Grant
- 2011-11-04 EP EP16186634.8A patent/EP3130605B1/en active Active
- 2011-11-04 KR KR1020137014442A patent/KR101931936B1/ko active IP Right Grant
- 2011-11-04 CN CN201710961050.XA patent/CN108562744A/zh active Pending
- 2011-11-04 CA CA2816991A patent/CA2816991C/en active Active
- 2011-11-04 WO PCT/US2011/059411 patent/WO2012061759A2/en active Application Filing
- 2011-11-04 ES ES11785862.1T patent/ES2627061T3/es active Active
- 2011-11-04 RU RU2017129266A patent/RU2764592C2/ru active
- 2011-11-04 RU RU2013125772A patent/RU2630608C2/ru active
- 2011-11-04 SG SG2013030424A patent/SG189957A1/en unknown
- 2011-11-04 JP JP2013537884A patent/JP6224456B2/ja active Active
- 2011-11-04 EP EP11785862.1A patent/EP2635304B1/en active Active
- 2011-11-04 CN CN201180064293.4A patent/CN103687618A/zh active Pending
- 2011-11-04 US US13/289,892 patent/US20120207771A1/en not_active Abandoned
-
2013
- 2013-04-21 IL IL225871A patent/IL225871B/en active IP Right Grant
-
2016
- 2016-05-25 AU AU2016203408A patent/AU2016203408A1/en not_active Abandoned
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2017
- 2017-10-04 JP JP2017194027A patent/JP6554152B2/ja active Active
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2018
- 2018-03-12 AU AU2018201760A patent/AU2018201760B2/en active Active
- 2018-07-13 IL IL260590A patent/IL260590B/en active IP Right Grant
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