MX357550B - Microarn plasmaticos para la deteccion de cancer colorrectal temprano. - Google Patents
Microarn plasmaticos para la deteccion de cancer colorrectal temprano.Info
- Publication number
- MX357550B MX357550B MX2014004810A MX2014004810A MX357550B MX 357550 B MX357550 B MX 357550B MX 2014004810 A MX2014004810 A MX 2014004810A MX 2014004810 A MX2014004810 A MX 2014004810A MX 357550 B MX357550 B MX 357550B
- Authority
- MX
- Mexico
- Prior art keywords
- subject
- micrornas
- colorectal cancer
- detection
- colorectal
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
La presente invención se refiere un método para diagnosticar o detectar neoplasia colorrectal en un sujeto humano que comprende las etapas de: a. a partir de una muestra biológica seleccionada de la lista que consiste de una muestra de plasma, una muestra de suero y una muestra de sangre del sujeto que se sospecha que padece neoplasia colorrectal: b. medir un nivel o patrón de expresión global de una biofirma de microARNs que comprende al menos microARN miR15b a partir de la(s) muestra(s) biológica(s) del sujeto; y c. comparar el patrón de expresión global de la biofirma de microARN a partir de la muestra biológica del sujeto que se sospecha que padece neoplasia colorrectal con el patrón de expresión global de la biofirma de microARN a partir de la muestra biológica de un sujeto normal, en donde el sujeto normal es un sujeto sano que no padece neoplasia colorreal, y en donde la sobreexpresión de al menos miR15b es indicativa de cáncer colorrectal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161550148P | 2011-10-21 | 2011-10-21 | |
PCT/IB2012/003035 WO2013093635A2 (en) | 2011-10-21 | 2012-10-20 | Plasma micrornas for the detection of early colorectal cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014004810A MX2014004810A (es) | 2014-11-25 |
MX357550B true MX357550B (es) | 2018-07-13 |
Family
ID=48136439
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014004810A MX357550B (es) | 2011-10-21 | 2012-10-20 | Microarn plasmaticos para la deteccion de cancer colorrectal temprano. |
MX2015002910A MX357119B (es) | 2011-10-21 | 2012-10-20 | Microarn plasmáticos para la detección de cáncer colorrectal temprano. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015002910A MX357119B (es) | 2011-10-21 | 2012-10-20 | Microarn plasmáticos para la detección de cáncer colorrectal temprano. |
Country Status (18)
Country | Link |
---|---|
US (6) | US20130102487A1 (es) |
EP (2) | EP2944700B1 (es) |
JP (2) | JP6159727B2 (es) |
KR (2) | KR101912731B1 (es) |
CN (2) | CN104651521B (es) |
AU (1) | AU2012356317B2 (es) |
BR (2) | BR112014009643B1 (es) |
CA (1) | CA2852850C (es) |
DK (2) | DK2944700T3 (es) |
ES (2) | ES2662401T3 (es) |
HU (2) | HUE035614T2 (es) |
IN (1) | IN2015DN01855A (es) |
MX (2) | MX357550B (es) |
NO (1) | NO3051026T3 (es) |
PL (2) | PL2944700T3 (es) |
PT (2) | PT2768986T (es) |
RU (2) | RU2611189C2 (es) |
WO (1) | WO2013093635A2 (es) |
Families Citing this family (35)
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US20120244530A1 (en) | 2011-01-26 | 2012-09-27 | Cepheid | Methods of detecting lung cancer |
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US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
KR102393608B1 (ko) | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
ES2784450T3 (es) | 2013-12-28 | 2020-09-25 | Guardant Health Inc | Métodos y sistemas para detectar variantes genéticas |
EP3108012A4 (en) | 2014-02-18 | 2017-10-11 | Baylor Research Institute | Mir-320e and colorectal cancer |
EP3156499B1 (en) | 2014-06-13 | 2021-09-15 | Toray Industries, Inc. | Colorectal cancer detection kit or device, and detection method |
WO2016034715A2 (fr) * | 2014-09-05 | 2016-03-10 | Prestizia | Methode de prediction de l'evolution clinique du cancer colorectal |
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CN104388541B (zh) * | 2014-10-21 | 2017-07-04 | 复旦大学附属肿瘤医院 | miR‑1914*和miR‑1915的用途 |
CN104372004B (zh) * | 2014-12-04 | 2018-04-27 | 广东医学院 | 一个与心肌梗死易感相关的miR-27a基因单核苷酸多态位点的检测方法及其应用 |
EP3147370A1 (en) * | 2015-09-28 | 2017-03-29 | Rheinische Friedrich-Wilhelms-Universität Bonn | Exosomal microrna in serum as an indicator for the activation of brown and beige fat tissue (bat) |
JP2019507585A (ja) | 2015-12-17 | 2019-03-22 | ガーダント ヘルス, インコーポレイテッド | 無細胞dnaの分析による腫瘍遺伝子コピー数を決定するための方法 |
CN110139936A (zh) * | 2016-08-18 | 2019-08-16 | N·特兰 | 口腔癌、咽癌和喉癌的生物标记 |
EP3327135A1 (en) * | 2016-11-28 | 2018-05-30 | Advanced Marker Discovery, S.L. | In vitro method for identifying colorectal adenomas or colorectal cancer |
CN106950370A (zh) * | 2017-01-25 | 2017-07-14 | 上海市第十人民医院 | 血液微小核酸大肠癌诊断分子组合 |
CN107254522A (zh) * | 2017-06-09 | 2017-10-17 | 中山大学附属第三医院 | miR‑664a‑5p的检测试剂在制备肝癌诊断试剂/试剂盒中的应用 |
CN107236799B (zh) * | 2017-06-15 | 2020-06-09 | 昆明医科大学第六附属医院 | 一种肾纤维化miRNA标记物 |
CN107326092B (zh) * | 2017-08-25 | 2021-07-20 | 深圳市恩普电子技术有限公司 | 大肠癌相关的miRNA作为生物标志物的应用及大肠癌检测试剂盒 |
CN107746886B (zh) * | 2017-09-11 | 2019-10-01 | 朱伟 | 一种与结直肠癌辅助诊断相关的血浆miRNA标志物及其应用 |
WO2019144183A1 (en) * | 2018-01-23 | 2019-08-01 | La Trobe University | Biomarkers of colorectal cancer |
CA3090785A1 (en) | 2018-02-14 | 2019-08-22 | John Daniel Dobak Iii | Novel gene classifiers and uses thereof in non-melanoma skin cancers |
CN110205367B (zh) * | 2018-02-28 | 2022-06-21 | 伽蓝(集团)股份有限公司 | 一种筛选保护皮肤细胞端粒的活性物的方法 |
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CN114438214B (zh) * | 2018-06-27 | 2023-12-22 | 深圳华大生命科学研究院 | 结直肠癌肿瘤标志物及其检测方法与装置 |
CN109557311B (zh) * | 2018-12-13 | 2022-02-15 | 中南大学湘雅医院 | 结直肠癌诊断标志物及结直肠癌的检测产品及其应用 |
KR102275465B1 (ko) * | 2019-01-18 | 2021-07-09 | 사회복지법인 삼성생명공익재단 | 전이성 대장암 치료물질 스크리닝 방법 |
CN112041463B (zh) * | 2019-03-11 | 2024-07-23 | 香港中文大学 | 结肠直肠癌的miRNA标志物 |
CN110438227A (zh) * | 2019-07-29 | 2019-11-12 | 广州中昱医学生物科技有限公司 | miR-17-92在结直肠癌诊断中的用途 |
CN112080568A (zh) * | 2020-09-27 | 2020-12-15 | 扬州大学 | 一种与湖羊肌肉细胞增殖相关的miRNA标志物及其检测引物和应用 |
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2009
- 2009-04-01 NO NO16160669A patent/NO3051026T3/no unknown
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2012
- 2012-10-20 PT PT12852462T patent/PT2768986T/pt unknown
- 2012-10-20 ES ES15158185.7T patent/ES2662401T3/es active Active
- 2012-10-20 RU RU2014120427A patent/RU2611189C2/ru active
- 2012-10-20 BR BR112014009643-0A patent/BR112014009643B1/pt active IP Right Grant
- 2012-10-20 US US13/656,690 patent/US20130102487A1/en not_active Abandoned
- 2012-10-20 ES ES12852462.6T patent/ES2688693T3/es active Active
- 2012-10-20 EP EP15158185.7A patent/EP2944700B1/en active Active
- 2012-10-20 DK DK15158185.7T patent/DK2944700T3/en active
- 2012-10-20 BR BR122015004941-5A patent/BR122015004941B1/pt active IP Right Grant
- 2012-10-20 MX MX2014004810A patent/MX357550B/es active IP Right Grant
- 2012-10-20 HU HUE15158185A patent/HUE035614T2/en unknown
- 2012-10-20 US US14/352,462 patent/US20150087525A1/en not_active Abandoned
- 2012-10-20 WO PCT/IB2012/003035 patent/WO2013093635A2/en active Application Filing
- 2012-10-20 JP JP2014536355A patent/JP6159727B2/ja active Active
- 2012-10-20 PT PT151581857T patent/PT2944700T/pt unknown
- 2012-10-20 CA CA2852850A patent/CA2852850C/en active Active
- 2012-10-20 DK DK12852462.6T patent/DK2768986T3/en active
- 2012-10-20 KR KR1020157005756A patent/KR101912731B1/ko active IP Right Grant
- 2012-10-20 IN IN1855DEN2015 patent/IN2015DN01855A/en unknown
- 2012-10-20 PL PL15158185T patent/PL2944700T3/pl unknown
- 2012-10-20 KR KR1020147013663A patent/KR101900872B1/ko active IP Right Grant
- 2012-10-20 AU AU2012356317A patent/AU2012356317B2/en active Active
- 2012-10-20 PL PL12852462T patent/PL2768986T3/pl unknown
- 2012-10-20 CN CN201510098369.5A patent/CN104651521B/zh active Active
- 2012-10-20 EP EP12852462.6A patent/EP2768986B1/en active Active
- 2012-10-20 CN CN201280064096.7A patent/CN104145024A/zh active Pending
- 2012-10-20 RU RU2015108970A patent/RU2662975C1/ru active
- 2012-10-20 MX MX2015002910A patent/MX357119B/es unknown
- 2012-10-20 HU HUE12852462A patent/HUE039522T2/hu unknown
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2015
- 2015-03-05 JP JP2015043433A patent/JP6203209B2/ja active Active
- 2015-03-05 US US14/639,539 patent/US20150176082A1/en not_active Abandoned
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2016
- 2016-06-14 US US15/181,578 patent/US20160289771A1/en not_active Abandoned
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2018
- 2018-06-28 US US16/022,597 patent/US20180346996A1/en active Pending
- 2018-08-08 US US16/058,940 patent/US20180355439A1/en active Pending
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