MX357119B - Microarn plasmáticos para la detección de cáncer colorrectal temprano. - Google Patents

Microarn plasmáticos para la detección de cáncer colorrectal temprano.

Info

Publication number
MX357119B
MX357119B MX2015002910A MX2015002910A MX357119B MX 357119 B MX357119 B MX 357119B MX 2015002910 A MX2015002910 A MX 2015002910A MX 2015002910 A MX2015002910 A MX 2015002910A MX 357119 B MX357119 B MX 357119B
Authority
MX
Mexico
Prior art keywords
subject
micrornas
colorectal cancer
detection
colorectal
Prior art date
Application number
MX2015002910A
Other languages
English (en)
Inventor
Jose Lozano Salvatella Juan
Cos Meritxell Gironella I
Garangou Antoni Castells I
Dolores Giraldez Maria
Original Assignee
Hospital Clinic Barcelona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hospital Clinic Barcelona filed Critical Hospital Clinic Barcelona
Publication of MX357119B publication Critical patent/MX357119B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La presente invención se refiere un método para diagnosticar o detectar adenomas colorrectales avanzados en un sujeto humano que comprende las etapas de: medir un patrón de expresión global o nivel del uno o más microARNs obtenidos a partir de una o más muestras biológicas del sujeto, en donde al menos uno de esos miARNs es miR18a; y comparar el patrón de expresión global de uno o más microARNs a partir de la muestra biológica del sujeto que se sospecha padece de adenomas colorrectales avanzados con el patrón de expresión global de uno o más microARNs a partir de una muestra biológica de un sujeto normal, en donde el sujeto normal es un sujeto sano que no padece de adenomas colorrectales avanzados, y en donde la sobreexpresión de miR18a es indicativa de adenomas colorrectales avanzados.
MX2015002910A 2011-10-21 2012-10-20 Microarn plasmáticos para la detección de cáncer colorrectal temprano. MX357119B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161550148P 2011-10-21 2011-10-21
PCT/IB2012/003035 WO2013093635A2 (en) 2011-10-21 2012-10-20 Plasma micrornas for the detection of early colorectal cancer

Publications (1)

Publication Number Publication Date
MX357119B true MX357119B (es) 2018-06-27

Family

ID=48136439

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015002910A MX357119B (es) 2011-10-21 2012-10-20 Microarn plasmáticos para la detección de cáncer colorrectal temprano.
MX2014004810A MX357550B (es) 2011-10-21 2012-10-20 Microarn plasmaticos para la deteccion de cancer colorrectal temprano.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014004810A MX357550B (es) 2011-10-21 2012-10-20 Microarn plasmaticos para la deteccion de cancer colorrectal temprano.

Country Status (18)

Country Link
US (6) US20130102487A1 (es)
EP (2) EP2768986B1 (es)
JP (2) JP6159727B2 (es)
KR (2) KR101912731B1 (es)
CN (2) CN104145024A (es)
AU (1) AU2012356317B2 (es)
BR (2) BR112014009643B1 (es)
CA (1) CA2852850C (es)
DK (2) DK2768986T3 (es)
ES (2) ES2688693T3 (es)
HU (2) HUE035614T2 (es)
IN (1) IN2015DN01855A (es)
MX (2) MX357119B (es)
NO (1) NO3051026T3 (es)
PL (2) PL2768986T3 (es)
PT (2) PT2768986T (es)
RU (2) RU2662975C1 (es)
WO (1) WO2013093635A2 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014513521A (ja) 2011-01-26 2014-06-05 セファイド 肺癌を検出する方法
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
IL305303A (en) 2012-09-04 2023-10-01 Guardant Health Inc Systems and methods for detecting rare mutations and changes in number of copies
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
JP6571665B2 (ja) 2013-12-28 2019-09-04 ガーダント ヘルス， インコーポレイテッド 遺伝的バリアントを検出するための方法およびシステム
EP3108012A4 (en) 2014-02-18 2017-10-11 Baylor Research Institute Mir-320e and colorectal cancer
EP3971299A3 (en) * 2014-06-13 2022-06-29 Toray Industries, Inc. Colorectal cancer detection kit or device, and detection method
WO2016034715A2 (fr) * 2014-09-05 2016-03-10 Prestizia Methode de prediction de l'evolution clinique du cancer colorectal
CN104313142B (zh) * 2014-10-16 2016-02-03 上海交通大学医学院附属仁济医院 miRNA-30a作为标记分子在制备诊断试剂中的用途
CN104388541B (zh) * 2014-10-21 2017-07-04 复旦大学附属肿瘤医院 miR‑1914*和miR‑1915的用途
CN104372004B (zh) * 2014-12-04 2018-04-27 广东医学院 一个与心肌梗死易感相关的miR-27a基因单核苷酸多态位点的检测方法及其应用
EP3147370A1 (en) 2015-09-28 2017-03-29 Rheinische Friedrich-Wilhelms-Universität Bonn Exosomal microrna in serum as an indicator for the activation of brown and beige fat tissue (bat)
CN108603228B (zh) 2015-12-17 2023-09-01 夸登特健康公司 通过分析无细胞dna确定肿瘤基因拷贝数的方法
CN110139936A (zh) * 2016-08-18 2019-08-16 N·特兰 口腔癌、咽癌和喉癌的生物标记
EP3327135A1 (en) * 2016-11-28 2018-05-30 Advanced Marker Discovery, S.L. In vitro method for identifying colorectal adenomas or colorectal cancer
CN106950370A (zh) * 2017-01-25 2017-07-14 上海市第十人民医院 血液微小核酸大肠癌诊断分子组合
CN107254522A (zh) * 2017-06-09 2017-10-17 中山大学附属第三医院 miR‑664a‑5p的检测试剂在制备肝癌诊断试剂/试剂盒中的应用
CN107236799B (zh) * 2017-06-15 2020-06-09 昆明医科大学第六附属医院 一种肾纤维化miRNA标记物
CN107326092B (zh) * 2017-08-25 2021-07-20 深圳市恩普电子技术有限公司 大肠癌相关的miRNA作为生物标志物的应用及大肠癌检测试剂盒
CN107746886B (zh) * 2017-09-11 2019-10-01 朱伟 一种与结直肠癌辅助诊断相关的血浆miRNA标志物及其应用
WO2019144183A1 (en) * 2018-01-23 2019-08-01 La Trobe University Biomarkers of colorectal cancer
AU2019222462A1 (en) 2018-02-14 2020-09-03 Dermtech, Inc. Novel gene classifiers and uses thereof in non-melanoma skin cancers
CN110205367B (zh) * 2018-02-28 2022-06-21 伽蓝（集团）股份有限公司 一种筛选保护皮肤细胞端粒的活性物的方法
JP7431812B2 (ja) * 2018-05-09 2024-02-15 ダームテック，インク． 自己免疫疾患における新規な遺伝子分類とその使用
CN108753974B (zh) * 2018-06-27 2022-05-06 深圳华大生命科学研究院 一种结直肠癌肿瘤标志物及其检测方法与装置
CN109557311B (zh) * 2018-12-13 2022-02-15 中南大学湘雅医院 结直肠癌诊断标志物及结直肠癌的检测产品及其应用
KR102275465B1 (ko) * 2019-01-18 2021-07-09 사회복지법인 삼성생명공익재단 전이성 대장암 치료물질 스크리닝 방법
WO2020182106A1 (en) * 2019-03-11 2020-09-17 The Chinese University Of Hong Kong Mirna markers for colorectal cancer
CN110438227A (zh) * 2019-07-29 2019-11-12 广州中昱医学生物科技有限公司 miR-17-92在结直肠癌诊断中的用途
CN112080568A (zh) * 2020-09-27 2020-12-15 扬州大学 一种与湖羊肌肉细胞增殖相关的miRNA标志物及其检测引物和应用
WO2023032452A1 (ja) * 2021-08-31 2023-03-09 国立大学法人大阪大学 ２型糖尿病・大腸がんを検査する方法
WO2023036266A1 (en) * 2021-09-08 2023-03-16 Guangdong Jiyin Biotech Co. Ltd Compositions and methods for diagnosing colorectal cancer
CN113981096A (zh) * 2021-11-30 2022-01-28 无锡市疾病预防控制中心 一种用于诊断结直肠癌的血浆miRNA标志物及其应用
WO2023222927A2 (en) 2022-05-20 2023-11-23 Novigenix Sa Biomarkers for colorectal neoplasia

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
GB0415277D0 (en) * 2004-07-07 2004-08-11 Colonix Ltd Apparatus and method for sampling mucosal surfaces
US7939255B2 (en) 2006-07-03 2011-05-10 Catholic University Industry Academy Cooperation Foundation Diagnostic methods for colorectal cancer
WO2008055158A2 (en) * 2006-10-30 2008-05-08 University Of South Alabama Microrna as biomarker in cancer
JP5501766B2 (ja) 2006-11-01 2014-05-28 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 肝細胞癌における生存および転移を予測するためのマイクロｒｎａ発現サイン
KR20100093539A (ko) * 2007-10-30 2010-08-25 베리덱스, 엘엘씨 대장암을 모니터링하는 방법
CN101424640B (zh) * 2007-11-02 2012-07-25 江苏命码生物科技有限公司 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法
EP2268832A2 (en) * 2008-03-06 2011-01-05 Asuragen, INC. Microrna markers for recurrence of colorectal cancer
WO2009140670A2 (en) * 2008-05-16 2009-11-19 Veridex, Llc Methods for assessing colorectal cancer and compositions for use therein
WO2010004562A2 (en) 2008-07-09 2010-01-14 Rosetta Genomics Ltd. Methods and compositions for detecting colorectal cancer
CA2743211A1 (en) * 2008-11-12 2010-05-20 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems of using exosomes for determining phenotypes
CN102439169B (zh) * 2008-11-13 2014-11-19 复旦大学 用于结肠直肠癌的微rna表达谱分析的组合物和方法
WO2010126355A1 (en) * 2009-04-29 2010-11-04 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for counteracting, preventing and/or determining heart failure, or a risk of heart failure
US20100317533A1 (en) 2009-06-05 2010-12-16 British Columbia Cancer Agency Branch Biomarkers of cancer metastasis
EP2336353A1 (en) * 2009-12-17 2011-06-22 febit holding GmbH miRNA fingerprints in the diagnosis of diseases
WO2011012136A1 (en) 2009-07-28 2011-02-03 Exiqon A/S A method for classifying a human cell sample as cancerous
CN101988060A (zh) * 2009-07-30 2011-03-23 江苏命码生物科技有限公司 结直肠癌检测标记物及其检测方法、试剂盒和生物芯片
US8956817B2 (en) * 2009-10-09 2015-02-17 Baylor Research Institute Identification of microRNAs (miRNAs) in fecal samples as biomarkers for gastroenterological cancers
WO2011076142A1 (en) 2009-12-24 2011-06-30 Fudan University Compositions and methods for microrna expession profiling in plasma of colorectal cancer
WO2011076147A1 (en) 2009-12-24 2011-06-30 Fudan University Plasma-based micro-rna biomarkers and methods for early detection of colorectal cancer
EP2524059A4 (en) 2010-01-13 2013-11-20 Caris Life Sciences Luxembourg Holdings DETECTION OF GASTROINTESTINAL DISEASES
TW201207395A (en) * 2010-06-23 2012-02-16 Univ Hong Kong Chinese Micro-RNA markers for colorectal cancer

Also Published As

Publication number Publication date
PL2768986T3 (pl) 2018-12-31
BR112014009643B1 (pt) 2020-12-15
PT2768986T (pt) 2018-10-23
CA2852850A1 (en) 2013-06-27
CN104145024A (zh) 2014-11-12
AU2012356317A1 (en) 2014-05-15
US20150176082A1 (en) 2015-06-25
MX357550B (es) 2018-07-13
ES2662401T3 (es) 2018-04-06
WO2013093635A3 (en) 2013-09-06
US20160289771A1 (en) 2016-10-06
RU2014120427A (ru) 2015-11-27
EP2944700B1 (en) 2017-10-18
CN104651521B (zh) 2021-08-27
HUE035614T2 (en) 2018-05-28
JP2015128442A (ja) 2015-07-16
DK2768986T3 (en) 2018-09-10
DK2944700T3 (en) 2018-01-22
MX2014004810A (es) 2014-11-25
EP2768986A2 (en) 2014-08-27
CN104651521A (zh) 2015-05-27
PT2944700T (pt) 2018-01-24
AU2012356317B2 (en) 2016-04-07
KR20150036804A (ko) 2015-04-07
JP6203209B2 (ja) 2017-09-27
KR101912731B1 (ko) 2018-10-29
BR112014009643A2 (pt) 2017-12-12
KR20140097195A (ko) 2014-08-06
IN2015DN01855A (es) 2015-07-10
WO2013093635A2 (en) 2013-06-27
EP2768986B1 (en) 2018-06-27
RU2611189C2 (ru) 2017-02-21
US20150087525A1 (en) 2015-03-26
JP2014530619A (ja) 2014-11-20
JP6159727B2 (ja) 2017-07-05
KR101900872B1 (ko) 2018-09-20
BR122015004941B1 (pt) 2021-09-28
US20180355439A1 (en) 2018-12-13
CA2852850C (en) 2020-07-28
HUE039522T2 (hu) 2019-01-28
RU2662975C1 (ru) 2018-07-31
PL2944700T3 (pl) 2018-05-30
EP2944700A1 (en) 2015-11-18
US20130102487A1 (en) 2013-04-25
ES2688693T3 (es) 2018-11-06
US20180346996A1 (en) 2018-12-06
BR122015004941A2 (pt) 2019-08-20
NO3051026T3 (es) 2018-07-28

Similar Documents

Publication Publication Date Title
MX357550B (es) Microarn plasmaticos para la deteccion de cancer colorrectal temprano.
NZ593514A (en) p-mTOR and p-AKT as Ratio Based Biomarkers for the Prognosis and/or Diagnosis of Cancer
MX2018008421A (es) Métodos para tratar cáncer y el uso de biomarcadores como predictor de sensibilidad clínica a terapias.
IN2013CN01129A (es)
NZ607282A (en) Method for using gene expression to determine prognosis of prostate cancer
WO2010096154A3 (en) Compositions and methods for diagnosis and prognosis of colorectal cancer
WO2012096545A3 (ko) 췌장암 암줄기세포 특성을 이용한 췌장암 신규 바이오마커 및 그의 용도
MX363201B (es) Procedimiento, matriz y uso para determinar la presencia de cancer pancreatico.
EP2566983A4 (en) SERIAL ANALYSIS OF BIOMARKERS FOR THE DIAGNOSIS OF A DISEASE
WO2013062931A3 (en) A molecular beacon based assay for the detection of biomarkers of breast cancer metastasis
GB201300533D0 (en) Methods of monitoring conditions by sequence analysis
WO2012047899A3 (en) Novel dna hypermethylation diagnostic biomarkers for colorectal cancer
EA201290311A1 (ru) Факторы риска и прогнозирование инфаркта миокарда
WO2012027631A3 (en) Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells
MX2012007009A (es) Método para diagnosticar un tumor maligno.
EP2619587A4 (en) BIOMARKERS FOR RECURRENCE PREDICTION OF COLORECTAL CANCER
EP2569635A4 (en) METHODS OF DIAGNOSING AND TREATING ENCEPHALITY OR EPILEPSY
WO2015091575A3 (en) Different levels in blood cell samples of emt-markers for the diagnosis of cancer, in particular of colorectal (crc) and pancreatic (pc) cancer
WO2015077382A3 (en) Combined cytology and molecular testing for early detection of esophageal adenocarcinoma
GB2494580A (en) Method for diagnosing lung cancer
EP2415877A3 (en) Means and methods for diagnosing pancreatic cancer
MX2015013993A (es) Procedimientos y series para su uso en los mismos.
GB201206323D0 (en) Methods and arrays for use in the same
WO2009099561A3 (en) Urinary ca125 peptides as biomarkers of ovarian cancer
MX2012000041A (es) Metodo para someter a prueba a un sujeto que se cree esta predispuesto a tener cancer metastasico usando delta133p53beta.