JP2010518854A5 - - Google Patents

Download PDF

Info

Publication number
JP2010518854A5
JP2010518854A5 JP2009550888A JP2009550888A JP2010518854A5 JP 2010518854 A5 JP2010518854 A5 JP 2010518854A5 JP 2009550888 A JP2009550888 A JP 2009550888A JP 2009550888 A JP2009550888 A JP 2009550888A JP 2010518854 A5 JP2010518854 A5 JP 2010518854A5
Authority
JP
Japan
Prior art keywords
seq
variable region
chain variable
antibody
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009550888A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010518854A (ja
JP5642972B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/001922 external-priority patent/WO2008108918A1/en
Publication of JP2010518854A publication Critical patent/JP2010518854A/ja
Publication of JP2010518854A5 publication Critical patent/JP2010518854A5/ja
Application granted granted Critical
Publication of JP5642972B2 publication Critical patent/JP5642972B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009550888A 2007-02-21 2008-02-13 Ｃ型肝炎ウイルス（ｈｃｖ）に対するヒト抗体およびその使用 Expired - Fee Related JP5642972B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90243207P 2007-02-21 2007-02-21
US60/902,432 2007-02-21
PCT/US2008/001922 WO2008108918A1 (en) 2007-02-21 2008-02-13 Human antibodies against hepatitis c virus (hcv) uses thereof

Publications (3)

Publication Number Publication Date
JP2010518854A JP2010518854A (ja) 2010-06-03
JP2010518854A5 true JP2010518854A5 (https=) 2011-03-31
JP5642972B2 JP5642972B2 (ja) 2014-12-17

Family

ID=39537518

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009550888A Expired - Fee Related JP5642972B2 (ja) 2007-02-21 2008-02-13 Ｃ型肝炎ウイルス（ｈｃｖ）に対するヒト抗体およびその使用

Country Status (21)

Country Link
US (2) US8551484B2 (https=)
EP (1) EP2125889B1 (https=)
JP (1) JP5642972B2 (https=)
KR (1) KR101518081B1 (https=)
CN (1) CN101679512A (https=)
AU (1) AU2008223561B2 (https=)
BR (1) BRPI0807929A2 (https=)
CA (1) CA2678888C (https=)
CY (1) CY1115282T1 (https=)
DK (1) DK2125889T3 (https=)
ES (1) ES2456961T3 (https=)
HR (1) HRP20140316T1 (https=)
IL (1) IL200432A (https=)
MX (1) MX2009008706A (https=)
NZ (1) NZ579706A (https=)
PL (1) PL2125889T3 (https=)
PT (1) PT2125889E (https=)
RS (1) RS53258B (https=)
SI (1) SI2125889T1 (https=)
WO (1) WO2008108918A1 (https=)
ZA (1) ZA200905762B (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009143345A2 (en) * 2008-05-22 2009-11-26 University Of Massachusetts Nucleic acid silencing agent-protein conjugates and use thereof for treating hcv-related disorders
WO2010035292A1 (en) * 2008-09-24 2010-04-01 Natimab Therapeutics S.R.L. The use of a human monoclonal anti-hcv antibody as a medicament for the therapeutic treatment and prevention of hcv infections
CA2658714A1 (en) 2009-03-17 2010-09-17 Thomas Krey Hcv-derived polypeptides and uses thereof
CN101899419B (zh) 2009-05-25 2013-06-05 中国科学院上海生命科学研究院 昆虫杆状病毒表达系统及用其表达e2蛋白的方法
BR112012000536A2 (pt) 2009-07-08 2020-08-11 Kymab Limited métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico
BR112014006394A2 (pt) * 2011-09-19 2017-03-28 Kymab Ltd manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
CN103889460B (zh) * 2011-10-24 2016-06-15 宾夕法尼亚大学理事会 改进的hcv疫苗及其使用方法
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
DE112014004537T5 (de) 2013-10-01 2016-07-21 Kymab Limited Tiermodelle und therapeutische Moleküle
RU2539770C1 (ru) * 2013-12-27 2015-01-27 Татьяна Николаевна Власик Способ нейтрализации вируса гепатита с, полностью человеческое моноклональное антитело против вируса гепатита с (варианты), композиция полностью человеческих моноклональных антител против вируса гепатита с и гибридная мышь/человек клеточная линия - продуцент полностью человеческих моноклональных антител против вируса гепатита с (варианты)
CN105330730A (zh) * 2014-07-29 2016-02-17 中国科学院上海巴斯德研究所 一种丙型肝炎病毒重组蛋白的制备及其应用
PL230663B1 (pl) * 2015-01-15 2018-11-30 Univ Gdanski Szczepionka, sposob jej otrzymywania, wyizolowane chimeryczne bialko, wektor ekspresyjny, zestaw zawierajacy szczepionke oraz kompozycja do zastosowania w profilaktyce zakazen powodowanych przez HCV i/lub HBV
US20180303925A1 (en) 2015-04-27 2018-10-25 The Trustees Of The University Of Pennsylvania Nucleoside-Modified RNA For Inducing an Adaptive Immune Response
CN105254756B (zh) * 2015-11-27 2018-09-07 武汉大学 一种针对丙型肝炎病毒包膜蛋白e2的单克隆抗体及应用
CN107011435B (zh) 2016-06-01 2019-02-12 苏州银河生物医药有限公司 抗丙型肝炎病毒的全人单克隆抗体8d6
JP7464954B2 (ja) * 2017-04-27 2024-04-10 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｃ型肝炎ウイルスに対するヌクレオシド修飾ｍＲＮＡ－脂質ナノ粒子系統ワクチン
CN109738648B (zh) * 2018-12-29 2021-09-17 山东莱博生物科技有限公司 稳定高效表达丙型肝炎病毒核心抗原抗体的工程细胞株及其应用
CN113138276B (zh) * 2020-01-19 2022-09-16 厦门万泰凯瑞生物技术有限公司 用于检测HBcAg的方法及抗体
CN115362175A (zh) * 2020-02-11 2022-11-18 瑞泽恩制药公司 抗acvr1抗体及其用途
US20240327502A1 (en) * 2021-02-12 2024-10-03 Merck Sharp & Dohme Llc Antibodies that bind metapneumovirus, antigenic metapneumovirus proteins, and uses thereof
CN119462863B (zh) * 2024-12-07 2025-07-22 湖南康润药业股份有限公司 抗hcv核心抗原单克隆抗体、杂交瘤细胞株及应用

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US5879936A (en) 1988-04-18 1999-03-09 Aluguisse Holding A.G. Recombinant DNA methods, vectors and host cells
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5308750A (en) 1989-12-22 1994-05-03 Abbott Laboratories Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same
US5891693A (en) 1990-01-25 1999-04-06 Alusuisse Holdings A.G. Recombinant DNA methods vectors and host cells
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
ATE300615T1 (de) 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
EP0552297A1 (en) 1990-10-12 1993-07-28 Abbott Laboratories Hepatitis c virus antibody
ATE167522T1 (de) 1991-01-31 1998-07-15 Abbott Lab Monoklonale antikörper gegen mögliche hcv- hüllregionen und methoden diese zu benutzen
FR2677372B1 (fr) 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
AU2235992A (en) 1991-06-14 1993-01-12 Genpharm International, Inc. Transgenic immunodeficient non-human animals
DE69224906T2 (de) 1991-07-08 1998-10-29 Univ Massachusetts Thermotropes flüssig-kristallines segment-blockcopolymer
JPH06510188A (ja) 1991-08-21 1994-11-17 アボツト・ラボラトリーズ 推定ｈｃｖ　ｎｓ５タンパクに対するモノクローナル抗体およびそれを使用する方法
ZA927837B (en) 1991-10-15 1994-03-11 Akzo Nv Monoclonal antibodiesto hepatitis C virus
JP2778886B2 (ja) 1992-10-16 1998-07-23 エバーニュー バイオテック インコーポレイティド Ｃ型肝炎ウィルスのコア抗原タンパク質及びそれを用いての診断方法及びキット
CA2161351C (en) 1993-04-26 2010-12-21 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
CN1189558C (zh) 1993-10-08 2005-02-16 诺沃奇梅兹有限公司 淀粉酶变体
CA2219361C (en) 1995-04-27 2012-02-28 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6747136B2 (en) 1996-04-19 2004-06-08 Karolinska Innovations Ab Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen
CA2269097C (en) 1996-11-08 2007-01-09 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Synthesis and purification of hepatitis c virus-like particles
WO1999024466A2 (en) 1997-11-06 1999-05-20 Innogenetics N.V. Multi-mer peptides derived from hepatitis c virus envelope proteins for diagnostic use and vaccination purposes
EP0947525A1 (en) 1998-03-27 1999-10-06 Innogenetics N.V. Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue
AU5285899A (en) 1998-07-21 2000-02-14 Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh Anti hepatitis c virus antibody and uses thereof
WO2000026418A1 (en) 1998-11-05 2000-05-11 The Board Of Trustees Of Leland Stanford Junior University Human pan-hcv human monoclonal antibodies
US20060188511A1 (en) * 1998-11-05 2006-08-24 Foung Steven K Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
US20030180284A1 (en) * 1998-11-05 2003-09-25 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
IL137522A (en) 2000-07-26 2007-06-17 Drk Blutspendediendst Baden Wu Human monoclonal antibody against hepatitis c virus e2 glycoprotein
CA2429946A1 (en) 2000-12-01 2002-07-18 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services Monoclonal antibodies specific for the e2 glycoprotein of hepatitis c virus and their use in the diagnosis, treatment, and prevention of hepatitis c
ATE425187T1 (de) 2001-01-12 2009-03-15 Molecules Of Man Ab Materialien und methoden zur behandlung von hepatitis c
ITRM20010336A1 (it) 2001-06-13 2002-12-13 Biostrands S R L Anticorpo umano ricombinante diretto contro la proteina non strutturale ns3 del virus dell'epatite c (hcv), acido nucleico codificante e usi
CA2491471A1 (en) 2002-07-03 2004-01-15 The Trustees Of The University Of Pennsylvania Compositions, methods and kits relating to anti-platelet autoantibodies and inhibitors thereof

Similar Documents

Publication Publication Date Title
JP2010518854A5 (https=)
KR102558839B1 (ko) 다가 b형 간염 바이러스 항원 결합 분자 및 그의 용도
US7727529B2 (en) Human monoclonal antibody Fab fragments directed against HCV E2 glycoprotein and endowed with in vitro neutralizing activity
JP2020516300A5 (https=)
JP2018513680A5 (https=)
HRP20140316T1 (hr) Humana antitijela protiv virusa hepatitisa c (hcv) i njihova uporaba
JP2012012402A5 (https=)
CN104031144B (zh) 特异结合戊型肝炎病毒3、4型的抗体及其用途
JP2011505867A5 (https=)
CN106565840A (zh) 抗乙肝表面抗原的抗体及其用途
WO2021212785A1 (zh) 一种全人源单克隆抗体及其应用
CN106749644B (zh) 一种全人源抗hcv的中和抗体-trn1001
JP2008532559A5 (https=)
JP2005510201A5 (https=)
JP2025504537A (ja) Ｈｂｖ感染及び関連疾患の治療のためのエピトープペプチド及び抗体
Chi et al. An engineered IgG–VHH bispecific antibody against SARS‐CoV‐2 and its variants
JP2004524829A (ja) Ｃ型肝炎ウイルスのｅ２糖タンパク質に特異的なモノクローナル抗体、ならびにｃ型肝炎の診断、治療、および予防におけるそれらの使用
KR102769097B1 (ko) 항-b형 간염 바이러스 항체 및 이의 용도
CN118085082A (zh) 抗猫TNF-α单克隆抗体及其应用
JPWO2022047033A5 (https=)
CN105177017A (zh) 抗多亚基因型hcv抗体基因r4-85及其应用
CN106188285B (zh) 一种中和新疆出血热病毒的单域抗体
CN107286237A (zh) 一种抗丙型肝炎病毒抗体的获取以及应用
HK40113952A (zh) 乙型肝炎病毒表面抗原的抗体及其应用
TW202432583A (zh) Ｂ型肝炎病毒表面抗原的抗體及其應用