JP2020502070A5 - - Google Patents

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JP2020502070A5
JP2020502070A5 JP2019528506A JP2019528506A JP2020502070A5 JP 2020502070 A5 JP2020502070 A5 JP 2020502070A5 JP 2019528506 A JP2019528506 A JP 2019528506A JP 2019528506 A JP2019528506 A JP 2019528506A JP 2020502070 A5 JP2020502070 A5 JP 2020502070A5
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refractory
disease
syndrome
corticosteroid
dermatomyositis
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JP2019528506A
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JP7595413B2 (ja
JP2020502070A (ja
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Priority claimed from PCT/US2017/063959 external-priority patent/WO2018102552A1/en
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JP2019528506A 2016-11-30 2017-11-30 １５－ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用 Active JP7595413B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662428259P 2016-11-30 2016-11-30
US62/428,259 2016-11-30
US201762510166P 2017-05-23 2017-05-23
US62/510,166 2017-05-23
PCT/US2017/063959 WO2018102552A1 (en) 2016-11-30 2017-11-30 Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof

Publications (3)

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JP2020502070A JP2020502070A (ja) 2020-01-23
JP2020502070A5 true JP2020502070A5 (enExample) 2021-01-28
JP7595413B2 JP7595413B2 (ja) 2024-12-06

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JP2019528506A Active JP7595413B2 (ja) 2016-11-30 2017-11-30 １５－ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用

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US (2) US11690847B2 (enExample)
EP (1) EP3548035A4 (enExample)
JP (1) JP7595413B2 (enExample)
WO (1) WO2018102552A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
US12336982B2 (en) 2018-11-21 2025-06-24 Rodeo Therapeutics Corporation Compositions and methods of modulating short-chain dehydrogenase activity
US12616681B2 (en) 2019-04-04 2026-05-05 Case Western Reserve University Compositions and methods for treating renal injury

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
WO2015065716A1 (en) 2013-10-15 2015-05-07 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
JP6585625B2 (ja) 2014-01-21 2019-10-02 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト
JP2018511581A (ja) 2015-03-08 2018-04-26 ケース ウエスタン リザーブ ユニバーシティ 線維症を処置するための短鎖デヒドロゲナーゼ活性阻害剤
JP7178360B2 (ja) 2017-04-07 2022-11-25 ケース ウエスタン リザーブ ユニバーシティ 冠状動脈障害を治療するための短鎖型デヒドロゲナーゼ活性の阻害剤
MA54395A (fr) 2018-12-07 2022-03-16 Neurocrine Biosciences Inc Antagoniste du récepteur crf1, formulations pharmaceutiques et formes solides correspondantes pour le traitement de l'hyperplasie surrénalienne congénitale
PH12021551324A1 (en) * 2019-01-08 2022-04-25 Kyorin Seiyaku Kk 15-pgdh inhibitor
CN114502162B (zh) 2019-09-27 2025-03-28 纽罗克里生物科学有限公司 Crf受体拮抗剂及使用方法
CN115335043B (zh) 2020-01-23 2025-03-28 迈欧伏特治疗公司 Pgdh抑制剂以及制备和使用方法
CR20220654A (es) 2020-05-20 2023-08-24 Rodeo Therapeutics Corp Composiciones y métodos para modular la actividad de deshidrogenasas de cadena corta
WO2022126125A1 (en) * 2020-12-09 2022-06-16 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of prostaglandin degrading enzyme 15-pgdh to improve joint structure and function
WO2025148611A1 (zh) * 2024-01-12 2025-07-17 新牛（郑州）生物科技有限公司 肿瘤抗原肽融合蛋白及其组合物的基因工程化递送和应用

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