JP2020502070A5 - - Google Patents

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JP2020502070A5
JP2020502070A5 JP2019528506A JP2019528506A JP2020502070A5 JP 2020502070 A5 JP2020502070 A5 JP 2020502070A5 JP 2019528506 A JP2019528506 A JP 2019528506A JP 2019528506 A JP2019528506 A JP 2019528506A JP 2020502070 A5 JP2020502070 A5 JP 2020502070A5
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refractory
disease
syndrome
corticosteroid
dermatomyositis
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JP2019528506A
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JP2020502070A (ja
JP7595413B2 (ja
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Priority claimed from PCT/US2017/063959 external-priority patent/WO2018102552A1/en
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JP2019528506A 2016-11-30 2017-11-30 15-pgdh阻害剤とコルチコステロイドおよび/またはtnf阻害剤との組み合わせならびにその使用 Active JP7595413B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662428259P 2016-11-30 2016-11-30
US62/428,259 2016-11-30
US201762510166P 2017-05-23 2017-05-23
US62/510,166 2017-05-23
PCT/US2017/063959 WO2018102552A1 (en) 2016-11-30 2017-11-30 Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof

Publications (3)

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JP2020502070A JP2020502070A (ja) 2020-01-23
JP2020502070A5 true JP2020502070A5 (enExample) 2021-01-28
JP7595413B2 JP7595413B2 (ja) 2024-12-06

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JP2019528506A Active JP7595413B2 (ja) 2016-11-30 2017-11-30 15-pgdh阻害剤とコルチコステロイドおよび/またはtnf阻害剤との組み合わせならびにその使用

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US (2) US11690847B2 (enExample)
EP (1) EP3548035A4 (enExample)
JP (1) JP7595413B2 (enExample)
WO (1) WO2018102552A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
US12336982B2 (en) 2018-11-21 2025-06-24 Rodeo Therapeutics Corporation Compositions and methods of modulating short-chain dehydrogenase activity

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016144958A1 (en) 2015-03-08 2016-09-15 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating fibrosis
CA2927730A1 (en) 2013-10-15 2015-05-07 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
CN106102740A (zh) 2014-01-21 2016-11-09 纽罗克里生物科学有限公司 治疗先天性肾上腺增生的crf1受体拮抗剂
CN110891568A (zh) 2017-04-07 2020-03-17 凯斯西储大学 用于治疗冠状动脉病症的短链脱氢酶活性的抑制剂
EP3984523B1 (en) 2018-12-07 2025-09-03 Neurocrine Biosciences, Inc. Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia
WO2020145250A1 (ja) * 2019-01-08 2020-07-16 杏林製薬株式会社 15-pgdh阻害薬
WO2021062246A1 (en) 2019-09-27 2021-04-01 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods of use
WO2021151014A1 (en) 2020-01-23 2021-07-29 Myoforte Therapeutics, Inc. Pgdh inhibitors and methods of making and using
TW202208376A (zh) 2020-05-20 2022-03-01 美國凱斯西方瑞瑟夫大學 調節短鏈脫氫酶活性之組成物及方法
AU2021396543A1 (en) * 2020-12-09 2023-07-06 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of prostaglandin degrading enzyme 15-pgdh to improve joint structure and function
WO2025148611A1 (zh) * 2024-01-12 2025-07-17 新牛(郑州)生物科技有限公司 肿瘤抗原肽融合蛋白及其组合物的基因工程化递送和应用

Family Cites Families (207)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3382247A (en) 1965-11-01 1968-05-07 Upjohn Co 6-amino-1, 2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidines
EP0142811A3 (en) 1983-11-14 1986-03-12 The Dow Chemical Company Method of preparing 1,2,4-triazolo [1,5-a] - pyrimidine-2-sulfonyl chlorides
SE8405924L (sv) 1984-11-23 1986-05-24 Pharmacia Ab Nya azoforeningar
EP0271273A3 (en) 1986-12-08 1989-07-12 Merck & Co. Inc. Thieno-and furopyridine sulfonamides
US4904672A (en) 1987-01-30 1990-02-27 Merck & Co., Inc. Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors
GB8709248D0 (en) 1987-04-16 1987-05-20 Wyeth John & Brother Ltd Azo compounds
US4910226A (en) 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
DE3812177A1 (de) 1988-04-13 1989-10-26 Bayer Ag 2-phenylsulfinyl-nitro-pyridine, verfahren zu ihrer herstellung und ihre verwendung
LU87308A1 (fr) 1988-08-01 1990-03-13 Oreal Nouveaux derives de diamino-2,4 pyrimidine oxyde-3 et leur utilisation pour le traitement et la prevention de la chute des cheveux
JPH04501851A (ja) * 1988-12-02 1992-04-02 ジ・アップジョン・カンパニー 脱毛症治療のためのミノキシジルおよび血管収縮薬組成物
EP0378508B1 (de) 1989-01-11 1995-03-01 Ciba-Geigy Ag Antidots zur Verbesserung der Kulturpflanzenvertäglichkeit agrochemischer Wirkstoffe
JP2821690B2 (ja) 1989-06-16 1998-11-05 日本ゼオン株式会社 医療用チューブ
US5015629A (en) 1989-06-26 1991-05-14 University Of Southern California Tissue repair
FR2651122B1 (fr) 1989-08-29 1994-10-28 Oreal Compositions destinees a etre utilisees pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives de l'amino-2 pyrimidine oxyde-3 et nouveaux composes derives de l'amino-2 pyrimidine oxyde-3.
US5480913A (en) 1989-09-27 1996-01-02 Arch Development Corporation Anti-androgen compounds
EP0434624B1 (de) 1989-12-22 1995-02-08 Ciba-Geigy Ag Triazolylsulfonamide
US5217521A (en) 1989-12-22 1993-06-08 Ciba-Geigy Corporation Triazolylsulfonamides
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
FR2662607B1 (fr) 1990-05-30 1992-08-28 Oreal Composition destinee a etre utilisee pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives d'alkyl-2 amino-4 (ou dialkyl-2-4) pyrimidine oxyde-3 .
US5411981A (en) 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2677884B1 (fr) 1991-06-20 1993-07-09 Oreal Composition pour freiner la chute des cheveux a base de pyrimidines n-oxyde trisubstitues ou leurs derives sulfoconjugues, nouveaux composes pyrimidines n-oxyde ou leurs derives sulfoconjugues.
FR2678929A1 (fr) 1991-07-11 1993-01-15 Oreal Compositions pour freiner la chute des cheveux et pour induire et stimuler leur croissance a base de derives de 2,4-diamino pyrimidine 3-oxyde, nouveaux derives 2,4-diamino pyrimidine 3-oxyde.
FR2683531B1 (fr) 1991-11-13 1993-12-31 Rhone Poulenc Rorer Sa Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent.
WO1993013664A2 (en) 1992-01-11 1993-07-22 Schering Agrochemicals Limited Biheterocyclic fungicidal compounds
US5460964A (en) 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
AU677614B2 (en) 1992-10-13 1997-05-01 Duke University Methods of detecting Alzheimer's disease
US5445164A (en) 1993-05-11 1995-08-29 Gynetech, Inc. Cervical tissue sampling device
CA2170357A1 (en) 1993-08-25 1995-03-02 David Digiusto Method for producing a highly enriched population of hematopoietic stem cells
TW369521B (en) 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5409813A (en) 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
FR2711060B1 (fr) 1993-10-13 1995-11-17 Oreal Procédé pour modifier la pousse des poils et/ou des cheveux et compositions utilisables à cet effet.
SE9303444D0 (sv) 1993-10-20 1993-10-20 Kabi Pharmacia Ab New use of prostaglandins
US5405842A (en) * 1994-01-28 1995-04-11 Silverman; Bernard A. Treatment of steroid dependent asthmatics
FR2719481B1 (fr) 1994-05-05 1996-05-31 Oreal Composition à base de composés antifongiques et de composés antibactériens halogènes pour diminuer la chute des cheveux.
US5516779A (en) 1994-06-08 1996-05-14 Merck & Co., Inc. 17β-substituted-6-azasteroid derivatives useful as 5α-reductase inhibitors
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
US5807895A (en) 1994-11-29 1998-09-15 Schwarz Pharma, Inc. Use of prostaglandin E1, E2 or analogs to prevent renal failure induced by medical tests that utilize contrast media agents
US5529769A (en) 1994-12-20 1996-06-25 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cosmetic compositions containing betulinic acid
FR2732597B1 (fr) 1995-04-05 1997-05-16 Oreal Utilisation dans une composition en tant qu'activateur et/ou stabilisateur de cyclooxygenase d'au moins un derive de pyrimidine substitue en 6
US6080772A (en) 1995-06-07 2000-06-27 Sugen, Inc. Thiazole compounds and methods of modulating signal transduction
US5631282A (en) 1995-06-07 1997-05-20 Merck & Co., Inc. Triterpenes
FR2739553B1 (fr) 1995-10-06 1998-01-02 Oreal Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
JP3049593B2 (ja) 1996-05-01 2000-06-05 株式会社ビメーク 育毛・養毛剤
US6281227B1 (en) 1996-12-13 2001-08-28 Aventis Pharma Deutschland Gmbh Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
DE69823852T2 (de) 1997-02-04 2005-05-19 Johnstone, Murray A., Seattle Verfahren zur förderung des haarwuchses und entwicklung des haarsystems
JP3217293B2 (ja) 1997-04-17 2001-10-09 株式会社アールテック・ウエノ 発毛・育毛剤
JP2001509480A (ja) 1997-07-09 2001-07-24 アンドロソリューションズ,インク. 男性勃起機能不全を治療するための改良された方法及び組成物
EP1036089B1 (en) 1997-12-12 2004-06-09 University Of Southern California Wound healing compositions
US6214533B1 (en) 1998-04-10 2001-04-10 Konica Corporation Thermally developable photosensitive material
US7473528B2 (en) 1999-01-06 2009-01-06 Genenews Inc. Method for the detection of Chagas disease related gene transcripts in blood
US20040241727A1 (en) 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of schizophrenia related gene transcripts in blood
US20040241726A1 (en) 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of allergies related gene transcripts in blood
US8068897B1 (en) 1999-03-01 2011-11-29 Gazdzinski Robert F Endoscopic smart probe and method
CA2332427A1 (en) 1999-03-16 2000-09-21 Toray Industries, Inc. Prostaglandin ep4 receptor agonist and treatment method
EP1214038A2 (en) 1999-09-09 2002-06-19 Androsolutions, Inc. Methods and compositions for preventing and treating prostate disorders
CN1366458A (zh) 2000-03-31 2002-08-28 东丽株式会社 毛发生长和毛发形成调节剂
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020146439A1 (en) 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
FR2812191B1 (fr) 2000-07-28 2003-10-17 Oreal Utilisation d'agonistes du recepteur des prostaglandines e2 (ep-3) pour attenuer, diminuer ou stopper la pousse des cheveux et des poils dans des preparations cosmetiques
FR2812190B1 (fr) 2000-07-28 2003-01-31 Oreal Utilisation d'agonistes non prostanoiques des recepteurs des prostaglandines ep-2 et/ou ep-4 comme agent cosmetique permettant d'attenuer, de diminuer ou d'arreter la chute des cheveux et des poils
NZ528406A (en) 2001-03-30 2004-03-26 Pfizer Prod Inc Pyridazinone aldose reductase inhibitors
US7004913B1 (en) 2001-05-04 2006-02-28 Cdx Laboratories, Inc. Retractable brush for use with endoscope for brush biopsy
FR2825261B1 (fr) 2001-06-01 2003-09-12 Maco Pharma Sa Ligne de prelevement du sang placentaire comprenant une poche de rincage
US20030096823A1 (en) 2001-11-16 2003-05-22 Beryl Asp Method for the treatment of cardiotoxicity induced by antitumor compounds
JP2003286171A (ja) 2002-03-28 2003-10-07 Sumitomo Pharmaceut Co Ltd Par阻害剤
US7320967B2 (en) 2002-04-23 2008-01-22 L'oreal Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair
FR2838641B1 (fr) 2002-04-23 2005-12-23 Oreal Composition cosmetique, procede de traitement cosmetique et preparation d'une composition pour favoriser la pousse et/ou empecher ou retarder la chute des cheveux
ATE375349T1 (de) 2002-08-02 2007-10-15 Merck & Co Inc Substituierte furo(2,3-b)pyridin derivate
US20060051540A1 (en) 2002-09-20 2006-03-09 Seiji Kagawa Shape-memory polybutylene terephthalate film, production process and use thereof, and process for production of polybutylene terephthalate film
FR2845000B1 (fr) 2002-09-27 2005-05-27 Oreal Utilisation d'un compose heterocyclique ou de l'un de ses sels pour stimuler ou induire la pousse des cheveux et/ou freiner leur chute
RU2324693C2 (ru) 2002-10-18 2008-05-20 Ф.Хоффманн-Ля Рош Аг 4-пиперазинилбензолсульфонилиндолы, характеризующиеся сродством к рецептору 5-нт6
FR2845917B1 (fr) 2002-10-21 2006-07-07 Negma Gild Composition pharmaceutique associant le tenatoprazole et un anti-inflammatoire
US7105117B2 (en) 2003-01-06 2006-09-12 General Motors Corporation Manufacturing method for increasing thermal and electrical conductivities of polymers
EP1587486A2 (en) 2003-01-15 2005-10-26 L'oreal Care or make-up composition comprising a 2-alkylideneaminooxyacetamide, its use for stimulating the growth of the hair or eyelashes and/or slowing down their loss
EP1594438B1 (fr) 2003-02-12 2013-07-17 L'Oréal Utilisation d'un inhibiteur de 15-hydroxy prostaglandine déshydrogénase pour favoriser la pigmentation de la peau ou des phanères
WO2004089415A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST
US7700583B2 (en) 2003-04-11 2010-04-20 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
JP2006522750A (ja) 2003-04-11 2006-10-05 ノボ ノルディスク アクティーゼルスカブ 代謝性症候群ならびに関連の疾患および障害を治療するために、11β−ヒドロキシステロイドデヒドロゲナーゼ1型阻害剤および抗高血圧剤を使用する併用療法
WO2004089471A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S NEW PYRAZOLO[1,5-a] PYRIMIDINES DERIVATIVES AND PHARMACEUTICAL USE THEREOF
US7189724B2 (en) 2003-04-15 2007-03-13 Valeant Research And Development Quinoxaline derivatives having antiviral activity
SE0301373D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
CN1589793A (zh) 2003-07-24 2005-03-09 山东绿叶天然药物研究开发有限公司 鞣酸小檗碱在制备治疗溃疡性结肠炎药物中的应用
ES2559779T3 (es) 2003-08-29 2016-02-15 Vernalis (R&D) Limited Compuestos de pirimidotiofeno
US20050187221A1 (en) 2003-09-08 2005-08-25 Japan Tobacco Inc. Method of treating ischemia reperfusion injury
TW200512298A (en) 2003-09-24 2005-04-01 Oncotherapy Science Inc Method of diagnosing breast cancer
JPWO2005030773A1 (ja) 2003-09-26 2006-12-07 大日本住友製薬株式会社 新規ピラゾロピリミジン誘導体
FR2860431A1 (fr) 2003-10-02 2005-04-08 Oreal Composition capillaire ou de mascara contenant un compose azoique, son utilisation pour stimuler ou induire la pousse des cheveux ou des cils et/ou freiner leur chute
US20050209181A1 (en) 2003-11-05 2005-09-22 Huda Akil Compositions and methods for diagnosing and treating mental disorders
EP1699865A1 (en) 2003-12-31 2006-09-13 Basell Poliolefine Italia S.r.l. Filled olefin polymer compositions having improved mechanical properties and scratch resistance
AU2005223738B2 (en) 2004-03-09 2011-08-11 Boehringer Ingelheim Pharmaceuticals, Inc. 3-'4-heterocyclyl -1,2,3,-triazol-1-yl-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases
JP2005325099A (ja) 2004-04-12 2005-11-24 Sankyo Co Ltd チエノピリジン誘導体
BRPI0509795A (pt) 2004-04-12 2007-10-23 Sankyo Co composto ou um sal farmacologicamente aceitável do mesmo, composição farmacêutica, uso do composto ou sal farmacologicamente aceitável do mesmo, e, método para promover osteogênese, supressão de ressorção óssea e/ou melhoramento da densidade óssea
US7981229B2 (en) 2004-06-04 2011-07-19 Cornerstone Research Group, Inc Method of making and using shape memory polymer patches
NZ553329A (en) 2004-07-22 2010-09-30 Ptc Therapeutics Inc Thienopyridines for treating hepatitis C
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
WO2006048266A2 (en) 2004-11-04 2006-05-11 Roche Diagnostics Gmbh Gene expression profiling of leukemias with mll gene rearrangements
WO2006048264A2 (en) 2004-11-04 2006-05-11 Roche Diagnostics Gmbh Gene expression profiling in acute lymphoblastic leukemia (all), biphenotypic acute leukemia (bal), and acute myeloid leukemia (aml) m0
US20070155884A1 (en) 2004-11-12 2007-07-05 Basell Poliolefine Italia S.R.L. Filled olefin polymer compositions having improved mechanical properties and scratch resistance
US8000795B2 (en) 2004-12-17 2011-08-16 Lozano Andres M Cognitive function within a human brain
WO2006074226A2 (en) 2005-01-05 2006-07-13 Novacea, Inc. Prevention of thrombotic disorders with active vitamin d compounds or mimics thereof
AU2006206573B9 (en) 2005-01-19 2011-09-29 Merck Sharp & Dohme Corp. Bicyclic pyrimidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
WO2006096649A2 (en) 2005-03-05 2006-09-14 Harc (Houston Advanced Research Center) Methods and biomarkers for detecting nanoparticle exposure
CA2599899A1 (en) 2005-03-09 2006-09-21 Schering Corporation Fused thieno [2, 3-b] pyridine and thiazolo [5, 4-b] pyridine compounds for inhibiting ksp kinesin activity
AR053579A1 (es) 2005-04-15 2007-05-09 Genentech Inc Tratamiento de la enfermedad inflamatoria intestinal (eii)
US20090118337A1 (en) 2005-06-03 2009-05-07 Davis Pamela B Methods and compositions for treating inflammation
EP1907858A4 (en) 2005-06-13 2009-04-08 Univ Michigan COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
US20070071699A1 (en) 2005-06-28 2007-03-29 L'oreal Benzylidene-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening
US20070059265A1 (en) * 2005-06-28 2007-03-15 L'oreal Benzylidene-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss and/or for increasing the density of keratin fibers
EP2295571A1 (en) 2005-07-27 2011-03-16 Oncotherapy Science, Inc. Method of diagnosing small cell lung cancer
US7875721B2 (en) 2005-08-04 2011-01-25 Stc.Unm Compounds for binding to ERα/β and GPR30, methods of treating disease states and conditions mediated through these receptors and identification thereof
CA2620864A1 (en) 2005-09-01 2007-03-08 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
AR056200A1 (es) 2005-09-27 2007-09-26 Wyeth Corp Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa
US20070078175A1 (en) 2005-10-05 2007-04-05 L'oreal Administration of novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds for stimulating or inducing the growth of keratinous fibers and/or slowing loss thereof
BRPI0620205A2 (pt) 2005-12-20 2011-11-01 Richter Gedeon Nyrt novos compostos
US8372861B2 (en) 2006-02-27 2013-02-12 The Board Of Trustees Of The Leland Stanford Junior University Inhibitors of the unfolded protein response and methods for their use
WO2007100775A2 (en) 2006-02-27 2007-09-07 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
KR101402474B1 (ko) 2006-04-26 2014-06-19 제넨테크, 인크. 포스포이노시티드 3-키나제 억제제 화합물 및 이를 포함하는 약학적 조성물
CA2670083A1 (en) 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
KR20100015414A (ko) 2007-03-09 2010-02-12 하이 포인트 파마슈티칼스, 엘엘씨 히드록시스테로이드 탈수소효소 억제제로서 인돌- 및 벤즈이미다졸 아미드
WO2008111295A1 (ja) * 2007-03-09 2008-09-18 Kowa Co., Ltd. 全身性エリテマトーデスの予防及び/又は治療剤
AR060498A1 (es) 2007-04-17 2008-06-18 Richter Gedeon Vegyeszet Compuestos de tieno [2,3-b] piridinas
CA2690557A1 (en) 2007-06-14 2008-12-24 Schering Corporation Imidazopyrazines as protein kinase inhibitors
KR100901127B1 (ko) 2007-06-22 2009-06-08 한국과학기술연구원 독소루비신 처리에 따른, 심장독성 유발 약물 검색용마커유전자 및 이를 이용한 심장독성 유발 약물 검색 방법
US20090007243A1 (en) 2007-06-27 2009-01-01 Trusteer Ltd. Method for rendering password theft ineffective
AU2008275025C1 (en) 2007-07-10 2016-01-28 The Regents Of The University Of Michigan Thermostabilization of proteins
CN101970002B (zh) 2007-08-27 2016-05-18 诺福麦德治疗学股份有限公司 用因子Bb特异性抗体抑制补体活化的方法
FR2920309B1 (fr) 2007-08-28 2010-05-28 Galderma Res & Dev Utilisation de travoprost pour traiter la chute des cheveux
DE102007049451A1 (de) 2007-10-16 2009-04-23 Merck Patent Gmbh 5-Cyano-thienopyridine
WO2009073460A2 (en) 2007-12-03 2009-06-11 Bausch & Lomb Incorporated Inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 for ocular neuroprotection
US9216983B2 (en) 2007-12-21 2015-12-22 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
US8642660B2 (en) 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
CN101977619B (zh) 2008-02-15 2013-06-05 诺沃百欧公司 姜黄素的可溶性复合物
WO2009111648A1 (en) 2008-03-05 2009-09-11 Vicus Therapeutics, Llc Compositions and methods for mucositis and oncology therapies
US20110117111A1 (en) 2008-03-26 2011-05-19 Johns Hopkins University Microrna-based diagnostic testing and therapies for inflammatory bowel disease and related diseases
US7629112B1 (en) 2008-05-30 2009-12-08 Eastman Kodak Company Color photographic materials with yellow minimum density colorants
JP5180882B2 (ja) 2008-07-29 2013-04-10 株式会社プライムポリマー ポリプロピレン樹脂組成物、およびその成形体
CN102186857A (zh) 2008-08-26 2011-09-14 贝林格尔·英格海姆国际有限公司 用于药物组合物的噻吩并嘧啶
US20100093764A1 (en) 2008-10-13 2010-04-15 Devraj Chakravarty AMINES AND SULFOXIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
GB2465405A (en) 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
EP2383263B1 (en) 2008-12-30 2014-04-16 Industry-academic Cooperation Foundation, Chosun University Novel thiazolidinedione derivative and use thereof
CA2749228C (en) 2009-01-08 2016-05-17 Curis, Inc. Phosphoinositide 3-kinase inhibitors with a zinc binding moiety
ES2580779T3 (es) 2009-02-13 2016-08-26 Bayer Intellectual Property Gmbh Pirimidinas fusionadas
CA2793276A1 (en) 2009-03-27 2010-09-30 Zacharon Pharmaceuticals, Inc. Ganglioside biosynthesis modulators
KR20100137090A (ko) 2009-06-22 2010-12-30 조선대학교산학협력단 신규한 티아졸리딘디온 유도체 및 그의 용도
CN102480969A (zh) * 2009-07-09 2012-05-30 科锐医疗有限公司 伤口愈合和瘢痕调制方法
CN102741255B (zh) 2009-09-29 2015-10-07 得克萨斯大学体系董事会 作为双氢乳清酸脱氢酶抑制剂的抗疟剂
EP2308883A1 (en) 2009-10-05 2011-04-13 Centre National De La Recherche Scientifique New derivatives of thieno[2,3-b]pyridine and 5,6,7,8 tetrahydrothieno[2,3 b]quinoline in particular useful in the treatment of malaria
WO2011094847A1 (en) 2010-02-04 2011-08-11 Penn Linda Z Methods and compositions for diagnosing and treating patients having multiple myeloma that respond to statin therapy
RU2016101363A (ru) * 2010-02-08 2018-11-21 Прэари Фармасьютикалз, Ллк Способ лечения заболеваний, связанных с глюкокортикоидной нечувствительностью
GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
GB201107197D0 (en) 2011-04-28 2011-06-15 Cxr Biosciences Ltd Compounds
JP6051632B2 (ja) 2011-07-20 2016-12-27 日立化成株式会社 研磨剤及び基板の研磨方法
GB201115635D0 (en) 2011-09-09 2011-10-26 Univ Liverpool Compositions of lopinavir and ritonavir
ES2721539T3 (es) 2011-09-23 2019-08-01 Acad Medisch Ct Materiales y métodos para pronóstico de evolución de esófago de Barrett
PT2785834T (pt) 2011-12-02 2020-11-13 Fate Therapeutics Inc Composição de células estaminais melhorada
GB201120993D0 (en) 2011-12-06 2012-01-18 Imp Innovations Ltd Novel compounds and their use in therapy
JP6049143B2 (ja) * 2011-12-15 2016-12-21 国立大学法人東京農工大学 オリゴヌクレオチド、グルココルチコイド感受性増強剤、医薬組成物、及び発現ベクター
AU2013202373B2 (en) 2012-01-25 2016-04-14 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
KR101370670B1 (ko) 2012-03-12 2014-03-06 조선대학교산학협력단 플라본 화합물의 15-하이드록시프로스타글란딘 탈수소효소 활성의 억제 효능 및 그의 용도
EP3295940A1 (en) 2012-04-16 2018-03-21 Case Western Reserve University Compositions and methods of modulating 15-pgdh activity
US9801863B2 (en) 2012-04-16 2017-10-31 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
WO2016144958A1 (en) 2015-03-08 2016-09-15 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating fibrosis
KR101244964B1 (ko) 2012-05-30 2013-03-18 조선대학교산학협력단 15-히드록시프로스타글란딘 디히드로게나제 및 pge2 활성을 조절하는 황칠나무 추출물의 용도
US9273033B2 (en) 2012-11-20 2016-03-01 Merck Sharp & Dohme Corp. Substituted pyridone derivatives as PDE10 inhibitors
EP2922548A4 (en) 2012-11-21 2016-06-01 Stategics Inc SUBSTITUTED TRIAZOLO-PYRIMIDINE COMPOUNDS FOR MODULATING CELL PROPOLATION, DIFFERENTIATION AND OVER LIVING
CA2905418C (en) 2013-03-13 2023-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for modulating chemotherapeutic cytotoxicity
WO2014160947A1 (en) 2013-03-29 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof
RU2636316C2 (ru) 2013-07-08 2017-11-22 Прайм Полимер Со., Лтд. Композиция пропиленовой смолы
CN105683192A (zh) 2013-09-25 2016-06-15 沃泰克斯药物股份有限公司 用作par-2信号传导途径抑制剂的咪唑并哒嗪类
CA2927730A1 (en) 2013-10-15 2015-05-07 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
WO2015077382A2 (en) 2013-11-19 2015-05-28 Fight Against Cancer Innovation Trust Combined cytology and molecular testing for early detection of esophageal adenocarcinoma
TW201625578A (zh) 2014-04-18 2016-07-16 千禧製藥公司 喹啉化合物及其用途
WO2016024211A1 (en) 2014-08-12 2016-02-18 University Of Pécs (Pécsi Tudományegyetem), The Methods and materials for reducing ischemia-reperfusion injury
KR102255308B1 (ko) * 2014-11-18 2021-05-24 삼성전자주식회사 아세틸살리실산을 포함하는 개체의 스테로이드 부작용을 예방 또는 치료하기 위한 조성물 및 그의 용도
CA2968359A1 (en) 2014-12-23 2016-06-30 Genentech, Inc. Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
AU2016245984B2 (en) 2015-04-10 2021-03-25 Bioresponse, L.L.C. Self-emulsifying formulations of DIM-related indoles
US20180118756A1 (en) 2015-04-14 2018-05-03 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
PL3095820T3 (pl) 2015-05-22 2019-10-31 Borealis Ag Kompozycja polimerowa wzmacniana włóknami
ES2733200T3 (es) 2015-05-22 2019-11-28 Borealis Ag Composite de polipropileno - fibra de carbono
JP2019513010A (ja) 2016-03-04 2019-05-23 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー プロスタグランジンe2を用いる、筋再生のための組成物および方法
CA3031091A1 (en) 2016-07-18 2018-01-25 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for promoting neurogenesis and inhibiting nerve cell death
JP7595413B2 (ja) 2016-11-30 2024-12-06 ケース ウエスタン リザーブ ユニバーシティ 15-pgdh阻害剤とコルチコステロイドおよび/またはtnf阻害剤との組み合わせならびにその使用
JP7211945B2 (ja) 2016-11-30 2023-01-24 アンスティテュ・パストゥール ヒト自然リンパ球前駆細胞:同定、特性評価、応用
WO2018145080A1 (en) 2017-02-06 2018-08-09 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
CN110891568A (zh) 2017-04-07 2020-03-17 凯斯西储大学 用于治疗冠状动脉病症的短链脱氢酶活性的抑制剂
US20210317132A1 (en) 2017-05-26 2021-10-14 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
AU2018280264B2 (en) 2017-06-09 2024-07-11 Myoforte Therapeutics, Inc. Compositions and methods for preventing or treating muscle conditions
WO2019010482A1 (en) 2017-07-07 2019-01-10 Case Western Reserve University COMPOSITIONS AND METHODS FOR MODULATING COLUMN MATURATION
JP2019066312A (ja) 2017-09-29 2019-04-25 ミネベアミツミ株式会社 ひずみゲージ
CA3095308A1 (en) 2018-04-04 2019-10-10 Case Western Reserve University Compositions and methods for treating renal injury
DK3784661T3 (da) 2018-04-25 2024-02-12 Bayer Ag Hidtil ukendte heteroaryl-triazol- og heteroaryl-tetrazol-forbindelser som pesticider
GB201807968D0 (en) 2018-05-16 2018-07-04 Naturex Sa Eutectic extract formation and purification
KR102528290B1 (ko) 2018-08-24 2023-05-03 썬전 샥 컴퍼니 리미티드 안경
CN113260609A (zh) 2018-09-04 2021-08-13 美真达治疗公司 芳烃受体拮抗剂及其使用方法
PE20212246A1 (es) 2018-11-21 2021-11-24 Univ Case Western Reserve Composiciones y metodos para modular la actividad de deshidrogenasas de cadena corta
US11198693B2 (en) * 2018-11-21 2021-12-14 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US12304897B2 (en) 2019-01-31 2025-05-20 Kyorin Pharmaceutical Co., Ltd. 15-PGDH inhibitors
KR20220019760A (ko) 2019-06-11 2022-02-17 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 15-하이드록시프로스타글란딘 데하이드로게나제(15-pgdh)를 억제하여 노화된 조직을 젊어지게 하는 방법
WO2021151014A1 (en) 2020-01-23 2021-07-29 Myoforte Therapeutics, Inc. Pgdh inhibitors and methods of making and using
MX2022010258A (es) 2020-02-21 2023-01-24 Univ Case Western Reserve Composiciones y métodos para tratar la lesión renal.
TW202208376A (zh) 2020-05-20 2022-03-01 美國凱斯西方瑞瑟夫大學 調節短鏈脫氫酶活性之組成物及方法
US20230210829A1 (en) 2020-06-11 2023-07-06 The Board Of Trustees Of The Leland Stanford Junior University Rejuvenation of aged tissues by inhibition of the pge2 degrading enzyme, 15-pgdh
WO2022032230A1 (en) 2020-08-07 2022-02-10 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating neurodegeneration

Cited By (3)

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US11690847B2 (en) 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
US12336982B2 (en) 2018-11-21 2025-06-24 Rodeo Therapeutics Corporation Compositions and methods of modulating short-chain dehydrogenase activity

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