JP2019513371A5 - - Google Patents

Info

Publication number

JP2019513371A5

JP2019513371A5 JP2018551978A JP2018551978A JP2019513371A5 JP 2019513371 A5 JP2019513371 A5 JP 2019513371A5 JP 2018551978 A JP2018551978 A JP 2018551978A JP 2018551978 A JP2018551978 A JP 2018551978A JP 2019513371 A5 JP2019513371 A5 JP 2019513371A5

Authority

JP

Japan

Prior art keywords

polynucleotide

molecule according

molecule

conjugated

binding fragments

Prior art date

2017-03-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 102000040430 polynucleotide Human genes 0.000 claims 14
• 108091033319 polynucleotide Proteins 0.000 claims 14
• 239000002157 polynucleotide Substances 0.000 claims 14
• 239000012634 fragment Substances 0.000 claims 7
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• 208000035657 Abasia Diseases 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 229960000549 4-dimethylaminophenol Drugs 0.000 claims 1
• VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-dimethylaminopyridine Substances CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims 1
• 239000005977 Ethylene Substances 0.000 claims 1
• 108010036176 Melitten Proteins 0.000 claims 1
• 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000000021 endosomolytic effect Effects 0.000 claims 1
• -1 ethylene nucleic acid Chemical class 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1