|
US1000075A
(en)
|
1910-07-27 |
1911-08-08 |
William R Collins |
Tunneling-machine.
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4694778A
(en)
|
1984-05-04 |
1987-09-22 |
Anicon, Inc. |
Chemical vapor deposition wafer boat
|
|
US5521063A
(en)
|
1985-03-15 |
1996-05-28 |
Antivirals Inc. |
Polynucleotide reagent containing chiral subunits and methods of use
|
|
WO1986005519A1
(en)
|
1985-03-15 |
1986-09-25 |
James Summerton |
Polynucleotide assay reagent and method
|
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5217866A
(en)
|
1985-03-15 |
1993-06-08 |
Anti-Gene Development Group |
Polynucleotide assay reagent and method
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5506337A
(en)
|
1985-03-15 |
1996-04-09 |
Antivirals Inc. |
Morpholino-subunit combinatorial library and method
|
|
US4828971A
(en)
|
1988-03-24 |
1989-05-09 |
Eastman Kodak Company |
Thermally processable element comprising a backing layer
|
|
CA1251835A
(en)
|
1988-04-05 |
1989-03-28 |
Wai-Cheung Tang |
Dielectric image-resonator multiplexer
|
|
WO1991004753A1
(en)
|
1989-10-02 |
1991-04-18 |
Cetus Corporation |
Conjugates of antisense oligonucleotides and therapeutic uses thereof
|
|
WO1992007065A1
(en)
|
1990-10-12 |
1992-04-30 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Modified ribozymes
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
US5736557A
(en)
|
1994-06-17 |
1998-04-07 |
Hoffman-La Roche, Inc. |
N,N-bis (quinolin-4-yl)-diamine derivatives, their preparation and their use as antimalarials
|
|
US5716824A
(en)
|
1995-04-20 |
1998-02-10 |
Ribozyme Pharmaceuticals, Inc. |
2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
|
|
US5889136A
(en)
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
|
DE69637256T2
(de)
|
1996-01-16 |
2008-06-19 |
Sirna Therapeutics, Inc., Boulder |
Synthese von Methoxynukleoside und enzymatische Nukleisäure Moleküle
|
|
ATE279947T1
(de)
|
1996-03-18 |
2004-11-15 |
Univ Texas |
Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
|
IL138608A0
(en)
|
1998-04-02 |
2001-10-31 |
Genentech Inc |
Antibody variants and fragments thereof
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
WO1999054459A2
(en)
|
1998-04-20 |
1999-10-28 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
GB9816575D0
(en)
|
1998-07-31 |
1998-09-30 |
Zeneca Ltd |
Novel compounds
|
|
CA2328356A1
(en)
|
1999-12-22 |
2001-06-22 |
Itty Atcravi |
Recreational vehicles
|
|
ES2274823T3
(es)
|
1999-12-29 |
2007-06-01 |
Immunogen, Inc. |
Agentes cototoxicos que comprenden doxorrubicinas y daunorrubicinas y su utilizacion terapeutica.
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
|
WO2001083740A2
(en)
|
2000-05-04 |
2001-11-08 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
AU2002257333A1
(en)
|
2002-02-22 |
2003-09-09 |
Linda L. Bambrick |
Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms
|
|
US20040023220A1
(en)
|
2002-07-23 |
2004-02-05 |
Lawrence Greenfield |
Integrated method for PCR cleanup and oligonucleotide removal
|
|
ES2280826T5
(es)
|
2002-08-05 |
2017-08-03 |
Silence Therapeutics Gmbh |
Nuevas formas adicionales de moléculas de ARN de interferencia
|
|
US7923547B2
(en)
|
2002-09-05 |
2011-04-12 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
JP2006507841A
(ja)
|
2002-11-14 |
2006-03-09 |
ダーマコン， インコーポレイテッド |
機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
|
|
US7902160B2
(en)
|
2002-11-25 |
2011-03-08 |
Masafumi Matsuo |
ENA nucleic acid drugs modifying splicing in mRNA precursor
|
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
|
AU2003225410A1
(en)
|
2003-03-21 |
2004-10-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
EP3434275A1
(en)
|
2003-11-06 |
2019-01-30 |
Seattle Genetics, Inc. |
Assay for cancer cells based on the use of auristatin conjugates with antibodies
|
|
PL1766010T3
(pl)
|
2004-06-28 |
2011-07-29 |
Univ Western Australia |
Antysensowne oligonukleotydy do indukcji pominięcia egzonu i sposoby ich zastosowania
|
|
FR2874384B1
(fr)
|
2004-08-17 |
2010-07-30 |
Genethon |
Vecteur viral adeno-associe pour realiser du saut d'exons dans un gene codant une proteine a domaines dispensables
|
|
JP2008519863A
(ja)
|
2004-11-12 |
2008-06-12 |
シアトル ジェネティクス インコーポレイティッド |
Ｎ末端にアミノ安息香酸単位を有するオーリスタチン
|
|
US7429482B2
(en)
|
2005-01-13 |
2008-09-30 |
United States Of America As Represented By The Department Of Veterans Affairs |
Screening tools for discovery of novel anabolic agents
|
|
US20090312532A1
(en)
|
2005-04-22 |
2009-12-17 |
Van Deutekom Judith Christina |
Modulation of exon recognition in pre-mrna by interfering with the binding of sr proteins and by interfering with secodary rna structure
|
|
US7736647B2
(en)
|
2005-06-15 |
2010-06-15 |
Monoclonal Antibodies Therapeutics |
Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells
|
|
WO2007028065A2
(en)
|
2005-08-30 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
|
ES2645410T3
(es)
|
2006-05-10 |
2017-12-05 |
Sarepta Therapeutics, Inc. |
Análogos de oligonucleótidos que tienen enlaces intersubunitarios catiónicos
|
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
|
JP6047270B2
(ja)
|
2006-08-11 |
2016-12-21 |
バイオマリン テクノロジーズ ベー．フェー． |
Ｄｎａリピートの不安定性に関連した遺伝的障害を治療するための方法及び手段
|
|
US9063129B2
(en)
*
|
2007-06-15 |
2015-06-23 |
Idexx Laboratories, Inc. |
Device, kit and method for hookworm antigen capture and detection
|
|
WO2009005793A2
(en)
|
2007-06-29 |
2009-01-08 |
Avi Biopharma, Inc. |
Tissue specific peptide conjugates and methods
|
|
EP2203173B1
(en)
*
|
2007-10-26 |
2015-12-23 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
US20110065774A1
(en)
|
2008-01-31 |
2011-03-17 |
Alnylam Pharmaceuticals |
Chemically modified oligonucleotides and uses thereof
|
|
WO2009099991A2
(en)
|
2008-01-31 |
2009-08-13 |
The Brigham And Women's Hospital, Inc. |
Treatment of cancer
|
|
EP2265283B1
(en)
|
2008-03-18 |
2014-09-03 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
|
EP3604533A1
(en)
|
2008-04-11 |
2020-02-05 |
Arbutus Biopharma Corporation |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
EP2119783A1
(en)
*
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US20110130346A1
(en)
*
|
2008-05-30 |
2011-06-02 |
Isis Innovation Limited |
Peptide conjugates for delvery of biologically active compounds
|
|
EP2283029A1
(en)
|
2008-06-04 |
2011-02-16 |
Medical Research Council |
Peptides
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
CN105779453A
(zh)
|
2008-10-24 |
2016-07-20 |
萨雷普塔治疗公司 |
用于dmd的多外显子跳跃组合物
|
|
AU2013204438B2
(en)
|
2008-10-24 |
2016-12-22 |
Sarepta Therapeutics, Inc. |
Multiple exon skipping compositions for DMD
|
|
PT2344637E
(pt)
|
2008-10-27 |
2015-03-23 |
Academisch Ziekenhuis Leiden |
Métodos e meios para o salto eficiente do exão 45 no pré-mrna de distrofia muscular de duchenne
|
|
KR101602431B1
(ko)
|
2008-11-05 |
2016-03-10 |
삼성전자 주식회사 |
냉장고
|
|
SG171914A1
(en)
|
2008-12-02 |
2011-07-28 |
Chiralgen Ltd |
Method for the synthesis of phosphorus atom modified nucleic acids
|
|
WO2010115033A2
(en)
|
2009-04-02 |
2010-10-07 |
Regents Of The University Of Minnesota |
Nucleotide repeat expansion-associated polypeptides and uses thereof
|
|
JP2012523225A
(ja)
|
2009-04-10 |
2012-10-04 |
アソシアシオン・アンスティテュ・ドゥ・ミオロジー |
疾患の処置のためのトリシクロ−ｄｎａアンチセンスオリゴヌクレオチド、組成物及び方法
|
|
EP2421971B1
(en)
|
2009-04-24 |
2016-07-06 |
BioMarin Technologies B.V. |
Oligonucleotide comprising an inosine for treating dmd
|
|
JP2012526130A
(ja)
|
2009-05-05 |
2012-10-25 |
アルテルムネ テクフノロジエス，エルエルシー |
化学的にプログラム可能な免疫
|
|
US20110269665A1
(en)
|
2009-06-26 |
2011-11-03 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
EP2473607A2
(en)
*
|
2009-08-31 |
2012-07-11 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Exon skipping therapy for functional amelioration of semi functional dystrophin in becker and duchenne muscular dystrophy
|
|
AU2010303415B2
(en)
|
2009-10-07 |
2015-02-19 |
Macrogenics, Inc. |
Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
|
|
BR122023023194A2
(pt)
*
|
2009-11-12 |
2023-12-26 |
The University Of Western Australia |
Oligonucleotídeo antissentido, composição e respectivo uso
|
|
WO2011078797A2
(en)
|
2009-12-22 |
2011-06-30 |
Singapore Health Services Pte. Ltd |
Antisense oligonucleotides and uses threreof
|
|
EP2558578B1
(en)
|
2010-04-13 |
2015-10-28 |
Life Technologies Corporation |
Compositions and methods for inhibition of nucleic acids function
|
|
JP5870400B2
(ja)
|
2010-04-15 |
2016-03-01 |
シアトル ジェネティクス，インコーポレーテッド |
標的化ピロロベンゾジアゼピンコンジュゲート
|
|
ES2623057T3
(es)
|
2010-04-15 |
2017-07-10 |
Medimmune Limited |
Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
|
|
KR102182663B1
(ko)
|
2010-05-28 |
2020-11-25 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
|
IT1400425B1
(it)
*
|
2010-06-08 |
2013-05-31 |
Amsterdam Molecular Therapeutics Bv |
Modified snrnas for use in therapy.
|
|
AU2011263642B2
(en)
|
2010-06-11 |
2014-09-04 |
Isarna Therapeutics Gmbh |
Method for selective oligonucleotide modification
|
|
EP3489360A3
(en)
|
2010-07-19 |
2019-08-28 |
Ionis Pharmaceuticals, Inc. |
Modulation of nuclear-retained rna
|
|
EP3766975A1
(en)
|
2010-10-29 |
2021-01-20 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
|
US8501930B2
(en)
|
2010-12-17 |
2013-08-06 |
Arrowhead Madison Inc. |
Peptide-based in vivo siRNA delivery system
|
|
CA2826836A1
(en)
|
2011-02-08 |
2012-08-16 |
The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Medical Center |
Antisense oligonucleotides
|
|
ES2692268T5
(en)
|
2011-03-29 |
2025-02-26 |
Roche Glycart Ag |
Antibody fc variants
|
|
SG10201605401WA
(en)
*
|
2011-04-01 |
2016-08-30 |
Wyeth Llc |
Antibody-drug conjugates
|
|
US20140128449A1
(en)
|
2011-04-07 |
2014-05-08 |
The Board Of Regents Of The University Of Texas System |
Oligonucleotide modulation of splicing
|
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
CN103534272B
(zh)
|
2011-05-09 |
2016-05-11 |
株式会社英仙蛋白质科学 |
能够特异性识别转铁蛋白受体的抗体
|
|
EP2732035A2
(en)
|
2011-07-15 |
2014-05-21 |
Sarepta Therapeutics, Inc. |
Methods and compositions for manipulating translation of protein isoforms from alternative initiation start sites
|
|
US9605019B2
(en)
|
2011-07-19 |
2017-03-28 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
US9418216B2
(en)
|
2011-07-21 |
2016-08-16 |
Microsoft Technology Licensing, Llc |
Cloud service authentication
|
|
AU2012300633B2
(en)
|
2011-08-30 |
2017-04-27 |
United Kingdom Research And Innovation |
Cell- penetrating peptides having a central hydrophobic domain
|
|
US9526798B2
(en)
|
2011-10-14 |
2016-12-27 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
IL303831A
(en)
|
2011-11-18 |
2023-08-01 |
Alnylam Pharmaceuticals Inc |
Adapted RNAI factors
|
|
CN118581086A
(zh)
|
2012-01-27 |
2024-09-03 |
比奥马林技术公司 |
用于治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
|
|
US10010623B2
(en)
|
2012-02-16 |
2018-07-03 |
Ucl Business Plc |
Lysosome-cleavable linker
|
|
AR090905A1
(es)
|
2012-05-02 |
2014-12-17 |
Merck Sharp & Dohme |
Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica
|
|
EP3925627A1
(en)
|
2012-05-15 |
2021-12-22 |
Concortis Biosystems, Corp |
Drug-conjugates and uses thereof
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
EP2870246B1
(en)
|
2012-07-03 |
2019-09-11 |
BioMarin Technologies B.V. |
Oligonucleotide for the treatment of muscular dystrophy patients
|
|
CN112007045B
(zh)
|
2012-07-13 |
2026-01-06 |
波涛生命科学有限公司 |
手性控制
|
|
ES2738310T3
(es)
|
2012-10-12 |
2020-01-21 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de las mismas
|
|
AU2012395148B2
(en)
|
2012-11-24 |
2016-10-27 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
|
|
JP2016502858A
(ja)
|
2012-12-20 |
2016-02-01 |
サレプタ セラピューティクス， インコーポレイテッド |
筋ジストロフィを処置するための改善されたエキソンスキッピング組成物
|
|
KR20150119848A
(ko)
|
2012-12-21 |
2015-10-26 |
바이오얼라이언스 씨.브이. |
친수성 자기-희생 링커 및 그것의 포합체
|
|
US9481905B2
(en)
|
2013-02-19 |
2016-11-01 |
Orizhan Bioscience Limited |
Method of using neutrilized DNA (N-DNA) as surface probe for high throughput detection platform
|
|
US9319764B2
(en)
|
2013-03-08 |
2016-04-19 |
Merry Electronics Co., Ltd. |
MEMS microphone packaging structure
|
|
EA202090946A3
(ru)
|
2013-03-14 |
2021-07-30 |
Сарепта Терапьютикс, Инк. |
Композиции, обеспечивающие пропускание экзонов, для лечения мышечной дистрофии
|
|
NZ631289A
(en)
|
2013-03-15 |
2017-08-25 |
Sarepta Therapeutics Inc |
Improved compositions for treating muscular dystrophy
|
|
EP3964237B1
(en)
|
2013-03-15 |
2026-02-18 |
Regeneron Pharmaceuticals, Inc. |
Biologically active molecules, conjugates thereof, and therapeutic uses
|
|
US9577459B2
(en)
|
2013-03-15 |
2017-02-21 |
Sequana Medical Ag |
Systems and methods for regulating inductive energy transfer to an implantable system
|
|
EP2777714A1
(en)
|
2013-03-15 |
2014-09-17 |
NBE-Therapeutics LLC |
Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
|
|
US9295731B2
(en)
|
2013-04-01 |
2016-03-29 |
Mark Quang Nguyen |
Cleavable drug conjugates, compositions thereof and methods of use
|
|
US9849066B2
(en)
|
2013-04-24 |
2017-12-26 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
GB2529356B
(en)
|
2013-04-28 |
2020-12-23 |
Genequantum Healthcare Co Ltd |
Novel linkers, coupling intermediates, conjugates, preparation method and application thereof
|
|
EA038367B1
(ru)
|
2013-05-20 |
2021-08-16 |
Дженентек, Инк. |
АНТИТЕЛА ПРОТИВ РЕЦЕПТОРА ТРАНСФЕРРИНА (TfR) И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ
|
|
RU2655439C2
(ru)
|
2013-05-31 |
2018-05-28 |
Займворкс Инк. |
Гетеромультимеры с уменьшенной или подавленной эффекторной функцией
|
|
ES3029138T3
(en)
|
2013-06-05 |
2025-06-23 |
Univ Duke |
Rna-guided gene editing and gene regulation
|
|
WO2014197854A1
(en)
|
2013-06-06 |
2014-12-11 |
Igenica Biotherapeutics, Inc. |
Novel linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
WO2015038426A1
(en)
|
2013-09-13 |
2015-03-19 |
Asana Biosciences, Llc |
Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
|
|
EP3052654A4
(en)
|
2013-09-30 |
2017-05-03 |
The Regents of the University of California |
Identification of structurally similar small molecules that enhance therapeutic exon skipping
|
|
EP3057610B1
(en)
|
2013-10-15 |
2021-09-22 |
Sorrento Therapeutics, Inc. |
Drug-conjugates with a targeting molecule and two different drugs
|
|
AU2014337555C1
(en)
|
2013-10-15 |
2021-01-28 |
Seagen Inc. |
PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics
|
|
EP3610884B1
(en)
|
2013-11-06 |
2021-08-18 |
Merck Sharp & Dohme Corp. |
Peptide containing conjugates for dual molecular delivery of oligonucleotides
|
|
WO2015075747A1
(en)
|
2013-11-19 |
2015-05-28 |
Council Of Scientific And Industrial Research |
Cell-penetrating peptide for biomolecule delivery
|
|
KR102423317B1
(ko)
|
2014-01-16 |
2022-07-22 |
웨이브 라이프 사이언시스 리미티드 |
키랄 디자인
|
|
RU2730681C2
(ru)
*
|
2014-03-12 |
2020-08-24 |
Ниппон Синяку Ко., Лтд. |
Антисмысловые нуклеиновые кислоты
|
|
AU2015277924B2
(en)
|
2014-06-17 |
2021-02-25 |
National Center Of Neurology And Psychiatry |
Antisense nucleic acids
|
|
US20180305689A1
(en)
|
2015-04-22 |
2018-10-25 |
Mina Therapeutics Limited |
Sarna compositions and methods of use
|
|
CN114681621B
(zh)
*
|
2015-05-19 |
2024-08-06 |
萨勒普塔医疗公司 |
肽寡核苷酸缀合物
|
|
CR20210429A
(es)
|
2015-06-24 |
2021-09-24 |
Hoffmann La Roche |
ANTICUERPOS ANTI-RECEPTOR DE TRANSFERRINA CON AFINIDAD DISEÑADA (Divisional 2017-0562)
|
|
TWI741988B
(zh)
*
|
2015-07-31 |
2021-10-11 |
日商新力股份有限公司 |
堆疊式透鏡結構及其製造方法，以及電子裝置
|
|
US20190054113A1
(en)
|
2015-09-30 |
2019-02-21 |
Sarepta Therapeutics, Inc. |
Methods for treating muscular dystrophy
|
|
GB2545898B
(en)
|
2015-12-21 |
2019-10-09 |
Sutura Therapeutics Ltd |
Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides
|
|
JP2019515874A
(ja)
|
2016-03-01 |
2019-06-13 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
改変された細胞死誘導を有するオビヌツズマブ変異体
|
|
KR102775461B1
(ko)
|
2016-04-01 |
2025-02-28 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩타이드 조성물 및 이의 용도
|
|
US20190249173A1
(en)
|
2016-05-04 |
2019-08-15 |
Chandra Vargeese |
Methods and compositions of biologically active agents
|
|
US20190240346A1
(en)
*
|
2016-06-20 |
2019-08-08 |
Genahead Bio, Inc. |
Antibody-drug conjugate
|
|
WO2018002812A1
(en)
|
2016-06-29 |
2018-01-04 |
Crispr Therapeutics Ag |
Materials and methods for treatment of myotonic dystrophy type 1 (dm1) and other related disorders
|
|
US10074359B2
(en)
|
2016-11-01 |
2018-09-11 |
Google Llc |
Dynamic text-to-speech provisioning
|
|
LT3554553T
(lt)
|
2016-12-19 |
2022-08-25 |
Sarepta Therapeutics, Inc. |
Egzoną šalinantys oligomero konjugatai nuo raumenų distrofojos
|
|
CN110381980A
(zh)
|
2017-01-06 |
2019-10-25 |
艾维迪提生物科学有限责任公司 |
核酸-多肽组合物以及诱导外显子跳读的方法
|
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
|
MA50269A
(fr)
|
2017-09-22 |
2020-07-29 |
Avidity Biosciences Inc |
Compositions d'acides nucléiques-polypeptides et méthodes d'induction de saut d'exon
|
|
CN118638788A
(zh)
|
2017-12-06 |
2024-09-13 |
艾维迪提生物科学公司 |
治疗肌萎缩和强直性肌营养不良的组合物和方法
|
|
WO2019232302A1
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Optoelectronic memristor devices
|
|
US12371694B2
(en)
|
2018-11-14 |
2025-07-29 |
University Of Hawaii |
Compositions and methods for the synthesis and identification of covalent aptamers
|
|
IL319265A
(en)
|
2018-12-21 |
2025-04-01 |
Avidity Biosciences Inc |
Anti-transferrin receptor antibodies and their uses
|
|
CA3137715A1
(en)
|
2019-04-25 |
2020-10-29 |
Avidity Biosciences, Inc. |
Nucleic acid compositions and methods of multi-exon skipping
|
|
WO2021003573A1
(en)
|
2019-07-09 |
2021-01-14 |
The Governors Of The University Of Alberta |
Exons 45-55 skipping using mutation-tailored cocktails of antisense morpholinos in the dmd gene
|
|
CA3163608A1
(en)
|
2020-01-10 |
2021-07-15 |
Romesh R. Subramanian |
Muscle-targeting complexes and uses thereof
|
|
US20250302979A1
(en)
|
2021-04-02 |
2025-10-02 |
Avidity Biosciences, Inc. |
Antibody-oligonucleotide conjugate and antibody-peptide-oligonucleotide conjugate compositions and methods of inducing exon skipping
|
|
US12071621B2
(en)
|
2022-04-05 |
2024-08-27 |
Avidity Biosciences, Inc. |
Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping
|