JP2018526029A5 - - Google Patents

Download PDF

Info

Publication number
JP2018526029A5
JP2018526029A5 JP2018530661A JP2018530661A JP2018526029A5 JP 2018526029 A5 JP2018526029 A5 JP 2018526029A5 JP 2018530661 A JP2018530661 A JP 2018530661A JP 2018530661 A JP2018530661 A JP 2018530661A JP 2018526029 A5 JP2018526029 A5 JP 2018526029A5
Authority
JP
Japan
Prior art keywords
seq
nos
primer pair
primers
methylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018530661A
Other languages
English (en)
Japanese (ja)
Other versions
JP6871926B2 (ja
JP2018526029A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/049653 external-priority patent/WO2017040627A1/en
Publication of JP2018526029A publication Critical patent/JP2018526029A/ja
Publication of JP2018526029A5 publication Critical patent/JP2018526029A5/ja
Priority to JP2021069789A priority Critical patent/JP2021118711A/ja
Application granted granted Critical
Publication of JP6871926B2 publication Critical patent/JP6871926B2/ja
Priority to JP2023085323A priority patent/JP7771126B2/ja
Priority to JP2025023534A priority patent/JP2025081468A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018530661A 2015-08-31 2016-08-31 胃の新生物を検出すること Active JP6871926B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021069789A JP2021118711A (ja) 2015-08-31 2021-04-16 胃の新生物を検出すること
JP2023085323A JP7771126B2 (ja) 2015-08-31 2023-05-24 胃の新生物を検出すること
JP2025023534A JP2025081468A (ja) 2015-08-31 2025-02-17 胃の新生物を検出すること

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562212221P 2015-08-31 2015-08-31
US62/212,221 2015-08-31
PCT/US2016/049653 WO2017040627A1 (en) 2015-08-31 2016-08-31 Detecting gastric neoplasm

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021069789A Division JP2021118711A (ja) 2015-08-31 2021-04-16 胃の新生物を検出すること

Publications (3)

Publication Number Publication Date
JP2018526029A JP2018526029A (ja) 2018-09-13
JP2018526029A5 true JP2018526029A5 (https=) 2019-08-08
JP6871926B2 JP6871926B2 (ja) 2021-05-19

Family

ID=58103876

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018530661A Active JP6871926B2 (ja) 2015-08-31 2016-08-31 胃の新生物を検出すること
JP2021069789A Pending JP2021118711A (ja) 2015-08-31 2021-04-16 胃の新生物を検出すること
JP2023085323A Active JP7771126B2 (ja) 2015-08-31 2023-05-24 胃の新生物を検出すること
JP2025023534A Pending JP2025081468A (ja) 2015-08-31 2025-02-17 胃の新生物を検出すること

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021069789A Pending JP2021118711A (ja) 2015-08-31 2021-04-16 胃の新生物を検出すること
JP2023085323A Active JP7771126B2 (ja) 2015-08-31 2023-05-24 胃の新生物を検出すること
JP2025023534A Pending JP2025081468A (ja) 2015-08-31 2025-02-17 胃の新生物を検出すること

Country Status (8)

Country Link
US (4) US10006093B2 (https=)
EP (1) EP3344784A4 (https=)
JP (4) JP6871926B2 (https=)
KR (3) KR102892240B1 (https=)
CN (2) CN108138235B (https=)
AU (2) AU2016315924B2 (https=)
CA (1) CA2992790A1 (https=)
WO (1) WO2017040627A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
ES2859645T3 (es) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
EP4234722A3 (en) 2014-03-31 2023-09-20 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
CN108138235B (zh) 2015-08-31 2022-04-15 梅约医药教育及研究基金会 检测胃肿瘤
AU2016343937B2 (en) 2015-10-30 2023-01-19 Exact Sciences Corporation Multiplex amplification detection assay and isolation and detection of DNA from plasma
WO2017171548A1 (en) * 2016-04-01 2017-10-05 Nanomed Diagnostics B.V. Detection of cancer in urine
US10370726B2 (en) * 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
US10975443B2 (en) 2017-11-30 2021-04-13 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
KR102085669B1 (ko) * 2019-01-02 2020-03-06 한국 한의학 연구원 Cyp26c1 유전자의 메틸화 수준을 이용한 소혈관폐색증의 예측 또는 진단을 위한 정보제공방법 및 이를 위한 조성물
AU2019200359A1 (en) * 2019-01-18 2020-09-10 Clinical Genomics Pty Ltd Screening method
US12584177B2 (en) 2019-01-24 2026-03-24 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
EP3948292A4 (en) * 2019-04-03 2023-01-18 Mayo Foundation for Medical Education and Research DETECTION OF DUCTAL PANCREATIC CARCINOMA IN PLASMA
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
CN114375340A (zh) * 2019-05-31 2022-04-19 通用诊断公司 结肠直肠癌的检测
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
JP7646577B2 (ja) * 2019-06-21 2025-03-17 ユニヴェルシテ・パリ・シテ 胃癌を診断するための高メチル化遺伝子の検出
CN110423814A (zh) * 2019-07-19 2019-11-08 江苏元丞生物科技有限公司 Elmo1基因甲基化检测试剂盒及其应用
CA3154354A1 (en) 2019-10-31 2021-05-06 William R. Taylor Detecting ovarian cancer
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN111549129B (zh) * 2020-03-30 2023-08-29 宁波美康盛德医学检验所有限公司 用于检测胃癌的试剂盒及其应用
US20220071605A1 (en) * 2020-04-17 2022-03-10 Exact Sciences Development Company, Llc Sampling device and analysis of methylated dna
WO2021228418A1 (en) 2020-05-15 2021-11-18 Universal Diagnostics, S.L. Methods and systems for identifying methylation biomarkers
WO2022002424A1 (en) 2020-06-30 2022-01-06 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
AU2022213409A1 (en) * 2021-01-29 2023-08-17 Exact Sciences Corporation Detecting the presence or absence of multiple types of cancer
CN115433778B (zh) * 2021-06-02 2023-06-16 武汉艾米森生命科技有限公司 一种用于检测结直肠癌或结直肠腺瘤相关基因甲基化的检测试剂、试剂盒及其应用
CN113308544B (zh) * 2021-06-04 2022-07-05 武汉艾米森生命科技有限公司 用于dna甲基化检测的试剂及食管癌检测试剂盒
CN114317740B (zh) * 2021-11-24 2024-01-23 博尔诚(北京)科技有限公司 用于胃癌筛查的标志物、探针组合物及其应用
CN118389691A (zh) * 2022-06-29 2024-07-26 广州市基准医疗有限责任公司 用于诊断胃癌的甲基化生物标记物组合、试剂盒及用途
US12606872B2 (en) 2022-11-16 2026-04-21 Universal Diagnostics, S.A. Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers
CN115976210B (zh) * 2022-12-08 2024-05-28 深圳市晋百慧生物有限公司 用于胃癌诊断和筛查的试剂盒、方法及其用途
CN117126942B (zh) * 2023-10-05 2026-01-06 上海奕谱生物科技有限公司 可用于肿瘤鉴定的新型DNA甲基化标志物TAGMe-3及其用途

Family Cites Families (379)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683890A (en) 1970-10-02 1972-08-15 Charles B Beal Carrier system for delivery of an end of an elongated member to the upper gastrointestinal tract
US4437975A (en) 1977-07-20 1984-03-20 Mobil Oil Corporation Manufacture of lube base stock oil
US4259964A (en) 1979-07-09 1981-04-07 Levine Robert A Device for obtaining stool samples
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
EP0070366B1 (de) 1981-07-16 1985-08-28 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zum Nachweisen von okkultem Humanblut in Humanstuhlproben
US4445235A (en) 1982-09-13 1984-05-01 Pearl Slover Stool specimen collector
AU529210B3 (en) 1983-02-02 1983-04-14 Australian Monoclonal Development Pty. Ltd. Monoclonal antibody in occult blood diagnosis
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4859610A (en) 1985-06-05 1989-08-22 Synbiotics Corporation Immunoassay incubation device
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US4735214A (en) 1986-09-05 1988-04-05 Berman Irwin R Gastrointestinal diagnostic capsule and method of use
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US5198365A (en) 1987-02-04 1993-03-30 International Immunoassay Laboratories, Inc. Fecal sample immunoassay method testing for hemoglobin
EP0281251A3 (en) 1987-02-04 1988-09-28 International Immunoassay Laboratories, Inc. A method for preparing a fecal sample composition for immunoassay testing
CA1340843C (en) 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
CA2005589C (en) 1988-12-16 2001-02-06 Akzo Nobel Nv Self-sustained, sequence replication system
US6800617B1 (en) 1989-03-29 2004-10-05 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US6677312B1 (en) 1989-03-29 2004-01-13 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
US5196167A (en) 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5137806A (en) 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
BR9106702A (pt) 1990-07-27 1993-06-08 Isis Pharmaceuticals Inc Analogo de oligonucleotideos e processos para modular a producao de uma proteina por um organismo e para tratar um organismo
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
AU645915B2 (en) 1991-07-23 1994-01-27 F. Hoffmann-La Roche Ag Improvements in the in situ PCR
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
AU3222793A (en) 1991-11-26 1993-06-28 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5965362A (en) 1992-03-04 1999-10-12 The Regents Of The University Of California Comparative genomic hybridization (CGH)
US5338671A (en) 1992-10-07 1994-08-16 Eastman Kodak Company DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody
ES2105698T3 (es) 1993-03-30 1997-10-16 Sanofi Sa Oligonucleotidos modificados con 7-deazapurina.
AU6632094A (en) 1993-04-19 1994-11-08 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
WO1995014106A2 (en) 1993-11-17 1995-05-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
AU1061395A (en) 1993-11-30 1995-06-19 Mcgill University Inhibition of dna methyltransferase
US5851770A (en) 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
AU693198B2 (en) 1994-04-25 1998-06-25 Avitech Diagnostics, Inc. Detection of mutation by resolvase cleavage
WO1996020287A2 (en) 1994-12-23 1996-07-04 Behringwerke Aktiengesellschaft Detection of nucleic acids by target-catalyzed product formation
US5882867A (en) 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
JP2001517925A (ja) 1995-12-22 2001-10-09 ベーリングウエルケ、アクティエンゲゼルシャフト 核酸の均質増幅および検出
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5612473A (en) 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
IL116824A0 (en) 1996-01-19 1996-05-14 Huliot Plastics Ind System for the collection and transportation of a pasty material sample
US7122364B1 (en) 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5891651A (en) 1996-03-29 1999-04-06 Mayo Foundation For Medical Education And Research Methods of recovering colorectal epithelial cells or fragments thereof from stool
EP0892808B1 (en) 1996-04-12 2008-05-14 PHRI Properties, Inc. Detection probes, kits and assays
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6143529A (en) 1996-08-14 2000-11-07 Exact Laboratories, Inc. Methods for improving sensitivity and specificity of screening assays
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
WO1998008869A1 (fr) 1996-08-27 1998-03-05 Kyowa Hakko Kogyo Co., Ltd. Facteur de croissance des cellules souches hematopoietiques (scgf)
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
WO1998023733A2 (en) 1996-11-27 1998-06-04 University Of Washington Thermostable polymerases having altered fidelity
US6251594B1 (en) 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US20090077685A1 (en) 1998-06-16 2009-03-19 Buehler Robert E Nucleic acid molecules and other molecules associated with plants
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
AU753273B2 (en) 1998-02-04 2002-10-10 Variagenics, Inc. Mismatch detection techniques
US6235502B1 (en) 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
AU752817B2 (en) 1999-02-25 2002-10-03 Exact Sciences Corporation Methods for preserving DNA integrity
US6335193B1 (en) 1999-04-15 2002-01-01 Padmanabhan P Nair Isolated colonocytes
AUPQ254199A0 (en) 1999-08-31 1999-09-23 University Of Western Australia, The Methods and devices for obtaining samples from hollow viscera
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US20060084054A1 (en) 1999-09-27 2006-04-20 John Alsobrook Novel proteins and nucleic acids encoding same
WO2001042781A2 (en) 1999-12-07 2001-06-14 Exact Sciences Corporation Supracolonic aerodigestive neoplasm detection
US6434762B2 (en) 2000-01-10 2002-08-20 Steven N. Gordon Stool collecting apparatus
US6329178B1 (en) 2000-01-14 2001-12-11 University Of Washington DNA polymerase mutant having one or more mutations in the active site
WO2001075172A1 (en) 2000-03-31 2001-10-11 University Of Southern California Epigenetic sequences for esophageal adenocarcinoma
BRPI0001536B1 (pt) 2000-04-04 2015-09-29 Fundacao Oswaldo Cruz método para diagnosticar a infecção por parasitos do genero schistosoma e kit para uso no diagnóstico da infecção por schistosoma sp
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
WO2002000926A2 (en) 2000-06-30 2002-01-03 Epigenomics Ag Diagnosis of diseases associated with signal transduction
DE10037769A1 (de) 2000-08-03 2002-02-21 Epigenomics Gmbh Diagnose von mit CD24 assoziierten Krankheiten
EP1942197A1 (de) 2000-09-01 2008-07-09 Epigenomics AG Verfahren zur Bestimmung des Methylierungsgrades von bestimmten Cytosinen in genomischer DNA im Sequenzkontext 5'-CpG-3'
US20050064401A1 (en) 2000-09-01 2005-03-24 Alexander Olek Diagnosis of illnesses or predisposition to certain illnesses
US20050021240A1 (en) 2000-11-02 2005-01-27 Epigenomics Ag Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen based on the methylation status of the DNA
CA2428798C (en) 2000-11-15 2013-09-03 Third Wave Technologies, Inc. Fen-1 endonucleases from archaeoglobus veneficus
US6582665B2 (en) 2001-01-25 2003-06-24 Biomedical Polymers, Inc. Universal collection and transfer system
US20020137086A1 (en) 2001-03-01 2002-09-26 Alexander Olek Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylation status of the genes
US6558907B2 (en) 2001-05-16 2003-05-06 Corning Incorporated Methods and compositions for arraying nucleic acids onto a solid support
ATE324830T1 (de) 2001-05-17 2006-06-15 Faergklaemman Ab Probenentnahmevorrichtung und verfahren zur entnahme von proben von körpersubstanzen sowie verfahren zur herstellung einer probenentnahmevorrichtung
GB2375964B (en) 2001-05-31 2003-12-24 Intermark Medical Innovations A device for colonic lavage
JP2004529363A (ja) 2001-06-05 2004-09-24 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア 膵臓に基づく脂肪吸収不良障害を診断するための方法およびキット
ITPS20010019A1 (it) 2001-06-26 2002-12-26 Muretto Pietro Aurelio Gaetano Capsula endogastrica
AU2002342004A1 (en) 2001-10-05 2003-04-22 Case Western Reserve University Methods and compositions for detecting colon cancers
US7482118B2 (en) 2001-11-15 2009-01-27 Third Wave Technologies, Inc. Endonuclease-substrate complexes
US20030157556A1 (en) 2002-02-13 2003-08-21 Maggiore Jack A. Biological fluid stabilizing composition and method of use thereof
IL163732A0 (en) 2002-03-07 2005-12-18 Univ Johns Hopkins Genomic screen for epigenetically silenced tumor suppressor genes
EP1497462A4 (en) 2002-03-07 2007-11-07 Univ Johns Hopkins Med GENOMIC SCREEN ON EPIGENETIC MUTED CANCER ASSOCIATED GENES
US20030186248A1 (en) 2002-03-29 2003-10-02 Erlander Mark G. Interpreting cytological specimens via molecular histological signatures
ITMI20020287U1 (it) 2002-05-31 2003-12-01 Sentinel Ch S R L Tubo di estrazione per la raccolta di campioni di feci
US6921370B2 (en) 2002-07-25 2005-07-26 Alfa Scientific Designs, Inc. Specimen collection and storage and transport device and method
US7662594B2 (en) 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
ATE437962T1 (de) 2002-10-01 2009-08-15 Epigenomics Ag Verfahren für die behandlung von proliferativen erkrankungen von brustzellen
AU2003295511A1 (en) 2002-11-13 2004-06-03 Genentech, Inc. Methods and compositions for diagnosing dysplasia
US8323897B2 (en) 2002-12-04 2012-12-04 Applied Biosystems, Llc Multiplex amplification of polynucleotides
WO2004067726A2 (en) 2003-01-29 2004-08-12 Keck Graduate Institute Isothermal reactions for the amplification of oligonucleotides
CA2519456A1 (en) 2003-03-17 2004-09-30 Michael G. Goggins Aberrantly methylated genes in pancreatic cancer
DE60330505D1 (de) 2003-03-19 2010-01-21 Hamamatsu Found Sci & Tech Pro Verfahren zur erkennung eines kolonkrebsmarkers
US20040194206A1 (en) 2003-04-01 2004-10-07 Kieturakis Maciej J. Screening methods and kits for gastrointestinal diseases
EP2345745A1 (en) 2003-06-23 2011-07-20 Epigenomics AG Methods and nucleic acids for analyses of colorectal cell proliferative disorders
GB0318702D0 (en) 2003-08-08 2003-09-10 Neill Ian O Method and apparatus for removing cellular material from faecal stools and container for collecting faecal stools
WO2005017207A2 (en) 2003-08-14 2005-02-24 Case Western Reserve University Methods and compositions for detecting colon cancers
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
EP2354253A3 (en) 2003-09-05 2011-11-16 Trustees of Boston University Method for non-invasive prenatal diagnosis
DE10345021A1 (de) 2003-09-23 2005-05-04 Univ Potsdam Verfahren zur nichtinvasiven Früherkennung von Dickdarmkrebs und/oder Darmkrebsvorläuferzellen
US20050075543A1 (en) 2003-10-03 2005-04-07 Calabrese Charles A. Method of anonymous medical testing and providing the patient with the test results
ES2432025T3 (es) 2003-10-09 2013-11-29 Epigenomics Ag Conversión mejorada de ADN con bisulfito
US20050186588A1 (en) 2003-10-16 2005-08-25 Third Wave Technologies, Inc. Direct nucleic acid detection in bodily fluids
US7371527B1 (en) 2003-10-21 2008-05-13 Johns Hopkins University School Of Medicine Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer
US20080039413A1 (en) 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
WO2005042713A2 (en) 2003-10-28 2005-05-12 The Johns Hopkins University Quantitative multiplex methylation-specific pcr
MXPA05001815A (es) 2004-02-20 2005-08-24 Hoffmann La Roche Adsorcion de acidos nucleicos a una fase solida.
SI3296407T1 (sl) 2004-03-02 2019-09-30 The Johns Hopkins University Mutacije gena PIK3CA pri rakih pri ljudeh
JP2005304497A (ja) * 2004-03-25 2005-11-04 Joji Inasawa 特定の癌関連遺伝子を用いる癌の検出方法及び癌の抑制方法
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US7381547B2 (en) 2004-04-28 2008-06-03 Tzam Diagnostics, Llc Methods and compositions to detect bacteria using multiplex PCR
US20080124714A1 (en) 2004-05-14 2008-05-29 Exact Sciences Corporation Method for Stabilizing Biological Samples for Nucleic Acid Analysis
CA2565405A1 (en) 2004-06-18 2005-12-29 F. Hoffmann-La Roche Ag Use of protein cbp2 as a marker for colorectal cancer
GB0415277D0 (en) 2004-07-07 2004-08-11 Colonix Ltd Apparatus and method for sampling mucosal surfaces
US7563598B2 (en) 2004-07-30 2009-07-21 Ambergen, Inc. Detection of truncation mutations by mass spectrometry
US20070048748A1 (en) 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
US7195878B2 (en) 2004-09-30 2007-03-27 Cryo-Genomics Device and method for fecal testing
EP1815021A2 (en) 2004-11-03 2007-08-08 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
MX2007005364A (es) 2004-11-03 2008-01-22 Third Wave Tech Inc Ensayo de deteccion de una sola etapa.
WO2006084132A2 (en) 2005-02-01 2006-08-10 Agencourt Bioscience Corp. Reagents, methods, and libraries for bead-based squencing
WO2006084078A2 (en) 2005-02-02 2006-08-10 Raven Biotechnologies, Inc. Jam-3 and antibodies that bind thereto
EP1848999A4 (en) 2005-02-16 2012-05-30 Gao Ping Epitope Diagnostics FECAL SAMPLE TESTING DEVICE AND METHODS OF USE THEREOF
WO2006094149A2 (en) 2005-03-01 2006-09-08 Exact Sciences Corporation Methods and compositions for detecting adenoma
US20060210448A1 (en) 2005-03-10 2006-09-21 Naishu Wang Fecal specimen collection, preserving and transport device and method
US7569183B2 (en) 2005-03-28 2009-08-04 Alfresa Pharma Corporation Fecal assay method and analyzer
US8309303B2 (en) 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
EP1712639B1 (en) 2005-04-06 2008-08-27 Maurice Stroun Method for the diagnosis of cancer by detecting circulating DNA and RNA
EP1869222A4 (en) 2005-04-15 2010-01-20 Oncomethylome Sciences S A METHYLATION MARKERS FOR THE DIAGNOSIS AND TREATMENT OF CANCER
WO2006113770A1 (en) 2005-04-15 2006-10-26 Epigenomics Ag A method for providing dna fragments derived from a remote sample
ES2446250T3 (es) 2005-05-02 2014-03-06 University Of Southern California Marcadores de metilación del ADN asociados con el fenotipo metilador de islas CpG (CIMP) en el cáncer colorrectal humano
US8114587B2 (en) 2005-06-23 2012-02-14 Ambergen, Inc. Methods for the detection of colorectal cancer
US7779489B2 (en) 2005-07-19 2010-08-24 Finell Rebecca M Potty bench with storage
US7851154B2 (en) 2005-07-22 2010-12-14 Simon Daniel Spivack GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra
US7288413B2 (en) 2005-08-12 2007-10-30 Beckman Coulter, Inc. Combined chemical and immunochemical fecal occult blood test
CN101292046B (zh) 2005-09-14 2013-03-13 人类遗传标记控股有限公司 健康状态的测定法
GB0521521D0 (en) 2005-10-21 2005-11-30 Medical Res Council Diagnostic methods and kits
US7514219B2 (en) 2005-11-16 2009-04-07 The Wistar Institute Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma
NZ593226A (en) 2006-01-11 2012-10-26 Genomic Health Inc Gene expression markers (efnb2) for colorectal cancer prognosis
US7794656B2 (en) 2006-01-23 2010-09-14 Quidel Corporation Device for handling and analysis of a biological sample
TR201910868T4 (tr) 2006-02-02 2019-08-21 Univ Leland Stanford Junior Dijital analizle invazif olmayan fetal genetik tarama.
JP4490382B2 (ja) 2006-02-28 2010-06-23 富士フイルム株式会社 感熱転写受像シートおよびその製造方法
US7829283B2 (en) 2006-03-29 2010-11-09 John Wayne Cancer Institute Methylation of estrogen receptor alpha and uses thereof
CN2902916Y (zh) * 2006-04-03 2007-05-23 漳明霖 瓦楞复合卡板托盘
WO2007116417A1 (en) 2006-04-07 2007-10-18 Silvia Sabbioni Novel dna methylation markers useful for the diagnosis of neoplastic diseases
CN101495654A (zh) 2006-04-19 2009-07-29 阿普里拉股份有限公司 无凝胶珠基测序的试剂、方法和文库
DE602007007209D1 (de) 2006-05-19 2010-07-29 Roche Diagnostics Gmbh Verwendung des proteins s100a 12 als marker für kolorektalkarzinom
EP2021515A4 (en) 2006-05-26 2010-06-02 Meltzer Stephen J METHYLATED PROMOTERS AS BIOMARKERS OF COLON CANCER
WO2009035447A1 (en) 2006-06-14 2009-03-19 Living Microsystems, Inc. Diagnosis of fetal abnormalities by comparative genomic hybridization analysis
WO2008010975A2 (en) 2006-07-14 2008-01-24 The Johns Hopkins University Early detection and prognosis of colon cancers
US9939441B2 (en) 2006-07-21 2018-04-10 Epigenomics Ag Methods and nucleic acids for analyses for cellular proliferative disorders
US7492199B2 (en) 2006-07-28 2009-02-17 International Business Machines Corporation Fully synchronous DLL with architected update window
US8158356B2 (en) 2006-10-16 2012-04-17 Agrigenomics, Inc. Screening for the genetic defect causing tibial hemimelia in bovines
US20090018031A1 (en) 2006-12-07 2009-01-15 Switchgear Genomics Transcriptional regulatory elements of biological pathways tools, and methods
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20090203011A1 (en) 2007-01-19 2009-08-13 Epigenomics Ag Methods and nucleic acids for analyses of cell proliferative disorders
US20090075264A1 (en) 2007-02-02 2009-03-19 Orion Genomics Llc Gene methylation in liver cancer diagnosis
CA2676227A1 (en) 2007-02-12 2008-08-21 The Johns Hopkins University Early detection and prognosis of colon cancers
CN104846092A (zh) 2007-02-21 2015-08-19 奥斯陆大学医院Hf 新型癌症标记物
US20080213870A1 (en) 2007-03-01 2008-09-04 Sean Wuxiong Cao Methods for obtaining modified DNA from a biological specimen
US20080227208A1 (en) 2007-03-16 2008-09-18 Hsiao-Ching Yee Devices and Methods for Detection of Occult Blood
WO2009034481A2 (en) 2007-04-16 2009-03-19 Korea Research Institute Of Bioscience And Biotechnology Methylation biomarker for early detection of gastric cancer
US8623599B2 (en) 2007-06-08 2014-01-07 Epigenomics Ag Method for methylation analysis
FR2919065B1 (fr) 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage de l'apolipoproteine ai pour le diagnostic in vitro du cancer colorectal
FR2919063B1 (fr) 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage du leucocyte elastase inhibitor pour le diagnostic in vitro du cancer colorectal.
CA2693098C (fr) 2007-07-19 2019-06-18 Yasemin Ataman-Onal Procede de dosage de la proteine de liaison hepatique aux acides gras, de l'antigene carcino-embryonnaire, et de l'antigene carbohydrate 19-9 pour le diagnostic in vitro du cancercolorectal
CN101353695B (zh) 2007-07-23 2013-05-01 上海市肿瘤研究所 尿沉淀dna甲基化谱式分析诊断膀胱癌的方法和试剂盒
CA2699853A1 (en) 2007-09-17 2009-03-26 Oncomethylome Sciences Sa Improved detection of mage-a expression
JP2009095262A (ja) 2007-10-15 2009-05-07 Japan Found Cancer Res Znフィンガータンパク質
JP5422108B2 (ja) 2007-10-16 2014-02-19 栄研化学株式会社 ヘムタンパク質の安定化方法及び保存溶液
US9428746B2 (en) 2007-10-31 2016-08-30 Akonni Biosystems, Inc. Method and kit for purifying nucleic acids
WO2009064481A1 (en) 2007-11-14 2009-05-22 Stc.Unm Identification of novel subgroups of high-risk pediatric precursor b acute lymphoblastic leukemia, outcome correlations and diagnostic and therapeutic methods related to same
DK2082745T3 (da) 2007-12-28 2013-03-25 Deutsches Krebsforsch Kræftterapi med en parvovirus kombineret med kemoterapi
EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US8256177B2 (en) 2008-03-12 2012-09-04 Masonite Corporation Impact resistant door skin, door including the same, and method of manufacturing an impact resistant door skin from a pre-formed door skin
WO2009114836A1 (en) 2008-03-14 2009-09-17 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
WO2009117327A2 (en) 2008-03-15 2009-09-24 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
EP2128169A1 (de) 2008-05-30 2009-12-02 Qiagen GmbH Verfahren zur Isolierung von kurzkettigen Nukleinsäuren
WO2009153667A2 (en) * 2008-06-17 2009-12-23 Occure Gmbh Method for the detection of ovarian cancer
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
WO2010037001A2 (en) 2008-09-26 2010-04-01 Immune Disease Institute, Inc. Selective oxidation of 5-methylcytosine by tet-family proteins
WO2010062914A1 (en) 2008-11-26 2010-06-03 The Johns Hopkins University Methods for identifying cancer risk
WO2010074924A1 (en) 2008-12-23 2010-07-01 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
WO2010083179A2 (en) 2009-01-16 2010-07-22 Monsanto Technology Llc Isolated novel nucleic acid and protein molecules from soybeans and methods of using those molecules to generate transgenic plants with enhanced agronomic traits
EP2233590A1 (en) 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Methylation assay
DK2394170T3 (en) 2009-02-03 2015-07-13 Mdxhealth Sa Methods for detecting colorectal cancer
IL313131A (en) 2009-02-11 2024-07-01 Caris Mpi Inc Molecular characterization of tumors
WO2010113529A1 (ja) 2009-04-03 2010-10-07 国立大学法人山口大学 大腸腫瘍の検出方法
WO2010136163A1 (en) 2009-05-29 2010-12-02 Roche Diagnostics Gmbh Secernin-1 as a marker for cancer
JP5757572B2 (ja) * 2009-07-03 2015-07-29 国立大学法人 東京大学 癌細胞の存否を判定する方法および癌患者の予後を判定する方法
CN102021233B (zh) 2009-09-22 2014-06-04 复旦大学附属华山医院 一种定量检测akap12甲基化水平的方法及其应用
US20120164110A1 (en) 2009-10-14 2012-06-28 Feinberg Andrew P Differentially methylated regions of reprogrammed induced pluripotent stem cells, method and compositions thereof
KR101142131B1 (ko) 2009-11-05 2012-05-11 (주)지노믹트리 장암 진단을 위한 장암 특이적 메틸화 마커 유전자의 메틸화 검출방법
GB0920014D0 (en) 2009-11-13 2009-12-30 Medical Res Council Cell sampling device
US8709736B2 (en) 2010-07-09 2014-04-29 Medical Research Council Biomarker for Barrett's Oesophagus
CA3043089A1 (en) 2009-11-23 2011-05-26 Genomic Health, Inc. Methods to predict clinical outcome of cancer
DE102010043541B4 (de) 2009-12-16 2012-01-26 Technische Universität Dresden Verfahren und Mittel zur Vorhersage der Überlebensdauer beim Pankreaskarzinom durch Analyse von Biomarkern
WO2011084108A1 (en) 2010-01-08 2011-07-14 Agency For Science, Technology And Research Methods and compositions for treating cancer
US20110236916A1 (en) 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
WO2011126768A2 (en) 2010-03-29 2011-10-13 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal cancer and adenoma
WO2011127136A1 (en) 2010-04-06 2011-10-13 University Of Chicago Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc)
US20110256538A1 (en) 2010-04-15 2011-10-20 Philadelphia Health & Education Corporation D/B/A Drexel University College Of Medicine Epigenomic dna modifications for tissue typing, early cancer detection, and disease management
WO2011133935A2 (en) 2010-04-22 2011-10-27 The Johns Hopkins University Methods and kits for risk assessment of barrett's neoplastic progression
WO2011139920A2 (en) 2010-04-29 2011-11-10 Life Technologies Corporation Methylation-specific competitive allele-specific taqman polymerase chain reaction (cast-pcr)
WO2011150075A2 (en) 2010-05-25 2011-12-01 The Johns Hopkins University Compositions and methods for detecting a neoplasia
WO2012012693A2 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
US20140045915A1 (en) 2010-08-31 2014-02-13 The General Hospital Corporation Cancer-related biological materials in microvesicles
BR112013005929B1 (pt) 2010-09-13 2021-02-09 Clinical Genomics Pty. Ltd. métodos de triagem de início ou predisposição para início de neoplasma do intestino grosso ou monitoramento do progresso de neoplasma em indivíduo
WO2012037128A2 (en) 2010-09-14 2012-03-22 The University Of North Carolina At Chapel Hill Methods and kits for detecting melanoma
WO2012047899A2 (en) 2010-10-04 2012-04-12 The Johns Hopkins University Novel dna hypermethylation diagnostic biomarkers for colorectal cancer
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
EP2655664A2 (en) 2010-12-21 2013-10-30 Sloan-Kettering Institute for Cancer Research Epigenomic markers of cancer metastasis
EP2481813A1 (en) 2011-02-01 2012-08-01 Centro di Riferimento Oncologico - Istituto Nazionale Tumori - Aviano Markers of cutaneous melanoma and uses thereof
EP3441479B1 (en) 2011-02-02 2020-09-02 Exact Sciences Development Company, LLC Digital sequence analysis of dna methylation
US20140057262A1 (en) 2011-03-14 2014-02-27 Mayo Foundation For Medical Education And Research Methods and materials for using the contents of phagocytes to detect neoplasms
EP2702173A1 (en) 2011-04-25 2014-03-05 OSI Pharmaceuticals, LLC Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
CN103649298A (zh) 2011-05-12 2014-03-19 精密科学公司 核酸的分离
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
US8980107B2 (en) 2011-05-12 2015-03-17 Exact Sciences Corporation Spin filter
WO2012167145A2 (en) 2011-06-01 2012-12-06 University Of Southern California Genome-scale analysis of aberrant dna methylation in colorectal cancer
US20130022974A1 (en) 2011-06-17 2013-01-24 The Regents Of The University Of Michigan Dna methylation profiles in cancer
WO2012175562A2 (en) 2011-06-21 2012-12-27 University Of Tartu Methylation and microrna markers of early-stage non-small cell lung cancer
WO2013012781A2 (en) 2011-07-15 2013-01-24 The Johns Hopkins University Genome-wide methylation analysis and use to identify genes specific to breast cancer hormone receptor status and risk of recurrence
NZ621638A (en) 2011-08-25 2016-03-31 Clinical Genomics Pty Ltd Dna methylation in colorectal and breast cancer diagnostic methods
WO2013033213A1 (en) 2011-08-30 2013-03-07 The J. David Gladstone Institutes Methods for generating cardiomyocytes
WO2013033627A2 (en) 2011-09-01 2013-03-07 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
US9575073B2 (en) 2011-10-10 2017-02-21 Rutgers, The State University Of New Jersey Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma
WO2013058868A2 (en) 2011-10-18 2013-04-25 Exact Sciences Corporation Multiplexed kras mutation detection assay
WO2013070950A1 (en) 2011-11-08 2013-05-16 University Of Southern California Identification of a dna methylation marker for blood-based detection of ovarian cancer
GB201120162D0 (en) 2011-11-22 2012-01-04 Medical Res Council Methods for detection of benign conditions
KR20140100938A (ko) * 2011-11-30 2014-08-18 도쿠리츠교세이호진 고쿠리츠간켄큐센터 유도 악성 줄기세포
US9546403B1 (en) 2011-12-14 2017-01-17 University Of Utah Research Foundation Substrate for methylated DNA testing
WO2013098797A2 (en) 2011-12-31 2013-07-04 Kuriakose Moni Abraham Diagnostic tests for predicting prognosis, recurrence, resistance or sensitivity to therapy and metastatic status in cancer
DK2809810T3 (da) 2012-01-06 2020-02-03 Viomics Inc System og fremgangsmåde til påvisning i perifert blod af rna'er der er forandret af lungecancer
KR20140114415A (ko) 2012-01-13 2014-09-26 제넨테크, 인크. Vegf 길항제로의 치료를 위한 환자를 확인하기 위한 생물학적 마커
CA2863215C (en) 2012-01-30 2021-05-04 Exact Sciences Corporation Modification of dna on magnetic beads
WO2013130880A1 (en) 2012-02-28 2013-09-06 The Johns Hopkins University Hypermethylated gene markers for head and neck cancer
CA2865087A1 (en) 2012-03-15 2013-09-19 Mayo Foundation For Medical Education And Research Methods and materials for noninvasive detection of colorectal neoplasia associated with inflammatory bowel disease
WO2013142545A1 (en) 2012-03-20 2013-09-26 Exact Sciences Corporation Marker panel for detecting cancer
US9375202B2 (en) 2012-05-04 2016-06-28 Given Imaging Ltd. Device and method for in vivo cytology acquisition
GB201208874D0 (en) 2012-05-18 2012-07-04 Medical Res Council Methods
MX2014014356A (es) 2012-05-24 2015-07-06 Fundació Inst D Investigació Biomédica De Bellvitge Idibell Metodo para la identificacion del origen de un cancer de origen primario desconocido.
US10106854B2 (en) 2012-06-14 2018-10-23 Aarhus Universitet Biomarkers for prostate cancer
EP2698436A1 (en) 2012-08-14 2014-02-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Colorectal cancer markers
GB2533006B (en) 2012-09-04 2017-06-07 Guardant Health Inc Systems and methods to detect copy number variation
EP2899275B1 (en) 2012-09-19 2018-06-27 Sysmex Corporation Method for obtaining information about endometrial cancer, and marker and kit for obtaining information about endometrial cancer
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
EP2900837A4 (en) 2012-09-26 2016-06-01 Agency Science Tech & Res BIOMARKERS FOR THE PRENATAL DIAGNOSIS OF THE DOWN SYNDROME
US10233495B2 (en) 2012-09-27 2019-03-19 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
WO2014062218A1 (en) 2012-10-16 2014-04-24 University Of Southern California Colorectal cancer dna methylation markers
EP2922861A4 (en) 2012-11-26 2016-09-14 Caris Life Sciences Switzerland Holdings Gmbh BIOMARKER COMPOSITIONS AND METHODS
US10648035B2 (en) 2012-11-26 2020-05-12 The Johns Hopkins University Methods and compositions for diagnosing and treating gastric cancer
EP2929350A4 (en) 2012-12-04 2016-11-16 Caris Mpi Inc MOLECULAR PROFILING OF CANCER
TWI500770B (zh) 2013-02-20 2015-09-21 Univ Taipei Medical Hoxa9基因作為檢測肝癌生物標記的用途
JP2014161308A (ja) * 2013-02-27 2014-09-08 St Marianna Univ School Of Medicine 胃癌の検出又は胃癌発症のリスク評価のための指標を得る方法
WO2014134607A1 (en) 2013-03-01 2014-09-04 The Johns Hopkins University Dual sequence-capture method for quantifying trans renal hpv dna in urine
EP2971171A4 (en) 2013-03-14 2016-11-02 Abbott Molecular Inc SYSTEMS AND METHODS FOR MULTIPLEX AMPLIFICATION SPECIFIC TO METHYLATION
US20140274757A1 (en) 2013-03-14 2014-09-18 Marie K. Kirby Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer
ES2859645T3 (es) * 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
US20140322243A1 (en) 2013-04-26 2014-10-30 The Translational Genomics Research Institute Methods of detecting breast cancer brain metastasis with genomic and epigenomic biomarkers
US10679730B2 (en) 2013-05-28 2020-06-09 The University Of Chicago Prognostic and predictive breast cancer signature
JP6369857B2 (ja) 2013-05-29 2018-08-08 シスメックス株式会社 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット
WO2015066695A1 (en) 2013-11-04 2015-05-07 Exact Sciences Corporation Multiple-control calibrators for dna quantitation
US20150259750A1 (en) 2013-11-26 2015-09-17 Genetic Research Institute Of The Desert Gene-gene model for estimating cancer susceptibility, risk of multiple tumor sites, and the aggressiveness of prostate cancer
EP4209600A1 (en) 2013-12-19 2023-07-12 Exact Sciences Corporation Synthetic nucleic acid control molecules
CN106232833A (zh) 2014-01-30 2016-12-14 加利福尼亚大学董事会 用于非侵入性诊断的甲基化单体型分析(monod)
EP4234722A3 (en) * 2014-03-31 2023-09-20 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
US9871506B2 (en) * 2014-04-16 2018-01-16 Qualcomm Incorporated Switchable decoupling capacitors
US20160010081A1 (en) 2014-07-11 2016-01-14 Exact Sciences Corporation Systems, methods and kits for extracting nucleic acid from digestive fluid
EP3189156B1 (en) 2014-08-08 2020-10-07 AIT Austrian Institute of Technology GmbH Thyroid cancer diagnosis by dna methylation analysis
US10292687B2 (en) 2014-08-15 2019-05-21 Covidien Lp Designs and methods to facilitate swallowing of a tethered cell collection device
WO2016041010A1 (en) 2014-09-15 2016-03-24 Garvan Institute Of Medical Research Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor
US10792020B2 (en) 2014-09-18 2020-10-06 Covidien Lp Tapered geometry in a compressible cell collection device
US11096677B2 (en) 2014-09-18 2021-08-24 Covidien Lp Regions of varying physical properties in a compressible cell collection device
US10751033B2 (en) 2014-09-18 2020-08-25 Covidien Lp Use of expansion-force elements in a compressible cell collection device
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2016094839A2 (en) * 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
ES2879964T3 (es) 2014-12-12 2021-11-23 Exact Sciences Dev Co Llc Composiciones y métodos para realizar ensayos de detección de metilación
EP3034624A1 (en) 2014-12-18 2016-06-22 Hospital Clínic de Barcelona Method for the prognosis of hepatocellular carcinoma
EP3239302A4 (en) 2014-12-26 2018-05-23 Peking University Method for detecting differentially methylated cpg islands associated with abnormal state of human body
WO2016109712A1 (en) 2014-12-31 2016-07-07 Case Western Reserve University Methods and compositions for detecting esophageal neoplasias and/or metaplasias in the esophagus
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN107532124B (zh) * 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
CN104762301B (zh) 2015-04-24 2017-12-26 武汉大学 一种检测肝癌风险基因tspyl5甲基化水平的试剂盒及方法
KR101693547B1 (ko) 2015-04-28 2017-01-06 서울대학교산학협력단 경구투여용 위장관 검체 채취 장치 및 방법
WO2016179751A1 (zh) 2015-05-08 2016-11-17 京信通信技术(广州)有限公司 有源das系统近端机的信号备份系统和方法
US11401552B2 (en) 2015-08-06 2022-08-02 University Of Utah Research Foundation Methods of identifying male fertility status and embryo quality
CN108138235B (zh) 2015-08-31 2022-04-15 梅约医药教育及研究基金会 检测胃肿瘤
AU2016343937B2 (en) 2015-10-30 2023-01-19 Exact Sciences Corporation Multiplex amplification detection assay and isolation and detection of DNA from plasma
JP6877704B2 (ja) 2015-11-16 2021-05-26 公立大学法人名古屋市立大学 膵臓癌の検出のための方法及びキット
CN109312404A (zh) 2016-01-29 2019-02-05 表观基因组股份有限公司 用于检测血液样品中肿瘤来源DNA的CpG甲基化的方法
US11162139B2 (en) 2016-03-02 2021-11-02 Shanghai Epican Genetech Co. Ltd. Method for genomic profiling of DNA 5-methylcytosine and 5-hydroxymethylcytosine
MX391039B (es) 2016-04-07 2025-03-21 Univ Leland Stanford Junior Diagnostico no invasivo por medio de la secuenciacion del adn libre de celulas 5-hidroxi-metilado.
CA3020628A1 (en) 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
EP4488686A3 (en) 2016-04-14 2025-04-30 Guardant Health, Inc. Methods for early detection of cancer
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
EP3452101A2 (en) 2016-05-04 2019-03-13 CureVac AG Rna encoding a therapeutic protein
CN116064796A (zh) 2016-05-05 2023-05-05 精密科学公司 通过分析甲基化dna来检测肺肿瘤
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
ES2915074T3 (es) 2016-05-31 2022-06-20 Translational Genomics Res Inst Métodos de marcaje molecular y bibliotecas de secuenciación
AU2017281099A1 (en) 2016-06-21 2019-01-03 The Wistar Institute Of Anatomy And Biology Compositions and methods for diagnosing lung cancers using gene expression profiles
EP3488004B1 (en) 2016-07-19 2021-10-06 Exact Sciences Development Company, LLC Methylated control dna
CN109790198B (zh) 2016-09-02 2022-09-09 梅约医学教育与研究基金会 检测肝细胞癌
US20180087113A1 (en) 2016-09-27 2018-03-29 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
PL3336197T3 (pl) 2016-12-16 2022-08-08 Eurofins Genomics Europe Sequencing GmbH Markery epigenetyczne oraz powiązane sposoby i środki wykrywania i leczenia raka jajnika
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
WO2018144562A1 (en) 2017-01-31 2018-08-09 University Of Kansas Imaging and collection device and related systems and methods
CN110431241B (zh) 2017-02-28 2024-04-19 梅约医学教育与研究基金会 检测前列腺癌
WO2019010429A1 (en) 2017-07-07 2019-01-10 The Trustees Of The University Of Pennsylvania METHODS OF DIAGNOSING PANCREATIC CANCER
IL319255A (en) 2017-08-07 2025-04-01 Univ Johns Hopkins Methods and materials for cancer assessment and treatment
WO2019035100A2 (en) 2017-08-18 2019-02-21 University Of Southern California PROGNOSTIC MARKERS OF CANCER RECIDIVE
US10975443B2 (en) 2017-11-30 2021-04-13 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
JP7136899B2 (ja) 2018-01-08 2022-09-13 ルドウイグ インスティテュート フォー キャンサー リサーチ エルティーディー シトシン修飾の、亜硫酸水素塩非含有、塩基分解能特定
US20230272474A1 (en) 2018-01-19 2023-08-31 The University Of North Carolina At Chapel Hill Methylation markers for melanoma and uses thereof
RU2020127753A (ru) 2018-01-22 2022-02-24 Джонсон энд Джонсон Консьюмер Инк. Перфорированные капсулы
CN119753091A (zh) 2018-04-02 2025-04-04 格里尔公司 用于扩增与癌症相关联的cfDNA分子的化验板
US20200071767A1 (en) 2018-04-09 2020-03-05 The Trustees Of Columbia University In The City Of New York Barrett's esophagus progression to cancer gene panel and methods of use thereof
SG11202106398WA (en) 2018-11-04 2021-07-29 Pfs Genomics Inc Methods and genomic classifiers for prognosis of breast cancer and predicting benefit from adjuvant radiotherapy
BR112021009795A2 (pt) 2018-11-27 2021-08-17 Exact Sciences Development Company, Llc métodos de caracterização e para caracterizar uma amostra, kit e composição
WO2020118274A1 (en) 2018-12-08 2020-06-11 Pfs Genomics, Inc. Transcriptomic profiling for prognosis of breast cancer
US12584177B2 (en) 2019-01-24 2026-03-24 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
EP3948292A4 (en) 2019-04-03 2023-01-18 Mayo Foundation for Medical Education and Research DETECTION OF DUCTAL PANCREATIC CARCINOMA IN PLASMA
US20220195535A1 (en) 2019-04-16 2022-06-23 The Johns Hopkins University Methods for Detecting and Treating Esophageal Cancer
WO2020236939A2 (en) 2019-05-23 2020-11-26 Paradigm Diagnostics Tissue preparation using nuclease
CA3142023A1 (en) 2019-05-28 2020-12-03 Case Western Reserve University Compositions and methods for preserving dna methylation
GB201908624D0 (en) 2019-06-17 2019-07-31 Vib Vzw Predicting age using dna methylation signatures
WO2020264220A1 (en) 2019-06-25 2020-12-30 The Translational Genomics Research Institute Detection and treatment of residual disease using circulating tumor dna analysis
WO2021041726A1 (en) 2019-08-27 2021-03-04 Exact Sciences Development Company, Llc Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia
WO2021055508A1 (en) 2019-09-16 2021-03-25 Exact Sciences Development Company, Llc Structure and temperature-dependent flap endonuclease substrates
JP7741067B2 (ja) 2019-10-18 2025-09-17 エグザクト サイエンシーズ コーポレーション 複数の分析物を用いた糞便抗原検査
CA3154354A1 (en) 2019-10-31 2021-05-06 William R. Taylor Detecting ovarian cancer
CA3167176A1 (en) 2020-02-07 2021-08-12 Gang Wang Ingestible apparatus and method for collecting samples in the gastrointestinal tract and/or delivering health-related substance thereto
US20220071605A1 (en) 2020-04-17 2022-03-10 Exact Sciences Development Company, Llc Sampling device and analysis of methylated dna
AU2021268333A1 (en) 2020-05-04 2022-11-24 Exact Sciences Corporation Detecting melanoma
EP4146678A4 (en) 2020-05-04 2025-08-27 Mayo Found Medical Education & Res DETECTION OF PANCREATIC NEUROENDOCRINE TUMORS
EP4189086B1 (en) 2020-07-29 2026-03-11 Exact Sciences Corporation Purification of sulfonated dna
EP4200445A4 (en) 2020-08-19 2025-08-27 Mayo Found Medical Education & Res DETECTION OF NON-HODGKIN'S LYMPHOMA
AU2022213409A1 (en) 2021-01-29 2023-08-17 Exact Sciences Corporation Detecting the presence or absence of multiple types of cancer
IL305500A (en) 2021-03-01 2023-10-01 Pfs Genomics Inc Genomic methods and classifiers for predicting breast cancer and identifying patients who may not benefit from radiotherapy
WO2022187695A1 (en) 2021-03-05 2022-09-09 Mayo Foundation For Medical Education And Research Detecting cervical cancer
US20220349009A1 (en) 2021-04-23 2022-11-03 Mayo Foundation For Medical Education And Research Detecting esophageal disorders
US20260071277A1 (en) 2021-11-05 2026-03-12 Mayo Foundation For Medical Education And Research Compositions and methods for detecting oropharyngeal cancer
TW202417642A (zh) 2022-09-16 2024-05-01 大陸商江蘇鵾遠生物科技股份有限公司 鑑別癌症的甲基化標誌物及應用

Similar Documents

Publication Publication Date Title
JP2018526029A5 (https=)
JP2019528704A5 (https=)
JP2019520037A5 (https=)
US10100351B2 (en) High-throughput sequencing detection method for methylated CpG islands
JP2025081468A5 (https=)
Ye et al. High-throughput sequencing in mitochondrial DNA research
JP2025114618A5 (https=)
EP3239302A1 (en) Method for detecting differentially methylated cpg islands associated with abnormal state of human body
Kakar et al. Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma
JP2019517781A5 (https=)
Rechsteiner et al. KRAS, BRAF, and TP53 deep sequencing for colorectal carcinoma patient diagnostics
JPWO2019108626A5 (https=)
CN106399476A (zh) 用于检测非小细胞肺癌的甲基化抑癌基因标志物及其检测方法
CN104694637A (zh) 粪便dna定量甲基化特异性pcr检测试剂盒及其用途
Kumar et al. A novel HRM-based gap-qRT-PCR for identification and quantitation of the vaccine and field strain (s) of lumpy skin disease virus
JPWO2020206256A5 (https=)
Peille et al. Prognostic value of PLAGL1-specific CpG site methylation in soft-tissue sarcomas
Moradi et al. Effects of p53 codon 72 and MDM2 SNP309 polymorphisms on gastric cancer risk among the Iranian population
CN110295234A (zh) 一种获取年龄、预测肿瘤疾病发生的实时荧光pcr试剂盒
RU2010149949A (ru) Тест-система для определения мутаций в генах фумарилацетоацетат гидролазы и альфа-1-антитрипсина человека
JP2011520456A5 (https=)
Kapitskaya et al. MIRA analysis of RARβ2 gene methylation in DNA circulating in the blood in lung cancer
CN108875314B (zh) 一种基于表观遗传学修饰差异的靶基因的检测方法
Rubatino et al. Manipulation of primer affinity improves high-resolution melting accuracy for imprinted genes
CN104726592B (zh) 可用于检测与大肠癌相关的PCDH‑γ‑A12基因启动子区甲基化程度的试剂盒及其应用