JP2019528704A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019528704A5 JP2019528704A5 JP2019512308A JP2019512308A JP2019528704A5 JP 2019528704 A5 JP2019528704 A5 JP 2019528704A5 JP 2019512308 A JP2019512308 A JP 2019512308A JP 2019512308 A JP2019512308 A JP 2019512308A JP 2019528704 A5 JP2019528704 A5 JP 2019528704A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nos
- methylation
- measuring
- genes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023019916A JP7704792B2 (ja) | 2016-09-02 | 2023-02-13 | 肝細胞癌の検出 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662383165P | 2016-09-02 | 2016-09-02 | |
| US62/383,165 | 2016-09-02 | ||
| PCT/US2017/049915 WO2018045322A1 (en) | 2016-09-02 | 2017-09-01 | Detecting hepatocellular carcinoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023019916A Division JP7704792B2 (ja) | 2016-09-02 | 2023-02-13 | 肝細胞癌の検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528704A JP2019528704A (ja) | 2019-10-17 |
| JP2019528704A5 true JP2019528704A5 (https=) | 2020-03-05 |
| JP7293109B2 JP7293109B2 (ja) | 2023-06-19 |
Family
ID=61282051
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512308A Active JP7293109B2 (ja) | 2016-09-02 | 2017-09-01 | 肝細胞癌の検出 |
| JP2023019916A Active JP7704792B2 (ja) | 2016-09-02 | 2023-02-13 | 肝細胞癌の検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023019916A Active JP7704792B2 (ja) | 2016-09-02 | 2023-02-13 | 肝細胞癌の検出 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20180066320A1 (https=) |
| EP (2) | EP3507298B1 (https=) |
| JP (2) | JP7293109B2 (https=) |
| KR (2) | KR102801197B1 (https=) |
| CN (2) | CN116064795A (https=) |
| AU (2) | AU2017318700B2 (https=) |
| CA (1) | CA3034903A1 (https=) |
| ES (1) | ES2956257T3 (https=) |
| WO (1) | WO2018045322A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2816122A1 (en) | 2008-02-15 | 2014-12-24 | Mayo Foundation For Medical Education And Research | Detecting neoplasm from a stool sample |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| CA2902916C (en) | 2013-03-14 | 2018-08-28 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| CN120700143A (zh) | 2014-03-31 | 2025-09-26 | 梅奥医学教育和研究基金会 | 检测结直肠赘生物 |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US10435755B2 (en) | 2015-03-27 | 2019-10-08 | Exact Sciences Development Company, Llc | Detecting esophageal disorders |
| CN114574585A (zh) | 2015-08-31 | 2022-06-03 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| CN108350485A (zh) | 2015-10-30 | 2018-07-31 | 精密科学发展有限责任公司 | 血浆dna的多重扩增检测测定以及分离和检测 |
| CN109563546B (zh) | 2016-05-05 | 2022-09-09 | 精密科学发展有限责任公司 | 通过分析甲基化dna来检测肺肿瘤 |
| KR102892245B1 (ko) | 2017-01-27 | 2025-11-27 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| JP7277460B2 (ja) | 2017-11-30 | 2023-05-19 | マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ | 乳癌の検出 |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| CA3127329A1 (en) | 2019-01-24 | 2020-07-30 | Mayo Foundation For Medical Education And Research | Detecting endometrial cancer |
| KR20210146983A (ko) * | 2019-04-03 | 2021-12-06 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 혈장에서 췌장 관상 선암종의 검출 |
| WO2020214798A1 (en) * | 2019-04-17 | 2020-10-22 | The Brigham And Women's Hospital, Inc. | Epigenetic signatures of alzheimer's disease |
| KR102103885B1 (ko) * | 2019-10-08 | 2020-04-24 | 주식회사 레피다인 | 생물학적 시료의 간 조직 유래 여부를 판별하는 방법 |
| KR102155044B1 (ko) * | 2019-10-08 | 2020-09-11 | 주식회사 레피다인 | 생물학적 시료의 간암 조직 기원 여부를 판별하는 방법 |
| KR102472253B1 (ko) * | 2019-10-14 | 2022-11-30 | 주식회사 젠큐릭스 | 특정 유전자의 CpG 메틸화 변화를 이용한 간암 진단용 조성물 및 이의 용도 |
| CN112176419B (zh) * | 2019-10-16 | 2022-03-22 | 中国医学科学院肿瘤医院 | 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法 |
| US11702704B2 (en) | 2019-10-31 | 2023-07-18 | Mayo Foundation For Medical Education And Research | Detecting ovarian cancer |
| EP4090772A4 (en) * | 2020-01-17 | 2024-07-24 | The Board of Trustees of the Leland Stanford Junior University | Methods for diagnosing hepatocellular carcinoma |
| WO2022018127A1 (en) * | 2020-07-21 | 2022-01-27 | Epigenomics Ag | Methods for detecting liver cancer |
| CN112011619A (zh) * | 2020-09-17 | 2020-12-01 | 山东大学深圳研究院 | Sfrp2作为标志物在乙型肝炎病毒相关肝细胞癌早期诊断中的应用及检测试剂盒 |
| CN114634981B (zh) * | 2020-12-16 | 2024-01-26 | 广州达健生物科技有限公司 | 肝癌基因甲基化检测引物探针组合及其试剂盒与应用 |
| US20240068040A1 (en) * | 2021-01-12 | 2024-02-29 | The Board Of Trustees Of The Leland Stanford Junior University | Layered analysis of methylated biomarkers for use in cancer diagnosis and prognosis |
| CN117355616A (zh) * | 2021-05-21 | 2024-01-05 | 奥弗奥密克斯生物技术研究与开发股份公司 | 用于肝细胞癌的dna甲基化生物标志物 |
| WO2023010129A2 (en) * | 2021-07-30 | 2023-02-02 | Active Genomes Expressed Diagnostics, Corp. | Methods and compositions for treating liver cancer and liver disease |
| CA3235235A1 (en) * | 2021-10-19 | 2023-04-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Dna methylation signature for diagnosing hepatocellular carcinoma |
| CN113897434A (zh) * | 2021-11-02 | 2022-01-07 | 北京艾克伦医疗科技有限公司 | 鉴定肝癌状态的方法和试剂盒 |
| CN113862370B (zh) * | 2021-12-02 | 2022-03-22 | 广州滴纳生物科技有限公司 | 用于筛查肝癌的引物和探针、试剂盒及其应用 |
| CN116287254B (zh) * | 2023-02-22 | 2024-04-30 | 中国人民解放军海军军医大学 | Scrn1在制备肝细胞癌分型诊断或索拉非尼疗效预测试剂盒中的应用 |
| CN116732175A (zh) * | 2023-03-09 | 2023-09-12 | 江苏鹍远生物技术有限公司 | 血浆游离dna甲基化标志物在肝脏肿瘤检测中的用途 |
| EP4678769A1 (en) * | 2023-03-09 | 2026-01-14 | Singlera Health Technologies (Shanghai) Ltd. | Use of plasma cell-free dna methylation marker in liver tumor detection |
| CN116200499B (zh) * | 2023-03-23 | 2024-01-19 | 北京和瑞精湛医学检验实验室有限公司 | 一种用于肝癌检测的基因组合与相关试剂和应用 |
| WO2024222519A1 (zh) * | 2023-04-26 | 2024-10-31 | 博尔诚（北京）科技有限公司 | 用于检测肝癌的组合物及其用途 |
| KR20250160630A (ko) * | 2024-05-07 | 2025-11-14 | 주식회사 지씨지놈 | 대장암 진단용 dna 메틸화 마커 및 이의 용도 |
| CN118685520B (zh) * | 2024-08-26 | 2024-11-26 | 湖南宏雅基因技术有限公司 | 一种肝癌基因甲基化检测的引物探针组合及试剂盒 |
| CN118834956B (zh) * | 2024-09-24 | 2024-12-06 | 上海信诺佰世医学检验有限公司 | 引物和探针组合物、试剂盒及在检测emx1、chfr基因甲基化中的应用 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5288609A (en) | 1984-04-27 | 1994-02-22 | Enzo Diagnostics, Inc. | Capture sandwich hybridization method and composition |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US5359100A (en) | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| CA2036946C (en) | 1990-04-06 | 2001-10-16 | Kenneth V. Deugau | Indexing linkers |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US5849481A (en) | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
| US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US5994069A (en) | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US6872816B1 (en) | 1996-01-24 | 2005-03-29 | Third Wave Technologies, Inc. | Nucleic acid detection kits |
| US5338671A (en) | 1992-10-07 | 1994-08-16 | Eastman Kodak Company | DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody |
| SE501439C2 (sv) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
| WO1995014106A2 (en) | 1993-11-17 | 1995-05-26 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| EP0734436B1 (en) | 1993-11-30 | 1999-04-14 | McGILL UNIVERSITY | Inhibition of dna methyltransferase |
| US5851770A (en) | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
| AU693198B2 (en) | 1994-04-25 | 1998-06-25 | Avitech Diagnostics, Inc. | Detection of mutation by resolvase cleavage |
| ES2185719T3 (es) | 1994-12-23 | 2003-05-01 | Dade Behring Inc | Deteccion de acidos nucleicos por formacion de un producto catalizada por diana. |
| US5882867A (en) | 1995-06-07 | 1999-03-16 | Dade Behring Marburg Gmbh | Detection of nucleic acids by formation of template-dependent product |
| US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| CA2239683A1 (en) | 1995-12-22 | 1997-07-03 | Dade Behring Marburg Gmbh | Homogeneous amplification and detection of nucleic acids |
| US5985557A (en) | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| AU713667B2 (en) | 1996-04-12 | 1999-12-09 | Phri Properties, Inc. | Detection probes, kits and assays |
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US6096273A (en) | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| US6251594B1 (en) | 1997-06-09 | 2001-06-26 | Usc/Norris Comprehensive Cancer Ctr. | Cancer diagnostic method based upon DNA methylation differences |
| US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| DE19754482A1 (de) | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
| US6063573A (en) | 1998-01-27 | 2000-05-16 | Clinical Micro Sensors, Inc. | Cycling probe technology using electron transfer detection |
| EP1053352B1 (en) | 1998-02-04 | 2002-09-18 | Variagenics, Inc. | Mismatch detection techniques |
| US6235502B1 (en) | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
| US7700324B1 (en) | 1998-11-03 | 2010-04-20 | The Johns Hopkins University School Of Medicine | Methylated CpG island amplification (MCA) |
| WO2002002807A2 (en) * | 2000-06-30 | 2002-01-10 | Epigenomics Ag | Diagnosis of diseases associated with cell signalling |
| US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| WO2005023091A2 (en) | 2003-09-05 | 2005-03-17 | The Trustees Of Boston University | Method for non-invasive prenatal diagnosis |
| US20080039413A1 (en) * | 2003-10-21 | 2008-02-14 | Morris David W | Novel compositions and methods in cancer |
| EP3591068A1 (en) | 2006-02-02 | 2020-01-08 | The Board of Trustees of the Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
| JP2009095262A (ja) * | 2007-10-15 | 2009-05-07 | Japan Found Cancer Res | Ｚｎフィンガータンパク質 |
| WO2009117327A2 (en) | 2008-03-15 | 2009-09-24 | Hologic, Inc. | Compositions and methods for analysis of nucleic acid molecules during amplification reactions |
| EP2233590A1 (en) * | 2009-01-28 | 2010-09-29 | AIT Austrian Institute of Technology GmbH | Methylation assay |
| TW201132813A (en) * | 2010-03-03 | 2011-10-01 | Koo Foundation Sun Yat Sen Cancer Ct | Methods for classifying and treating breast cancers |
| US20110256538A1 (en) | 2010-04-15 | 2011-10-20 | Philadelphia Health & Education Corporation D/B/A Drexel University College Of Medicine | Epigenomic dna modifications for tissue typing, early cancer detection, and disease management |
| WO2012037128A2 (en) * | 2010-09-14 | 2012-03-22 | The University Of North Carolina At Chapel Hill | Methods and kits for detecting melanoma |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| US8715937B2 (en) | 2010-11-15 | 2014-05-06 | Exact Sciences Corporation | Mutation detection assay |
| US8916344B2 (en) | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| WO2013033627A2 (en) * | 2011-09-01 | 2013-03-07 | The Regents Of The University Of California | Diagnosis and treatment of arthritis using epigenetics |
| AU2012380717B2 (en) | 2012-05-24 | 2018-08-16 | Fundacio Institucio Catalana De Recerca I Estudis Avancats | Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis |
| JP6269492B2 (ja) * | 2012-09-19 | 2018-01-31 | シスメックス株式会社 | 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット |
| WO2014052855A1 (en) * | 2012-09-27 | 2014-04-03 | Population Diagnostics, Inc. | Methods and compositions for screening and treating developmental disorders |
| CA2902916C (en) * | 2013-03-14 | 2018-08-28 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| JP6369857B2 (ja) * | 2013-05-29 | 2018-08-08 | シスメックス株式会社 | 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット |
| US20160340740A1 (en) * | 2014-01-30 | 2016-11-24 | The Regents Of The University Of California | Methylation haplotyping for non-invasive diagnosis (monod) |
| US10184154B2 (en) * | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| EP3034624A1 (en) * | 2014-12-18 | 2016-06-22 | Hospital Clínic de Barcelona | Method for the prognosis of hepatocellular carcinoma |
| US10435755B2 (en) * | 2015-03-27 | 2019-10-08 | Exact Sciences Development Company, Llc | Detecting esophageal disorders |
| CN104762301B (zh) * | 2015-04-24 | 2017-12-26 | 武汉大学 | 一种检测肝癌风险基因tspyl5甲基化水平的试剂盒及方法 |
| JP7481804B2 (ja) * | 2016-04-14 | 2024-05-13 | マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ | 高度膵異形成の検出 |
-
2017
- 2017-09-01 EP EP17847642.0A patent/EP3507298B1/en active Active
- 2017-09-01 CA CA3034903A patent/CA3034903A1/en active Pending
- 2017-09-01 EP EP23191397.1A patent/EP4293128A3/en active Pending
- 2017-09-01 US US15/694,300 patent/US20180066320A1/en not_active Abandoned
- 2017-09-01 KR KR1020247008512A patent/KR102801197B1/ko active Active
- 2017-09-01 CN CN202210999151.7A patent/CN116064795A/zh active Pending
- 2017-09-01 AU AU2017318700A patent/AU2017318700B2/en active Active
- 2017-09-01 JP JP2019512308A patent/JP7293109B2/ja active Active
- 2017-09-01 CN CN201780053034.9A patent/CN109790198B/zh active Active
- 2017-09-01 KR KR1020197005873A patent/KR102648965B1/ko active Active
- 2017-09-01 WO PCT/US2017/049915 patent/WO2018045322A1/en not_active Ceased
- 2017-09-01 ES ES17847642T patent/ES2956257T3/es active Active
-
2019
- 2019-10-08 US US16/596,513 patent/US20200115761A1/en active Pending
-
2022
- 2022-12-21 AU AU2022291502A patent/AU2022291502C1/en active Active
-
2023
- 2023-02-13 JP JP2023019916A patent/JP7704792B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019528704A5 (https=) | ||
| JP2019520037A5 (https=) | ||
| JP2018526029A5 (https=) | ||
| JP2022526415A5 (https=) | ||
| JP2021503943A5 (https=) | ||
| Mitchell et al. | A panel of genes methylated with high frequency in colorectal cancer | |
| JP2023524740A5 (https=) | ||
| Estécio et al. | Dissecting DNA hypermethylation in cancer | |
| JP2025063204A5 (https=) | ||
| JP2016195614A5 (https=) | ||
| HK1223987A1 (zh) | 用序列标签进行大规模生物分子分析 | |
| Bethge et al. | Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma | |
| HRP20210953T1 (hr) | Postupci i pripravci za određivanje dnk profila | |
| CN113151458A (zh) | 实体瘤甲基化标志物及其用途 | |
| EA202192446A1 (ru) | Диагностика фетальной хромосомной анэуплоидии с использованием геномного секвенирования | |
| JP2008506407A5 (https=) | ||
| NZ596545A (en) | Improved detection of mage-a expression | |
| JP2016512437A5 (https=) | ||
| RU2019109011A (ru) | Композиции и способы с использованием фармакогеномного маркера | |
| DK3105324T3 (en) | NGS SYSTEM CONTROL AND PROCEDURES COMPREHENSIVE THESE | |
| EP3428291A3 (en) | Ion torrent genomic sequencing | |
| Yassi et al. | DMRFusion: A differentially methylated region detection tool based on the ranked fusion method | |
| US20220177973A1 (en) | Methylation modification-based tumor marker stamp-ep6 | |
| Sant et al. | Methods for analysis of DNA methylation | |
| WO2016060537A3 (fr) | Sondes et amorces pour la quantification rapide et fiable des gènes spécifiques au cancer de la prostate en utilisant des gènes contrôles adéquats |