JP2018510207A5 - - Google Patents
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- JP2018510207A5 JP2018510207A5 JP2017560843A JP2017560843A JP2018510207A5 JP 2018510207 A5 JP2018510207 A5 JP 2018510207A5 JP 2017560843 A JP2017560843 A JP 2017560843A JP 2017560843 A JP2017560843 A JP 2017560843A JP 2018510207 A5 JP2018510207 A5 JP 2018510207A5
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 90
- 150000001875 compounds Chemical class 0.000 claims 54
- 201000010099 disease Diseases 0.000 claims 48
- 208000035475 disorder Diseases 0.000 claims 42
- 230000002265 prevention Effects 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 23
- 239000012453 solvate Substances 0.000 claims 23
- -1 perhaloalkyl Chemical group 0.000 claims 22
- 229940002612 prodrug Drugs 0.000 claims 20
- 239000000651 prodrug Substances 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 208000011580 syndromic disease Diseases 0.000 claims 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 11
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 11
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 9
- 206010061218 Inflammation Diseases 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
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- 230000004054 inflammatory process Effects 0.000 claims 8
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- 108091008099 NLRP3 inflammasome Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 6
- 208000023504 respiratory system disease Diseases 0.000 claims 6
- 208000017520 skin disease Diseases 0.000 claims 6
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 4
- 102100026210 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Human genes 0.000 claims 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims 4
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- 206010016207 Familial Mediterranean fever Diseases 0.000 claims 4
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- 101000691589 Homo sapiens 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Proteins 0.000 claims 4
- 206010072219 Mevalonic aciduria Diseases 0.000 claims 4
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- 206010072221 mevalonate kinase deficiency Diseases 0.000 claims 4
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- 208000026082 sterile multifocal osteomyelitis with periostitis and pustulosis Diseases 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 2
- 208000012414 A20 haploinsufficiency Diseases 0.000 claims 2
- 206010000748 Acute febrile neutrophilic dermatosis Diseases 0.000 claims 2
- 208000026326 Adult-onset Still disease Diseases 0.000 claims 2
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- 241000710929 Alphavirus Species 0.000 claims 2
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- 208000022210 Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation Diseases 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 208000009137 Behcet syndrome Diseases 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 206010063094 Cerebral malaria Diseases 0.000 claims 2
- 201000009182 Chikungunya Diseases 0.000 claims 2
- 206010008690 Chondrocalcinosis pyrophosphate Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
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- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 108700036803 Deficiency of interleukin-1 receptor antagonist Proteins 0.000 claims 2
- 208000001490 Dengue Diseases 0.000 claims 2
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- 208000026072 Motor neurone disease Diseases 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 101710126825 NACHT, LRR and PYD domains-containing protein 3 Proteins 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 2
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- 208000006311 Pyoderma Diseases 0.000 claims 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 201000010848 Schnitzler Syndrome Diseases 0.000 claims 2
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- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 206010042496 Sunburn Diseases 0.000 claims 2
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- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
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- 241000700605 Viruses Species 0.000 claims 2
- 241000907316 Zika virus Species 0.000 claims 2
- 208000002223 abdominal aortic aneurysm Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
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- 208000002849 chondrocalcinosis Diseases 0.000 claims 2
- 208000020832 chronic kidney disease Diseases 0.000 claims 2
- 206010009887 colitis Diseases 0.000 claims 2
- 208000024858 congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome Diseases 0.000 claims 2
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- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
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- 201000005956 sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay Diseases 0.000 claims 2
- 230000037432 silent mutation Effects 0.000 claims 2
- 230000000392 somatic effect Effects 0.000 claims 2
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
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- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 1
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
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- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
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- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 0 *c(c1c2***1)c(***1)c1c2NC(NSC1**B[*+]1)=O Chemical compound *c(c1c2***1)c(***1)c1c2NC(NSC1**B[*+]1)=O 0.000 description 3
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021131251A JP7566699B2 (ja) | 2015-02-16 | 2021-08-11 | スルホニル尿素及び関連化合物並びにその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015900507 | 2015-02-16 | ||
| AU2015900507A AU2015900507A0 (en) | 2015-02-16 | Sulfonylureas and related compounds and use of same | |
| PCT/AU2016/050103 WO2016131098A1 (en) | 2015-02-16 | 2016-02-16 | Sulfonylureas and related compounds and use of same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021131251A Division JP7566699B2 (ja) | 2015-02-16 | 2021-08-11 | スルホニル尿素及び関連化合物並びにその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510207A JP2018510207A (ja) | 2018-04-12 |
| JP2018510207A5 true JP2018510207A5 (enExample) | 2019-03-28 |
| JP6929792B2 JP6929792B2 (ja) | 2021-09-01 |
Family
ID=56691944
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560843A Active JP6929792B2 (ja) | 2015-02-16 | 2016-02-16 | スルホニル尿素及び関連化合物並びにその使用 |
| JP2021131251A Active JP7566699B2 (ja) | 2015-02-16 | 2021-08-11 | スルホニル尿素及び関連化合物並びにその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021131251A Active JP7566699B2 (ja) | 2015-02-16 | 2021-08-11 | スルホニル尿素及び関連化合物並びにその使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US10538487B2 (enExample) |
| EP (3) | EP3888749A1 (enExample) |
| JP (2) | JP6929792B2 (enExample) |
| KR (2) | KR20240162585A (enExample) |
| CN (3) | CN113582889B (enExample) |
| AU (3) | AU2016222278B2 (enExample) |
| CA (2) | CA3250390A1 (enExample) |
| CL (2) | CL2017002097A1 (enExample) |
| CY (1) | CY1122832T1 (enExample) |
| DK (2) | DK3578547T3 (enExample) |
| ES (2) | ES2777626T3 (enExample) |
| HR (2) | HRP20200214T1 (enExample) |
| HU (1) | HUE055755T2 (enExample) |
| IL (2) | IL273065B2 (enExample) |
| LT (2) | LT3259253T (enExample) |
| MA (3) | MA47440B1 (enExample) |
| MD (1) | MD3259253T2 (enExample) |
| ME (1) | ME03737B (enExample) |
| MX (2) | MX2017010528A (enExample) |
| MY (2) | MY193765A (enExample) |
| NZ (1) | NZ733948A (enExample) |
| PE (2) | PE20180160A1 (enExample) |
| PL (2) | PL3578547T3 (enExample) |
| PT (2) | PT3578547T (enExample) |
| RS (2) | RS60048B1 (enExample) |
| RU (1) | RU2739356C2 (enExample) |
| SG (2) | SG11201706664QA (enExample) |
| SI (2) | SI3259253T1 (enExample) |
| SM (1) | SMT202000192T1 (enExample) |
| WO (1) | WO2016131098A1 (enExample) |
Families Citing this family (136)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY193765A (en) * | 2015-02-16 | 2022-10-27 | Univ Queensland | Sulfonylureas and related compounds and use of same |
| FR3046933B1 (fr) * | 2016-01-25 | 2018-03-02 | Galderma Research & Development | Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires |
| US11858922B2 (en) * | 2016-02-16 | 2024-01-02 | The University Of Queensland | Sulfonylureas and related compounds and use of same |
| JP7050751B2 (ja) | 2016-04-18 | 2022-04-08 | ノバルティス アーゲー | Ｎｌｒｐ活性に関連する状態を処置するための化合物および組成物 |
| WO2018103583A1 (en) * | 2016-12-05 | 2018-06-14 | Zibo Anxuan Pharmaceutical Science And Technology Co., Ltd. | N-hydroxy-benzene-sulfonamide derivatives and their uses thereof |
| JP7163293B2 (ja) | 2017-01-23 | 2022-10-31 | ジェネンテック， インコーポレイテッド | インターロイキン－１活性の阻害剤としての化学化合物 |
| GB2561540A (en) | 2017-03-13 | 2018-10-24 | Nodthera Ltd | Chemical compounds |
| US11840543B2 (en) | 2017-05-24 | 2023-12-12 | The University Of Queensland | Compounds and uses |
| US11236045B2 (en) | 2017-06-09 | 2022-02-01 | Cadila Healthcare Limited | Substituted sulfoximine compounds |
| HRP20220195T1 (hr) * | 2017-07-07 | 2022-04-15 | Inflazome Limited | Novi spojevi sulfonamid karboksamida |
| WO2019008029A1 (en) * | 2017-07-07 | 2019-01-10 | Inflazome Limited | SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3 |
| CN111793060B (zh) * | 2017-07-14 | 2023-06-06 | 先天肿瘤免疫公司 | Nlrp3调节剂 |
| EP3658538B1 (en) * | 2017-07-24 | 2023-04-19 | Novartis AG | Compounds and compositions for treating conditions associated with nlrp activity |
| CN117209447A (zh) | 2017-07-24 | 2023-12-12 | 诺华股份有限公司 | 用于治疗与nlrp活性相关的病症的化合物和组合物 |
| GB201712282D0 (en) * | 2017-07-31 | 2017-09-13 | Nodthera Ltd | Selective inhibitors of NLRP3 inflammasome |
| DE102017118230B4 (de) * | 2017-08-10 | 2021-04-22 | Christoph Lucks | Verfahren zur Analyse und/oder Überwachung von Brücken sowie entsprechendes System und entsprechende Verwendung |
| TW201910317A (zh) | 2017-08-15 | 2019-03-16 | 愛爾蘭商英弗雷佐姆有限公司 | 新穎化合物 |
| CN111132974B (zh) * | 2017-08-15 | 2023-11-21 | 英夫拉索姆有限公司 | 新颖的磺酰胺羧酰胺化合物 |
| PE20200758A1 (es) | 2017-08-15 | 2020-07-27 | Inflazome Ltd | Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3 |
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