MX2018009840A - Sulfonilureas y compuestos relacionados y sus usos. - Google Patents

Sulfonilureas y compuestos relacionados y sus usos.

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Publication number
MX2018009840A
MX2018009840A MX2018009840A MX2018009840A MX2018009840A MX 2018009840 A MX2018009840 A MX 2018009840A MX 2018009840 A MX2018009840 A MX 2018009840A MX 2018009840 A MX2018009840 A MX 2018009840A MX 2018009840 A MX2018009840 A MX 2018009840A
Authority
MX
Mexico
Prior art keywords
present
compounds
formula
independently selected
relates
Prior art date
Application number
MX2018009840A
Other languages
English (en)
Inventor
Cooper Matthew
Robertson Avril
Schroder Kate
Coll Rebecca
O''neill Luke
Murray Macleod Angus
John Miller David
Original Assignee
Univ Queensland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2016900535A external-priority patent/AU2016900535A0/en
Application filed by Univ Queensland filed Critical Univ Queensland
Publication of MX2018009840A publication Critical patent/MX2018009840A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

La presente invencion hace referencia a compuestos de formula (I), y sales, solvatos y profarmacos farmaceuticamente aceptable de estos: (ver fórmula) en los que Q se selecciona de O, S y Se; J es S o Se; W1 y W2, cuando se encuentran presentes, se seleccionan de forma independiente de N y C; R1 y R2 se seleccionan de forma independiente del grupo que consiste en hidrogeno, alquilo C1-C12, alquenilo C2-C12, alquinilo C2-C12, arilo, heterociclilo, heteroarilo, cicloalquilo, cicloalquenilo, amino, amido, alquiltio, acilo, arilalquilo y acilamido, todos los cuales se pueden encontrar opcionalmente sustituidos; y en los que al menos uno de W1 y W2 se encuentra presente y es un atomo de nitrogeno y cuando R1 o R2 son restos ciclicos, W1 o W2 puede formar parte de la estructura anular. La presente invencion tambien hace referencia a composiciones farmaceuticas que incluyen dichos compuestos, a metodos de tratamiento que emplean dichos compuestos, en particular, en lo que respecta a trastornos mediados por inflamasoma NLRP3, y a usos diagnosticos asociados.
MX2018009840A 2016-02-16 2017-02-16 Sulfonilureas y compuestos relacionados y sus usos. MX2018009840A (es)

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